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GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-6

Z-value: 0.58

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Transcription factors associated with Nkx2-6

Gene Symbol Gene ID Gene Info
ENSMUSG00000044186.9 NK2 homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-6mm10_v2_chr14_+_69171576_69171576-0.889.3e-13Click!

Activity profile of Nkx2-6 motif

Sorted Z-values of Nkx2-6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_41704339 13.72 ENSMUST00000031899.8
Kell blood group
chr14_-_20269162 12.08 ENSMUST00000024155.7
potassium channel, subfamily K, member 16
chr15_+_73723131 3.95 ENSMUST00000165541.1
ENSMUST00000167582.1
protein tyrosine phosphatase 4a3
chr7_-_116031047 2.38 ENSMUST00000106612.1
SRY-box containing gene 6
chr2_-_119229885 1.69 ENSMUST00000076084.5
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr19_+_8802486 1.60 ENSMUST00000172175.1
zinc finger and BTB domain containing 3
chr5_+_110330697 1.31 ENSMUST00000112481.1
polymerase (DNA directed), epsilon
chr2_-_119229849 1.13 ENSMUST00000110820.2
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr10_+_100488289 1.00 ENSMUST00000164751.1
centrosomal protein 290
chr12_-_108702265 0.83 ENSMUST00000167978.1
ENSMUST00000021691.4
degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase
chr15_-_78773452 0.74 ENSMUST00000018313.5
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_+_22087878 0.71 ENSMUST00000091739.1
vomeronasal 1 receptor 188
chr2_+_3114220 0.46 ENSMUST00000072955.5
family with sequence similarity 171, member A1
chr4_-_109665249 0.41 ENSMUST00000063531.4
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chrX_+_107149580 0.32 ENSMUST00000137107.1
ENSMUST00000067249.2
RIKEN cDNA A630033H20 gene
chr1_+_179961110 0.29 ENSMUST00000076687.5
ENSMUST00000097450.3
CDC42 binding protein kinase alpha
chr7_-_116237767 0.25 ENSMUST00000182834.1
pleckstrin homology domain containing, family A member 7
chrX_+_107149454 0.23 ENSMUST00000125676.1
ENSMUST00000180182.1
RIKEN cDNA A630033H20 gene
chr14_-_73049107 0.14 ENSMUST00000044664.4
ENSMUST00000169168.1
cysteinyl leukotriene receptor 2
chr19_+_8819401 0.10 ENSMUST00000096753.3
heterogeneous nuclear ribonucleoprotein U-like 2
chr1_+_179960472 0.07 ENSMUST00000097453.2
ENSMUST00000111117.1
CDC42 binding protein kinase alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 13.7 GO:0031133 regulation of axon diameter(GO:0031133)
0.8 12.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.4 1.3 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 0.8 GO:0006667 sphinganine metabolic process(GO:0006667)
0.3 3.9 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.2 2.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.7 GO:0019236 response to pheromone(GO:0019236)
0.0 1.0 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 2.8 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.0 0.4 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.0 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 0.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.8 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.2 1.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 13.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.7 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 3.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 12.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.3 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes