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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxd12

Z-value: 0.72

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Transcription factors associated with Hoxd12

Gene Symbol Gene ID Gene Info
Hoxd12
ENSMUSG00000001823.4 homeobox D12

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxd12mm10_v2_chr2_+_74674929_74675032-0.344.1e-02Click!

Activity profile of Hoxd12 motif

Sorted Z-values of Hoxd12 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_5105232 4.92 ENSMUST00000023835.1
Slc10a2
solute carrier family 10, member 2
chr19_+_40089688 3.80 ENSMUST00000068094.6
ENSMUST00000080171.2
Cyp2c50
cytochrome P450, family 2, subfamily c, polypeptide 50
chr3_+_138415484 3.76 ENSMUST00000161312.1
ENSMUST00000013458.8
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr6_+_71199827 2.99 ENSMUST00000067492.7
Fabp1
fatty acid binding protein 1, liver
chr10_-_92375367 2.73 ENSMUST00000182870.1
Gm20757
predicted gene, 20757
chr1_+_74713551 2.67 ENSMUST00000027356.5
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr14_-_118052235 2.62 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr11_-_113710017 2.46 ENSMUST00000018871.1
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr19_+_24875679 2.34 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr3_+_138374121 2.32 ENSMUST00000171054.1
Adh6-ps1
alcohol dehydrogenase 6 (class V), pseudogene 1
chr4_+_144893127 2.28 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chrX_-_143933089 2.04 ENSMUST00000087313.3
Dcx
doublecortin
chr17_+_3397189 1.89 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr8_+_45069137 1.82 ENSMUST00000067984.7
Mtnr1a
melatonin receptor 1A
chr8_-_25038875 1.74 ENSMUST00000084031.4
Htra4
HtrA serine peptidase 4
chr14_-_68533689 1.62 ENSMUST00000022640.7
Adam7
a disintegrin and metallopeptidase domain 7
chr4_+_144893077 1.59 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr16_+_42907563 1.51 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20
zinc finger and BTB domain containing 20
chr4_+_144892813 1.49 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_43641262 1.45 ENSMUST00000123351.1
ENSMUST00000128549.1
Npr2
natriuretic peptide receptor 2
chr8_-_69902558 1.44 ENSMUST00000110167.3
Ndufa13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chrM_+_5319 1.40 ENSMUST00000082402.1
mt-Co1
mitochondrially encoded cytochrome c oxidase I
chr17_-_91092715 1.20 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1
neurexin I
chr16_+_11405648 1.13 ENSMUST00000096273.2
Snx29
sorting nexin 29
chr10_-_42583628 1.13 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr9_+_74848437 1.13 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
Gm16551
Gm20649
predicted gene 16551
predicted gene 20649
chr6_-_119388671 1.13 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chrX_-_143933204 1.08 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx
doublecortin
chr18_-_3281712 1.06 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
Crem
cAMP responsive element modulator
chr2_-_18048784 1.02 ENSMUST00000142856.1
Skida1
SKI/DACH domain containing 1
chr16_-_35769356 1.01 ENSMUST00000023554.8
Dirc2
disrupted in renal carcinoma 2 (human)
chr17_+_31433054 0.97 ENSMUST00000136384.1
Pde9a
phosphodiesterase 9A
chr3_+_122419772 0.97 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr3_-_154330543 0.92 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8
LIM homeobox protein 8
chr4_-_83285141 0.91 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr19_-_35924488 0.87 ENSMUST00000178904.1
A830019P07Rik
RIKEN cDNA A830019P07 gene
chr7_+_43690418 0.86 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chr17_+_34263209 0.85 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr2_+_116900152 0.79 ENSMUST00000126467.1
ENSMUST00000128305.1
ENSMUST00000155323.1
D330050G23Rik
RIKEN cDNA D330050G23 gene
chr8_+_45507768 0.79 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
Sorbs2
sorbin and SH3 domain containing 2
chr13_+_24943144 0.76 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chrM_+_3906 0.75 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr6_+_15185203 0.75 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr10_+_43524080 0.73 ENSMUST00000057649.6
Gm9803
predicted gene 9803
chr1_+_59256906 0.71 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15
cyclin-dependent kinase 15
chr17_-_35897073 0.71 ENSMUST00000150056.1
ENSMUST00000156817.1
ENSMUST00000146451.1
ENSMUST00000148482.1
2310061I04Rik
RIKEN cDNA 2310061I04 gene
chr14_-_48662740 0.70 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr1_-_69108039 0.70 ENSMUST00000121473.1
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr13_-_99344652 0.69 ENSMUST00000022153.6
Ptcd2
pentatricopeptide repeat domain 2
chr18_-_3281752 0.63 ENSMUST00000140332.1
ENSMUST00000147138.1
Crem
cAMP responsive element modulator
chr10_-_107486077 0.63 ENSMUST00000000445.1
Myf5
myogenic factor 5
chr10_+_52391606 0.63 ENSMUST00000067085.4
Nepn
nephrocan
chrX_+_140456613 0.62 ENSMUST00000033809.3
Prps1
phosphoribosyl pyrophosphate synthetase 1
chr10_+_4611971 0.61 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1
estrogen receptor 1 (alpha)
chr1_+_153874335 0.59 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr9_+_43829963 0.57 ENSMUST00000180221.1
Gm3898
predicted gene 3898
chr11_-_101894355 0.56 ENSMUST00000057054.7
Meox1
mesenchyme homeobox 1
chr5_-_24842579 0.55 ENSMUST00000030787.8
Rheb
Ras homolog enriched in brain
chr11_-_99337930 0.55 ENSMUST00000100482.2
Krt26
keratin 26
chr5_-_28467093 0.54 ENSMUST00000002708.3
Shh
sonic hedgehog
chr7_+_81213567 0.54 ENSMUST00000026672.7
Pde8a
phosphodiesterase 8A
chr13_-_23622502 0.53 ENSMUST00000062045.2
Hist1h1e
histone cluster 1, H1e
chr4_-_82505707 0.53 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib
nuclear factor I/B
chr5_-_74531619 0.52 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2
Sec1 family domain containing 2
chr1_-_176213934 0.52 ENSMUST00000111167.1
Pld5
phospholipase D family, member 5
chr7_-_37772868 0.52 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr4_-_82505749 0.52 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib
nuclear factor I/B
chr5_-_62766153 0.51 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_+_160768013 0.51 ENSMUST00000033650.7
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr11_-_53470479 0.51 ENSMUST00000057722.2
Gm9837
predicted gene 9837
chr1_-_56969864 0.50 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chrX_-_43274786 0.49 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr14_+_32085804 0.48 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1
oxidoreductase NAD-binding domain containing 1
chr19_-_47464406 0.46 ENSMUST00000111800.2
ENSMUST00000081619.2
Sh3pxd2a
SH3 and PX domains 2A
chr9_+_45319072 0.44 ENSMUST00000034597.7
Tmprss13
transmembrane protease, serine 13
chrX_+_160768179 0.44 ENSMUST00000112368.2
Rs1
retinoschisis (X-linked, juvenile) 1 (human)
chr7_+_30458280 0.44 ENSMUST00000126297.1
Nphs1
nephrosis 1, nephrin
chr4_+_31964081 0.44 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
Map3k7
mitogen-activated protein kinase kinase kinase 7
chr9_-_89738414 0.44 ENSMUST00000060700.1
Ankrd34c
ankyrin repeat domain 34C
chr12_+_33147693 0.43 ENSMUST00000077456.6
ENSMUST00000110824.2
Atxn7l1
ataxin 7-like 1
chr9_-_123978297 0.42 ENSMUST00000071404.3
Ccr1l1
chemokine (C-C motif) receptor 1-like 1
chr10_-_116896879 0.42 ENSMUST00000048229.7
Myrfl
myelin regulatory factor-like
chr10_+_23938572 0.41 ENSMUST00000079134.4
Taar2
trace amine-associated receptor 2
chr9_-_37669170 0.41 ENSMUST00000011262.2
Panx3
pannexin 3
chr1_-_165934900 0.40 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1
POU domain, class 2, transcription factor 1
chr3_+_67892189 0.40 ENSMUST00000063263.3
Iqcj
IQ motif containing J
chr6_+_15185439 0.39 ENSMUST00000118133.1
Foxp2
forkhead box P2
chr1_+_6734827 0.38 ENSMUST00000139838.1
St18
suppression of tumorigenicity 18
chr3_+_103575231 0.38 ENSMUST00000121834.1
Syt6
synaptotagmin VI
chr2_+_73271925 0.38 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr16_-_89508313 0.37 ENSMUST00000056118.2
Krtap7-1
keratin associated protein 7-1
chr19_-_6987621 0.37 ENSMUST00000130048.1
ENSMUST00000025914.6
Vegfb
vascular endothelial growth factor B
chr13_+_80883403 0.37 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr3_-_155055341 0.37 ENSMUST00000064076.3
Tnni3k
TNNI3 interacting kinase
chr3_+_66985700 0.36 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1
arginine/serine-rich coiled-coil 1
chr18_-_25753852 0.36 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4
CUGBP, Elav-like family member 4
chr1_+_153891646 0.36 ENSMUST00000050660.4
Teddm1
transmembrane epididymal protein 1
chr18_-_37020679 0.35 ENSMUST00000097612.2
Gm10545
predicted gene 10545
chr6_+_15185456 0.35 ENSMUST00000115472.1
ENSMUST00000115474.1
ENSMUST00000031545.7
ENSMUST00000137628.1
Foxp2
forkhead box P2
chr2_-_180824596 0.35 ENSMUST00000148700.1
Gm14340
predicted gene 14340
chr11_-_46690306 0.34 ENSMUST00000169584.1
Timd2
T cell immunoglobulin and mucin domain containing 2
chr3_-_88410295 0.34 ENSMUST00000056370.7
Pmf1
polyamine-modulated factor 1
chr1_+_81077204 0.33 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr12_+_33147754 0.32 ENSMUST00000146040.1
ENSMUST00000125192.1
Atxn7l1
ataxin 7-like 1
chr5_-_101665195 0.32 ENSMUST00000044125.8
Nkx6-1
NK6 homeobox 1
chr18_-_20002093 0.31 ENSMUST00000115848.3
Dsc3
desmocollin 3
chr18_-_35215008 0.31 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr7_+_4922251 0.30 ENSMUST00000047309.5
Nat14
N-acetyltransferase 14
chr13_-_56895737 0.30 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7
transient receptor potential cation channel, subfamily C, member 7
chr3_-_30509462 0.30 ENSMUST00000173899.1
Mecom
MDS1 and EVI1 complex locus
chr6_-_73138947 0.29 ENSMUST00000114038.1
Dnah6
dynein, axonemal, heavy chain 6
chr15_-_8710409 0.29 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_74695601 0.29 ENSMUST00000152027.1
Gm14396
predicted gene 14396
chr3_+_66985947 0.29 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1
arginine/serine-rich coiled-coil 1
chr14_-_66868572 0.28 ENSMUST00000022629.8
Dpysl2
dihydropyrimidinase-like 2
chr3_+_66985647 0.28 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1
arginine/serine-rich coiled-coil 1
chrM_+_7759 0.28 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr5_-_148552783 0.27 ENSMUST00000079324.7
ENSMUST00000164904.1
Ubl3
ubiquitin-like 3
chr2_-_36104060 0.27 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6
LIM homeobox protein 6
chr3_+_103575275 0.26 ENSMUST00000090697.4
Syt6
synaptotagmin VI
chr9_-_14903752 0.26 ENSMUST00000148155.1
ENSMUST00000121116.1
Folr4
folate receptor 4 (delta)
chr9_-_77347889 0.25 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr15_-_103448455 0.25 ENSMUST00000065978.7
BC048502
cDNA sequence BC048502
chr11_-_99285260 0.24 ENSMUST00000017255.3
Krt24
keratin 24
chrX_-_72918284 0.23 ENSMUST00000152200.1
Cetn2
centrin 2
chrX_+_36195968 0.21 ENSMUST00000115256.1
Zcchc12
zinc finger, CCHC domain containing 12
chr14_-_36919314 0.21 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr7_-_128596278 0.21 ENSMUST00000179317.1
Gm7258
predicted gene 7258
chrX_+_36195904 0.19 ENSMUST00000115258.2
Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_36195950 0.19 ENSMUST00000115257.1
Zcchc12
zinc finger, CCHC domain containing 12
chr9_-_14903932 0.18 ENSMUST00000034409.7
ENSMUST00000117620.1
Folr4
folate receptor 4 (delta)
chr14_+_66868850 0.17 ENSMUST00000100453.1
Gm5464
predicted gene 5464
chrX_+_36195938 0.16 ENSMUST00000048067.3
Zcchc12
zinc finger, CCHC domain containing 12
chr4_+_105790534 0.16 ENSMUST00000185012.1
Gm12728
predicted gene 12728
chr5_+_31054821 0.16 ENSMUST00000174367.1
ENSMUST00000170329.1
ENSMUST00000031049.6
Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr3_+_76074270 0.15 ENSMUST00000038364.8
Fstl5
follistatin-like 5
chr9_+_65361049 0.15 ENSMUST00000147185.1
Gm514
predicted gene 514
chr17_-_44736648 0.15 ENSMUST00000113572.2
Runx2
runt related transcription factor 2
chr13_-_18382041 0.15 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2
POU domain, class 6, transcription factor 2
chr9_-_21067093 0.14 ENSMUST00000115494.2
Zglp1
zinc finger, GATA-like protein 1
chr16_-_50432340 0.14 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
Bbx
bobby sox homolog (Drosophila)
chr9_+_120929216 0.14 ENSMUST00000130466.1
Ctnnb1
catenin (cadherin associated protein), beta 1
chr5_+_31054766 0.14 ENSMUST00000013773.5
ENSMUST00000114646.1
Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr2_+_85991819 0.13 ENSMUST00000050942.2
Olfr1031
olfactory receptor 1031
chr16_+_65520503 0.12 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1
POU domain, class 1, transcription factor 1
chr1_+_106980979 0.12 ENSMUST00000027564.1
Serpinb13
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
chr8_+_25720054 0.12 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b
phosphatidic acid phosphatase type 2 domain containing 1B
chr4_+_105789869 0.11 ENSMUST00000184254.1
Gm12728
predicted gene 12728
chr5_+_88487982 0.10 ENSMUST00000031222.8
Enam
enamelin
chrX_-_134541847 0.10 ENSMUST00000054213.4
Timm8a1
translocase of inner mitochondrial membrane 8A1
chr1_-_173277756 0.10 ENSMUST00000111224.3
Mptx2
mucosal pentraxin 2
chr11_-_100105626 0.10 ENSMUST00000107416.2
Krt36
keratin 36
chr15_+_25773985 0.10 ENSMUST00000125667.1
Myo10
myosin X
chr10_-_107912134 0.10 ENSMUST00000165341.3
Otogl
otogelin-like
chr6_+_83086365 0.09 ENSMUST00000041265.2
Lbx2
ladybird homeobox homolog 2 (Drosophila)
chr10_+_116177217 0.09 ENSMUST00000148731.1
Ptprr
protein tyrosine phosphatase, receptor type, R
chr11_+_96316684 0.09 ENSMUST00000049241.7
Hoxb4
homeobox B4
chr19_+_55741810 0.08 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr2_+_65930117 0.08 ENSMUST00000176109.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr14_-_36919513 0.08 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr17_+_73804841 0.08 ENSMUST00000024860.7
Ehd3
EH-domain containing 3
chr3_-_141931523 0.07 ENSMUST00000106232.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr9_-_14903866 0.07 ENSMUST00000069408.3
Folr4
folate receptor 4 (delta)
chr3_+_32515295 0.07 ENSMUST00000029203.7
Zfp639
zinc finger protein 639
chr1_-_63176653 0.07 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr5_+_92809372 0.07 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr17_-_36190121 0.06 ENSMUST00000097329.3
ENSMUST00000025312.6
ENSMUST00000102675.3
H2-T3
histocompatibility 2, T region locus 3
chr5_-_62765618 0.06 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_-_118966395 0.06 ENSMUST00000035515.4
Abcb5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr12_+_55836365 0.05 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr6_-_132957919 0.04 ENSMUST00000082085.4
Tas2r131
taste receptor, type 2, member 131
chr7_-_5014645 0.04 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr1_-_44118757 0.04 ENSMUST00000027213.7
ENSMUST00000065767.2
Kdelc1
KDEL (Lys-Asp-Glu-Leu) containing 1
chr1_+_137928100 0.03 ENSMUST00000054333.2
A130050O07Rik
RIKEN cDNA A130050O07 gene
chr10_+_19356558 0.03 ENSMUST00000053225.5
Olig3
oligodendrocyte transcription factor 3
chr9_+_109812280 0.03 ENSMUST00000154663.1
Spink8
serine peptidase inhibitor, Kazal type 8
chr3_-_72967854 0.02 ENSMUST00000167334.1
Sis
sucrase isomaltase (alpha-glucosidase)
chr15_-_8710734 0.02 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_-_106101157 0.01 ENSMUST00000169588.1
Gm4775
predicted gene 4775
chr11_-_67116831 0.01 ENSMUST00000153497.1
2310065F04Rik
RIKEN cDNA 2310065F04 gene
chr10_+_90071095 0.01 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd12

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0006069 ethanol oxidation(GO:0006069)
0.9 2.6 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.4 5.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 3.8 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.3 1.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.3 1.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.3 0.8 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.3 1.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 0.8 GO:0006507 GPI anchor release(GO:0006507)
0.2 1.0 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.2 0.7 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.2 1.1 GO:0021764 amygdala development(GO:0021764)
0.2 0.6 GO:0046101 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.2 2.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 3.0 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 1.2 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.2 4.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 3.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 1.5 GO:0061042 vascular wound healing(GO:0061042)
0.1 0.7 GO:2000327 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.1 1.5 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.6 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.4 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.7 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 1.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.6 GO:0061056 sclerotome development(GO:0061056)
0.1 0.6 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 1.8 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.1 1.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.4 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.1 0.6 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.5 GO:0072675 osteoclast fusion(GO:0072675)
0.1 0.5 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.9 GO:0007320 insemination(GO:0007320)
0.1 1.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.5 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.3 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.1 GO:0060769 negative regulation of mitotic cell cycle, embryonic(GO:0045976) foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.0 0.3 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.4 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 1.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.4 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.1 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.0 1.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.7 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.5 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.1 GO:0097283 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.0 0.4 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.4 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.5 GO:0002076 osteoblast development(GO:0002076)
0.0 2.7 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.3 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:0044062 regulation of excretion(GO:0044062)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.3 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 0.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.3 GO:0097286 iron ion import(GO:0097286)
0.0 0.1 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.7 GO:0055010 ventricular cardiac muscle tissue morphogenesis(GO:0055010)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 GO:0045179 apical cortex(GO:0045179)
0.2 0.6 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 2.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 1.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 2.6 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.2 GO:0071942 XPC complex(GO:0071942)
0.1 0.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 1.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.9 GO:0000502 proteasome complex(GO:0000502)
0.0 1.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0070469 respiratory chain(GO:0070469)
0.0 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0030057 desmosome(GO:0030057)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0004024 NADPH:quinone reductase activity(GO:0003960) alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.9 3.8 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
0.8 5.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.7 4.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 3.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 1.8 GO:0008502 melatonin receptor activity(GO:0008502)
0.3 1.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.3 1.1 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.2 0.6 GO:0038052 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 0.6 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 2.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.3 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.4 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.1 1.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.0 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.8 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.5 GO:0005113 patched binding(GO:0005113)
0.1 2.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.3 GO:0070287 ferritin receptor activity(GO:0070287)
0.1 0.8 GO:1990405 protein antigen binding(GO:1990405)
0.1 0.5 GO:0032564 dATP binding(GO:0032564)
0.1 0.4 GO:0031013 troponin I binding(GO:0031013)
0.1 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 2.7 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 2.5 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 1.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.7 GO:0032183 SUMO binding(GO:0032183)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.4 GO:0022829 wide pore channel activity(GO:0022829)
0.0 3.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 3.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 5.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.5 4.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 2.7 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.4 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.0 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 4.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.3 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 2.5 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors