Motif ID: Nkx2-5

Z-value: 1.213


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-5mm10_v2_chr17_-_26841565_268415910.363.3e-02Click!


Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_30639218 19.305 ENSMUST00000031806.9
Cpa1
carboxypeptidase A1, pancreatic
chr6_+_41521782 18.693 ENSMUST00000070380.4
Prss2
protease, serine, 2
chr6_+_41302265 16.905 ENSMUST00000031913.4
Try4
trypsin 4
chr6_+_30541582 11.260 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr4_-_137409777 9.932 ENSMUST00000024200.6
Gm13011
predicted gene 13011
chr4_-_141846277 8.431 ENSMUST00000105781.1
Ctrc
chymotrypsin C (caldecrin)
chr6_-_136922169 5.894 ENSMUST00000032343.6
Erp27
endoplasmic reticulum protein 27
chr4_-_4138432 4.045 ENSMUST00000070375.7
Penk
preproenkephalin
chr14_+_80000292 3.059 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr17_+_47726834 2.923 ENSMUST00000024782.5
ENSMUST00000144955.1
Pgc

progastricsin (pepsinogen C)

chr6_+_72304592 2.347 ENSMUST00000183018.1
Sftpb
surfactant associated protein B
chr1_-_170927540 1.648 ENSMUST00000162136.1
ENSMUST00000162887.1
Fcrla

Fc receptor-like A

chr1_-_170927567 1.586 ENSMUST00000046322.7
ENSMUST00000159171.1
Fcrla

Fc receptor-like A

chr11_+_115974709 1.257 ENSMUST00000021107.7
ENSMUST00000106461.1
ENSMUST00000169928.1
Itgb4


integrin beta 4


chr3_-_106024911 1.149 ENSMUST00000066537.3
ENSMUST00000054973.3
Chi3l7

chitinase 3-like 7

chr1_+_74278550 1.145 ENSMUST00000077985.3
Gpbar1
G protein-coupled bile acid receptor 1
chr14_+_41131777 1.103 ENSMUST00000022314.3
ENSMUST00000170719.1
Sftpa1

surfactant associated protein A1

chr1_-_75133866 0.906 ENSMUST00000027405.4
Slc23a3
solute carrier family 23 (nucleobase transporters), member 3
chr9_+_57940104 0.833 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr8_+_72761868 0.827 ENSMUST00000058099.8
F2rl3
coagulation factor II (thrombin) receptor-like 3
chr15_-_82224330 0.751 ENSMUST00000089161.2
ENSMUST00000109535.2
Tnfrsf13c

tumor necrosis factor receptor superfamily, member 13c

chr15_-_98778150 0.727 ENSMUST00000023732.5
Wnt10b
wingless related MMTV integration site 10b
chr6_-_5193817 0.698 ENSMUST00000002663.5
Pon1
paraoxonase 1
chr15_-_99457712 0.637 ENSMUST00000161948.1
Nckap5l
NCK-associated protein 5-like
chr15_+_99591028 0.593 ENSMUST00000169082.1
Aqp5
aquaporin 5
chr9_+_54917252 0.570 ENSMUST00000039742.7
Hykk
hydroxylysine kinase 1
chr11_-_98018308 0.563 ENSMUST00000107561.2
Cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr4_+_103619580 0.545 ENSMUST00000106827.1
Dab1
disabled 1
chr4_+_119637704 0.536 ENSMUST00000024015.2
Guca2a
guanylate cyclase activator 2a (guanylin)
chr8_+_113643206 0.534 ENSMUST00000034219.4
ENSMUST00000095173.1
Syce1l

synaptonemal complex central element protein 1 like

chr3_+_52268337 0.519 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr18_-_68429235 0.518 ENSMUST00000052347.6
Mc2r
melanocortin 2 receptor
chr6_+_72304625 0.511 ENSMUST00000070437.8
Sftpb
surfactant associated protein B
chr11_+_67171095 0.509 ENSMUST00000018641.7
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr14_+_51893610 0.500 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr16_+_44943678 0.481 ENSMUST00000114613.2
ENSMUST00000114612.1
ENSMUST00000077178.6
ENSMUST00000048479.7
ENSMUST00000114611.3
ENSMUST00000164007.1
ENSMUST00000171779.1
Cd200r3






CD200 receptor 3






chr5_+_128601106 0.472 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr14_+_20674311 0.468 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr2_-_127270032 0.467 ENSMUST00000099407.1
Gm10766
predicted gene 10766
chr11_+_67171027 0.458 ENSMUST00000170159.1
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr2_+_148395369 0.441 ENSMUST00000109962.2
ENSMUST00000047292.2
Sstr4

somatostatin receptor 4

chr14_+_21500879 0.433 ENSMUST00000182964.1
Kat6b
K(lysine) acetyltransferase 6B
chr6_+_115853470 0.422 ENSMUST00000112925.1
ENSMUST00000112923.1
ENSMUST00000038234.6
Ift122


intraflagellar transport 122


chr5_-_8997324 0.417 ENSMUST00000003720.4
Crot
carnitine O-octanoyltransferase
chr12_+_4082596 0.411 ENSMUST00000049584.5
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr11_+_101987050 0.405 ENSMUST00000010985.7
1700006E09Rik
RIKEN cDNA 1700006E09 gene
chr18_-_31949571 0.367 ENSMUST00000064016.5
Gpr17
G protein-coupled receptor 17
chr7_+_29170204 0.361 ENSMUST00000098609.2
Ggn
gametogenetin
chr8_+_124793061 0.354 ENSMUST00000041106.7
Trim67
tripartite motif-containing 67
chr2_+_174076296 0.351 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr2_+_32288317 0.349 ENSMUST00000131712.1
ENSMUST00000133113.1
ENSMUST00000081670.6
ENSMUST00000147707.1
ENSMUST00000129193.1
Golga2




golgi autoantigen, golgin subfamily a, 2




chr15_-_79328154 0.347 ENSMUST00000166977.2
Pla2g6
phospholipase A2, group VI
chr9_-_44526397 0.340 ENSMUST00000062215.7
Cxcr5
chemokine (C-X-C motif) receptor 5
chrX_+_114474312 0.337 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4

kelch-like 4

chrX_-_75416533 0.325 ENSMUST00000033542.4
Mtcp1
mature T cell proliferation 1
chr16_-_44139630 0.323 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr7_-_4844665 0.321 ENSMUST00000066041.5
ENSMUST00000172377.1
Shisa7

shisa homolog 7 (Xenopus laevis)

chr18_+_49832622 0.319 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr12_+_91400990 0.318 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr

thyroid stimulating hormone receptor

chr15_-_54919961 0.312 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr5_-_124327812 0.301 ENSMUST00000184951.1
Mphosph9
M-phase phosphoprotein 9
chr18_-_79109391 0.300 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1

SET binding protein 1

chr15_-_99457742 0.298 ENSMUST00000023747.7
Nckap5l
NCK-associated protein 5-like
chr19_-_57360668 0.294 ENSMUST00000181921.1
B230217O12Rik
RIKEN cDNA B230217O12 gene
chr4_-_41275091 0.275 ENSMUST00000030143.6
ENSMUST00000108068.1
Ubap2

ubiquitin-associated protein 2

chrX_+_114474509 0.261 ENSMUST00000113370.2
Klhl4
kelch-like 4
chr14_+_51129055 0.254 ENSMUST00000095923.3
Rnase6
ribonuclease, RNase A family, 6
chr2_-_173276144 0.249 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr2_+_32608704 0.247 ENSMUST00000129165.1
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr4_+_137594140 0.236 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
Usp48



ubiquitin specific peptidase 48



chr13_+_30136529 0.225 ENSMUST00000152798.1
Mboat1
membrane bound O-acyltransferase domain containing 1
chr6_-_101377342 0.220 ENSMUST00000151175.1
Pdzrn3
PDZ domain containing RING finger 3
chr11_+_69655314 0.208 ENSMUST00000047373.5
Sox15
SRY-box containing gene 15
chr2_-_5942740 0.207 ENSMUST00000026924.5
ENSMUST00000095147.2
ENSMUST00000169865.1
Dhtkd1


dehydrogenase E1 and transketolase domain containing 1


chr4_-_87806276 0.203 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_-_86359455 0.197 ENSMUST00000027438.6
Ncl
nucleolin
chr2_+_23069210 0.195 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr15_-_79328201 0.194 ENSMUST00000173163.1
ENSMUST00000047816.8
ENSMUST00000172403.2
ENSMUST00000173632.1
Pla2g6



phospholipase A2, group VI



chr1_-_66817536 0.188 ENSMUST00000068168.3
ENSMUST00000113987.1
Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr15_-_54920115 0.186 ENSMUST00000171545.1
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr5_-_124327883 0.178 ENSMUST00000031344.6
Mphosph9
M-phase phosphoprotein 9
chr4_-_126968124 0.164 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr11_+_64435315 0.164 ENSMUST00000058652.5
Hs3st3a1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chrX_-_111463149 0.162 ENSMUST00000096348.3
ENSMUST00000113428.2
Rps6ka6

ribosomal protein S6 kinase polypeptide 6

chr14_-_7994563 0.160 ENSMUST00000026315.7
Dnase1l3
deoxyribonuclease 1-like 3
chr7_+_128246953 0.148 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr6_-_115853346 0.137 ENSMUST00000032469.6
Mbd4
methyl-CpG binding domain protein 4
chr12_+_4082574 0.135 ENSMUST00000020986.7
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr19_-_47171134 0.130 ENSMUST00000169692.1
Gm6970
predicted gene 6970
chr6_+_127577963 0.119 ENSMUST00000071563.4
Efcab4b
EF-hand calcium binding domain 4B
chr11_+_87566653 0.100 ENSMUST00000060360.5
Gm11492
predicted gene 11492
chr5_+_90561102 0.098 ENSMUST00000094615.4
5830473C10Rik
RIKEN cDNA 5830473C10 gene
chr18_-_15063560 0.096 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr7_+_29170345 0.064 ENSMUST00000033886.7
Ggn
gametogenetin
chr14_-_63271682 0.063 ENSMUST00000132122.1
Gata4
GATA binding protein 4
chr4_+_85205120 0.058 ENSMUST00000107188.3
Sh3gl2
SH3-domain GRB2-like 2
chr9_+_106170918 0.057 ENSMUST00000020490.5
Wdr82
WD repeat domain containing 82
chr13_+_30136498 0.042 ENSMUST00000047311.8
Mboat1
membrane bound O-acyltransferase domain containing 1
chr3_-_153725062 0.042 ENSMUST00000064460.5
St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr15_+_76351303 0.032 ENSMUST00000023212.8
ENSMUST00000160172.1
Maf1

MAF1 homolog (S. cerevisiae)

chr7_+_128246812 0.017 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr4_-_87806296 0.015 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr11_-_101987004 0.010 ENSMUST00000107173.2
ENSMUST00000107172.1
Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chrX_-_75416562 0.008 ENSMUST00000114081.1
ENSMUST00000033543.7
ENSMUST00000149863.2
Mtcp1
Mtcp1

mature T cell proliferation 1
mature T cell proliferation 1

chr9_-_120023558 0.002 ENSMUST00000111635.2
Xirp1
xin actin-binding repeat containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 18.7 GO:0031000 response to caffeine(GO:0031000)
0.7 4.0 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.6 2.9 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 0.7 GO:1902617 response to fluoride(GO:1902617)
0.2 1.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.2 0.8 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.2 0.8 GO:0031296 B cell costimulation(GO:0031296)
0.2 0.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.2 0.7 GO:0071374 positive regulation of timing of anagen(GO:0051885) cellular response to parathyroid hormone stimulus(GO:0071374)
0.2 0.5 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 1.1 GO:0008228 opsonization(GO:0008228)
0.1 17.1 GO:0007586 digestion(GO:0007586)
0.1 1.3 GO:0035878 nail development(GO:0035878)
0.1 0.4 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 0.5 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 0.4 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 0.2 GO:0048627 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) myoblast development(GO:0048627)
0.1 0.5 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.0 GO:0001778 plasma membrane repair(GO:0001778)
0.1 3.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.3 GO:1904587 response to glycoprotein(GO:1904587)
0.1 0.5 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 0.8 GO:0070493 thrombin-activated receptor signaling pathway(GO:0070493)
0.0 0.3 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
0.0 0.5 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.0 2.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.4 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.5 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.3 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0030242 autophagy of peroxisome(GO:0030242) peroxisome disassembly(GO:1905683)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:2000232 regulation of rRNA processing(GO:2000232)
0.0 0.1 GO:0003285 septum secundum development(GO:0003285) cardiac muscle tissue regeneration(GO:0061026) negative regulation of connective tissue replacement(GO:1905204)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 36.6 GO:0006508 proteolysis(GO:0006508)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309) programmed cell death involved in cell development(GO:0010623)
0.0 0.5 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.3 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0032280 symmetric synapse(GO:0032280)
0.2 2.9 GO:0097208 alveolar lamellar body(GO:0097208)
0.2 2.9 GO:0042581 specific granule(GO:0042581)
0.1 1.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 1.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.2 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:0005771 multivesicular body(GO:0005771)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.9 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 64.4 GO:0005615 extracellular space(GO:0005615)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.4 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 30.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 4.0 GO:0001515 opioid peptide activity(GO:0001515)
0.2 0.7 GO:0004063 aryldialkylphosphatase activity(GO:0004063)
0.2 1.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.2 0.8 GO:0015057 thrombin-activated receptor activity(GO:0015057)
0.2 1.3 GO:0038132 neuregulin binding(GO:0038132)
0.1 43.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.5 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.1 0.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 0.5 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 2.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.4 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.0 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 0.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 0.3 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.1 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.0 0.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 1.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 18.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 3.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 18.7 REACTOME_DEFENSINS Genes involved in Defensins
0.0 0.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 5.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.0 0.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.1 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.1 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.3 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)