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GSE58827: Dynamics of the Mouse Liver

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Results for Mecom

Z-value: 0.79

Motif logo

Transcription factors associated with Mecom

Gene Symbol Gene ID Gene Info
ENSMUSG00000027684.10 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mecommm10_v2_chr3_-_30509462_30509514-0.363.1e-02Click!

Activity profile of Mecom motif

Sorted Z-values of Mecom motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_62087261 10.72 ENSMUST00000107488.3
ENSMUST00000107472.1
ENSMUST00000084531.4
major urinary protein 3
chr4_-_61303802 10.29 ENSMUST00000125461.1
major urinary protein 14
chr1_+_152399824 6.18 ENSMUST00000044311.8
collagen beta(1-O)galactosyltransferase 2
chr4_+_60003438 3.83 ENSMUST00000107517.1
ENSMUST00000107520.1
major urinary protein 6
chr13_+_89540636 2.70 ENSMUST00000022108.7
hyaluronan and proteoglycan link protein 1
chr3_-_56890593 2.37 ENSMUST00000099093.3
RIKEN cDNA F830104G03 gene
chr6_+_138140298 2.03 ENSMUST00000008684.4
microsomal glutathione S-transferase 1
chr8_+_12385769 1.70 ENSMUST00000080795.8
predicted gene 5607
chr1_+_185454803 1.68 ENSMUST00000061093.6
solute carrier family 30, member 10
chr5_-_66080971 1.62 ENSMUST00000127275.1
ENSMUST00000113724.1
RNA binding motif protein 47
chr9_-_104337700 1.34 ENSMUST00000112590.2
ENSMUST00000062723.6
acid phosphatase, prostate
chr6_-_34910869 1.20 ENSMUST00000081214.5
WD repeat domain 91
chr14_-_56211407 1.16 ENSMUST00000022757.3
granzyme F
chr1_-_162984519 1.06 ENSMUST00000028010.7
flavin containing monooxygenase 3
chrX_+_21714896 0.94 ENSMUST00000033414.7
solute carrier family 6 (neurotransmitter transporter), member 14
chr2_+_34874396 0.89 ENSMUST00000113068.2
ENSMUST00000047447.8
cutA divalent cation tolerance homolog-like
chr8_-_36953139 0.84 ENSMUST00000179501.1
deleted in liver cancer 1
chrX_-_113185485 0.84 ENSMUST00000026607.8
ENSMUST00000113388.2
choroidermia
chr3_+_41742615 0.83 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
DNA segment, Chr 3, ERATO Doi 751, expressed
chr11_-_50953745 0.82 ENSMUST00000162420.1
ENSMUST00000051159.2
paired like homeodomain factor 1
chr2_+_34874486 0.81 ENSMUST00000028228.3
cutA divalent cation tolerance homolog-like
chrX_+_98149666 0.80 ENSMUST00000052837.7
androgen receptor
chrX_+_140381971 0.76 ENSMUST00000044702.6
FERM and PDZ domain containing 3
chr9_+_64235201 0.75 ENSMUST00000039011.3
ubiquitin carboxyl-terminal esterase L4
chrY_+_897782 0.72 ENSMUST00000055032.7
lysine (K)-specific demethylase 5D
chrX_+_9350599 0.71 ENSMUST00000073949.2
predicted gene 14501
chr4_+_133039482 0.68 ENSMUST00000105914.1
AT hook, DNA binding motif, containing 1
chrX_+_9885622 0.65 ENSMUST00000067529.2
ENSMUST00000086165.3
synaptotagmin-like 5
chrX_+_11302432 0.65 ENSMUST00000179428.1
predicted gene 14474
chr10_-_68278713 0.62 ENSMUST00000020106.7
AT rich interactive domain 5B (MRF1-like)
chr17_+_33432890 0.61 ENSMUST00000174088.2
actin-like 9
chr19_-_37176055 0.60 ENSMUST00000142973.1
ENSMUST00000154376.1
cytoplasmic polyadenylation element binding protein 3
chrX_+_11311934 0.59 ENSMUST00000178979.1
predicted gene 14484
chrX_+_9283764 0.59 ENSMUST00000177926.1
RIKEN cDNA 1700012L04 gene
chr14_+_87416610 0.56 ENSMUST00000168275.1
ENSMUST00000169504.1
ENSMUST00000170865.1
tudor domain containing 3
chr5_+_65131184 0.55 ENSMUST00000031089.5
ENSMUST00000101191.3
kelch-like 5
chr16_+_56477838 0.55 ENSMUST00000048471.7
ENSMUST00000096013.3
ENSMUST00000096012.3
ENSMUST00000171000.1
ABI gene family, member 3 (NESH) binding protein
chr9_+_59589288 0.54 ENSMUST00000121266.1
ENSMUST00000118164.1
CUGBP, Elav-like family member 6
chr18_-_43477764 0.54 ENSMUST00000057110.9
eukaryotic translation initiation factor 3, subunit J2
chrX_+_11324659 0.53 ENSMUST00000164729.2
predicted gene 14475
chrX_+_11308824 0.52 ENSMUST00000178595.1
predicted gene 14476
chr5_+_66259890 0.50 ENSMUST00000065530.6
NOL1/NOP2/Sun domain family, member 7
chr13_+_109260481 0.50 ENSMUST00000153234.1
phosphodiesterase 4D, cAMP specific
chr10_+_61648552 0.48 ENSMUST00000020286.6
pyrophosphatase (inorganic) 1
chr2_+_18672384 0.46 ENSMUST00000171845.1
ENSMUST00000061158.4
COMM domain containing 3
chrX_+_11321423 0.45 ENSMUST00000178196.1
predicted gene 14478
chrX_+_11305655 0.45 ENSMUST00000178806.1
predicted gene 14477
chrX_+_11299257 0.44 ENSMUST00000178729.1
predicted gene 14483
chr4_+_128846163 0.43 ENSMUST00000138291.1
predicted gene 12968
chrX_+_11315158 0.42 ENSMUST00000179004.1
predicted gene 14479
chrX_+_11318256 0.41 ENSMUST00000179859.1
predicted gene 14482
chrX_+_76264281 0.40 ENSMUST00000096389.4
predicted gene 4937
chr2_-_45110241 0.34 ENSMUST00000177302.1
zinc finger E-box binding homeobox 2
chr5_+_34525797 0.33 ENSMUST00000125817.1
ENSMUST00000067638.7
SH3-domain binding protein 2
chrX_-_37110257 0.33 ENSMUST00000076265.6
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr9_-_13245741 0.32 ENSMUST00000110582.2
jerky homolog-like (mouse)
chr15_-_36140393 0.31 ENSMUST00000172831.1
regulator of G-protein signalling 22
chrX_-_21221564 0.30 ENSMUST00000155208.1
ENSMUST00000125569.1
RIKEN cDNA 4930453H23 gene
chrX_-_89409689 0.30 ENSMUST00000113959.1
ENSMUST00000113960.2
plasmacytoma expressed transcript 2
chr3_+_36552600 0.29 ENSMUST00000029269.5
ENSMUST00000136890.1
exosome component 9
chr1_-_189343342 0.29 ENSMUST00000079451.6
potassium channel, subfamily K, member 2
chr16_-_48771956 0.29 ENSMUST00000170861.1
T cell receptor associated transmembrane adaptor 1
chr3_+_106034661 0.28 ENSMUST00000170669.2
predicted gene 4540
chr7_+_6222278 0.26 ENSMUST00000072662.5
ENSMUST00000155314.1
zinc finger and SCAN domain containing 5B
chr12_-_11208948 0.25 ENSMUST00000049877.1
mesogenin 1
chr11_-_83020722 0.25 ENSMUST00000108152.2
schlafen 8
chrX_+_14211148 0.25 ENSMUST00000079952.2
predicted gene 5382
chr18_+_4994600 0.24 ENSMUST00000140448.1
supervillin
chr9_+_105053239 0.24 ENSMUST00000035177.8
ENSMUST00000149243.1
mitochondrial ribosomal protein L3
chr9_-_117252111 0.22 ENSMUST00000111772.3
RNA binding motif, single stranded interacting protein
chr7_+_140690884 0.22 ENSMUST00000084454.3
olfactory receptor 45
chr11_-_115367667 0.21 ENSMUST00000123428.1
ENSMUST00000044152.6
ENSMUST00000106542.2
HID1 domain containing
chr10_+_3740348 0.20 ENSMUST00000120274.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr11_-_83020788 0.20 ENSMUST00000038141.8
ENSMUST00000092838.4
schlafen 8
chr13_-_27513206 0.20 ENSMUST00000018389.3
ENSMUST00000110350.1
prolactin family 8, subfamily a, member 81
chr2_-_45110336 0.19 ENSMUST00000028229.6
ENSMUST00000152232.1
zinc finger E-box binding homeobox 2
chr6_+_96113146 0.19 ENSMUST00000122120.1
family with sequence similarity 19, member A1
chr2_+_97467657 0.18 ENSMUST00000059049.7
leucine rich repeat containing 4C
chr16_+_94425083 0.17 ENSMUST00000141176.1
tetratricopeptide repeat domain 3
chr8_+_46490968 0.16 ENSMUST00000110372.1
ENSMUST00000130563.1
acyl-CoA synthetase long-chain family member 1
chr9_+_115937142 0.16 ENSMUST00000121770.1
glutamate decarboxylase-like 1
chrX_-_155128409 0.15 ENSMUST00000076671.3
RIKEN cDNA 1700042B14 gene
chr11_+_96302595 0.15 ENSMUST00000049272.3
homeobox B5
chr7_+_82337218 0.14 ENSMUST00000173828.1
ADAMTS-like 3
chr6_-_99435345 0.13 ENSMUST00000113322.2
ENSMUST00000176850.1
ENSMUST00000176632.1
forkhead box P1
chr14_-_124677089 0.13 ENSMUST00000095529.3
fibroblast growth factor 14
chr14_+_115042752 0.12 ENSMUST00000134140.2
Mir17 host gene 1 (non-protein coding)
chr13_+_21495218 0.12 ENSMUST00000104942.1
cDNA sequence AK157302
chr6_-_29609607 0.11 ENSMUST00000115251.1
transportin 3
chr6_+_30401866 0.10 ENSMUST00000068240.6
ENSMUST00000068259.6
kelch domain containing 10
chr11_-_88718078 0.10 ENSMUST00000092794.5
musashi RNA-binding protein 2
chr3_+_87357874 0.10 ENSMUST00000015998.6
CD5 antigen-like
chr9_-_117251801 0.07 ENSMUST00000172564.1
RNA binding motif, single stranded interacting protein
chr14_+_61599493 0.06 ENSMUST00000039562.6
tripartite motif-containing 13
chr3_-_123236134 0.06 ENSMUST00000106427.1
ENSMUST00000106426.1
ENSMUST00000051443.5
synaptopodin 2
chr16_-_29541483 0.06 ENSMUST00000057018.8
ENSMUST00000182627.1
ATPase type 13A4
chr8_-_43306991 0.05 ENSMUST00000082120.3
zinc finger protein 42
chr5_-_136198908 0.05 ENSMUST00000149151.1
ENSMUST00000151786.1
Prkr interacting protein 1 (IL11 inducible)
chr4_-_110292719 0.05 ENSMUST00000106601.1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_-_152830266 0.04 ENSMUST00000140436.1
BCL2-like 1
chr4_+_11704439 0.04 ENSMUST00000108304.2
GTP binding protein (gene overexpressed in skeletal muscle)
chr5_+_129715488 0.03 ENSMUST00000119576.1
ENSMUST00000042191.5
ENSMUST00000118420.1
ENSMUST00000154358.1
ENSMUST00000121339.1
ENSMUST00000119604.1
ENSMUST00000136108.1
ENSMUST00000121813.1
ENSMUST00000119985.1
ENSMUST00000138812.1
mitochondrial ribosomal protein S17
chr16_-_38713235 0.01 ENSMUST00000023487.4
Rho GTPase activating protein 31
chr5_-_120467296 0.01 ENSMUST00000132916.1
serine dehydratase-like
chr6_-_29609811 0.01 ENSMUST00000012679.8
transportin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecom

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.5 2.0 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.4 1.3 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.4 0.8 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.4 10.7 GO:0035634 response to stilbenoid(GO:0035634)
0.3 0.8 GO:0060599 lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.2 0.6 GO:1900248 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 0.3 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.1 0.8 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.5 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.6 GO:0060613 fat pad development(GO:0060613)
0.1 0.3 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.8 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.5 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.1 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 1.2 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.5 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.0 GO:0019050 suppression by virus of host apoptotic process(GO:0019050) modulation by virus of host apoptotic process(GO:0039526) response to cycloheximide(GO:0046898)
0.0 0.3 GO:0007379 segment specification(GO:0007379)
0.0 0.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 1.3 GO:0005771 multivesicular body(GO:0005771)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 2.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.7 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.7 GO:0005550 pheromone binding(GO:0005550)
0.2 6.2 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.2 1.3 GO:0033265 choline binding(GO:0033265)
0.2 0.9 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.5 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.7 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 2.0 GO:0043295 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.0 0.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 1.7 GO:0005507 copper ion binding(GO:0005507)
0.0 0.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.0 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events