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GSE58827: Dynamics of the Mouse Liver

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Results for Hnf1b

Z-value: 2.40

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Transcription factors associated with Hnf1b

Gene Symbol Gene ID Gene Info
Hnf1b
ENSMUSG00000020679.5 HNF1 homeobox B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1bmm10_v2_chr11_+_83850832_838508550.076.9e-01Click!

Activity profile of Hnf1b motif

Sorted Z-values of Hnf1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_87337165 25.70 ENSMUST00000031195.2
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr11_-_84167466 25.05 ENSMUST00000050771.7
Gm11437
predicted gene 11437
chr8_-_5105232 24.67 ENSMUST00000023835.1
Slc10a2
solute carrier family 10, member 2
chr5_-_89457763 23.29 ENSMUST00000049209.8
Gc
group specific component
chr9_-_48605147 20.82 ENSMUST00000034808.5
ENSMUST00000119426.1
Nnmt
nicotinamide N-methyltransferase
chr15_+_10215955 19.12 ENSMUST00000130720.1
Prlr
prolactin receptor
chr13_-_23914998 18.89 ENSMUST00000021769.8
ENSMUST00000110407.2
Slc17a4
solute carrier family 17 (sodium phosphate), member 4
chr1_-_130661584 17.91 ENSMUST00000137276.2
C4bp
complement component 4 binding protein
chr1_-_130661613 17.54 ENSMUST00000027657.7
C4bp
complement component 4 binding protein
chr11_-_78422217 16.97 ENSMUST00000001122.5
Slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr11_+_101367542 16.79 ENSMUST00000019469.2
G6pc
glucose-6-phosphatase, catalytic
chr13_+_4233730 15.96 ENSMUST00000081326.6
Akr1c19
aldo-keto reductase family 1, member C19
chr2_-_134554348 14.49 ENSMUST00000028704.2
Hao1
hydroxyacid oxidase 1, liver
chr1_+_88211956 14.47 ENSMUST00000073049.6
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr4_+_138967112 14.23 ENSMUST00000116094.2
Rnf186
ring finger protein 186
chr19_+_30232921 13.57 ENSMUST00000025797.5
Mbl2
mannose-binding lectin (protein C) 2
chr4_-_104876383 13.55 ENSMUST00000064873.8
ENSMUST00000106808.3
ENSMUST00000048947.8
C8a
complement component 8, alpha polypeptide
chr1_+_181051232 13.12 ENSMUST00000036819.6
9130409I23Rik
RIKEN cDNA 9130409I23 gene
chr16_+_22951072 13.05 ENSMUST00000023590.8
Hrg
histidine-rich glycoprotein
chr1_+_88070765 12.67 ENSMUST00000073772.4
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr1_+_88166004 12.59 ENSMUST00000097659.4
Ugt1a5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr19_-_46672883 12.51 ENSMUST00000026012.7
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
chr13_+_23807027 12.27 ENSMUST00000006786.4
ENSMUST00000099697.2
Slc17a2
solute carrier family 17 (sodium phosphate), member 2
chr5_-_87254804 12.02 ENSMUST00000075858.3
Ugt2b37
UDP glucuronosyltransferase 2 family, polypeptide B37
chr13_-_4279420 11.95 ENSMUST00000021632.3
Akr1c12
aldo-keto reductase family 1, member C12
chr5_+_90518932 11.42 ENSMUST00000113179.2
ENSMUST00000128740.1
Afm
afamin
chr5_-_87092546 11.03 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chr2_-_35100677 10.86 ENSMUST00000045776.4
ENSMUST00000113050.3
AI182371
expressed sequence AI182371
chr13_+_4191163 10.81 ENSMUST00000021634.2
Akr1c13
aldo-keto reductase family 1, member C13
chr1_+_88138364 10.45 ENSMUST00000014263.4
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr2_-_62412219 10.28 ENSMUST00000047812.7
Dpp4
dipeptidylpeptidase 4
chr4_-_108144986 9.99 ENSMUST00000130776.1
Scp2
sterol carrier protein 2, liver
chr3_+_129836729 9.95 ENSMUST00000077918.5
Cfi
complement component factor i
chr5_-_87569023 9.77 ENSMUST00000113314.2
Sult1d1
sulfotransferase family 1D, member 1
chr5_-_87535113 9.53 ENSMUST00000120150.1
Sult1b1
sulfotransferase family 1B, member 1
chr17_+_12378603 9.14 ENSMUST00000014578.5
Plg
plasminogen
chr11_-_11898044 8.91 ENSMUST00000066237.3
Ddc
dopa decarboxylase
chr11_-_11898092 8.78 ENSMUST00000178704.1
Ddc
dopa decarboxylase
chr2_-_86347764 8.72 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chr13_+_93674403 8.50 ENSMUST00000048001.6
Dmgdh
dimethylglycine dehydrogenase precursor
chr1_+_88055377 8.39 ENSMUST00000138182.1
ENSMUST00000113142.3
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr13_+_23839445 8.24 ENSMUST00000091698.4
ENSMUST00000110422.1
Slc17a3
solute carrier family 17 (sodium phosphate), member 3
chr1_+_88055467 8.24 ENSMUST00000173325.1
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr16_+_43247278 8.17 ENSMUST00000114691.1
ENSMUST00000079441.6
Zbtb20
zinc finger and BTB domain containing 20
chr13_+_23839401 8.10 ENSMUST00000039721.7
ENSMUST00000166467.1
Slc17a3
solute carrier family 17 (sodium phosphate), member 3
chr5_+_90460889 7.98 ENSMUST00000031314.8
Alb
albumin
chr4_-_140617062 7.94 ENSMUST00000154979.1
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr6_+_90333270 7.92 ENSMUST00000164761.1
ENSMUST00000046128.9
Uroc1
urocanase domain containing 1
chr12_+_59095653 7.81 ENSMUST00000021384.4
Mia2
melanoma inhibitory activity 2
chr7_+_119561699 7.62 ENSMUST00000167935.2
ENSMUST00000130583.1
Acsm2
acyl-CoA synthetase medium-chain family member 2
chr15_-_50890396 7.57 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr2_-_35061431 7.39 ENSMUST00000028233.3
Hc
hemolytic complement
chr3_+_115080965 6.92 ENSMUST00000051309.8
Olfm3
olfactomedin 3
chr10_-_89533550 6.85 ENSMUST00000105297.1
Nr1h4
nuclear receptor subfamily 1, group H, member 4
chr11_+_70519619 6.81 ENSMUST00000179000.1
Gltpd2
glycolipid transfer protein domain containing 2
chr11_-_73326807 6.77 ENSMUST00000134079.1
Aspa
aspartoacylase
chr3_-_138131356 6.68 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr3_-_98564038 6.63 ENSMUST00000058728.5
Gm10681
predicted gene 10681
chr2_+_163547148 6.58 ENSMUST00000109411.1
ENSMUST00000018094.6
Hnf4a
hepatic nuclear factor 4, alpha
chr9_+_21835506 6.26 ENSMUST00000058777.6
Gm6484
predicted gene 6484
chr7_-_119895446 6.25 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr1_-_20617992 6.20 ENSMUST00000088448.5
Pkhd1
polycystic kidney and hepatic disease 1
chr10_+_4611971 6.00 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1
estrogen receptor 1 (alpha)
chr13_-_93674300 5.97 ENSMUST00000015941.7
Bhmt2
betaine-homocysteine methyltransferase 2
chr2_+_162987330 5.95 ENSMUST00000018012.7
Sgk2
serum/glucocorticoid regulated kinase 2
chr4_-_6275629 5.88 ENSMUST00000029905.1
Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
chr2_+_162987502 5.85 ENSMUST00000117123.1
Sgk2
serum/glucocorticoid regulated kinase 2
chr11_-_73326472 5.80 ENSMUST00000155630.2
Aspa
aspartoacylase
chr4_+_150853919 5.78 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr16_+_96361654 5.77 ENSMUST00000113794.1
Igsf5
immunoglobulin superfamily, member 5
chr11_+_78465697 5.71 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chr9_-_71163224 5.60 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr10_-_89621253 5.53 ENSMUST00000020102.7
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr19_+_43782181 5.53 ENSMUST00000026208.4
Abcc2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr5_+_102845007 5.41 ENSMUST00000070000.4
Arhgap24
Rho GTPase activating protein 24
chr13_+_89540636 5.21 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr3_-_116712696 5.20 ENSMUST00000169530.1
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr3_+_14480692 5.14 ENSMUST00000037321.7
ENSMUST00000120484.1
ENSMUST00000120801.1
Slc7a12
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr16_+_96361749 5.09 ENSMUST00000000163.6
ENSMUST00000081093.3
ENSMUST00000113795.1
Igsf5
immunoglobulin superfamily, member 5
chr13_+_55152640 5.02 ENSMUST00000005452.5
Fgfr4
fibroblast growth factor receptor 4
chr5_-_108675569 4.97 ENSMUST00000051757.7
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr15_+_99393574 4.92 ENSMUST00000162624.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr12_+_76533540 4.91 ENSMUST00000075249.4
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_+_101376359 4.86 ENSMUST00000119080.1
Gjb1
gap junction protein, beta 1
chr1_+_133246092 4.85 ENSMUST00000038295.8
ENSMUST00000105082.2
Plekha6
pleckstrin homology domain containing, family A member 6
chr7_-_45103747 4.85 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr10_+_61089327 4.73 ENSMUST00000020298.6
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr15_+_99393610 4.73 ENSMUST00000159531.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr4_+_99030946 4.57 ENSMUST00000030280.6
Angptl3
angiopoietin-like 3
chr7_-_27166732 4.44 ENSMUST00000080058.4
Egln2
EGL nine homolog 2 (C. elegans)
chr4_+_48279794 4.36 ENSMUST00000030029.3
Invs
inversin
chr11_+_108395288 4.31 ENSMUST00000000049.5
Apoh
apolipoprotein H
chr2_-_164221605 4.22 ENSMUST00000018355.4
ENSMUST00000109376.2
Wfdc15b
WAP four-disulfide core domain 15B
chr5_+_31297551 4.21 ENSMUST00000072228.5
Gckr
glucokinase regulatory protein
chr15_-_55113460 4.17 ENSMUST00000100659.2
ENSMUST00000110230.1
Gm9920
predicted gene 9920
chr11_+_70519183 4.13 ENSMUST00000057685.2
Gltpd2
glycolipid transfer protein domain containing 2
chr19_+_42045792 3.89 ENSMUST00000172244.1
ENSMUST00000081714.4
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr7_-_127895578 3.88 ENSMUST00000033074.6
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr11_+_4883186 3.85 ENSMUST00000139737.1
Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr16_+_24448082 3.80 ENSMUST00000078988.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr11_+_78037931 3.79 ENSMUST00000072289.5
ENSMUST00000100784.2
Flot2
flotillin 2
chr5_+_35041539 3.76 ENSMUST00000030985.6
Hgfac
hepatocyte growth factor activator
chr2_+_163506808 3.71 ENSMUST00000143911.1
Hnf4a
hepatic nuclear factor 4, alpha
chrX_+_140907602 3.69 ENSMUST00000033806.4
Vsig1
V-set and immunoglobulin domain containing 1
chr12_+_4769375 3.68 ENSMUST00000178879.1
Pfn4
profilin family, member 4
chr17_+_74395607 3.60 ENSMUST00000179074.1
ENSMUST00000024870.6
Slc30a6
solute carrier family 30 (zinc transporter), member 6
chr9_+_72958785 3.53 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1
dyslexia susceptibility 1 candidate 1 homolog (human)
chr5_-_38491948 3.49 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr5_-_114444036 3.48 ENSMUST00000031560.7
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr19_+_5878622 3.46 ENSMUST00000136833.1
ENSMUST00000141362.1
Slc25a45
solute carrier family 25, member 45
chr9_+_54538984 3.45 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7
SH2 domain containing 7
chr1_-_136960427 3.41 ENSMUST00000027649.7
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr19_+_60889749 3.40 ENSMUST00000003313.8
Grk5
G protein-coupled receptor kinase 5
chr5_-_114443993 3.38 ENSMUST00000112245.1
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr13_+_66932802 3.37 ENSMUST00000021990.3
Ptdss1
phosphatidylserine synthase 1
chr10_+_63061582 3.36 ENSMUST00000020266.8
ENSMUST00000178684.1
Pbld1
phenazine biosynthesis-like protein domain containing 1
chr9_+_120149733 3.33 ENSMUST00000068698.7
ENSMUST00000093773.1
ENSMUST00000111627.1
Mobp
myelin-associated oligodendrocytic basic protein
chr1_+_133309778 3.27 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
Golt1a
Kiss1
GOLT1A
golgi transport 1 homolog A (S. cerevisiae)
KiSS-1 metastasis-suppressor
KISS1 isoform e
chr6_+_73248382 3.26 ENSMUST00000064740.6
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
chr3_+_154597352 3.19 ENSMUST00000140644.1
ENSMUST00000144764.1
ENSMUST00000155232.1
Cryz
crystallin, zeta
chr3_+_90537242 3.17 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr3_-_98457031 3.16 ENSMUST00000167753.1
Gm4450
predicted gene 4450
chr1_+_172126750 3.11 ENSMUST00000075895.2
ENSMUST00000111252.3
Pex19
peroxisomal biogenesis factor 19
chr11_+_78037959 3.08 ENSMUST00000073660.6
Flot2
flotillin 2
chr18_+_33464163 3.06 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr19_+_56287943 3.03 ENSMUST00000166049.1
Habp2
hyaluronic acid binding protein 2
chr12_-_103631404 3.03 ENSMUST00000121625.1
ENSMUST00000044231.5
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chrX_+_52791179 3.01 ENSMUST00000101588.1
Ccdc160
coiled-coil domain containing 160
chr9_+_95559817 2.88 ENSMUST00000079597.5
Paqr9
progestin and adipoQ receptor family member IX
chr19_+_56287911 2.87 ENSMUST00000095948.4
Habp2
hyaluronic acid binding protein 2
chr3_-_116712644 2.86 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr7_-_5805445 2.77 ENSMUST00000075085.6
Vmn1r63
vomeronasal 1 receptor 63
chr18_+_20310738 2.73 ENSMUST00000077146.3
Dsg1a
desmoglein 1 alpha
chr6_-_129100903 2.72 ENSMUST00000032258.6
Clec2e
C-type lectin domain family 2, member e
chr7_+_120173847 2.62 ENSMUST00000033201.5
Anks4b
ankyrin repeat and sterile alpha motif domain containing 4B
chr11_+_46571536 2.54 ENSMUST00000050937.6
BC053393
cDNA sequence BC053393
chr8_+_95715901 2.53 ENSMUST00000034096.4
Setd6
SET domain containing 6
chr7_-_45062393 2.51 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr9_-_70934808 2.46 ENSMUST00000034731.8
Lipc
lipase, hepatic
chrM_+_2743 2.45 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr4_-_139968026 2.40 ENSMUST00000105031.2
Klhdc7a
kelch domain containing 7A
chr14_-_36919314 2.29 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr3_+_90537306 2.24 ENSMUST00000107335.1
S100a16
S100 calcium binding protein A16
chr11_+_110968016 2.24 ENSMUST00000106636.1
ENSMUST00000180023.1
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_+_65348386 2.21 ENSMUST00000031096.7
Klb
klotho beta
chr4_-_150909428 2.17 ENSMUST00000128075.1
ENSMUST00000105674.1
ENSMUST00000105673.1
Park7
Parkinson disease (autosomal recessive, early onset) 7
chr14_-_36919513 2.13 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr5_-_87490869 2.10 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr7_-_6011010 2.08 ENSMUST00000086338.1
Vmn1r65
vomeronasal 1 receptor 65
chr11_+_118428203 2.06 ENSMUST00000124861.1
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr11_-_75937726 1.97 ENSMUST00000121287.1
Rph3al
rabphilin 3A-like (without C2 domains)
chr17_+_23660477 1.96 ENSMUST00000062967.8
Ccdc64b
coiled-coil domain containing 64B
chr7_+_141216626 1.96 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr17_+_57062486 1.96 ENSMUST00000163628.1
Crb3
crumbs homolog 3 (Drosophila)
chr6_+_48647224 1.92 ENSMUST00000078223.3
Gimap8
GTPase, IMAP family member 8
chr18_-_66022580 1.91 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr11_-_75937677 1.90 ENSMUST00000108420.2
Rph3al
rabphilin 3A-like (without C2 domains)
chr6_-_24168083 1.87 ENSMUST00000031713.8
Slc13a1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr8_-_67974567 1.85 ENSMUST00000098696.3
ENSMUST00000038959.9
ENSMUST00000093469.4
Psd3
pleckstrin and Sec7 domain containing 3
chr11_+_78178105 1.83 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chr3_-_83049797 1.82 ENSMUST00000048246.3
Fgb
fibrinogen beta chain
chr7_+_83148644 1.80 ENSMUST00000066005.5
A530021J07Rik
Riken cDNA A530021J07 gene
chr1_+_58795371 1.75 ENSMUST00000027189.8
Casp8
caspase 8
chr15_-_10713537 1.72 ENSMUST00000090339.3
Rai14
retinoic acid induced 14
chr1_-_187215454 1.72 ENSMUST00000183819.1
Spata17
spermatogenesis associated 17
chr14_+_48446128 1.72 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr1_-_141257158 1.62 ENSMUST00000179202.1
Gm4845
predicted gene 4845
chr6_-_128437653 1.56 ENSMUST00000151796.1
Fkbp4
FK506 binding protein 4
chr16_-_92358874 1.50 ENSMUST00000166707.1
Kcne1
potassium voltage-gated channel, Isk-related subfamily, member 1
chrM_+_7759 1.49 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr2_+_91265252 1.47 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr14_+_48446340 1.44 ENSMUST00000111735.2
Tmem260
transmembrane protein 260
chr13_-_73678005 1.39 ENSMUST00000022105.7
ENSMUST00000109680.2
ENSMUST00000109679.2
Slc6a18
solute carrier family 6 (neurotransmitter transporter), member 18
chr2_+_3770673 1.35 ENSMUST00000177037.1
Fam107b
family with sequence similarity 107, member B
chr19_-_11856001 1.33 ENSMUST00000079875.3
Olfr1418
olfactory receptor 1418
chr19_+_26885925 1.33 ENSMUST00000099536.2
Gm815
predicted gene 815
chr2_+_125152505 1.32 ENSMUST00000110494.2
ENSMUST00000028630.2
ENSMUST00000110495.2
Slc12a1
solute carrier family 12, member 1
chr5_-_106926245 1.32 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr6_-_52240841 1.32 ENSMUST00000121043.1
Hoxa10
homeobox A10
chr9_+_54980880 1.29 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr5_-_90640464 1.29 ENSMUST00000031317.6
Rassf6
Ras association (RalGDS/AF-6) domain family member 6
chr10_-_7212222 1.28 ENSMUST00000015346.5
Cnksr3
Cnksr family member 3
chr2_+_151494274 1.27 ENSMUST00000028949.9
ENSMUST00000103160.4
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr19_-_30549516 1.26 ENSMUST00000025803.8
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr1_-_187215421 1.25 ENSMUST00000110945.3
ENSMUST00000183931.1
ENSMUST00000027908.6
Spata17
spermatogenesis associated 17
chr1_-_12991109 1.23 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1
solute carrier organic anion transporter family, member 5A1
chr17_+_57062231 1.23 ENSMUST00000097299.3
ENSMUST00000169543.1
ENSMUST00000163763.1
Crb3
crumbs homolog 3 (Drosophila)
chr5_+_95742014 1.23 ENSMUST00000154086.1
Gm7982
predicted gene 7982
chrY_-_35130404 1.22 ENSMUST00000180170.1
Gm20855
predicted gene, 20855
chr11_+_110968056 1.21 ENSMUST00000125692.1
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_-_76795489 1.15 ENSMUST00000082431.3
Gpx2
glutathione peroxidase 2
chr11_+_23665615 1.13 ENSMUST00000109525.1
ENSMUST00000020520.4
Pus10
pseudouridylate synthase 10
chr10_+_79468943 1.07 ENSMUST00000167976.2
Vmn2r83
vomeronasal 2, receptor 83
chr8_-_22694061 1.04 ENSMUST00000131767.1
Ikbkb
inhibitor of kappaB kinase beta
chr19_-_57197556 1.00 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr13_-_21453714 0.98 ENSMUST00000032820.7
ENSMUST00000110485.1
Zscan26
zinc finger and SCAN domain containing 26
chr5_-_121527186 0.98 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr11_+_85832551 0.94 ENSMUST00000000095.6
Tbx2
T-box 2
chr8_+_70724064 0.91 ENSMUST00000034307.7
ENSMUST00000110095.2
Pde4c
phosphodiesterase 4C, cAMP specific
chr9_+_109096659 0.91 ENSMUST00000130366.1
Plxnb1
plexin B1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 66.8 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
5.6 27.8 GO:0052695 cellular glucuronidation(GO:0052695)
5.5 5.5 GO:0050787 detoxification of mercury ion(GO:0050787)
4.4 13.1 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
4.2 16.7 GO:0009441 glycolate metabolic process(GO:0009441)
3.4 10.3 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
3.4 10.3 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
3.2 19.1 GO:0038161 prolactin signaling pathway(GO:0038161)
3.2 9.5 GO:0009812 flavonoid metabolic process(GO:0009812)
2.8 16.8 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
2.7 8.0 GO:0051659 maintenance of mitochondrion location(GO:0051659)
2.5 17.7 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
2.5 10.0 GO:0032379 positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
2.3 6.9 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
2.3 6.9 GO:0034971 histone H3-R17 methylation(GO:0034971)
2.1 12.6 GO:0006083 acetate metabolic process(GO:0006083)
2.0 9.8 GO:0000103 sulfate assimilation(GO:0000103)
1.9 9.6 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.8 9.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.7 5.0 GO:0061144 alveolar secondary septum development(GO:0061144)
1.6 8.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
1.6 79.9 GO:0006958 complement activation, classical pathway(GO:0006958)
1.6 7.9 GO:0006548 histidine catabolic process(GO:0006548)
1.6 11.0 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
1.5 24.0 GO:0046415 urate metabolic process(GO:0046415)
1.4 5.7 GO:0015886 heme transport(GO:0015886)
1.4 5.6 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
1.3 3.9 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
1.3 7.6 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
1.2 23.3 GO:0042359 vitamin D metabolic process(GO:0042359)
1.2 5.9 GO:1904253 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
1.2 5.8 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
1.1 3.4 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
1.1 3.3 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
1.1 8.5 GO:0019695 choline metabolic process(GO:0019695)
1.0 24.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.0 6.0 GO:0060745 Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523) mammary gland branching involved in pregnancy(GO:0060745)
1.0 6.0 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
1.0 6.9 GO:0009235 cobalamin metabolic process(GO:0009235)
1.0 3.9 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.9 4.6 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.9 4.4 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.8 3.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.8 2.3 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.7 5.0 GO:0019532 oxalate transport(GO:0019532)
0.7 3.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.7 12.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.6 5.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.6 1.8 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.6 4.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.5 4.7 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.5 3.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.5 25.9 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.5 3.4 GO:0061113 pancreas morphogenesis(GO:0061113)
0.5 0.5 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.5 1.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.4 4.9 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.4 1.3 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.4 3.7 GO:0042989 sequestering of actin monomers(GO:0042989)
0.4 0.8 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.4 6.2 GO:0010225 response to UV-C(GO:0010225)
0.4 3.7 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.3 10.3 GO:0055090 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.3 7.9 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.3 3.3 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.3 3.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.3 2.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 0.9 GO:0007521 muscle cell fate determination(GO:0007521)
0.3 7.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.3 3.6 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.3 0.8 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.3 1.3 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.3 1.0 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.2 30.8 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.2 3.5 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 0.5 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 2.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2 0.9 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.2 5.5 GO:0015813 L-glutamate transport(GO:0015813)
0.2 8.5 GO:0051180 vitamin transport(GO:0051180)
0.2 1.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 8.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 6.2 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 4.3 GO:0010107 potassium ion import(GO:0010107)
0.1 0.4 GO:0044860 protein localization to plasma membrane raft(GO:0044860)
0.1 1.7 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 1.0 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 12.4 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.1 0.6 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.1 2.4 GO:0033194 response to hydroperoxide(GO:0033194)
0.1 17.8 GO:0098656 anion transmembrane transport(GO:0098656)
0.1 0.5 GO:0010159 specification of organ position(GO:0010159)
0.1 1.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 1.3 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 1.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.6 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 3.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.4 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 4.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.9 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.5 GO:0032328 alanine transport(GO:0032328)
0.1 0.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 21.1 GO:0032259 methylation(GO:0032259)
0.0 4.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.3 GO:0060065 uterus development(GO:0060065)
0.0 0.8 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.9 GO:0070232 regulation of T cell apoptotic process(GO:0070232)
0.0 2.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 12.9 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 0.2 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.0 0.6 GO:0030238 male sex determination(GO:0030238)
0.0 1.1 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0072114 regulation of pronephros size(GO:0035565) pronephric nephron tubule development(GO:0039020) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) pronephros morphogenesis(GO:0072114) mesonephric duct formation(GO:0072181) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.0 1.9 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 3.9 GO:0019233 sensory perception of pain(GO:0019233)
0.0 0.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 4.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 3.0 GO:0051592 response to calcium ion(GO:0051592)
0.0 0.1 GO:0051001 negative regulation of monooxygenase activity(GO:0032769) negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.2 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0 0.0 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 3.5 GO:0006839 mitochondrial transport(GO:0006839)
0.0 2.6 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.1 GO:0032010 phagolysosome(GO:0032010)
2.3 9.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
2.1 20.9 GO:0005579 membrane attack complex(GO:0005579)
1.5 4.4 GO:0097543 ciliary inversin compartment(GO:0097543)
1.4 5.5 GO:0097450 astrocyte end-foot(GO:0097450)
1.3 10.3 GO:0071438 invadopodium membrane(GO:0071438)
1.0 14.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.9 6.0 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.8 10.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.8 0.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.6 1.8 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.6 1.7 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.5 3.3 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.5 6.9 GO:0001931 uropod(GO:0001931) flotillin complex(GO:0016600) cell trailing edge(GO:0031254)
0.5 5.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.4 4.3 GO:0042627 chylomicron(GO:0042627)
0.3 8.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.3 42.1 GO:0072562 blood microparticle(GO:0072562)
0.3 24.7 GO:0000502 proteasome complex(GO:0000502)
0.2 2.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 4.9 GO:0005922 connexon complex(GO:0005922)
0.2 6.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 15.6 GO:0005581 collagen trimer(GO:0005581)
0.1 6.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.9 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 15.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 4.6 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.7 GO:0030057 desmosome(GO:0030057)
0.1 31.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 6.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 17.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 14.8 GO:0008021 synaptic vesicle(GO:0008021)
0.1 1.0 GO:0035631 IkappaB kinase complex(GO:0008385) CD40 receptor complex(GO:0035631)
0.1 24.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 16.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 1.0 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 0.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 9.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 1.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 5.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 18.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 41.7 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 5.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 6.9 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)
0.0 0.2 GO:0031201 SNARE complex(GO:0031201)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 23.3 GO:1902271 D3 vitamins binding(GO:1902271)
5.6 16.8 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
4.4 17.7 GO:0004058 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
4.2 12.6 GO:0019807 aspartoacylase activity(GO:0019807)
3.9 19.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
3.8 19.1 GO:0004925 prolactin receptor activity(GO:0004925)
3.8 11.4 GO:0008431 vitamin E binding(GO:0008431)
3.7 47.5 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
3.6 14.5 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
3.5 24.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
3.4 10.3 GO:0070540 stearic acid binding(GO:0070540)
3.3 13.1 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
3.1 117.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
2.5 10.0 GO:0033814 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
2.3 6.9 GO:0038181 bile acid receptor activity(GO:0038181)
2.1 8.5 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
2.0 6.0 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
1.9 13.6 GO:0005534 galactose binding(GO:0005534)
1.6 9.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.4 5.7 GO:0015232 heme transporter activity(GO:0015232)
1.1 5.6 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
1.1 7.6 GO:0003996 acyl-CoA ligase activity(GO:0003996)
1.1 3.3 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.1 3.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
1.0 16.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
1.0 6.0 GO:0008172 S-methyltransferase activity(GO:0008172)
1.0 22.8 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
1.0 4.8 GO:0019770 IgG receptor activity(GO:0019770)
0.9 4.7 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.9 10.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.9 3.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.7 2.2 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.7 9.1 GO:1990405 protein antigen binding(GO:1990405)
0.7 4.6 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.6 4.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.6 12.4 GO:0019825 oxygen binding(GO:0019825)
0.6 5.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 4.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.5 11.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.5 12.5 GO:0001848 complement binding(GO:0001848)
0.4 1.3 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.4 1.8 GO:0035877 death effector domain binding(GO:0035877)
0.4 2.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.4 6.8 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.3 8.1 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.3 3.9 GO:0030274 LIM domain binding(GO:0030274)
0.3 1.6 GO:0032767 copper-dependent protein binding(GO:0032767)
0.3 3.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.3 0.6 GO:0019864 IgG binding(GO:0019864)
0.3 4.9 GO:0005243 gap junction channel activity(GO:0005243)
0.3 5.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.3 3.5 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 3.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 23.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.2 6.2 GO:0097602 cullin family protein binding(GO:0097602)
0.2 5.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 3.9 GO:0048038 quinone binding(GO:0048038)
0.2 1.0 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 0.6 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.2 5.1 GO:0042165 neurotransmitter binding(GO:0042165)
0.2 7.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 0.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.2 10.1 GO:0005549 odorant binding(GO:0005549)
0.2 13.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 5.9 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.3 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 7.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 3.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 2.7 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.8 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 6.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 3.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 3.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 12.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 2.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 3.7 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.9 GO:0005537 mannose binding(GO:0005537)
0.1 6.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 11.3 GO:0030165 PDZ domain binding(GO:0030165)
0.1 11.7 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.1 1.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 12.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.5 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 0.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 6.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 0.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 1.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 1.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.5 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 5.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 2.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 4.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 4.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.7 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 5.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.3 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.8 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 19.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 9.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 15.7 PID FOXO PATHWAY FoxO family signaling
0.2 4.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 8.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 1.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 6.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 6.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 5.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 5.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 7.2 PID FGF PATHWAY FGF signaling pathway
0.1 5.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 10.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 7.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 17.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.8 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.6 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 1.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 12.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID AR TF PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 32.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
3.2 41.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
1.7 13.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.4 18.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
1.3 18.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
1.0 19.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.9 23.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.9 17.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.8 23.3 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.7 9.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.7 10.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.5 10.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 3.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.4 21.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.4 10.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.4 20.8 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.3 3.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 9.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.3 7.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 5.0 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 4.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 3.5 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 4.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 8.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 8.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 1.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 6.0 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 2.8 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.2 2.3 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.1 3.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 27.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 12.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 7.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 5.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 6.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 4.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.7 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.7 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 6.7 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 5.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.6 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell