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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxa7_Hoxc8

Z-value: 0.38

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Transcription factors associated with Hoxa7_Hoxc8

Gene Symbol Gene ID Gene Info
Hoxa7
ENSMUSG00000038236.6 homeobox A7
Hoxc8
ENSMUSG00000001657.6 homeobox C8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc8mm10_v2_chr15_+_102990576_102990622-0.212.2e-01Click!
Hoxa7mm10_v2_chr6_-_52218686_52218716-0.202.4e-01Click!

Activity profile of Hoxa7_Hoxc8 motif

Sorted Z-values of Hoxa7_Hoxc8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_80000292 1.09 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr6_+_30541582 1.04 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr3_-_75270073 0.62 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr2_+_69897255 0.43 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr9_-_90255927 0.39 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr14_-_100149764 0.32 ENSMUST00000097079.4
Klf12
Kruppel-like factor 12
chr15_+_25773985 0.32 ENSMUST00000125667.1
Myo10
myosin X
chr4_+_108719649 0.32 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr12_-_55014329 0.30 ENSMUST00000172875.1
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr3_+_5218516 0.30 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr3_-_81924463 0.29 ENSMUST00000069880.2
Gm9989
predicted gene 9989
chr3_+_103832562 0.26 ENSMUST00000062945.5
Bcl2l15
BCLl2-like 15
chr15_+_98571004 0.25 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr17_+_23853519 0.24 ENSMUST00000061725.7
Prss32
protease, serine, 32
chr4_+_34893772 0.24 ENSMUST00000029975.3
ENSMUST00000135871.1
ENSMUST00000108130.1
Cga
glycoprotein hormones, alpha subunit
chr12_-_40248073 0.23 ENSMUST00000169926.1
Ifrd1
interferon-related developmental regulator 1
chr2_+_69219971 0.23 ENSMUST00000005364.5
ENSMUST00000112317.2
G6pc2
glucose-6-phosphatase, catalytic, 2
chr5_-_62766153 0.23 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_+_94152607 0.23 ENSMUST00000034211.8
Mt3
metallothionein 3
chr4_-_82850721 0.22 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr2_-_121235689 0.22 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr15_-_75905349 0.21 ENSMUST00000127550.1
Eef1d
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr5_-_62765618 0.21 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_-_102905740 0.20 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr10_-_45470201 0.19 ENSMUST00000079390.6
Lin28b
lin-28 homolog B (C. elegans)
chr14_+_27000362 0.19 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chr13_-_102906046 0.19 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr19_-_50678642 0.19 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1
VPS10 domain receptor protein SORCS 1
chr11_-_99374895 0.18 ENSMUST00000006963.2
Krt28
keratin 28
chr13_+_23575753 0.18 ENSMUST00000105105.1
Hist1h3d
histone cluster 1, H3d
chr1_+_72284367 0.17 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169
transmembrane protein 169
chr1_-_134955847 0.16 ENSMUST00000168381.1
Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr10_+_37139558 0.16 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr15_-_100425050 0.15 ENSMUST00000123461.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr3_-_59220150 0.15 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr1_-_126738167 0.15 ENSMUST00000160693.1
Nckap5
NCK-associated protein 5
chr7_+_45621805 0.14 ENSMUST00000033100.4
Izumo1
izumo sperm-egg fusion 1
chr14_-_36919314 0.14 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr15_-_37458523 0.14 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr4_+_145585166 0.14 ENSMUST00000105739.1
ENSMUST00000119718.1
Gm13212
predicted gene 13212
chr15_+_81744848 0.13 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chrX_+_159303266 0.13 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr8_+_45885479 0.13 ENSMUST00000034053.5
Pdlim3
PDZ and LIM domain 3
chr4_+_102589687 0.13 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b
phosphodiesterase 4B, cAMP specific
chrX_+_114474569 0.13 ENSMUST00000133447.1
Klhl4
kelch-like 4
chr15_-_8710734 0.12 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_-_55919605 0.12 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr6_-_118479237 0.12 ENSMUST00000161170.1
Zfp9
zinc finger protein 9
chr3_+_5218589 0.12 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr11_+_31832660 0.12 ENSMUST00000132857.1
Gm12107
predicted gene 12107
chr3_+_121291725 0.12 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14
chr9_+_119063429 0.11 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill
villin-like
chr2_-_45117349 0.11 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr17_+_34039437 0.11 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2
collagen, type XI, alpha 2
chr10_-_20724696 0.11 ENSMUST00000170265.1
Pde7b
phosphodiesterase 7B
chr6_-_130193112 0.11 ENSMUST00000112032.1
ENSMUST00000071554.2
Klra9
killer cell lectin-like receptor subfamily A, member 9
chr3_+_59952185 0.10 ENSMUST00000094227.3
Gm9696
predicted gene 9696
chr9_+_72806874 0.09 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr9_+_113812547 0.09 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2
CLIP associating protein 2
chr13_-_55021196 0.09 ENSMUST00000153665.1
Hk3
hexokinase 3
chr3_+_96645579 0.09 ENSMUST00000119365.1
ENSMUST00000029744.5
Itga10
integrin, alpha 10
chr2_+_110721340 0.09 ENSMUST00000111016.2
Muc15
mucin 15
chr19_-_53944621 0.09 ENSMUST00000135402.2
Bbip1
BBSome interacting protein 1
chr1_-_132367879 0.09 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr10_-_76110956 0.08 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr11_+_29373618 0.08 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a
coiled coil domain containing 88A
chr3_-_86548268 0.08 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr2_-_116067391 0.08 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr10_-_117148474 0.08 ENSMUST00000020381.3
Frs2
fibroblast growth factor receptor substrate 2
chr2_-_164171113 0.08 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr3_+_55782500 0.08 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr19_-_32196393 0.08 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr18_+_53551594 0.07 ENSMUST00000115398.1
Prdm6
PR domain containing 6
chr2_+_36230426 0.07 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr16_-_75909272 0.07 ENSMUST00000114239.2
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1
chr6_+_37870786 0.07 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24
tripartite motif-containing 24
chr18_+_4920509 0.07 ENSMUST00000126977.1
Svil
supervillin
chr7_+_30493622 0.07 ENSMUST00000058280.6
ENSMUST00000133318.1
ENSMUST00000142575.1
ENSMUST00000131040.1
Prodh2
proline dehydrogenase (oxidase) 2
chr7_+_126950687 0.07 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr19_-_55241236 0.06 ENSMUST00000069183.6
Gucy2g
guanylate cyclase 2g
chr18_+_37518341 0.06 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr14_+_54431597 0.06 ENSMUST00000089688.4
Mmp14
matrix metallopeptidase 14 (membrane-inserted)
chr16_-_50330987 0.06 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr17_-_45659312 0.06 ENSMUST00000120717.1
Capn11
calpain 11
chr10_-_86011833 0.06 ENSMUST00000105304.1
ENSMUST00000061699.5
Bpifc
BPI fold containing family C
chr10_+_76147451 0.06 ENSMUST00000020450.3
Slc5a4a
solute carrier family 5, member 4a
chr3_+_5214763 0.06 ENSMUST00000177924.1
Gm10748
predicted gene 10748
chr9_-_79977782 0.06 ENSMUST00000093811.4
Filip1
filamin A interacting protein 1
chr6_-_30693676 0.06 ENSMUST00000169422.1
ENSMUST00000115131.1
ENSMUST00000115130.2
ENSMUST00000031810.8
Cep41
centrosomal protein 41
chr4_-_115133977 0.06 ENSMUST00000051400.7
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr3_-_17230976 0.05 ENSMUST00000177874.1
Gm5283
predicted gene 5283
chr2_-_79456750 0.05 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chrM_+_9870 0.05 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr8_-_24725762 0.05 ENSMUST00000171438.1
ENSMUST00000171611.1
ENSMUST00000033958.7
Adam3
a disintegrin and metallopeptidase domain 3 (cyritestin)
chr18_-_56975333 0.05 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik
RIKEN cDNA C330018D20 gene
chr12_+_98746935 0.05 ENSMUST00000110105.2
ENSMUST00000110104.2
ENSMUST00000057000.9
Zc3h14
zinc finger CCCH type containing 14
chr7_-_46667303 0.05 ENSMUST00000168335.1
Tph1
tryptophan hydroxylase 1
chr5_+_66968559 0.04 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr5_+_138187485 0.04 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr2_-_177267036 0.04 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr16_-_45724600 0.04 ENSMUST00000096057.4
Tagln3
transgelin 3
chr2_+_23069210 0.04 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr1_-_24612700 0.04 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr12_+_71170589 0.04 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr10_+_41303968 0.04 ENSMUST00000173517.2
Ak9
adenylate kinase 9
chr18_+_23753708 0.04 ENSMUST00000115830.1
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr1_-_172027269 0.03 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr2_+_83724397 0.03 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav
integrin alpha V
chr13_-_81710937 0.03 ENSMUST00000161920.1
ENSMUST00000048993.5
Polr3g
polymerase (RNA) III (DNA directed) polypeptide G
chr3_+_5218546 0.03 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr19_+_5474681 0.03 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2
epidermal growth factor-containing fibulin-like extracellular matrix protein 2
chr15_-_8710409 0.03 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_104202609 0.03 ENSMUST00000066708.5
Dmp1
dentin matrix protein 1
chr16_+_45224315 0.03 ENSMUST00000102802.3
ENSMUST00000063654.4
Btla
B and T lymphocyte associated
chr1_-_150164943 0.03 ENSMUST00000181308.1
Gm26687
predicted gene, 26687
chr1_-_134955908 0.02 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chrX_-_101086020 0.02 ENSMUST00000113710.1
Slc7a3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr3_+_55461758 0.02 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr6_-_137169710 0.02 ENSMUST00000117919.1
Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr19_-_41933276 0.02 ENSMUST00000075280.4
ENSMUST00000112123.2
Exosc1
exosome component 1
chr2_+_127854628 0.02 ENSMUST00000028859.1
Acoxl
acyl-Coenzyme A oxidase-like
chrX_+_166170449 0.01 ENSMUST00000130880.2
ENSMUST00000056410.4
ENSMUST00000096252.3
ENSMUST00000087169.4
Gemin8
gem (nuclear organelle) associated protein 8
chr11_-_73326472 0.01 ENSMUST00000155630.2
Aspa
aspartoacylase
chr11_-_65269941 0.01 ENSMUST00000102635.3
Myocd
myocardin
chr9_+_38877126 0.01 ENSMUST00000078289.2
Olfr926
olfactory receptor 926
chr15_-_67113909 0.01 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr4_-_136602641 0.01 ENSMUST00000105847.1
ENSMUST00000116273.2
Kdm1a
lysine (K)-specific demethylase 1A
chr17_+_88440711 0.01 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2
forkhead box N2
chr8_+_23411490 0.01 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chr1_+_82316452 0.00 ENSMUST00000027322.7
Rhbdd1
rhomboid domain containing 1
chr18_+_55057557 0.00 ENSMUST00000181765.1
Gm4221
predicted gene 4221

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.2 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 0.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.2 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.2 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.2 GO:0030916 otic vesicle formation(GO:0030916)
0.0 1.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.2 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.0 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.0 0.0 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.2 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.1 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008623 CHRAC(GO:0008623)
0.1 1.1 GO:0042581 specific granule(GO:0042581)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.0 GO:0034684 integrin alphav-beta5 complex(GO:0034684) integrin alphav-beta6 complex(GO:0034685)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 1.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.0 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors