Motif ID: Hnf1b

Z-value: 2.402


Transcription factors associated with Hnf1b:

Gene SymbolEntrez IDGene Name
Hnf1b ENSMUSG00000020679.5 Hnf1b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hnf1bmm10_v2_chr11_+_83850832_838508550.076.9e-01Click!


Activity profile for motif Hnf1b.

activity profile for motif Hnf1b


Sorted Z-values histogram for motif Hnf1b

Sorted Z-values for motif Hnf1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1b

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_87337165 25.700 ENSMUST00000031195.2
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr11_-_84167466 25.046 ENSMUST00000050771.7
Gm11437
predicted gene 11437
chr8_-_5105232 24.670 ENSMUST00000023835.1
Slc10a2
solute carrier family 10, member 2
chr5_-_89457763 23.294 ENSMUST00000049209.8
Gc
group specific component
chr9_-_48605147 20.822 ENSMUST00000034808.5
ENSMUST00000119426.1
Nnmt

nicotinamide N-methyltransferase

chr15_+_10215955 19.119 ENSMUST00000130720.1
Prlr
prolactin receptor
chr13_-_23914998 18.889 ENSMUST00000021769.8
ENSMUST00000110407.2
Slc17a4

solute carrier family 17 (sodium phosphate), member 4

chr1_-_130661584 17.911 ENSMUST00000137276.2
C4bp
complement component 4 binding protein
chr1_-_130661613 17.542 ENSMUST00000027657.7
C4bp
complement component 4 binding protein
chr11_-_78422217 16.969 ENSMUST00000001122.5
Slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr11_+_101367542 16.791 ENSMUST00000019469.2
G6pc
glucose-6-phosphatase, catalytic
chr13_+_4233730 15.957 ENSMUST00000081326.6
Akr1c19
aldo-keto reductase family 1, member C19
chr2_-_134554348 14.489 ENSMUST00000028704.2
Hao1
hydroxyacid oxidase 1, liver
chr1_+_88211956 14.470 ENSMUST00000073049.6
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr4_+_138967112 14.232 ENSMUST00000116094.2
Rnf186
ring finger protein 186
chr19_+_30232921 13.574 ENSMUST00000025797.5
Mbl2
mannose-binding lectin (protein C) 2
chr4_-_104876383 13.553 ENSMUST00000064873.8
ENSMUST00000106808.3
ENSMUST00000048947.8
C8a


complement component 8, alpha polypeptide


chr1_+_181051232 13.119 ENSMUST00000036819.6
9130409I23Rik
RIKEN cDNA 9130409I23 gene
chr16_+_22951072 13.052 ENSMUST00000023590.8
Hrg
histidine-rich glycoprotein
chr1_+_88070765 12.673 ENSMUST00000073772.4
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr1_+_88166004 12.589 ENSMUST00000097659.4
Ugt1a5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr19_-_46672883 12.515 ENSMUST00000026012.7
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
chr13_+_23807027 12.273 ENSMUST00000006786.4
ENSMUST00000099697.2
Slc17a2

solute carrier family 17 (sodium phosphate), member 2

chr5_-_87254804 12.022 ENSMUST00000075858.3
Ugt2b37
UDP glucuronosyltransferase 2 family, polypeptide B37
chr13_-_4279420 11.949 ENSMUST00000021632.3
Akr1c12
aldo-keto reductase family 1, member C12
chr5_+_90518932 11.418 ENSMUST00000113179.2
ENSMUST00000128740.1
Afm

afamin

chr5_-_87092546 11.027 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
Ugt2b36


UDP glucuronosyltransferase 2 family, polypeptide B36


chr2_-_35100677 10.859 ENSMUST00000045776.4
ENSMUST00000113050.3
AI182371

expressed sequence AI182371

chr13_+_4191163 10.808 ENSMUST00000021634.2
Akr1c13
aldo-keto reductase family 1, member C13
chr1_+_88138364 10.455 ENSMUST00000014263.4
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr2_-_62412219 10.278 ENSMUST00000047812.7
Dpp4
dipeptidylpeptidase 4
chr4_-_108144986 9.992 ENSMUST00000130776.1
Scp2
sterol carrier protein 2, liver
chr3_+_129836729 9.948 ENSMUST00000077918.5
Cfi
complement component factor i
chr5_-_87569023 9.770 ENSMUST00000113314.2
Sult1d1
sulfotransferase family 1D, member 1
chr5_-_87535113 9.531 ENSMUST00000120150.1
Sult1b1
sulfotransferase family 1B, member 1
chr17_+_12378603 9.138 ENSMUST00000014578.5
Plg
plasminogen
chr11_-_11898044 8.910 ENSMUST00000066237.3
Ddc
dopa decarboxylase
chr11_-_11898092 8.779 ENSMUST00000178704.1
Ddc
dopa decarboxylase
chr2_-_86347764 8.718 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chr13_+_93674403 8.504 ENSMUST00000048001.6
Dmgdh
dimethylglycine dehydrogenase precursor
chr1_+_88055377 8.392 ENSMUST00000138182.1
ENSMUST00000113142.3
Ugt1a10

UDP glycosyltransferase 1 family, polypeptide A10

chr13_+_23839445 8.243 ENSMUST00000091698.4
ENSMUST00000110422.1
Slc17a3

solute carrier family 17 (sodium phosphate), member 3

chr1_+_88055467 8.236 ENSMUST00000173325.1
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr16_+_43247278 8.174 ENSMUST00000114691.1
ENSMUST00000079441.6
Zbtb20

zinc finger and BTB domain containing 20

chr13_+_23839401 8.103 ENSMUST00000039721.7
ENSMUST00000166467.1
Slc17a3

solute carrier family 17 (sodium phosphate), member 3

chr5_+_90460889 7.982 ENSMUST00000031314.8
Alb
albumin
chr4_-_140617062 7.941 ENSMUST00000154979.1
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr6_+_90333270 7.920 ENSMUST00000164761.1
ENSMUST00000046128.9
Uroc1

urocanase domain containing 1

chr12_+_59095653 7.812 ENSMUST00000021384.4
Mia2
melanoma inhibitory activity 2
chr7_+_119561699 7.621 ENSMUST00000167935.2
ENSMUST00000130583.1
Acsm2

acyl-CoA synthetase medium-chain family member 2

chr15_-_50890396 7.568 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr2_-_35061431 7.387 ENSMUST00000028233.3
Hc
hemolytic complement
chr3_+_115080965 6.922 ENSMUST00000051309.8
Olfm3
olfactomedin 3
chr10_-_89533550 6.852 ENSMUST00000105297.1
Nr1h4
nuclear receptor subfamily 1, group H, member 4
chr11_+_70519619 6.814 ENSMUST00000179000.1
Gltpd2
glycolipid transfer protein domain containing 2
chr11_-_73326807 6.774 ENSMUST00000134079.1
Aspa
aspartoacylase
chr3_-_138131356 6.677 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr3_-_98564038 6.632 ENSMUST00000058728.5
Gm10681
predicted gene 10681
chr2_+_163547148 6.578 ENSMUST00000109411.1
ENSMUST00000018094.6
Hnf4a

hepatic nuclear factor 4, alpha

chr9_+_21835506 6.261 ENSMUST00000058777.6
Gm6484
predicted gene 6484
chr7_-_119895446 6.248 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr1_-_20617992 6.205 ENSMUST00000088448.5
Pkhd1
polycystic kidney and hepatic disease 1
chr10_+_4611971 6.004 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1

estrogen receptor 1 (alpha)

chr13_-_93674300 5.968 ENSMUST00000015941.7
Bhmt2
betaine-homocysteine methyltransferase 2
chr2_+_162987330 5.945 ENSMUST00000018012.7
Sgk2
serum/glucocorticoid regulated kinase 2
chr4_-_6275629 5.882 ENSMUST00000029905.1
Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
chr2_+_162987502 5.845 ENSMUST00000117123.1
Sgk2
serum/glucocorticoid regulated kinase 2
chr11_-_73326472 5.800 ENSMUST00000155630.2
Aspa
aspartoacylase
chr4_+_150853919 5.784 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr16_+_96361654 5.772 ENSMUST00000113794.1
Igsf5
immunoglobulin superfamily, member 5
chr11_+_78465697 5.713 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chr9_-_71163224 5.597 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr10_-_89621253 5.535 ENSMUST00000020102.7
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr19_+_43782181 5.530 ENSMUST00000026208.4
Abcc2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr5_+_102845007 5.406 ENSMUST00000070000.4
Arhgap24
Rho GTPase activating protein 24
chr13_+_89540636 5.210 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr3_-_116712696 5.197 ENSMUST00000169530.1
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr3_+_14480692 5.144 ENSMUST00000037321.7
ENSMUST00000120484.1
ENSMUST00000120801.1
Slc7a12


solute carrier family 7 (cationic amino acid transporter, y+ system), member 12


chr16_+_96361749 5.092 ENSMUST00000000163.6
ENSMUST00000081093.3
ENSMUST00000113795.1
Igsf5


immunoglobulin superfamily, member 5


chr13_+_55152640 5.021 ENSMUST00000005452.5
Fgfr4
fibroblast growth factor receptor 4
chr5_-_108675569 4.975 ENSMUST00000051757.7
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr15_+_99393574 4.923 ENSMUST00000162624.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr12_+_76533540 4.909 ENSMUST00000075249.4
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_+_101376359 4.856 ENSMUST00000119080.1
Gjb1
gap junction protein, beta 1
chr1_+_133246092 4.851 ENSMUST00000038295.8
ENSMUST00000105082.2
Plekha6

pleckstrin homology domain containing, family A member 6

chr7_-_45103747 4.848 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr10_+_61089327 4.731 ENSMUST00000020298.6
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr15_+_99393610 4.726 ENSMUST00000159531.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr4_+_99030946 4.570 ENSMUST00000030280.6
Angptl3
angiopoietin-like 3
chr7_-_27166732 4.440 ENSMUST00000080058.4
Egln2
EGL nine homolog 2 (C. elegans)
chr4_+_48279794 4.359 ENSMUST00000030029.3
Invs
inversin
chr11_+_108395288 4.311 ENSMUST00000000049.5
Apoh
apolipoprotein H
chr2_-_164221605 4.222 ENSMUST00000018355.4
ENSMUST00000109376.2
Wfdc15b

WAP four-disulfide core domain 15B

chr5_+_31297551 4.210 ENSMUST00000072228.5
Gckr
glucokinase regulatory protein
chr15_-_55113460 4.165 ENSMUST00000100659.2
ENSMUST00000110230.1
Gm9920

predicted gene 9920

chr11_+_70519183 4.125 ENSMUST00000057685.2
Gltpd2
glycolipid transfer protein domain containing 2
chr19_+_42045792 3.895 ENSMUST00000172244.1
ENSMUST00000081714.4
Hoga1

4-hydroxy-2-oxoglutarate aldolase 1

chr7_-_127895578 3.885 ENSMUST00000033074.6
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr11_+_4883186 3.852 ENSMUST00000139737.1
Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr16_+_24448082 3.796 ENSMUST00000078988.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr11_+_78037931 3.793 ENSMUST00000072289.5
ENSMUST00000100784.2
Flot2

flotillin 2

chr5_+_35041539 3.757 ENSMUST00000030985.6
Hgfac
hepatocyte growth factor activator
chr2_+_163506808 3.711 ENSMUST00000143911.1
Hnf4a
hepatic nuclear factor 4, alpha
chrX_+_140907602 3.685 ENSMUST00000033806.4
Vsig1
V-set and immunoglobulin domain containing 1
chr12_+_4769375 3.684 ENSMUST00000178879.1
Pfn4
profilin family, member 4
chr17_+_74395607 3.597 ENSMUST00000179074.1
ENSMUST00000024870.6
Slc30a6

solute carrier family 30 (zinc transporter), member 6

chr9_+_72958785 3.533 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr5_-_38491948 3.490 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr5_-_114444036 3.482 ENSMUST00000031560.7
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr19_+_5878622 3.460 ENSMUST00000136833.1
ENSMUST00000141362.1
Slc25a45

solute carrier family 25, member 45

chr9_+_54538984 3.447 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr1_-_136960427 3.406 ENSMUST00000027649.7
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr19_+_60889749 3.401 ENSMUST00000003313.8
Grk5
G protein-coupled receptor kinase 5
chr5_-_114443993 3.377 ENSMUST00000112245.1
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr13_+_66932802 3.368 ENSMUST00000021990.3
Ptdss1
phosphatidylserine synthase 1
chr10_+_63061582 3.364 ENSMUST00000020266.8
ENSMUST00000178684.1
Pbld1

phenazine biosynthesis-like protein domain containing 1

chr9_+_120149733 3.330 ENSMUST00000068698.7
ENSMUST00000093773.1
ENSMUST00000111627.1
Mobp


myelin-associated oligodendrocytic basic protein


chr1_+_133309778 3.271 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
Golt1a

Kiss1

GOLT1A
golgi transport 1 homolog A (S. cerevisiae)

KiSS-1 metastasis-suppressor

KISS1 isoform e
chr6_+_73248382 3.260 ENSMUST00000064740.6
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
chr3_+_154597352 3.188 ENSMUST00000140644.1
ENSMUST00000144764.1
ENSMUST00000155232.1
Cryz


crystallin, zeta


chr3_+_90537242 3.173 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr3_-_98457031 3.161 ENSMUST00000167753.1
Gm4450
predicted gene 4450
chr1_+_172126750 3.112 ENSMUST00000075895.2
ENSMUST00000111252.3
Pex19

peroxisomal biogenesis factor 19

chr11_+_78037959 3.079 ENSMUST00000073660.6
Flot2
flotillin 2
chr18_+_33464163 3.063 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr19_+_56287943 3.035 ENSMUST00000166049.1
Habp2
hyaluronic acid binding protein 2
chr12_-_103631404 3.029 ENSMUST00000121625.1
ENSMUST00000044231.5
Serpina10

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

chrX_+_52791179 3.014 ENSMUST00000101588.1
Ccdc160
coiled-coil domain containing 160
chr9_+_95559817 2.880 ENSMUST00000079597.5
Paqr9
progestin and adipoQ receptor family member IX
chr19_+_56287911 2.868 ENSMUST00000095948.4
Habp2
hyaluronic acid binding protein 2
chr3_-_116712644 2.864 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr7_-_5805445 2.770 ENSMUST00000075085.6
Vmn1r63
vomeronasal 1 receptor 63
chr18_+_20310738 2.733 ENSMUST00000077146.3
Dsg1a
desmoglein 1 alpha
chr6_-_129100903 2.716 ENSMUST00000032258.6
Clec2e
C-type lectin domain family 2, member e
chr7_+_120173847 2.618 ENSMUST00000033201.5
Anks4b
ankyrin repeat and sterile alpha motif domain containing 4B
chr11_+_46571536 2.545 ENSMUST00000050937.6
BC053393
cDNA sequence BC053393
chr8_+_95715901 2.528 ENSMUST00000034096.4
Setd6
SET domain containing 6
chr7_-_45062393 2.509 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr9_-_70934808 2.457 ENSMUST00000034731.8
Lipc
lipase, hepatic
chrM_+_2743 2.446 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr4_-_139968026 2.403 ENSMUST00000105031.2
Klhdc7a
kelch domain containing 7A
chr14_-_36919314 2.292 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr3_+_90537306 2.241 ENSMUST00000107335.1
S100a16
S100 calcium binding protein A16
chr11_+_110968016 2.238 ENSMUST00000106636.1
ENSMUST00000180023.1
Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr5_+_65348386 2.209 ENSMUST00000031096.7
Klb
klotho beta
chr4_-_150909428 2.165 ENSMUST00000128075.1
ENSMUST00000105674.1
ENSMUST00000105673.1
Park7


Parkinson disease (autosomal recessive, early onset) 7


chr14_-_36919513 2.126 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr5_-_87490869 2.104 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr7_-_6011010 2.082 ENSMUST00000086338.1
Vmn1r65
vomeronasal 1 receptor 65
chr11_+_118428203 2.063 ENSMUST00000124861.1
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr11_-_75937726 1.972 ENSMUST00000121287.1
Rph3al
rabphilin 3A-like (without C2 domains)
chr17_+_23660477 1.964 ENSMUST00000062967.8
Ccdc64b
coiled-coil domain containing 64B
chr7_+_141216626 1.959 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr17_+_57062486 1.959 ENSMUST00000163628.1
Crb3
crumbs homolog 3 (Drosophila)
chr6_+_48647224 1.916 ENSMUST00000078223.3
Gimap8
GTPase, IMAP family member 8
chr18_-_66022580 1.907 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr11_-_75937677 1.895 ENSMUST00000108420.2
Rph3al
rabphilin 3A-like (without C2 domains)
chr6_-_24168083 1.870 ENSMUST00000031713.8
Slc13a1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr8_-_67974567 1.852 ENSMUST00000098696.3
ENSMUST00000038959.9
ENSMUST00000093469.4
Psd3


pleckstrin and Sec7 domain containing 3


chr11_+_78178105 1.831 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chr3_-_83049797 1.816 ENSMUST00000048246.3
Fgb
fibrinogen beta chain
chr7_+_83148644 1.798 ENSMUST00000066005.5
A530021J07Rik
Riken cDNA A530021J07 gene
chr1_+_58795371 1.752 ENSMUST00000027189.8
Casp8
caspase 8
chr15_-_10713537 1.724 ENSMUST00000090339.3
Rai14
retinoic acid induced 14
chr1_-_187215454 1.720 ENSMUST00000183819.1
Spata17
spermatogenesis associated 17
chr14_+_48446128 1.717 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr1_-_141257158 1.618 ENSMUST00000179202.1
Gm4845
predicted gene 4845
chr6_-_128437653 1.559 ENSMUST00000151796.1
Fkbp4
FK506 binding protein 4
chr16_-_92358874 1.496 ENSMUST00000166707.1
Kcne1
potassium voltage-gated channel, Isk-related subfamily, member 1
chrM_+_7759 1.488 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr2_+_91265252 1.472 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr14_+_48446340 1.445 ENSMUST00000111735.2
Tmem260
transmembrane protein 260
chr13_-_73678005 1.390 ENSMUST00000022105.7
ENSMUST00000109680.2
ENSMUST00000109679.2
Slc6a18


solute carrier family 6 (neurotransmitter transporter), member 18


chr2_+_3770673 1.355 ENSMUST00000177037.1
Fam107b
family with sequence similarity 107, member B
chr19_-_11856001 1.332 ENSMUST00000079875.3
Olfr1418
olfactory receptor 1418
chr19_+_26885925 1.332 ENSMUST00000099536.2
Gm815
predicted gene 815
chr2_+_125152505 1.321 ENSMUST00000110494.2
ENSMUST00000028630.2
ENSMUST00000110495.2
Slc12a1


solute carrier family 12, member 1


chr5_-_106926245 1.319 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr6_-_52240841 1.317 ENSMUST00000121043.1
Hoxa10
homeobox A10
chr9_+_54980880 1.290 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr5_-_90640464 1.288 ENSMUST00000031317.6
Rassf6
Ras association (RalGDS/AF-6) domain family member 6
chr10_-_7212222 1.278 ENSMUST00000015346.5
Cnksr3
Cnksr family member 3
chr2_+_151494274 1.270 ENSMUST00000028949.9
ENSMUST00000103160.4
Nsfl1c

NSFL1 (p97) cofactor (p47)

chr19_-_30549516 1.256 ENSMUST00000025803.8
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr1_-_187215421 1.252 ENSMUST00000110945.3
ENSMUST00000183931.1
ENSMUST00000027908.6
Spata17


spermatogenesis associated 17


chr1_-_12991109 1.231 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chr17_+_57062231 1.229 ENSMUST00000097299.3
ENSMUST00000169543.1
ENSMUST00000163763.1
Crb3


crumbs homolog 3 (Drosophila)


chr5_+_95742014 1.228 ENSMUST00000154086.1
Gm7982
predicted gene 7982
chrY_-_35130404 1.222 ENSMUST00000180170.1
Gm20855
predicted gene, 20855
chr11_+_110968056 1.210 ENSMUST00000125692.1
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_-_76795489 1.152 ENSMUST00000082431.3
Gpx2
glutathione peroxidase 2
chr11_+_23665615 1.131 ENSMUST00000109525.1
ENSMUST00000020520.4
Pus10

pseudouridylate synthase 10

chr10_+_79468943 1.068 ENSMUST00000167976.2
Vmn2r83
vomeronasal 2, receptor 83
chr8_-_22694061 1.039 ENSMUST00000131767.1
Ikbkb
inhibitor of kappaB kinase beta
chr19_-_57197556 0.997 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr13_-_21453714 0.979 ENSMUST00000032820.7
ENSMUST00000110485.1
Zscan26

zinc finger and SCAN domain containing 26

chr5_-_121527186 0.977 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr11_+_85832551 0.943 ENSMUST00000000095.6
Tbx2
T-box 2
chr8_+_70724064 0.914 ENSMUST00000034307.7
ENSMUST00000110095.2
Pde4c

phosphodiesterase 4C, cAMP specific

chr9_+_109096659 0.912 ENSMUST00000130366.1
Plxnb1
plexin B1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 66.8 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
5.6 27.8 GO:0052695 cellular glucuronidation(GO:0052695)
5.5 5.5 GO:0050787 detoxification of mercury ion(GO:0050787)
4.4 13.1 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
4.2 16.7 GO:0009441 glycolate metabolic process(GO:0009441)
3.4 10.3 GO:1902569 negative regulation of activation of Janus kinase activity(GO:1902569)
3.4 10.3 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
3.2 19.1 GO:0038161 prolactin signaling pathway(GO:0038161)
3.2 9.5 GO:0009812 flavonoid metabolic process(GO:0009812)
2.8 16.8 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
2.7 8.0 GO:0051659 maintenance of mitochondrion location(GO:0051659)
2.6 47.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
2.5 17.7 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
2.5 10.0 GO:1901373 lipid hydroperoxide transport(GO:1901373)
2.3 6.9 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
2.3 6.9 GO:0034971 histone H3-R17 methylation(GO:0034971)
2.1 12.6 GO:0006083 acetate metabolic process(GO:0006083)
2.0 9.8 GO:0000103 sulfate assimilation(GO:0000103)
1.9 9.6 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.8 9.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.7 5.0 GO:0061144 alveolar secondary septum development(GO:0061144)
1.6 8.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
1.6 79.9 GO:0006958 complement activation, classical pathway(GO:0006958)
1.6 7.9 GO:0006548 histidine catabolic process(GO:0006548)
1.6 11.0 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
1.3 3.9 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
1.3 7.6 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
1.2 10.9 GO:0120009 intermembrane lipid transfer(GO:0120009)
1.2 5.9 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
1.2 23.3 GO:0042359 vitamin D metabolic process(GO:0042359)
1.2 5.8 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
1.1 3.4 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
1.1 5.6 GO:0015855 purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
1.1 3.3 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
1.1 8.5 GO:0019695 choline metabolic process(GO:0019695)
1.1 4.2 GO:0009750 response to fructose(GO:0009750)
1.0 6.0 GO:0060745 Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523) mammary gland branching involved in pregnancy(GO:0060745)
1.0 6.0 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
1.0 6.9 GO:0009235 cobalamin metabolic process(GO:0009235)
1.0 3.9 GO:0009436 glyoxylate catabolic process(GO:0009436)
1.0 5.7 GO:0015886 heme transport(GO:0015886)
0.9 4.6 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.9 4.4 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.8 3.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.8 24.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.8 2.3 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.7 12.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.6 5.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.6 1.8 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.6 4.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.5 4.7 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.5 3.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.5 3.4 GO:0061113 pancreas morphogenesis(GO:0061113)
0.5 3.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.5 25.9 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.5 0.5 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.5 1.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.4 4.8 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.4 1.3 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.4 3.7 GO:0042989 sequestering of actin monomers(GO:0042989)
0.4 6.8 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.4 0.8 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.4 6.2 GO:0010225 response to UV-C(GO:0010225)
0.4 3.7 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.3 10.3 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.3 7.9 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.3 3.3 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.3 3.2 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.3 3.5 GO:0046415 urate metabolic process(GO:0046415)
0.3 2.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 0.9 GO:0007521 muscle cell fate determination(GO:0007521)
0.3 5.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.3 7.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.3 3.6 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.3 0.8 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.3 1.3 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.3 1.0 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.2 3.5 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 4.9 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.2 0.5 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.2 2.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2 0.9 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.2 1.7 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.2 8.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 8.5 GO:0051180 vitamin transport(GO:0051180)
0.1 6.2 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.1 1.0 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 1.5 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315) positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.1 0.6 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.1 4.3 GO:0010107 potassium ion import(GO:0010107)
0.1 13.7 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.1 2.4 GO:0033194 response to hydroperoxide(GO:0033194)
0.1 0.5 GO:0010159 specification of animal organ position(GO:0010159)
0.1 0.8 GO:0015705 iodide transport(GO:0015705)
0.1 1.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 1.3 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.4 GO:0044860 protein localization to plasma membrane raft(GO:0044860)
0.1 0.4 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 1.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 1.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.6 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 4.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 0.9 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 1.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 3.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 1.3 GO:0060065 uterus development(GO:0060065)
0.1 21.1 GO:0032259 methylation(GO:0032259)
0.0 8.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.5 GO:0015838 amino-acid betaine transport(GO:0015838)
0.0 1.9 GO:0070232 regulation of T cell apoptotic process(GO:0070232)
0.0 2.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.8 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 14.8 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.2 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.0 4.9 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 0.6 GO:0030238 male sex determination(GO:0030238)
0.0 0.1 GO:0072181 regulation of pronephros size(GO:0035565) pronephric nephron tubule development(GO:0039020) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) pronephros morphogenesis(GO:0072114) mesonephric duct formation(GO:0072181) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.0 0.9 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 3.9 GO:0019233 sensory perception of pain(GO:0019233)
0.0 1.9 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 1.1 GO:0007417 central nervous system development(GO:0007417)
0.0 3.0 GO:0051592 response to calcium ion(GO:0051592)
0.0 4.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.2 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0 0.0 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.1 GO:0032769 negative regulation of monooxygenase activity(GO:0032769) negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 4.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 3.5 GO:0006839 mitochondrial transport(GO:0006839)
0.0 2.6 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.0 1.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 13.1 GO:0032010 phagolysosome(GO:0032010)
2.3 9.1 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
2.1 20.9 GO:0005579 membrane attack complex(GO:0005579)
1.5 4.4 GO:0097543 ciliary inversin compartment(GO:0097543)
1.4 5.5 GO:0097450 astrocyte end-foot(GO:0097450)
1.3 10.3 GO:0071438 invadopodium membrane(GO:0071438)
1.0 14.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.9 6.0 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.8 10.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.8 0.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.6 1.8 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.6 1.7 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.5 3.3 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.5 6.9 GO:0031254 uropod(GO:0001931) flotillin complex(GO:0016600) cell trailing edge(GO:0031254)
0.5 5.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.4 4.3 GO:0042627 chylomicron(GO:0042627)
0.3 24.7 GO:0000502 proteasome complex(GO:0000502)
0.3 8.7 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.3 42.1 GO:0072562 blood microparticle(GO:0072562)
0.2 2.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 4.9 GO:0005922 connexin complex(GO:0005922)
0.2 6.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 15.6 GO:0005581 collagen trimer(GO:0005581)
0.1 6.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.9 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 15.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 4.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.7 GO:0030057 desmosome(GO:0030057)
0.1 6.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 17.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 31.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 14.8 GO:0008021 synaptic vesicle(GO:0008021)
0.1 1.0 GO:0035631 IkappaB kinase complex(GO:0008385) CD40 receptor complex(GO:0035631)
0.1 24.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 16.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 1.0 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 0.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 9.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 1.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 2.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 5.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 3.7 GO:0005938 cell cortex(GO:0005938)
0.0 41.7 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 18.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 5.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 3.2 GO:0005769 early endosome(GO:0005769)
0.0 9.7 GO:0005813 centrosome(GO:0005813)
0.0 6.9 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 3.3 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.2 GO:0031201 SNARE complex(GO:0031201)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 23.3 GO:1902271 D3 vitamins binding(GO:1902271)
5.6 16.8 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
4.2 12.6 GO:0019807 aspartoacylase activity(GO:0019807)
3.9 19.3 GO:0004062 aryl sulfotransferase activity(GO:0004062)
3.8 19.1 GO:0004925 prolactin receptor activity(GO:0004925)
3.8 11.4 GO:0008431 vitamin E binding(GO:0008431)
3.7 47.5 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
3.6 14.5 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
3.5 24.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
3.4 10.3 GO:0070540 stearic acid binding(GO:0070540)
3.3 13.1 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
3.1 117.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
2.8 19.9 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
2.5 10.0 GO:0050632 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632)
2.3 6.9 GO:0038181 bile acid receptor activity(GO:0038181)
2.1 8.5 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
2.0 6.0 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
1.9 13.6 GO:0005534 galactose binding(GO:0005534)
1.6 9.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.6 10.9 GO:0120013 intermembrane lipid transfer activity(GO:0120013)
1.4 5.7 GO:0015232 heme transporter activity(GO:0015232)
1.1 5.6 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
1.1 7.6 GO:0003996 acyl-CoA ligase activity(GO:0003996)
1.1 3.3 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.1 3.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
1.0 22.8 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
1.0 3.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.0 4.8 GO:0019770 IgG receptor activity(GO:0019770)
0.9 4.7 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.9 10.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.9 3.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.7 9.1 GO:1990405 protein antigen binding(GO:1990405)
0.7 6.0 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.7 4.6 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.6 4.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.6 12.4 GO:0019825 oxygen binding(GO:0019825)
0.6 5.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 4.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.5 11.8 GO:0017081 chloride channel regulator activity(GO:0017081)
0.4 1.8 GO:0035877 death effector domain binding(GO:0035877)
0.4 2.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.4 12.5 GO:0001848 complement binding(GO:0001848)
0.4 6.8 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.4 12.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 8.1 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.3 3.9 GO:0030274 LIM domain binding(GO:0030274)
0.3 1.6 GO:0032767 copper-dependent protein binding(GO:0032767)
0.3 3.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.3 0.6 GO:0019864 IgG binding(GO:0019864)
0.3 4.9 GO:0005243 gap junction channel activity(GO:0005243)
0.3 5.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.3 3.5 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 1.3 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.3 3.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 23.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.2 6.2 GO:0097602 cullin family protein binding(GO:0097602)
0.2 5.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 3.9 GO:0048038 quinone binding(GO:0048038)
0.2 1.0 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 0.6 GO:0022850 serotonin-gated cation-selective channel activity(GO:0022850)
0.2 7.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 0.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.2 13.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.3 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 5.8 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 10.1 GO:0005549 odorant binding(GO:0005549)
0.1 2.7 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 4.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 3.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 6.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 1.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 3.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.8 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 12.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.8 GO:0023029 MHC class Ib protein binding(GO:0023029)
0.1 1.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 2.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 3.7 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.9 GO:0005537 mannose binding(GO:0005537)
0.1 11.3 GO:0030165 PDZ domain binding(GO:0030165)
0.1 6.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 1.3 GO:0022848 acetylcholine-gated cation-selective channel activity(GO:0022848)
0.1 11.7 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.1 6.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 1.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 12.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 3.5 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 7.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 6.3 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 0.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 1.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.1 1.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.5 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 1.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 3.9 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 5.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 0.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 5.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 2.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 4.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.3 GO:0015081 sodium ion transmembrane transporter activity(GO:0015081)
0.0 5.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.5 GO:0015293 symporter activity(GO:0015293)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.8 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.3 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.1 GO:0004532 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0 2.7 GO:0030246 carbohydrate binding(GO:0030246)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 19.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 9.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 15.7 PID_FOXO_PATHWAY FoxO family signaling
0.2 4.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 8.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 1.8 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 6.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 6.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 5.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 5.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 7.2 PID_FGF_PATHWAY FGF signaling pathway
0.1 5.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 10.3 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 7.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 17.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 4.6 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 1.8 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 12.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.0 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 32.7 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
3.2 41.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
1.7 13.6 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.4 18.4 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
1.3 18.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
1.0 19.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.9 23.5 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.9 17.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.8 23.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.7 9.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.7 10.0 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.5 10.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 3.9 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.4 21.0 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.4 10.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.4 20.8 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation
0.3 3.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 9.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.3 7.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 5.0 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 4.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 3.5 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 4.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 8.6 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 8.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 1.8 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.2 6.0 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.2 2.8 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.2 2.3 REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR ligand binding and activation
0.1 3.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 27.1 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 12.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 7.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 5.3 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 6.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.3 REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1 4.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.7 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 6.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 0.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 5.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.4 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.6 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell