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GSE58827: Dynamics of the Mouse Liver

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Results for Irx4

Z-value: 0.29

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Transcription factors associated with Irx4

Gene Symbol Gene ID Gene Info
ENSMUSG00000021604.9 Iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx4mm10_v2_chr13_+_73260473_732604970.281.0e-01Click!

Activity profile of Irx4 motif

Sorted Z-values of Irx4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_11970540 2.83 ENSMUST00000109653.1
growth factor receptor bound protein 10
chr6_-_83317589 1.31 ENSMUST00000005810.6
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr16_+_17146937 1.24 ENSMUST00000115706.1
ENSMUST00000069064.4
YdjC homolog (bacterial)
chr1_-_174250976 0.95 ENSMUST00000061990.4
olfactory receptor 419
chr8_-_24725762 0.94 ENSMUST00000171438.1
ENSMUST00000171611.1
ENSMUST00000033958.7
a disintegrin and metallopeptidase domain 3 (cyritestin)
chr18_+_44334062 0.88 ENSMUST00000025349.5
ENSMUST00000115498.1
myotilin
chr12_-_111980751 0.84 ENSMUST00000170525.1
cDNA sequence BC048943
chr2_+_24345282 0.79 ENSMUST00000114485.2
interleukin 1 receptor antagonist
chr2_+_24345305 0.75 ENSMUST00000114482.1
interleukin 1 receptor antagonist
chr4_+_48663502 0.71 ENSMUST00000030033.4
muscle-related coiled-coil protein
chr3_+_88376023 0.60 ENSMUST00000179946.1
predicted gene, 21956
chr3_+_88381004 0.49 ENSMUST00000107540.2
predicted gene 6821
chr8_+_84872105 0.40 ENSMUST00000136026.1
ENSMUST00000170296.1
synaptonemal complex central element protein 2
chr3_+_59925214 0.35 ENSMUST00000049476.2
RIKEN cDNA C130079G13 gene
chr4_+_147150494 0.33 ENSMUST00000151022.1
predicted gene 13139
chr18_-_37178493 0.23 ENSMUST00000181887.1
ENSMUST00000180516.1
predicted gene 10544
chr6_-_3494587 0.16 ENSMUST00000049985.8
HEPACAM family member 2
chr14_-_50299330 0.15 ENSMUST00000163469.1
olfactory receptor 733
chr3_+_84925476 0.12 ENSMUST00000107675.1
F-box and WD-40 domain protein 7
chr7_+_106814135 0.09 ENSMUST00000075414.1
ENSMUST00000166880.1
olfactory receptor 701
chr9_-_58202281 0.05 ENSMUST00000163897.1
immunoglobulin superfamily containing leucine-rich repeat 2
chr2_-_79908389 0.02 ENSMUST00000090756.4
phosphodiesterase 1A, calmodulin-dependent
chr1_-_59003443 0.01 ENSMUST00000054653.6
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (human)

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 2.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.1 1.3 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 0.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.4 GO:0007130 synaptonemal complex assembly(GO:0007130)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0045353 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
0.4 1.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 2.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.8 PID IGF1 PATHWAY IGF1 pathway
0.0 1.5 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 1.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling