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GSE58827: Dynamics of the Mouse Liver

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Results for Mtf1

Z-value: 1.04

Motif logo

Transcription factors associated with Mtf1

Gene Symbol Gene ID Gene Info
ENSMUSG00000028890.7 metal response element binding transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.539.7e-04Click!

Activity profile of Mtf1 motif

Sorted Z-values of Mtf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_94172618 25.30 ENSMUST00000034214.6
metallothionein 2
chr8_+_94179089 17.13 ENSMUST00000034215.6
metallothionein 1
chr9_+_98490522 13.23 ENSMUST00000035029.2
retinol binding protein 2, cellular
chr6_+_90619241 4.59 ENSMUST00000032177.8
solute carrier family 41, member 3
chr9_-_14381242 4.40 ENSMUST00000167549.1
endonuclease domain containing 1
chr1_-_169531343 4.37 ENSMUST00000028000.7
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_-_56635624 3.95 ENSMUST00000114256.1
leucine rich repeat and Ig domain containing 1
chr1_+_75400070 3.89 ENSMUST00000113589.1
SPEG complex locus
chr1_-_169531447 3.72 ENSMUST00000111368.1
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_+_103619580 3.32 ENSMUST00000106827.1
disabled 1
chr3_+_107895916 3.25 ENSMUST00000172247.1
ENSMUST00000167387.1
glutathione S-transferase, mu 5
chr3_+_107895821 3.09 ENSMUST00000004134.4
glutathione S-transferase, mu 5
chr10_+_20952547 3.03 ENSMUST00000105525.4
Abelson helper integration site 1
chr3_+_107896247 2.88 ENSMUST00000169365.1
glutathione S-transferase, mu 5
chr1_-_167393826 2.86 ENSMUST00000028005.2
microsomal glutathione S-transferase 3
chr5_-_34637107 2.76 ENSMUST00000124668.1
ENSMUST00000001109.4
ENSMUST00000155577.1
ENSMUST00000114329.1
major facilitator superfamily domain containing 10
chr19_-_4615453 2.76 ENSMUST00000053597.2
leucine rich repeat and fibronectin type III domain containing 4
chr2_+_119112793 2.69 ENSMUST00000140939.1
ENSMUST00000028795.3
RAD51 homolog
chr5_-_34637203 2.67 ENSMUST00000114331.3
major facilitator superfamily domain containing 10
chr7_+_43440782 2.66 ENSMUST00000040227.1
claudin domain containing 2
chr19_-_4615647 2.60 ENSMUST00000113822.2
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_63133068 2.52 ENSMUST00000108700.1
peripheral myelin protein 22
chr4_-_43040279 2.43 ENSMUST00000107958.1
ENSMUST00000107959.1
ENSMUST00000152846.1
family with sequence similarity 214, member B
chr1_+_135729147 2.30 ENSMUST00000027677.7
cysteine and glycine-rich protein 1
chr11_+_63132569 2.27 ENSMUST00000108701.1
peripheral myelin protein 22
chr4_-_126163470 2.26 ENSMUST00000097891.3
SH3 domain containing 21
chr4_+_129985098 2.15 ENSMUST00000106017.1
ENSMUST00000121049.1
brain-specific angiogenesis inhibitor 2
chr11_-_32222233 1.91 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
rhomboid family 1 (Drosophila)
chr2_+_29889720 1.91 ENSMUST00000113767.1
outer dense fiber of sperm tails 2
chr3_-_89960562 1.89 ENSMUST00000069805.7
ATPase, class I, type 8B, member 2
chr9_-_65391652 1.81 ENSMUST00000068307.3
kelch repeat and BTB (POZ) domain containing 13
chr5_+_105415738 1.79 ENSMUST00000112707.1
leucine rich repeat containing 8 family, member B
chr2_+_29889785 1.64 ENSMUST00000113763.1
ENSMUST00000113757.1
ENSMUST00000113756.1
ENSMUST00000133233.1
ENSMUST00000113759.2
ENSMUST00000113755.1
ENSMUST00000137558.1
ENSMUST00000046571.7
outer dense fiber of sperm tails 2
chr19_-_4201591 1.55 ENSMUST00000025740.6
RAD9 homolog A
chr3_-_121532271 1.48 ENSMUST00000039197.7
solute carrier family 44, member 3
chr4_-_93335510 1.42 ENSMUST00000066774.4
tumor suppressor candidate 1
chr8_+_70905970 1.41 ENSMUST00000019405.2
microtubule-associated protein 1S
chrX_+_6873484 1.40 ENSMUST00000145302.1
diacylglycerol kinase kappa
chr4_+_129984833 1.29 ENSMUST00000120204.1
brain-specific angiogenesis inhibitor 2
chr7_+_119794102 1.26 ENSMUST00000084644.2
RIKEN cDNA 2610020H08 gene
chr5_-_99978914 1.25 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
heterogeneous nuclear ribonucleoprotein D
chr6_+_18848571 1.24 ENSMUST00000056398.8
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr4_-_126162619 1.21 ENSMUST00000094760.2
SH3 domain containing 21
chr1_-_37719782 1.20 ENSMUST00000160589.1
RIKEN cDNA 2010300C02 gene
chr7_+_119793987 1.15 ENSMUST00000033218.8
ENSMUST00000106520.1
RIKEN cDNA 2610020H08 gene
chr7_-_109865586 1.13 ENSMUST00000007423.5
ENSMUST00000106728.2
ENSMUST00000106729.1
signal peptide, CUB domain, EGF-like 2
chr4_-_152152207 1.13 ENSMUST00000030785.8
ENSMUST00000105658.1
ENSMUST00000105659.2
espin
chr7_-_119793958 1.13 ENSMUST00000106523.1
ENSMUST00000063902.7
ENSMUST00000150844.1
exoribonuclease 2
chr12_-_36156781 1.12 ENSMUST00000020856.4
basic leucine zipper and W2 domains 2
chr1_+_66386968 1.10 ENSMUST00000145419.1
microtubule-associated protein 2
chr7_+_5056856 1.10 ENSMUST00000131368.1
ENSMUST00000123956.1
coiled-coil domain containing 106
chr15_-_83149307 1.09 ENSMUST00000100375.4
polymerase (DNA-directed), delta interacting protein 3
chr5_-_112356033 1.08 ENSMUST00000051117.2
predicted gene 6583
chr2_+_31759932 1.08 ENSMUST00000028190.6
c-abl oncogene 1, non-receptor tyrosine kinase
chr6_-_56923927 1.07 ENSMUST00000031793.5
5'-nucleotidase, cytosolic III
chr10_-_81001338 1.06 ENSMUST00000099462.1
ENSMUST00000118233.1
guanine nucleotide binding protein (G protein), gamma 7
chr15_+_85017138 1.05 ENSMUST00000023070.5
uroplakin 3A
chr9_-_66124872 1.03 ENSMUST00000034946.8
sorting nexin 1
chr8_+_84872105 0.97 ENSMUST00000136026.1
ENSMUST00000170296.1
synaptonemal complex central element protein 2
chr9_+_57940104 0.95 ENSMUST00000043059.7
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr15_-_93519499 0.82 ENSMUST00000109255.2
prickle homolog 1 (Drosophila)
chr12_+_111758923 0.72 ENSMUST00000118471.1
ENSMUST00000122300.1
kinesin light chain 1
chr1_+_179668202 0.68 ENSMUST00000040538.3
saccharopine dehydrogenase (putative)
chr8_+_106210936 0.65 ENSMUST00000071592.5
protein arginine N-methyltransferase 7
chr12_+_111758848 0.64 ENSMUST00000084941.5
kinesin light chain 1
chr5_+_57718021 0.61 ENSMUST00000094783.3
ENSMUST00000068110.7
protocadherin 7
chr12_+_33957645 0.58 ENSMUST00000049089.5
twist basic helix-loop-helix transcription factor 1
chr17_+_71673255 0.58 ENSMUST00000097284.3
family with sequence similarity 179, member A
chr17_+_47688992 0.57 ENSMUST00000156118.1
fibroblast growth factor receptor substrate 3
chr3_-_94412883 0.56 ENSMUST00000181305.1
RIKEN cDNA 1700040D17 gene
chr4_+_134343181 0.55 ENSMUST00000105873.1
ENSMUST00000105874.2
solute carrier family 30 (zinc transporter), member 2
chr16_-_91597636 0.53 ENSMUST00000023686.8
transmembrane protein 50B
chr2_+_31759993 0.53 ENSMUST00000124089.1
c-abl oncogene 1, non-receptor tyrosine kinase
chr5_-_141000590 0.49 ENSMUST00000085786.5
caspase recruitment domain family, member 11
chr8_+_106211016 0.49 ENSMUST00000109297.1
protein arginine N-methyltransferase 7
chr1_+_128103297 0.34 ENSMUST00000036288.4
R3H domain containing 1
chr2_+_150323702 0.33 ENSMUST00000133235.2
predicted gene 10130
chr2_-_119787504 0.32 ENSMUST00000110793.1
ENSMUST00000099529.2
ENSMUST00000048493.5
RNA polymerase II associated protein 1
chr8_+_92827273 0.31 ENSMUST00000034187.7
matrix metallopeptidase 2
chr9_-_112187898 0.30 ENSMUST00000178410.1
ENSMUST00000172380.3
cyclic AMP-regulated phosphoprotein, 21
chr9_+_108490676 0.30 ENSMUST00000178075.1
ENSMUST00000085044.7
ENSMUST00000166103.2
ENSMUST00000006854.7
ubiquitin specific peptidase 19
chr4_+_134343466 0.26 ENSMUST00000105872.1
solute carrier family 30 (zinc transporter), member 2
chr17_-_83631892 0.23 ENSMUST00000051482.1
potassium voltage-gated channel, subfamily G, member 3
chr14_-_26170283 0.23 ENSMUST00000100809.4
placenta specific 9b
chrX_-_79671434 0.21 ENSMUST00000052283.6
melanoma antigen family B, 16
chr11_+_4895328 0.17 ENSMUST00000038237.1
THO complex 5
chr8_-_70776650 0.16 ENSMUST00000034296.8
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr1_-_166002591 0.15 ENSMUST00000111429.4
ENSMUST00000176800.1
POU domain, class 2, transcription factor 1
chr18_-_84589491 0.14 ENSMUST00000125763.1
zinc finger protein 407
chr10_+_81136223 0.13 ENSMUST00000048128.8
zinc finger and BTB domain containing 7a
chr11_+_4895316 0.11 ENSMUST00000101615.2
THO complex 5
chr16_+_18348181 0.11 ENSMUST00000115614.2
ENSMUST00000115613.1
ENSMUST00000090103.3
armadillo repeat gene deleted in velo-cardio-facial syndrome
chr11_-_5898771 0.07 ENSMUST00000102921.3
myosin, light polypeptide 7, regulatory
chr5_-_125341043 0.01 ENSMUST00000111390.1
ENSMUST00000086075.6
scavenger receptor class B, member 1
chr18_+_11839220 0.01 ENSMUST00000171109.1
ENSMUST00000046948.8
CDK5 and Abl enzyme substrate 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Mtf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 42.4 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
1.7 13.2 GO:0006776 vitamin A metabolic process(GO:0006776)
1.3 9.2 GO:0051410 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
1.1 3.3 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
1.0 3.0 GO:0030862 positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.9 5.4 GO:0042891 antibiotic transport(GO:0042891)
0.7 2.7 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.5 1.6 GO:1900275 negative regulation of phospholipase C activity(GO:1900275) activation of protein kinase C activity(GO:1990051)
0.4 1.3 GO:1901355 response to rapamycin(GO:1901355)
0.3 0.8 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.3 1.4 GO:0035617 stress granule disassembly(GO:0035617)
0.3 0.8 GO:0061090 positive regulation of sequestering of zinc ion(GO:0061090)
0.2 4.8 GO:0032060 bleb assembly(GO:0032060)
0.2 1.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.2 4.0 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.2 8.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 0.6 GO:2000793 cell proliferation involved in heart valve development(GO:2000793)
0.2 1.1 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.2 1.1 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.2 1.1 GO:0015840 urea transport(GO:0015840)
0.1 1.4 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 1.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.5 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 0.9 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 1.0 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 0.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 1.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 1.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.5 GO:0070970 interleukin-2 secretion(GO:0070970)
0.0 3.6 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.3 GO:2000002 regulation of mRNA export from nucleus(GO:0010793) negative regulation of DNA damage checkpoint(GO:2000002)
0.0 1.0 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 3.9 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 1.9 GO:0015914 phospholipid transport(GO:0015914)
0.0 2.3 GO:0070527 platelet aggregation(GO:0070527)
0.0 1.1 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 1.9 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 0.3 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 1.8 GO:0098656 anion transmembrane transport(GO:0098656)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.1 GO:0031262 Ndc80 complex(GO:0031262)
0.5 9.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 1.2 GO:0031417 NatC complex(GO:0031417)
0.3 1.0 GO:0030905 retromer, tubulation complex(GO:0030905)
0.2 3.6 GO:0097539 ciliary transition fiber(GO:0097539)
0.2 1.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 3.0 GO:0036038 MKS complex(GO:0036038)
0.2 4.8 GO:0043218 compact myelin(GO:0043218)
0.1 1.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.0 GO:0000801 central element(GO:0000801)
0.1 2.7 GO:0035861 site of double-strand break(GO:0035861)
0.1 1.4 GO:0000346 transcription export complex(GO:0000346)
0.1 1.4 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.0 5.4 GO:0031526 brush border membrane(GO:0031526)
0.0 3.3 GO:0005903 brush border(GO:0005903)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 9.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 12.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.4 GO:0042895 antibiotic transporter activity(GO:0042895)
0.9 13.2 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.4 2.7 GO:0000150 recombinase activity(GO:0000150)
0.3 9.2 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.3 1.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.3 1.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.3 1.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.3 1.0 GO:1990460 leptin receptor binding(GO:1990460)
0.2 15.5 GO:0005507 copper ion binding(GO:0005507)
0.2 2.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 1.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 4.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 1.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 3.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.5 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 3.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 4.4 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 19.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.6 GO:0043425 bHLH transcription factor binding(GO:0043425)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 14.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 4.2 PID ATR PATHWAY ATR signaling pathway
0.1 3.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 4.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID SHP2 PATHWAY SHP2 signaling
0.0 0.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 13.2 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.3 12.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 8.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.4 REACTOME KINESINS Genes involved in Kinesins
0.0 1.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.5 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 4.0 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.7 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 1.3 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.6 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix