Motif ID: Mef2c

Z-value: 1.159


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83573577_835736070.411.4e-02Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_98383811 7.729 ENSMUST00000008021.2
Tcap
titin-cap
chr5_+_122100951 6.696 ENSMUST00000014080.6
ENSMUST00000111750.1
ENSMUST00000139213.1
ENSMUST00000111751.1
ENSMUST00000155612.1
Myl2




myosin, light polypeptide 2, regulatory, cardiac, slow




chr1_-_66935333 6.316 ENSMUST00000120415.1
ENSMUST00000119429.1
Myl1

myosin, light polypeptide 1

chr3_-_123034943 5.313 ENSMUST00000029761.7
Myoz2
myozenin 2
chr7_+_142498832 5.213 ENSMUST00000078497.8
ENSMUST00000105953.3
ENSMUST00000179658.1
ENSMUST00000105954.3
ENSMUST00000105952.3
ENSMUST00000105955.1
ENSMUST00000074187.6
ENSMUST00000180152.1
ENSMUST00000105950.4
ENSMUST00000105957.3
ENSMUST00000169299.2
ENSMUST00000105958.3
ENSMUST00000105949.1
Tnnt3












troponin T3, skeletal, fast












chr7_+_142441808 4.985 ENSMUST00000105971.1
ENSMUST00000145287.1
Tnni2

troponin I, skeletal, fast 2

chr15_-_77022632 4.637 ENSMUST00000019037.8
ENSMUST00000169226.1
Mb

myoglobin

chr11_+_67798269 4.144 ENSMUST00000168612.1
ENSMUST00000040574.4
Dhrs7c

dehydrogenase/reductase (SDR family) member 7C

chr14_-_34588654 4.141 ENSMUST00000022328.6
ENSMUST00000064098.6
ENSMUST00000022327.5
ENSMUST00000022330.7
Ldb3



LIM domain binding 3



chr9_+_110763646 4.116 ENSMUST00000079784.7
Myl3
myosin, light polypeptide 3
chr15_-_78206391 4.075 ENSMUST00000120592.1
Pvalb
parvalbumin
chr1_+_40805578 3.920 ENSMUST00000114765.2
Tmem182
transmembrane protein 182
chr1_-_172219715 3.699 ENSMUST00000170700.1
ENSMUST00000003554.4
Casq1

calsequestrin 1

chr8_+_15057646 3.402 ENSMUST00000033842.3
Myom2
myomesin 2
chr7_+_142442330 3.293 ENSMUST00000149529.1
Tnni2
troponin I, skeletal, fast 2
chr11_-_94976327 3.216 ENSMUST00000103162.1
ENSMUST00000166320.1
Sgca

sarcoglycan, alpha (dystrophin-associated glycoprotein)

chr4_+_130308595 3.055 ENSMUST00000070532.7
Fabp3
fatty acid binding protein 3, muscle and heart
chr5_-_112896350 2.864 ENSMUST00000086617.4
Myo18b
myosin XVIIIb
chr14_-_34588607 2.820 ENSMUST00000090040.4
Ldb3
LIM domain binding 3
chr14_-_20664562 2.759 ENSMUST00000119483.1
Synpo2l
synaptopodin 2-like
chr7_+_102101736 2.711 ENSMUST00000033300.2
Art1
ADP-ribosyltransferase 1
chrX_-_95478107 2.672 ENSMUST00000033549.2
Asb12
ankyrin repeat and SOCS box-containing 12
chr10_+_33083476 2.504 ENSMUST00000095762.4
Trdn
triadin
chr7_+_128003911 2.338 ENSMUST00000106248.1
Trim72
tripartite motif-containing 72
chr3_+_102086471 2.223 ENSMUST00000165540.2
ENSMUST00000164123.1
Casq2

calsequestrin 2

chr14_-_20668269 2.201 ENSMUST00000057090.5
ENSMUST00000117386.1
Synpo2l

synaptopodin 2-like

chr7_-_128206346 2.185 ENSMUST00000033049.7
Cox6a2
cytochrome c oxidase subunit VIa polypeptide 2
chr14_-_32685246 2.183 ENSMUST00000096038.3
3425401B19Rik
RIKEN cDNA 3425401B19 gene
chr14_-_54966570 2.175 ENSMUST00000124930.1
ENSMUST00000134256.1
ENSMUST00000081857.6
ENSMUST00000145322.1
Myh6



myosin, heavy polypeptide 6, cardiac muscle, alpha



chr9_+_121777607 2.139 ENSMUST00000098272.2
Klhl40
kelch-like 40
chr1_+_135799402 2.104 ENSMUST00000152208.1
ENSMUST00000152075.1
ENSMUST00000154463.1
ENSMUST00000139986.1
Tnni1



troponin I, skeletal, slow 1



chr3_+_102086415 2.075 ENSMUST00000029454.5
Casq2
calsequestrin 2
chr11_+_77462325 2.048 ENSMUST00000102493.1
Coro6
coronin 6
chr3_+_103074009 2.035 ENSMUST00000090715.6
Ampd1
adenosine monophosphate deaminase 1
chr14_-_21714570 1.913 ENSMUST00000073870.5
Dupd1
dual specificity phosphatase and pro isomerase domain containing 1
chr1_+_135799833 1.898 ENSMUST00000148201.1
Tnni1
troponin I, skeletal, slow 1
chr11_+_67238017 1.859 ENSMUST00000018632.4
Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr13_-_113663670 1.803 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr2_-_76982455 1.678 ENSMUST00000011934.5
ENSMUST00000099981.2
ENSMUST00000099980.3
ENSMUST00000111882.2
ENSMUST00000140091.1
Ttn




titin




chr6_+_30541582 1.659 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr2_+_69670100 1.653 ENSMUST00000100050.3
Klhl41
kelch-like 41
chr3_+_103074035 1.646 ENSMUST00000176440.1
Ampd1
adenosine monophosphate deaminase 1
chr4_-_73950834 1.635 ENSMUST00000095023.1
ENSMUST00000030101.3
2310002L09Rik

RIKEN cDNA 2310002L09 gene

chr2_+_32628390 1.536 ENSMUST00000156578.1
Ak1
adenylate kinase 1
chr17_+_71019548 1.441 ENSMUST00000073211.5
ENSMUST00000179759.1
Myom1

myomesin 1

chr11_+_70657196 1.421 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
Eno3



enolase 3, beta muscle



chr4_+_156215920 1.399 ENSMUST00000105572.1
2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr11_-_107716517 1.387 ENSMUST00000021065.5
Cacng1
calcium channel, voltage-dependent, gamma subunit 1
chr11_+_70657687 1.374 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3

enolase 3, beta muscle

chr2_-_104028287 1.326 ENSMUST00000056170.3
4931422A03Rik
RIKEN cDNA 4931422A03 gene
chr17_+_71019503 1.320 ENSMUST00000024847.7
Myom1
myomesin 1
chr1_-_44019929 1.314 ENSMUST00000061421.3
Mettl21c
methyltransferase like 21C
chr6_+_112273758 1.281 ENSMUST00000032376.5
Lmcd1
LIM and cysteine-rich domains 1
chr1_+_187608755 1.247 ENSMUST00000127489.1
Esrrg
estrogen-related receptor gamma
chr5_+_66745835 1.232 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
Limch1



LIM and calponin homology domains 1



chr15_+_25940846 1.222 ENSMUST00000110438.1
Fam134b
family with sequence similarity 134, member B
chr7_-_4514558 1.177 ENSMUST00000163538.1
Tnnt1
troponin T1, skeletal, slow
chr19_+_6384395 1.177 ENSMUST00000035269.8
ENSMUST00000113483.1
Pygm

muscle glycogen phosphorylase

chr14_+_26894557 1.137 ENSMUST00000090337.4
ENSMUST00000165929.2
Asb14

ankyrin repeat and SOCS box-containing 14

chr2_-_67433181 1.100 ENSMUST00000180773.1
Gm26727
predicted gene, 26727
chr10_+_127501672 1.076 ENSMUST00000160019.1
ENSMUST00000160610.1
Stac3

SH3 and cysteine rich domain 3

chr4_+_135759705 1.048 ENSMUST00000105854.1
Myom3
myomesin family, member 3
chr5_+_122101146 1.026 ENSMUST00000147178.1
Myl2
myosin, light polypeptide 2, regulatory, cardiac, slow
chr4_-_130308674 1.006 ENSMUST00000097865.1
Gm10570
predicted gene 10570
chr7_+_45405960 0.997 ENSMUST00000107774.1
Kcna7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr7_-_4514609 0.958 ENSMUST00000166959.1
Tnnt1
troponin T1, skeletal, slow
chr9_-_120023558 0.957 ENSMUST00000111635.2
Xirp1
xin actin-binding repeat containing 1
chr4_+_137862270 0.952 ENSMUST00000130407.1
Ece1
endothelin converting enzyme 1
chr5_+_92386879 0.946 ENSMUST00000128246.1
Art3
ADP-ribosyltransferase 3
chrX_+_164438039 0.945 ENSMUST00000033755.5
Asb11
ankyrin repeat and SOCS box-containing 11
chr4_+_49059256 0.932 ENSMUST00000076670.2
E130309F12Rik
RIKEN cDNA E130309F12 gene
chr5_-_62765618 0.917 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr10_+_127501707 0.902 ENSMUST00000035839.2
Stac3
SH3 and cysteine rich domain 3
chr3_+_32817520 0.901 ENSMUST00000072312.5
ENSMUST00000108228.1
Usp13

ubiquitin specific peptidase 13 (isopeptidase T-3)

chr11_+_75656103 0.897 ENSMUST00000136935.1
Myo1c
myosin IC
chr2_+_91118136 0.896 ENSMUST00000169776.1
ENSMUST00000111430.3
ENSMUST00000137942.1
Mybpc3


myosin binding protein C, cardiac


chr5_-_122002340 0.871 ENSMUST00000134326.1
Cux2
cut-like homeobox 2
chr15_-_91191733 0.868 ENSMUST00000069511.6
Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr8_+_45658273 0.865 ENSMUST00000153798.1
Sorbs2
sorbin and SH3 domain containing 2
chr7_+_130865835 0.845 ENSMUST00000075181.4
ENSMUST00000048180.5
Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr12_+_88953399 0.826 ENSMUST00000057634.7
Nrxn3
neurexin III
chr13_+_83573577 0.812 ENSMUST00000185052.1
Mef2c
myocyte enhancer factor 2C
chr2_+_72054598 0.765 ENSMUST00000028525.5
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_67445994 0.720 ENSMUST00000112347.1
ENSMUST00000028410.3
Xirp2

xin actin-binding repeat containing 2

chr13_+_37826904 0.704 ENSMUST00000149745.1
Rreb1
ras responsive element binding protein 1
chr7_+_122671378 0.697 ENSMUST00000182563.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr2_-_77170592 0.668 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr14_+_101840501 0.665 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chrX_+_73774397 0.655 ENSMUST00000002081.5
Srpk3
serine/arginine-rich protein specific kinase 3
chr15_-_58324161 0.644 ENSMUST00000022985.1
Klhl38
kelch-like 38
chr1_+_187609028 0.643 ENSMUST00000110939.1
Esrrg
estrogen-related receptor gamma
chr9_+_77636494 0.634 ENSMUST00000057781.7
Klhl31
kelch-like 31
chr10_+_94550852 0.633 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr5_-_51553896 0.611 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr14_+_66344296 0.596 ENSMUST00000152093.1
ENSMUST00000074523.6
Stmn4

stathmin-like 4

chr9_-_79977782 0.577 ENSMUST00000093811.4
Filip1
filamin A interacting protein 1
chrX_+_106583184 0.576 ENSMUST00000101296.2
ENSMUST00000101297.3
Gm5127

predicted gene 5127

chr8_+_31089471 0.572 ENSMUST00000036631.7
ENSMUST00000170204.1
Dusp26

dual specificity phosphatase 26 (putative)

chr6_-_142702259 0.565 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr19_+_4003334 0.550 ENSMUST00000025806.3
Doc2g
double C2, gamma
chr5_-_88527841 0.547 ENSMUST00000087033.3
Igj
immunoglobulin joining chain
chr6_+_42286676 0.537 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr1_+_135836380 0.530 ENSMUST00000178204.1
Tnnt2
troponin T2, cardiac
chr7_+_130865756 0.520 ENSMUST00000120441.1
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr9_-_65391652 0.519 ENSMUST00000068307.3
Kbtbd13
kelch repeat and BTB (POZ) domain containing 13
chr5_+_107497762 0.516 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr6_-_128526703 0.504 ENSMUST00000143664.1
ENSMUST00000112132.1
ENSMUST00000032510.7
Pzp


pregnancy zone protein


chrX_+_159303266 0.500 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr5_-_24540439 0.496 ENSMUST00000048302.6
ENSMUST00000119657.1
Asb10

ankyrin repeat and SOCS box-containing 10

chr17_-_14694223 0.494 ENSMUST00000170872.1
Thbs2
thrombospondin 2
chr7_-_4514368 0.491 ENSMUST00000166161.1
Tnnt1
troponin T1, skeletal, slow
chr1_-_172329261 0.490 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr17_-_67950908 0.488 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr7_-_81566939 0.483 ENSMUST00000042318.5
Fsd2
fibronectin type III and SPRY domain containing 2
chr10_-_69212996 0.480 ENSMUST00000170048.1
A930033H14Rik
RIKEN cDNA A930033H14 gene
chrX_+_56779699 0.480 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
Fhl1


four and a half LIM domains 1


chr5_-_129879038 0.454 ENSMUST00000026617.6
Phkg1
phosphorylase kinase gamma 1
chr7_+_112742025 0.441 ENSMUST00000164363.1
Tead1
TEA domain family member 1
chr6_+_5390387 0.417 ENSMUST00000183358.1
Asb4
ankyrin repeat and SOCS box-containing 4
chr13_-_64497792 0.416 ENSMUST00000180282.1
1190003K10Rik
RIKEN cDNA 1190003K10 gene
chr14_+_66344369 0.411 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
Stmn4



stathmin-like 4



chr2_+_48949495 0.407 ENSMUST00000112745.1
Mbd5
methyl-CpG binding domain protein 5
chrX_+_56779437 0.399 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr5_+_66968559 0.393 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr17_+_75435886 0.391 ENSMUST00000164192.1
Rasgrp3
RAS, guanyl releasing protein 3
chr1_+_75375271 0.389 ENSMUST00000087122.5
Speg
SPEG complex locus
chr2_+_27676440 0.382 ENSMUST00000129514.1
Rxra
retinoid X receptor alpha
chr15_-_89425856 0.379 ENSMUST00000109313.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr19_-_5802640 0.378 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr14_-_54966925 0.370 ENSMUST00000111456.1
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr5_-_123141067 0.363 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chr14_+_55575617 0.352 ENSMUST00000022826.5
Fitm1
fat storage-inducing transmembrane protein 1
chr14_-_57058030 0.347 ENSMUST00000061614.6
Gja3
gap junction protein, alpha 3
chr3_-_142395661 0.339 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5



PDZ and LIM domain 5



chr1_+_63445842 0.335 ENSMUST00000087374.3
ENSMUST00000114107.1
ENSMUST00000182642.1
Adam23


a disintegrin and metallopeptidase domain 23


chr8_-_41016749 0.334 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr1_-_64122256 0.332 ENSMUST00000135075.1
Klf7
Kruppel-like factor 7 (ubiquitous)
chr19_-_24861828 0.322 ENSMUST00000047666.4
Pgm5
phosphoglucomutase 5
chr9_+_74953053 0.321 ENSMUST00000170846.1
Fam214a
family with sequence similarity 214, member A
chr16_+_11313812 0.320 ENSMUST00000023140.5
Tnfrsf17
tumor necrosis factor receptor superfamily, member 17
chr13_-_59556845 0.315 ENSMUST00000170378.1
ENSMUST00000169434.1
Agtpbp1

ATP/GTP binding protein 1

chr15_-_76232045 0.305 ENSMUST00000167754.1
Plec
plectin
chr15_-_89425795 0.305 ENSMUST00000168376.1
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr9_-_7873157 0.304 ENSMUST00000159323.1
ENSMUST00000115673.2
Birc3

baculoviral IAP repeat-containing 3

chr16_+_7069825 0.303 ENSMUST00000056416.7
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr18_-_38918642 0.298 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr14_-_50897456 0.296 ENSMUST00000170855.1
A930018M24Rik
RIKEN cDNA A930018M24 gene
chr10_+_63457505 0.290 ENSMUST00000105440.1
Ctnna3
catenin (cadherin associated protein), alpha 3
chr4_-_55532453 0.287 ENSMUST00000132746.1
ENSMUST00000107619.2
Klf4

Kruppel-like factor 4 (gut)

chr4_-_83021102 0.280 ENSMUST00000071708.5
Frem1
Fras1 related extracellular matrix protein 1
chr5_-_17888884 0.279 ENSMUST00000169095.1
Cd36
CD36 antigen
chr1_-_134234492 0.275 ENSMUST00000169927.1
Adora1
adenosine A1 receptor
chr12_+_69241832 0.274 ENSMUST00000063445.6
Klhdc1
kelch domain containing 1
chr8_+_81342556 0.271 ENSMUST00000172167.1
ENSMUST00000169116.1
ENSMUST00000109852.2
ENSMUST00000172031.1
Inpp4b



inositol polyphosphate-4-phosphatase, type II



chrX_+_6577259 0.267 ENSMUST00000089520.2
Shroom4
shroom family member 4
chr8_+_40307458 0.265 ENSMUST00000068999.7
Micu3
mitochondrial calcium uptake family, member 3
chr12_+_109747903 0.262 ENSMUST00000183084.1
ENSMUST00000182300.1
Mirg

miRNA containing gene

chr1_+_180109192 0.246 ENSMUST00000143176.1
ENSMUST00000135056.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr5_+_25759987 0.243 ENSMUST00000128727.1
ENSMUST00000088244.4
Actr3b

ARP3 actin-related protein 3B

chr6_+_108213086 0.241 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr5_-_113081579 0.240 ENSMUST00000131708.1
ENSMUST00000117143.1
ENSMUST00000119627.1
Crybb3


crystallin, beta B3


chr17_+_8283762 0.240 ENSMUST00000155364.1
ENSMUST00000046754.8
ENSMUST00000124023.1
Mpc1


mitochondrial pyruvate carrier 1


chr3_-_149185495 0.239 ENSMUST00000066092.3
Gm9912
predicted gene 9912
chr3_+_51693771 0.228 ENSMUST00000099104.2
Gm10729
predicted gene 10729
chr5_-_24540976 0.225 ENSMUST00000117900.1
Asb10
ankyrin repeat and SOCS box-containing 10
chr5_+_66968416 0.224 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr14_-_93888732 0.222 ENSMUST00000068992.2
Pcdh9
protocadherin 9
chr6_+_21986887 0.221 ENSMUST00000151315.1
Cped1
cadherin-like and PC-esterase domain containing 1
chr6_-_71262232 0.220 ENSMUST00000129630.2
ENSMUST00000114186.2
ENSMUST00000074301.3
Smyd1


SET and MYND domain containing 1


chr3_+_138143429 0.215 ENSMUST00000040321.6
Trmt10a
tRNA methyltransferase 10A
chr13_-_85127514 0.214 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr12_+_59130994 0.205 ENSMUST00000177460.1
Ctage5
CTAGE family, member 5
chr8_-_61902669 0.197 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr17_+_44188564 0.193 ENSMUST00000024755.5
Clic5
chloride intracellular channel 5
chr6_-_14755250 0.192 ENSMUST00000045096.4
Ppp1r3a
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr13_+_102693522 0.189 ENSMUST00000022124.3
ENSMUST00000171267.1
ENSMUST00000167144.1
ENSMUST00000170878.1
Cd180



CD180 antigen



chr10_+_69785507 0.184 ENSMUST00000182993.1
Ank3
ankyrin 3, epithelial
chr1_-_88702121 0.184 ENSMUST00000159814.1
Arl4c
ADP-ribosylation factor-like 4C
chr3_-_56183678 0.179 ENSMUST00000029374.6
Nbea
neurobeachin
chr13_-_107890059 0.157 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chrX_+_164373363 0.155 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr9_-_66514567 0.149 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr6_+_42286709 0.145 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr18_+_45268876 0.143 ENSMUST00000183850.1
ENSMUST00000066890.7
Kcnn2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

chr7_-_67372846 0.143 ENSMUST00000156690.1
ENSMUST00000107476.1
ENSMUST00000076325.5
ENSMUST00000032776.8
ENSMUST00000133074.1
Mef2a




myocyte enhancer factor 2A




chr5_+_107497718 0.142 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr9_+_55326913 0.139 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr3_-_49757257 0.137 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr16_+_30065333 0.123 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr5_+_65348386 0.121 ENSMUST00000031096.7
Klb
klotho beta
chr3_-_51340628 0.116 ENSMUST00000062009.7
Elf2
E74-like factor 2
chr7_+_30121915 0.114 ENSMUST00000098596.3
ENSMUST00000153792.1
Zfp382

zinc finger protein 382

chr11_+_3330401 0.107 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_+_27165233 0.105 ENSMUST00000000910.6
Dbh
dopamine beta hydroxylase
chr17_+_12378603 0.104 ENSMUST00000014578.5
Plg
plasminogen
chr16_+_45093611 0.101 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chrX_-_47892396 0.096 ENSMUST00000153548.2
Smarca1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr4_+_123201503 0.094 ENSMUST00000068262.5
Nt5c1a
5'-nucleotidase, cytosolic IA
chr4_+_133553370 0.085 ENSMUST00000042706.2
Nr0b2
nuclear receptor subfamily 0, group B, member 2
chr8_-_124569696 0.082 ENSMUST00000063278.6
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.4 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
1.2 3.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.1 7.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.9 4.3 GO:0071313 cellular response to caffeine(GO:0071313)
0.8 2.5 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.8 3.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.7 7.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.5 2.6 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.5 4.6 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.5 5.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.4 2.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.4 3.7 GO:0032264 IMP salvage(GO:0032264)
0.4 19.5 GO:0003009 skeletal muscle contraction(GO:0003009)
0.3 0.9 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 0.9 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.3 0.8 GO:0007521 muscle cell fate determination(GO:0007521)
0.3 0.5 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.3 1.5 GO:0006172 ADP biosynthetic process(GO:0006172)
0.2 6.8 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.2 14.3 GO:0030239 myofibril assembly(GO:0030239)
0.2 0.8 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.2 0.6 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 1.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 4.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.2 0.6 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.1 0.4 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 1.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.7 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.3 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 0.3 GO:0070543 response to linoleic acid(GO:0070543)
0.1 0.3 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.1 3.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 1.9 GO:0014823 response to activity(GO:0014823)
0.1 1.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 0.4 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.1 0.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 1.2 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 4.9 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 0.4 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 0.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.9 GO:0007614 short-term memory(GO:0007614)
0.0 0.4 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 4.7 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 0.1 GO:2000978 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.8 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.1 GO:0006589 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.2 GO:0061732 mitochondrial pyruvate transport(GO:0006850) mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.0 0.4 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.0 0.7 GO:2000311 regulation of AMPA receptor activity(GO:2000311)
0.0 0.2 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 0.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.0 0.9 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 1.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.7 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.7 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.3 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 1.8 GO:0003012 muscle system process(GO:0003012)
0.0 0.0 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.0 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.1 20.6 GO:0005861 troponin complex(GO:0005861)
0.8 7.3 GO:0097512 cardiac myofibril(GO:0097512)
0.8 2.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.4 10.4 GO:0005859 muscle myosin complex(GO:0005859)
0.4 3.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 2.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 5.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 3.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.2 1.9 GO:0032982 myosin filament(GO:0032982)
0.2 32.3 GO:0031674 I band(GO:0031674)
0.2 0.8 GO:0044316 cone cell pedicle(GO:0044316)
0.1 1.0 GO:0031430 M band(GO:0031430)
0.1 0.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 1.2 GO:0005916 fascia adherens(GO:0005916)
0.1 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.5 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 6.0 GO:0016528 sarcoplasm(GO:0016528)
0.1 7.1 GO:0030016 myofibril(GO:0030016)
0.1 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.3 GO:0016460 myosin II complex(GO:0016460)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic vesicle lumen(GO:0060205)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.1 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 3.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.5 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 1.9 GO:0042383 sarcolemma(GO:0042383)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0005922 connexin complex(GO:0005922)
0.0 0.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.0 GO:0090537 CERF complex(GO:0090537)
0.0 0.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 13.0 GO:0051373 FATZ binding(GO:0051373)
1.1 7.8 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
1.1 10.9 GO:0031014 troponin T binding(GO:0031014)
0.6 15.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.4 3.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 3.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 3.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 1.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.3 11.8 GO:0003785 actin monomer binding(GO:0003785)
0.3 0.5 GO:0030172 troponin C binding(GO:0030172)
0.3 3.7 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.2 6.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.2 0.6 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 0.9 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.7 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 2.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 2.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.3 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.8 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 1.0 GO:0031005 filamin binding(GO:0031005)
0.0 1.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.7 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0071820 N-box binding(GO:0071820)
0.0 1.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.3 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 1.5 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 2.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 8.8 GO:0003779 actin binding(GO:0003779)
0.0 0.8 GO:0030552 cAMP binding(GO:0030552)
0.0 14.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.0 7.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.7 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 ST_ADRENERGIC Adrenergic Pathway
0.0 0.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.6 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 43.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.7 REACTOME_DEFENSINS Genes involved in Defensins
0.2 3.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 1.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 1.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.4 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)