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GSE58827: Dynamics of the Mouse Liver

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Results for Irf5_Irf6

Z-value: 0.64

Motif logo

Transcription factors associated with Irf5_Irf6

Gene Symbol Gene ID Gene Info
ENSMUSG00000029771.6 interferon regulatory factor 5
ENSMUSG00000026638.9 interferon regulatory factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf6mm10_v2_chr1_+_193153107_1931531160.492.3e-03Click!
Irf5mm10_v2_chr6_+_29526625_295266850.057.8e-01Click!

Activity profile of Irf5_Irf6 motif

Sorted Z-values of Irf5_Irf6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_141010759 4.59 ENSMUST00000026565.6
interferon induced transmembrane protein 3
chr1_+_130826676 3.62 ENSMUST00000027675.7
polymeric immunoglobulin receptor
chr1_+_130826762 3.49 ENSMUST00000133792.1
polymeric immunoglobulin receptor
chr17_-_34862122 3.37 ENSMUST00000154526.1
complement factor B
chr17_+_31433054 2.75 ENSMUST00000136384.1
phosphodiesterase 9A
chr9_+_55326913 2.45 ENSMUST00000085754.3
ENSMUST00000034862.4
expressed sequence AI118078
chr17_-_34862473 1.68 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
complement factor B
chr4_-_40239779 1.65 ENSMUST00000037907.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_124911636 1.62 ENSMUST00000032217.1
lymphocyte-activation gene 3
chr2_-_77170534 1.53 ENSMUST00000111833.2
coiled-coil domain containing 141
chr9_+_45042425 1.48 ENSMUST00000034600.4
myelin protein zero-like 2
chr6_+_113471481 1.42 ENSMUST00000113062.1
interleukin 17 receptor C
chrM_+_9452 1.39 ENSMUST00000082411.1
mitochondrially encoded NADH dehydrogenase 3
chr6_+_113471427 1.33 ENSMUST00000058300.7
interleukin 17 receptor C
chr1_-_105356658 1.19 ENSMUST00000058688.5
ENSMUST00000172299.1
ring finger protein 152
chr10_+_80249441 1.18 ENSMUST00000020361.6
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr3_-_142395661 1.17 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
PDZ and LIM domain 5
chr6_-_39118211 0.99 ENSMUST00000038398.6
poly (ADP-ribose) polymerase family, member 12
chr4_-_46536134 0.98 ENSMUST00000046897.6
tripartite motif-containing 14
chr16_+_35938972 0.98 ENSMUST00000023622.6
ENSMUST00000114877.1
poly (ADP-ribose) polymerase family, member 9
chr4_-_46536096 0.96 ENSMUST00000102924.2
tripartite motif-containing 14
chr13_-_100552442 0.93 ENSMUST00000159515.1
ENSMUST00000160859.1
ENSMUST00000069756.4
occludin
chr7_+_128523576 0.89 ENSMUST00000033136.7
BCL2-associated athanogene 3
chr16_-_35871544 0.89 ENSMUST00000042665.8
poly (ADP-ribose) polymerase family, member 14
chr5_-_91402905 0.88 ENSMUST00000121044.2
betacellulin, epidermal growth factor family member
chr1_+_175631996 0.88 ENSMUST00000040250.8
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr6_-_13608011 0.87 ENSMUST00000031554.2
transmembrane protein 168
chr1_+_175632169 0.86 ENSMUST00000097458.3
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr13_-_100552704 0.85 ENSMUST00000022140.5
occludin
chr5_-_24447587 0.85 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
transmembrane and ubiquitin-like domain containing 1
chr2_-_69586021 0.84 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
low density lipoprotein receptor-related protein 2
chr10_+_80249106 0.84 ENSMUST00000105364.1
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr5_-_45857473 0.83 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
ligand dependent nuclear receptor corepressor-like
chr7_-_141266415 0.81 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
interferon regulatory factor 7
chr9_+_20868628 0.79 ENSMUST00000043911.7
RIKEN cDNA A230050P20 gene
chr17_-_32189457 0.78 ENSMUST00000087721.3
ENSMUST00000162117.1
epoxide hydrolase 3
chr13_-_100552598 0.78 ENSMUST00000159459.1
occludin
chr7_-_44375006 0.78 ENSMUST00000107933.1
RIKEN cDNA 1700008O03 gene
chr7_+_49246131 0.67 ENSMUST00000064395.6
neuron navigator 2
chr3_+_142496924 0.67 ENSMUST00000090127.2
guanylate binding protein 5
chr9_-_123851855 0.67 ENSMUST00000184082.1
ENSMUST00000167595.2
FYVE and coiled-coil domain containing 1
chr4_-_116651644 0.65 ENSMUST00000030455.8
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr11_+_72301613 0.64 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
XIAP associated factor 1
chr11_-_78984946 0.61 ENSMUST00000108268.3
lectin, galactose binding, soluble 9
chr11_-_78984831 0.60 ENSMUST00000073001.4
ENSMUST00000108269.3
lectin, galactose binding, soluble 9
chr2_-_77519565 0.60 ENSMUST00000111830.2
zinc finger protein 385B
chr16_+_23609895 0.58 ENSMUST00000038423.5
receptor transporter protein 4
chr16_-_35939082 0.57 ENSMUST00000081933.7
ENSMUST00000114885.1
deltex 3-like (Drosophila)
chrX_+_77511002 0.57 ENSMUST00000088217.5
transducin (beta)-like 1 X-linked
chr19_+_44756049 0.55 ENSMUST00000174490.2
paired box gene 2
chr4_-_40239700 0.55 ENSMUST00000142055.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_77170592 0.55 ENSMUST00000164114.2
ENSMUST00000049544.7
coiled-coil domain containing 141
chr1_+_52119438 0.54 ENSMUST00000070968.7
signal transducer and activator of transcription 1
chr5_+_139543889 0.52 ENSMUST00000174792.1
ENSMUST00000031523.8
UNC homeobox
chr19_-_7295394 0.52 ENSMUST00000025921.8
MAP/microtubule affinity-regulating kinase 2
chr16_+_35938470 0.50 ENSMUST00000114878.1
poly (ADP-ribose) polymerase family, member 9
chr12_-_31950170 0.50 ENSMUST00000176520.1
high mobility group box transcription factor 1
chr16_-_5255923 0.49 ENSMUST00000139584.1
ENSMUST00000064635.5
family with sequence similarity 86
chr3_+_135438722 0.47 ENSMUST00000166033.1
ubiquitin-conjugating enzyme E2D 3
chr15_-_76243401 0.46 ENSMUST00000165738.1
ENSMUST00000075689.6
poly (ADP-ribose) polymerase family, member 10
chrM_+_8600 0.46 ENSMUST00000082409.1
mitochondrially encoded cytochrome c oxidase III
chr8_+_61928081 0.45 ENSMUST00000154398.1
ENSMUST00000093485.2
ENSMUST00000156980.1
ENSMUST00000070631.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr16_-_67620805 0.44 ENSMUST00000120594.1
cell adhesion molecule 2
chr5_+_92809372 0.44 ENSMUST00000113054.2
shroom family member 3
chr3_+_138065052 0.40 ENSMUST00000163080.2
RIKEN cDNA 1110002E22 gene
chr17_+_34203527 0.40 ENSMUST00000025197.5
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_-_31950210 0.39 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
high mobility group box transcription factor 1
chr6_-_38354243 0.35 ENSMUST00000114900.1
zinc finger CCCH type, antiviral 1
chr16_-_55838827 0.32 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr7_-_65370908 0.32 ENSMUST00000032729.6
tight junction protein 1
chr9_-_123862023 0.31 ENSMUST00000182350.1
ENSMUST00000078755.2
chemokine (C motif) receptor 1
chr11_+_88999376 0.27 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
tripartite motif-containing 25
chr17_+_34644764 0.23 ENSMUST00000036720.8
FK506 binding protein-like
chr2_+_58470116 0.19 ENSMUST00000167423.1
predicted gene, 17409
chr17_+_34644805 0.18 ENSMUST00000174796.1
FK506 binding protein-like
chr16_-_67620880 0.18 ENSMUST00000114292.1
ENSMUST00000120898.1
cell adhesion molecule 2
chr12_-_31950535 0.12 ENSMUST00000172314.2
high mobility group box transcription factor 1
chr4_-_58911902 0.08 ENSMUST00000134848.1
ENSMUST00000107557.2
ENSMUST00000149301.1
expressed sequence AI314180
chr19_+_47937648 0.04 ENSMUST00000066308.7
coiled-coil domain containing 147
chr11_+_29130733 0.03 ENSMUST00000020756.8
polyribonucleotide nucleotidyltransferase 1
chr10_-_43174521 0.03 ENSMUST00000040275.7
sine oculis-binding protein homolog (Drosophila)
chr1_-_163313661 0.03 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
paired related homeobox 1
chr1_-_75316998 0.01 ENSMUST00000113605.3
aspartyl aminopeptidase
chr16_+_11313812 0.00 ENSMUST00000023140.5
tumor necrosis factor receptor superfamily, member 17

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf5_Irf6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.4 2.2 GO:0009597 detection of virus(GO:0009597)
0.3 1.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.3 1.6 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.3 5.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 1.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.3 6.5 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 1.2 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.2 0.5 GO:2000595 optic nerve formation(GO:0021634) optic chiasma development(GO:0061360) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597)
0.2 2.6 GO:0070673 response to interleukin-18(GO:0070673)
0.2 0.7 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.2 0.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.2 2.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.5 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 3.4 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.7 GO:0021564 vagus nerve development(GO:0021564)
0.1 0.4 GO:0046968 positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591) peptide antigen transport(GO:0046968)
0.1 0.7 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.5 GO:0034238 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239)
0.1 1.5 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 1.0 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 1.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.9 GO:0035810 positive regulation of urine volume(GO:0035810)
0.1 0.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 2.0 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.8 GO:0045056 transcytosis(GO:0045056)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 2.1 GO:0021799 cerebral cortex radially oriented cell migration(GO:0021799)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.4 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.8 GO:0034340 response to type I interferon(GO:0034340)
0.0 1.2 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.7 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 1.2 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.9 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 3.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.5 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 4.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.8 GO:0043204 perikaryon(GO:0043204)
0.0 2.1 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 7.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.3 2.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 1.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 0.8 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.2 1.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 1.2 GO:0016936 galactoside binding(GO:0016936)
0.1 0.6 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 3.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 3.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.4 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.5 GO:0050664 superoxide-generating NADPH oxidase activity(GO:0016175) oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.1 1.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 8.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.5 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.0 PID MYC PATHWAY C-MYC pathway
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 3.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 2.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 5.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 2.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions