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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc9

Z-value: 0.53

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Transcription factors associated with Hoxc9

Gene Symbol Gene ID Gene Info
ENSMUSG00000036139.6 homeobox C9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_1029770320.086.5e-01Click!

Activity profile of Hoxc9 motif

Sorted Z-values of Hoxc9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_102658640 4.46 ENSMUST00000080210.3
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_+_70474923 2.33 ENSMUST00000100043.2
trans-acting transcription factor 5
chr7_+_131032061 1.33 ENSMUST00000084509.3
deleted in malignant brain tumors 1
chr1_+_187997835 1.25 ENSMUST00000110938.1
estrogen-related receptor gamma
chr1_+_187997821 1.22 ENSMUST00000027906.6
estrogen-related receptor gamma
chr4_-_109202217 1.12 ENSMUST00000160774.1
ENSMUST00000030288.7
ENSMUST00000162787.2
oxysterol binding protein-like 9
chr8_+_118283719 1.05 ENSMUST00000117160.1
cadherin 13
chr6_+_54269135 0.95 ENSMUST00000114401.1
chimerin (chimaerin) 2
chr18_+_65582281 0.92 ENSMUST00000183319.1
zinc finger protein 532
chr10_+_4710119 0.85 ENSMUST00000105588.1
ENSMUST00000105589.1
estrogen receptor 1 (alpha)
chr4_+_136143497 0.84 ENSMUST00000008016.2
inhibitor of DNA binding 3
chrX_-_18461371 0.79 ENSMUST00000044188.4
RIKEN cDNA 4930578C19 gene
chr4_+_144893127 0.76 ENSMUST00000142808.1
dehydrogenase/reductase (SDR family) member 3
chr7_-_139582790 0.75 ENSMUST00000106095.2
NK6 homeobox 2
chr15_+_8968389 0.73 ENSMUST00000053308.9
ENSMUST00000166524.1
RAN binding protein 3-like
chr6_-_119388671 0.72 ENSMUST00000169744.1
adiponectin receptor 2
chr15_-_55113460 0.71 ENSMUST00000100659.2
ENSMUST00000110230.1
predicted gene 9920
chr19_+_24875679 0.71 ENSMUST00000073080.5
predicted gene 10053
chrX_-_143933089 0.66 ENSMUST00000087313.3
doublecortin
chr1_+_74284930 0.62 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
paroxysmal nonkinesiogenic dyskinesia
chr1_+_136624901 0.60 ENSMUST00000047734.8
ENSMUST00000112046.1
zinc finger protein 281
chr16_-_37384915 0.55 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
syntaxin binding protein 5-like
chr6_+_116650674 0.54 ENSMUST00000067354.5
ENSMUST00000178241.1
RIKEN cDNA 8430408G22 gene
chr5_+_102768771 0.50 ENSMUST00000112852.1
Rho GTPase activating protein 24
chr4_-_91376433 0.49 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_91376490 0.49 ENSMUST00000107124.3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr13_+_89540636 0.49 ENSMUST00000022108.7
hyaluronan and proteoglycan link protein 1
chr19_-_10880370 0.47 ENSMUST00000133303.1
transmembrane protein 109
chr16_-_37384940 0.45 ENSMUST00000114781.1
ENSMUST00000114780.1
syntaxin binding protein 5-like
chr2_-_128967725 0.42 ENSMUST00000099385.2
predicted gene 10762
chr3_+_67892189 0.40 ENSMUST00000063263.3
IQ motif containing J
chr2_+_91255954 0.39 ENSMUST00000134699.1
protein kinase C and casein kinase substrate in neurons 3
chr2_+_126034967 0.38 ENSMUST00000110442.1
fibroblast growth factor 7
chr1_+_60908993 0.38 ENSMUST00000027164.2
cytotoxic T-lymphocyte-associated protein 4
chrX_+_56609751 0.37 ENSMUST00000144068.1
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr19_+_20405280 0.36 ENSMUST00000179640.1
RIKEN cDNA 1500015L24 gene
chr2_-_26516620 0.36 ENSMUST00000132820.1
notch 1
chr4_-_150003130 0.36 ENSMUST00000084117.6
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr15_+_37425554 0.35 ENSMUST00000022897.1
RIKEN cDNA 4930447A16 gene
chr18_+_61687911 0.35 ENSMUST00000025471.2
interleukin 17B
chr2_-_84650760 0.33 ENSMUST00000111691.1
catenin (cadherin associated protein), delta 1
chr2_+_91256144 0.33 ENSMUST00000154959.1
ENSMUST00000059566.4
protein kinase C and casein kinase substrate in neurons 3
chr3_+_129199960 0.33 ENSMUST00000173645.2
paired-like homeodomain transcription factor 2
chr4_-_137118135 0.32 ENSMUST00000154285.1
predicted gene 13001
chr2_-_84650676 0.32 ENSMUST00000067232.3
catenin (cadherin associated protein), delta 1
chr17_+_24426676 0.32 ENSMUST00000024946.5
enoyl-Coenzyme A delta isomerase 1
chr10_+_52391606 0.32 ENSMUST00000067085.4
nephrocan
chr7_+_99735145 0.30 ENSMUST00000098264.1
olfactory receptor 520
chr10_+_69925954 0.30 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
ankyrin 3, epithelial
chr18_+_82855894 0.29 ENSMUST00000181345.1
ENSMUST00000180631.1
RIKEN cDNA 4930445N18 gene
chr13_-_64089179 0.29 ENSMUST00000039832.6
hydroxysteroid (17-beta) dehydrogenase 3
chrX_+_56609843 0.29 ENSMUST00000077741.5
ENSMUST00000114784.2
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr2_-_84650714 0.27 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
catenin (cadherin associated protein), delta 1
chr19_+_22448242 0.27 ENSMUST00000037901.6
transient receptor potential cation channel, subfamily M, member 3
chr5_+_67260565 0.26 ENSMUST00000037918.5
ENSMUST00000162543.1
transmembrane protein 33
chr2_-_84650490 0.26 ENSMUST00000066177.3
catenin (cadherin associated protein), delta 1
chr2_+_126034647 0.26 ENSMUST00000064794.7
fibroblast growth factor 7
chr1_+_11414089 0.25 ENSMUST00000048613.7
ENSMUST00000171690.2
ENSMUST00000137824.1
ENSMUST00000135014.1
ENSMUST00000179089.1
RIKEN cDNA A830018L16 gene
RIKEN cDNA A830018L16 gene
chrX_-_105928547 0.25 ENSMUST00000101305.2
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr5_+_67260696 0.23 ENSMUST00000161233.1
ENSMUST00000160352.1
transmembrane protein 33
chr9_+_121710389 0.23 ENSMUST00000035113.9
differentially expressed in B16F10 1
chr11_+_96271453 0.23 ENSMUST00000000010.8
ENSMUST00000174042.1
homeobox B9
chr11_+_85353156 0.22 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
breast carcinoma amplified sequence 3
chr3_+_66985647 0.20 ENSMUST00000162362.1
ENSMUST00000065074.7
arginine/serine-rich coiled-coil 1
chr10_-_67912620 0.20 ENSMUST00000064656.7
zinc finger protein 365
chr3_+_66985700 0.20 ENSMUST00000046542.6
ENSMUST00000162693.1
arginine/serine-rich coiled-coil 1
chr16_+_27307489 0.19 ENSMUST00000066852.8
osteocrin
chr10_+_43524080 0.19 ENSMUST00000057649.6
predicted gene 9803
chr4_+_150997081 0.19 ENSMUST00000030803.1
urotensin 2
chr10_-_61979073 0.18 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
collagen, type XIII, alpha 1
chrX_-_143933204 0.18 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
doublecortin
chr13_-_64089197 0.17 ENSMUST00000166224.1
hydroxysteroid (17-beta) dehydrogenase 3
chr2_-_42653598 0.17 ENSMUST00000052550.6
low density lipoprotein-related protein 1B (deleted in tumors)
chr3_+_92957386 0.17 ENSMUST00000059053.9
late cornified envelope 3D
chr1_+_60909148 0.16 ENSMUST00000097720.3
cytotoxic T-lymphocyte-associated protein 4
chr13_-_106547060 0.15 ENSMUST00000076359.2
DPH3B, KTI11 homolog B (S. cerevisiae), pseudogene
chr13_+_113209659 0.15 ENSMUST00000038144.8
endothelial cell-specific molecule 1
chr2_+_74721978 0.14 ENSMUST00000047904.3
homeobox D3
chr12_-_8499985 0.14 ENSMUST00000067384.4
ras homolog gene family, member B
chr13_+_94083490 0.13 ENSMUST00000156071.1
lipoma HMGIC fusion partner-like 2
chr11_-_98022594 0.12 ENSMUST00000103144.3
ENSMUST00000017552.6
ENSMUST00000092736.4
ENSMUST00000107562.1
calcium channel, voltage-dependent, beta 1 subunit
chr2_+_3513035 0.11 ENSMUST00000036350.2
cerebral dopamine neurotrophic factor
chr5_+_20702129 0.11 ENSMUST00000101556.4
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr17_-_40914350 0.11 ENSMUST00000166343.1
glycine-N-acyltransferase-like 3
chr3_+_66985680 0.10 ENSMUST00000065047.6
arginine/serine-rich coiled-coil 1
chr6_+_134396316 0.10 ENSMUST00000032321.4
BCL2-like 14 (apoptosis facilitator)
chr4_+_137594140 0.08 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
ubiquitin specific peptidase 48
chr15_-_48791933 0.07 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
CUB and Sushi multiple domains 3
chr8_-_120228221 0.07 ENSMUST00000183235.1
RIKEN cDNA A330074K22 gene
chr2_-_177578199 0.07 ENSMUST00000108945.1
ENSMUST00000108943.1
predicted gene 14406
chr11_+_98664341 0.06 ENSMUST00000017348.2
gasdermin A
chr10_-_88605017 0.05 ENSMUST00000119185.1
ENSMUST00000121629.1
myosin binding protein C, slow-type
chr2_+_175010241 0.04 ENSMUST00000109069.1
ENSMUST00000109070.2
predicted gene 14444
chr2_-_38714491 0.04 ENSMUST00000028084.4
nuclear receptor subfamily 5, group A, member 1
chr18_-_56975333 0.04 ENSMUST00000139243.2
ENSMUST00000025488.8
RIKEN cDNA C330018D20 gene
chr2_+_128967383 0.02 ENSMUST00000110320.2
ENSMUST00000110319.2
zinc finger CCCH type containing 6
chr17_-_49564262 0.02 ENSMUST00000057610.6
dishevelled associated activator of morphogenesis 2
chr3_-_33844255 0.02 ENSMUST00000029222.5
coiled-coil domain containing 39
chr1_-_74284636 0.01 ENSMUST00000178235.1
ENSMUST00000006462.7
angio-associated migratory protein
chrX_-_103186618 0.01 ENSMUST00000121720.1
nucleosome assembly protein 1-like 2
chr11_+_67695314 0.01 ENSMUST00000021290.1
recoverin
chr11_-_101894355 0.01 ENSMUST00000057054.7
mesenchyme homeobox 1
chr8_+_15057646 0.00 ENSMUST00000033842.3
myomesin 2
chr1_-_63769267 0.00 ENSMUST00000027102.1
RIKEN cDNA 4933402D24 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.5 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 1.2 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.2 0.6 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.2 1.1 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.2 0.7 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.9 GO:0060523 Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523)
0.1 0.5 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 0.4 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1 0.8 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.7 GO:0061042 vascular wound healing(GO:0061042)
0.1 2.3 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 1.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.7 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.2 GO:1903860 negative regulation of dendrite extension(GO:1903860)
0.1 0.3 GO:1901581 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 0.2 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 3.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.5 GO:0061370 testosterone biosynthetic process(GO:0061370)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.8 GO:0030903 notochord development(GO:0030903)
0.0 0.3 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.4 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 4.5 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:0044308 axonal spine(GO:0044308)
0.1 1.2 GO:0005915 zonula adherens(GO:0005915)
0.1 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.3 GO:1990707 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.5 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 1.8 GO:0055100 adiponectin binding(GO:0055100)
0.3 0.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.4 GO:0047936 glucose 1-dehydrogenase [NAD(P)] activity(GO:0047936)
0.1 2.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.5 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035) testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.7 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 3.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides