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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc6

Z-value: 0.44

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Transcription factors associated with Hoxc6

Gene Symbol Gene ID Gene Info
ENSMUSG00000001661.4 homeobox C6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc6mm10_v2_chr15_+_103009479_1030095070.212.1e-01Click!

Activity profile of Hoxc6 motif

Sorted Z-values of Hoxc6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_113532288 1.60 ENSMUST00000132353.1
amylase 2a1
chr7_-_14123042 1.50 ENSMUST00000098809.2
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr3_-_145032765 1.49 ENSMUST00000029919.5
chloride channel calcium activated 3
chr14_+_27000362 1.09 ENSMUST00000035433.8
homeobox gene expressed in ES cells
chr3_-_92485886 0.78 ENSMUST00000054599.7
small proline-rich protein 1A
chr11_-_109472611 0.65 ENSMUST00000168740.1
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr6_+_128399881 0.62 ENSMUST00000120405.1
nuclear receptor interacting protein 2
chr6_-_65144908 0.62 ENSMUST00000031982.4
hematopoietic prostaglandin D synthase
chr6_+_128399766 0.57 ENSMUST00000001561.5
nuclear receptor interacting protein 2
chr6_+_36388055 0.52 ENSMUST00000172278.1
cholinergic receptor, muscarinic 2, cardiac
chr3_+_146150174 0.51 ENSMUST00000098524.4
mucolipin 2
chr10_-_61784014 0.49 ENSMUST00000020283.4
H2A histone family, member Y2
chrX_-_94212638 0.48 ENSMUST00000113922.1
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr5_+_24413406 0.47 ENSMUST00000049346.5
acid-sensing (proton-gated) ion channel 3
chrX_+_49463926 0.45 ENSMUST00000130558.1
Rho GTPase activating protein 36
chr13_+_93304066 0.44 ENSMUST00000109493.1
homer homolog 1 (Drosophila)
chr13_+_93304799 0.43 ENSMUST00000080127.5
homer homolog 1 (Drosophila)
chr15_+_91673175 0.42 ENSMUST00000060642.6
leucine-rich repeat kinase 2
chr16_-_21995478 0.41 ENSMUST00000074230.4
ENSMUST00000060673.6
lipase, member H
chr10_-_100589205 0.39 ENSMUST00000054471.8
RIKEN cDNA 4930430F08 gene
chr7_+_45554893 0.37 ENSMUST00000107752.3
hydroxysteroid (17-beta) dehydrogenase 14
chr1_-_138175238 0.37 ENSMUST00000182536.1
protein tyrosine phosphatase, receptor type, C
chr7_-_115846080 0.36 ENSMUST00000166207.1
SRY-box containing gene 6
chr6_+_52177498 0.35 ENSMUST00000070587.3
RIKEN cDNA 5730596B20 gene
chr1_-_138175283 0.35 ENSMUST00000182755.1
ENSMUST00000183262.1
ENSMUST00000027645.7
ENSMUST00000112036.2
ENSMUST00000182283.1
protein tyrosine phosphatase, receptor type, C
chr1_-_138175126 0.33 ENSMUST00000183301.1
protein tyrosine phosphatase, receptor type, C
chr19_-_11660516 0.32 ENSMUST00000135994.1
ENSMUST00000121793.1
ENSMUST00000069681.3
placenta-specific 1-like
chrX_-_94212685 0.31 ENSMUST00000050328.8
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr11_-_94782500 0.30 ENSMUST00000162809.2
transmembrane protein 92
chr11_-_94782703 0.30 ENSMUST00000100554.1
transmembrane protein 92
chr19_+_11469353 0.28 ENSMUST00000165310.1
membrane-spanning 4-domains, subfamily A, member 6C
chr18_+_53551594 0.27 ENSMUST00000115398.1
PR domain containing 6
chr6_-_141773810 0.27 ENSMUST00000148411.1
predicted gene 5724
chr2_+_150786735 0.23 ENSMUST00000045441.7
brain glycogen phosphorylase
chr15_+_44619551 0.23 ENSMUST00000022964.7
estrogen receptor-binding fragment-associated gene 9
chrX_+_164162167 0.23 ENSMUST00000131543.1
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr16_-_58718724 0.22 ENSMUST00000089318.3
G protein-coupled receptor 15
chr5_-_110046486 0.22 ENSMUST00000167969.1
predicted gene, 17655
chr7_-_24299310 0.21 ENSMUST00000145131.1
zinc finger protein 61
chr3_+_5218516 0.21 ENSMUST00000175866.1
zinc finger homeodomain 4
chr1_-_22315792 0.21 ENSMUST00000164877.1
regulating synaptic membrane exocytosis 1
chr4_+_132351768 0.21 ENSMUST00000172202.1
predicted gene, 17300
chr9_+_107551516 0.21 ENSMUST00000093786.2
ENSMUST00000122225.1
Ras association (RalGDS/AF-6) domain family member 1
chr4_-_132351636 0.21 ENSMUST00000105951.1
regulator of chromosome condensation 1
chr3_+_136670076 0.21 ENSMUST00000070198.7
protein phosphatase 3, catalytic subunit, alpha isoform
chr4_-_147642496 0.20 ENSMUST00000133006.1
ENSMUST00000037565.7
ENSMUST00000105720.1
RIKEN cDNA 2610305D13 gene
chr15_+_100154379 0.20 ENSMUST00000023768.6
ENSMUST00000108971.2
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr3_+_151437887 0.20 ENSMUST00000046977.7
EGF, latrophilin seven transmembrane domain containing 1
chr10_+_37139558 0.20 ENSMUST00000062667.3
RIKEN cDNA 5930403N24 gene
chr5_+_17574268 0.19 ENSMUST00000030568.7
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr15_-_50889043 0.18 ENSMUST00000183997.1
ENSMUST00000183757.1
trichorhinophalangeal syndrome I (human)
chr3_+_66985680 0.18 ENSMUST00000065047.6
arginine/serine-rich coiled-coil 1
chr3_+_66985647 0.16 ENSMUST00000162362.1
ENSMUST00000065074.7
arginine/serine-rich coiled-coil 1
chr3_+_66985700 0.16 ENSMUST00000046542.6
ENSMUST00000162693.1
arginine/serine-rich coiled-coil 1
chr10_-_70655934 0.16 ENSMUST00000162144.1
ENSMUST00000162793.1
phytanoyl-CoA hydroxylase interacting protein-like
chr7_+_45554937 0.16 ENSMUST00000133242.3
hydroxysteroid (17-beta) dehydrogenase 14
chr3_+_129213920 0.15 ENSMUST00000042587.10
paired-like homeodomain transcription factor 2
chr11_-_23895208 0.15 ENSMUST00000102863.2
ENSMUST00000020513.3
poly(A) polymerase gamma
chr11_-_111800870 0.14 ENSMUST00000124855.1
predicted gene 11674
chr15_-_50889691 0.14 ENSMUST00000165201.2
ENSMUST00000184458.1
trichorhinophalangeal syndrome I (human)
chr14_+_53845234 0.13 ENSMUST00000103674.4
T cell receptor alpha variable 19
chr7_-_16285454 0.13 ENSMUST00000174270.1
coiled-coil domain containing 9
chr4_+_107707030 0.12 ENSMUST00000140321.1
RIKEN cDNA 1700047F07 gene
chr6_-_53978662 0.12 ENSMUST00000166545.1
carboxypeptidase, vitellogenic-like
chr9_-_27155418 0.12 ENSMUST00000167074.1
ENSMUST00000034472.8
junction adhesion molecule 3
chr1_+_19208914 0.12 ENSMUST00000027059.4
transcription factor AP-2 beta
chr17_-_35115428 0.12 ENSMUST00000172854.1
ENSMUST00000062657.4
lymphocyte antigen 6 complex, locus G5B
chr3_+_5218546 0.11 ENSMUST00000026284.6
zinc finger homeodomain 4
chr6_-_3494587 0.10 ENSMUST00000049985.8
HEPACAM family member 2
chr10_+_112083345 0.10 ENSMUST00000148897.1
ENSMUST00000020434.3
GLI pathogenesis-related 1 like 2
chr8_-_9976294 0.10 ENSMUST00000095476.4
ligase IV, DNA, ATP-dependent
chr7_+_123123870 0.09 ENSMUST00000094053.5
trinucleotide repeat containing 6a
chr4_+_107707056 0.09 ENSMUST00000147654.1
RIKEN cDNA 1700047F07 gene
chr7_+_83148644 0.09 ENSMUST00000066005.5
Riken cDNA A530021J07 gene
chr2_-_51149100 0.09 ENSMUST00000154545.1
ENSMUST00000017288.2
Rho family GTPase 3
chr17_+_12876034 0.08 ENSMUST00000075296.2
MAS-related GPR, member H
chr10_-_107719978 0.08 ENSMUST00000050702.7
protein tyrosine phosphatase, receptor type, Q
chr18_+_56572822 0.08 ENSMUST00000008445.5
phosphorylated adaptor for RNA export
chr19_+_6364557 0.06 ENSMUST00000155973.1
splicing factor 1
chr6_-_129917650 0.06 ENSMUST00000118060.1
killer cell lectin-like receptor, subfamily A, member 5
chr3_+_5218589 0.06 ENSMUST00000177488.1
zinc finger homeodomain 4
chr7_-_19604444 0.05 ENSMUST00000086041.5
CLK4-associating serine/arginine rich protein
chr4_+_99656299 0.04 ENSMUST00000087285.3
forkhead box D3
chr5_-_23616528 0.03 ENSMUST00000088392.4
serine/arginine-rich protein specific kinase 2
chr19_+_11518493 0.03 ENSMUST00000025580.3
membrane-spanning 4-domains, subfamily A, member 6B
chr7_+_5020376 0.02 ENSMUST00000076251.4
zinc finger protein 865
chrX_+_102802963 0.02 ENSMUST00000118218.1
DMRT-like family C1c1
chr9_-_21760275 0.01 ENSMUST00000098942.4
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr13_-_64903888 0.01 ENSMUST00000091554.4
contactin associated protein-like 3
chr11_-_24075054 0.01 ENSMUST00000068360.1
RIKEN cDNA A830031A19 gene
chr4_+_33062999 0.00 ENSMUST00000108162.1
ENSMUST00000024035.2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr16_-_56712825 0.00 ENSMUST00000136394.1
Trk-fused gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:2000473 immunoglobulin biosynthetic process(GO:0002378) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.1 0.4 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 0.5 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.5 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.2 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.1 0.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0051030 snRNA transport(GO:0051030)
0.0 0.8 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.5 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.1 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.2 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044753 amphisome(GO:0044753)
0.1 0.8 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.8 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.2 0.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 0.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.4 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.5 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 0.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 1.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors