Motif ID: Nkx3-1

Z-value: 1.875


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx3-1mm10_v2_chr14_+_69190638_691906910.241.6e-01Click!


Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_58759700 36.558 ENSMUST00000026081.3
Pnliprp2
pancreatic lipase-related protein 2
chr4_-_137430517 34.021 ENSMUST00000102522.4
Cela3b
chymotrypsin-like elastase family, member 3B
chr6_+_78425973 28.660 ENSMUST00000079926.5
Reg1
regenerating islet-derived 1
chr4_-_137409777 27.209 ENSMUST00000024200.6
Gm13011
predicted gene 13011
chr6_-_41035501 23.526 ENSMUST00000031931.5
2210010C04Rik
RIKEN cDNA 2210010C04 gene
chr3_-_113324052 21.763 ENSMUST00000179314.1
Amy2a3
amylase 2a3
chr3_-_113258837 19.265 ENSMUST00000098673.3
Amy2a5
amylase 2a5
chr3_-_113291449 18.127 ENSMUST00000179568.1
Amy2a4
amylase 2a4
chr3_-_113532288 16.519 ENSMUST00000132353.1
Amy2a1
amylase 2a1
chr3_-_113356658 15.907 ENSMUST00000098667.3
Amy2a2
amylase 2a2
chr5_-_145805862 8.329 ENSMUST00000067479.5
Cyp3a44
cytochrome P450, family 3, subfamily a, polypeptide 44
chr4_-_115496129 7.960 ENSMUST00000030487.2
Cyp4a14
cytochrome P450, family 4, subfamily a, polypeptide 14
chr5_-_145720124 7.513 ENSMUST00000094111.4
Cyp3a41a
cytochrome P450, family 3, subfamily a, polypeptide 41A
chr5_-_145584723 7.155 ENSMUST00000075837.6
Cyp3a41b
cytochrome P450, family 3, subfamily a, polypeptide 41B
chr6_-_69284319 5.884 ENSMUST00000103349.1
Igkv4-69
immunoglobulin kappa variable 4-69
chrX_+_7919816 5.005 ENSMUST00000041096.3
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr6_-_129913166 4.314 ENSMUST00000169901.2
ENSMUST00000167079.2
ENSMUST00000014683.6
Klra5


killer cell lectin-like receptor, subfamily A, member 5


chr6_-_83527773 4.201 ENSMUST00000152029.1
Actg2
actin, gamma 2, smooth muscle, enteric
chr6_-_83527986 4.191 ENSMUST00000121731.1
Actg2
actin, gamma 2, smooth muscle, enteric
chr6_-_83527452 4.118 ENSMUST00000141904.1
Actg2
actin, gamma 2, smooth muscle, enteric
chr4_-_140774196 3.580 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr11_+_69098937 3.033 ENSMUST00000021271.7
Per1
period circadian clock 1
chr14_+_53709902 2.604 ENSMUST00000103638.4
Trav6-7-dv9
T cell receptor alpha variable 6-7-DV9
chr16_+_87553313 2.511 ENSMUST00000026700.7
Map3k7cl
Map3k7 C-terminal like
chr15_-_74983430 2.377 ENSMUST00000023250.4
ENSMUST00000166694.1
Ly6i

lymphocyte antigen 6 complex, locus I

chr18_+_60963517 2.321 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chrX_+_164438039 2.298 ENSMUST00000033755.5
Asb11
ankyrin repeat and SOCS box-containing 11
chr6_+_86078070 2.271 ENSMUST00000032069.5
Add2
adducin 2 (beta)
chr15_-_75238768 2.213 ENSMUST00000089689.3
Gm10238
predicted pseudogene 10238
chr11_-_58613481 2.166 ENSMUST00000048801.7
2210407C18Rik
RIKEN cDNA 2210407C18 gene
chr1_+_139501692 2.164 ENSMUST00000027615.5
F13b
coagulation factor XIII, beta subunit
chr16_+_32756336 2.138 ENSMUST00000135753.1
Muc4
mucin 4
chr12_-_100899436 1.975 ENSMUST00000053668.3
Gpr68
G protein-coupled receptor 68
chr15_-_75111684 1.816 ENSMUST00000100542.3
Ly6c2
lymphocyte antigen 6 complex, locus C2
chr1_+_171155512 1.717 ENSMUST00000111334.1
Mpz
myelin protein zero
chr13_-_41828418 1.606 ENSMUST00000137905.1
Adtrp
androgen dependent TFPI regulating protein
chr3_+_62419668 1.590 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr9_+_72438519 1.495 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr1_-_175688353 1.444 ENSMUST00000104984.1
Chml
choroideremia-like
chr13_+_4436094 1.437 ENSMUST00000156277.1
Akr1c6
aldo-keto reductase family 1, member C6
chr13_-_41847599 1.430 ENSMUST00000179758.1
Adtrp
androgen dependent TFPI regulating protein
chr1_-_163289214 1.398 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr3_-_20242173 1.387 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chr1_-_52953179 1.360 ENSMUST00000114492.1
1700019D03Rik
RIKEN cDNA 1700019D03 gene
chrX_+_56454871 1.352 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr6_-_130231638 1.265 ENSMUST00000088011.4
ENSMUST00000112013.1
ENSMUST00000049304.7
Klra7


killer cell lectin-like receptor, subfamily A, member 7


chr11_-_99155067 1.233 ENSMUST00000103134.3
Ccr7
chemokine (C-C motif) receptor 7
chr15_-_75048837 1.224 ENSMUST00000179762.1
ENSMUST00000065408.9
Ly6c1

lymphocyte antigen 6 complex, locus C1

chr13_-_41847482 1.189 ENSMUST00000072012.3
Adtrp
androgen dependent TFPI regulating protein
chr2_+_84734050 1.143 ENSMUST00000090729.2
Ypel4
yippee-like 4 (Drosophila)
chr8_+_47824459 1.123 ENSMUST00000038693.6
Cldn22
claudin 22
chr3_-_64287417 1.115 ENSMUST00000170244.1
ENSMUST00000176328.1
Vmn2r3

vomeronasal 2, receptor 3

chr1_+_171503410 1.114 ENSMUST00000081527.1
Alyref2
Aly/REF export factor 2
chr14_+_41131777 1.101 ENSMUST00000022314.3
ENSMUST00000170719.1
Sftpa1

surfactant associated protein A1

chr2_-_93849679 1.090 ENSMUST00000068513.4
ENSMUST00000041593.8
ENSMUST00000130077.1
Accs


1-aminocyclopropane-1-carboxylate synthase (non-functional)


chr13_+_51408618 1.059 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr17_+_35135196 1.030 ENSMUST00000172571.1
ENSMUST00000173491.1
Bag6

BCL2-associated athanogene 6

chr11_+_46055973 1.023 ENSMUST00000011400.7
Adam19
a disintegrin and metallopeptidase domain 19 (meltrin beta)
chrX_+_100625737 1.010 ENSMUST00000048962.3
Kif4
kinesin family member 4
chr5_-_110046486 0.995 ENSMUST00000167969.1
Gm17655
predicted gene, 17655
chr1_-_174921813 0.991 ENSMUST00000055294.3
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr10_-_13324160 0.987 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr17_-_25727364 0.958 ENSMUST00000170070.1
ENSMUST00000048054.7
Chtf18

CTF18, chromosome transmission fidelity factor 18

chr17_+_56304313 0.951 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr10_-_59441748 0.936 ENSMUST00000009798.4
Oit3
oncoprotein induced transcript 3
chr12_-_78983476 0.928 ENSMUST00000070174.7
Tmem229b
transmembrane protein 229B
chrX_+_157699113 0.925 ENSMUST00000112521.1
Smpx
small muscle protein, X-linked
chr18_-_6241470 0.894 ENSMUST00000163210.1
Kif5b
kinesin family member 5B
chr1_+_66364623 0.892 ENSMUST00000077355.5
ENSMUST00000114012.1
Map2

microtubule-associated protein 2

chr2_+_25403044 0.883 ENSMUST00000071442.5
Npdc1
neural proliferation, differentiation and control 1
chr12_+_52516077 0.875 ENSMUST00000110725.1
Arhgap5
Rho GTPase activating protein 5
chr18_-_6241486 0.872 ENSMUST00000025083.7
Kif5b
kinesin family member 5B
chr6_-_124857707 0.870 ENSMUST00000023958.3
Leprel2
leprecan-like 2
chr10_-_128211788 0.862 ENSMUST00000061995.8
Spryd4
SPRY domain containing 4
chr5_-_86676346 0.818 ENSMUST00000038448.6
Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr9_+_89199209 0.818 ENSMUST00000068569.4
Bcl2a1b
B cell leukemia/lymphoma 2 related protein A1b
chr10_-_13324250 0.807 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chr6_-_145434925 0.807 ENSMUST00000111708.2
Ifltd1
intermediate filament tail domain containing 1
chr1_+_135799833 0.783 ENSMUST00000148201.1
Tnni1
troponin I, skeletal, slow 1
chr7_-_63938862 0.781 ENSMUST00000063694.8
Klf13
Kruppel-like factor 13
chr3_-_127408937 0.778 ENSMUST00000183095.1
ENSMUST00000182610.1
Ank2

ankyrin 2, brain

chr11_-_121519326 0.775 ENSMUST00000092298.5
Zfp750
zinc finger protein 750
chr16_-_48771956 0.768 ENSMUST00000170861.1
Trat1
T cell receptor associated transmembrane adaptor 1
chr14_-_43923368 0.767 ENSMUST00000163652.1
Ear10
eosinophil-associated, ribonuclease A family, member 10
chr14_-_73049107 0.752 ENSMUST00000044664.4
ENSMUST00000169168.1
Cysltr2

cysteinyl leukotriene receptor 2

chr9_-_103222063 0.704 ENSMUST00000170904.1
Trf
transferrin
chr19_+_4711153 0.698 ENSMUST00000008991.6
Sptbn2
spectrin beta, non-erythrocytic 2
chr8_-_106011422 0.685 ENSMUST00000058579.5
Ddx28
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr3_-_127409014 0.684 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
Ank2


ankyrin 2, brain


chr17_+_35135174 0.679 ENSMUST00000166426.2
ENSMUST00000025250.7
Bag6

BCL2-associated athanogene 6

chr9_+_77921908 0.641 ENSMUST00000133757.1
Elovl5
ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr5_+_32247351 0.640 ENSMUST00000101376.2
Plb1
phospholipase B1
chr3_-_127408986 0.637 ENSMUST00000182588.1
ENSMUST00000182959.1
ENSMUST00000182452.1
Ank2


ankyrin 2, brain


chr2_+_25403128 0.633 ENSMUST00000154809.1
ENSMUST00000055921.7
ENSMUST00000141567.1
Npdc1


neural proliferation, differentiation and control 1


chr9_-_43116514 0.631 ENSMUST00000061833.4
Tmem136
transmembrane protein 136
chr9_-_62537036 0.628 ENSMUST00000048043.5
Coro2b
coronin, actin binding protein, 2B
chr1_-_173766876 0.616 ENSMUST00000111214.2
Ifi204
interferon activated gene 204
chr3_-_104818539 0.611 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Mov10



Moloney leukemia virus 10



chr9_-_18512885 0.608 ENSMUST00000034653.6
Muc16
mucin 16
chr1_-_133907053 0.577 ENSMUST00000149380.1
ENSMUST00000124051.2
Optc

opticin

chr6_+_128362919 0.576 ENSMUST00000073316.6
Foxm1
forkhead box M1
chr17_-_65772686 0.573 ENSMUST00000070673.7
Rab31
RAB31, member RAS oncogene family
chr8_-_69791170 0.565 ENSMUST00000131784.1
Zfp866
zinc finger protein 866
chr3_+_57425314 0.534 ENSMUST00000029377.7
Tm4sf4
transmembrane 4 superfamily member 4
chr1_-_173741717 0.534 ENSMUST00000127730.1
AI607873
expressed sequence AI607873
chr11_+_118443471 0.524 ENSMUST00000133558.1
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr1_+_152954966 0.505 ENSMUST00000043313.8
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr2_+_23069210 0.489 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr4_-_108217897 0.486 ENSMUST00000106690.1
ENSMUST00000043793.6
Zyg11a

zyg-11 family member A, cell cycle regulator

chr10_-_60752773 0.478 ENSMUST00000117513.1
ENSMUST00000119595.1
Slc29a3

solute carrier family 29 (nucleoside transporters), member 3

chrX_-_101222426 0.469 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr19_-_17356631 0.460 ENSMUST00000174236.1
Gcnt1
glucosaminyl (N-acetyl) transferase 1, core 2
chr1_-_193035651 0.458 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr4_+_116708571 0.455 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
Ccdc163



coiled-coil domain containing 163



chr3_-_101029543 0.454 ENSMUST00000147399.2
Cd101
CD101 antigen
chr18_+_82910863 0.440 ENSMUST00000171238.1
Zfp516
zinc finger protein 516
chrX_+_8843994 0.427 ENSMUST00000115563.1
Gm6592
predicted gene 6592
chr19_-_59943000 0.426 ENSMUST00000170819.1
Rab11fip2
RAB11 family interacting protein 2 (class I)
chr2_-_27142429 0.412 ENSMUST00000151224.2
Fam163b
family with sequence similarity 163, member B
chr5_-_38491948 0.391 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr1_-_133906973 0.388 ENSMUST00000126123.1
Optc
opticin
chr3_-_127409044 0.380 ENSMUST00000182704.1
Ank2
ankyrin 2, brain
chr8_+_69791163 0.366 ENSMUST00000034326.6
Atp13a1
ATPase type 13A1
chr13_+_80886095 0.365 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr14_-_55788810 0.360 ENSMUST00000022830.6
ENSMUST00000168716.1
ENSMUST00000178399.1
Ripk3


receptor-interacting serine-threonine kinase 3


chr14_+_61309753 0.333 ENSMUST00000055159.7
Arl11
ADP-ribosylation factor-like 11
chr15_+_75268379 0.324 ENSMUST00000023247.6
Ly6f
lymphocyte antigen 6 complex, locus F
chr9_+_72438534 0.321 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr17_+_38145393 0.320 ENSMUST00000173610.1
Olfr133
olfactory receptor 133
chr6_-_108185552 0.320 ENSMUST00000167338.1
ENSMUST00000172188.1
ENSMUST00000032191.9
Sumf1


sulfatase modifying factor 1


chr11_-_61378306 0.315 ENSMUST00000148671.1
Slc47a1
solute carrier family 47, member 1
chr5_+_66968416 0.314 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr2_+_174076296 0.305 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr4_-_129378116 0.304 ENSMUST00000030610.2
Zbtb8a
zinc finger and BTB domain containing 8a
chr2_+_3114220 0.303 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr10_+_5639210 0.292 ENSMUST00000019906.4
Vip
vasoactive intestinal polypeptide
chr6_+_145953429 0.287 ENSMUST00000111701.1
Sspn
sarcospan
chr14_-_52213379 0.278 ENSMUST00000140603.1
Chd8
chromodomain helicase DNA binding protein 8
chr1_+_106980979 0.244 ENSMUST00000027564.1
Serpinb13
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
chr4_-_99654983 0.244 ENSMUST00000136525.1
Gm12688
predicted gene 12688
chr12_-_52028063 0.242 ENSMUST00000040161.4
Gpr33
G protein-coupled receptor 33
chr11_-_106193511 0.237 ENSMUST00000007444.7
ENSMUST00000152008.1
ENSMUST00000103072.3
ENSMUST00000106867.1
Strada



STE20-related kinase adaptor alpha



chr7_+_75455534 0.236 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr2_-_149017237 0.218 ENSMUST00000099266.2
Gm10750
predicted gene 10750
chr19_-_61297069 0.214 ENSMUST00000179346.1
Gm21060
predicted gene, 21060
chr11_-_17008647 0.194 ENSMUST00000102881.3
Plek
pleckstrin
chr1_+_157506728 0.189 ENSMUST00000086130.2
Sec16b
SEC16 homolog B (S. cerevisiae)
chrY_-_38800793 0.182 ENSMUST00000180177.1
Gm20901
predicted gene, 20901
chr1_+_157506777 0.177 ENSMUST00000027881.8
Sec16b
SEC16 homolog B (S. cerevisiae)
chr1_-_86111970 0.174 ENSMUST00000027431.6
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B
chr7_+_58658181 0.169 ENSMUST00000168747.1
Atp10a
ATPase, class V, type 10A
chr11_-_21370452 0.152 ENSMUST00000102875.4
Ugp2
UDP-glucose pyrophosphorylase 2
chr12_+_59095653 0.140 ENSMUST00000021384.4
Mia2
melanoma inhibitory activity 2
chr10_+_69219357 0.136 ENSMUST00000172261.1
Rhobtb1
Rho-related BTB domain containing 1
chrX_+_134187492 0.124 ENSMUST00000064476.4
Arl13a
ADP-ribosylation factor-like 13A
chr8_-_123318553 0.118 ENSMUST00000118395.1
ENSMUST00000035495.8
Fanca

Fanconi anemia, complementation group A

chrX_+_56317608 0.106 ENSMUST00000151426.1
ENSMUST00000138262.1
1600025M17Rik

RIKEN cDNA 1600025M17 gene

chr15_+_78597047 0.097 ENSMUST00000043069.5
Cyth4
cytohesin 4
chr5_+_10236829 0.097 ENSMUST00000101606.3
Gm10482
predicted gene 10482
chr17_-_15564322 0.096 ENSMUST00000147532.1
Prdm9
PR domain containing 9
chr5_+_138161071 0.090 ENSMUST00000019638.8
ENSMUST00000110951.1
Cops6

COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)

chr6_+_24748325 0.085 ENSMUST00000031691.2
Hyal4
hyaluronoglucosaminidase 4
chr17_+_37270214 0.080 ENSMUST00000038580.6
H2-M3
histocompatibility 2, M region locus 3
chr1_+_174041933 0.068 ENSMUST00000052975.4
Olfr433
olfactory receptor 433
chr14_+_47663756 0.046 ENSMUST00000022391.7
Ktn1
kinectin 1
chr9_+_74976096 0.044 ENSMUST00000081746.5
Fam214a
family with sequence similarity 214, member A
chr17_+_22689771 0.040 ENSMUST00000055305.8
Gm9805
predicted gene 9805
chr4_-_149737957 0.039 ENSMUST00000105687.2
ENSMUST00000054459.4
ENSMUST00000103208.1
Tmem201


transmembrane protein 201


chr12_+_101404673 0.036 ENSMUST00000055156.4
Catsperb
catsper channel auxiliary subunit beta
chr11_-_103697661 0.035 ENSMUST00000107013.2
Gosr2
golgi SNAP receptor complex member 2
chr5_-_122697603 0.016 ENSMUST00000071235.4
Gm10064
predicted gene 10064
chr10_-_4432285 0.010 ENSMUST00000155172.1
Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr5_-_72559599 0.007 ENSMUST00000074948.4
ENSMUST00000087216.5
Nfxl1

nuclear transcription factor, X-box binding-like 1

chr7_+_110627650 0.000 ENSMUST00000033054.8
Adm
adrenomedullin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 36.6 GO:0019377 galactolipid metabolic process(GO:0019374) glycolipid catabolic process(GO:0019377)
1.9 28.7 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.7 3.6 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.6 3.0 GO:0097167 circadian regulation of translation(GO:0097167)
0.5 2.0 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.5 1.4 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.4 1.2 GO:2000547 lymphocyte migration into lymphoid organs(GO:0097021) positive regulation of thymocyte migration(GO:2000412) regulation of dendritic cell dendrite assembly(GO:2000547)
0.4 2.1 GO:0002838 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.4 1.8 GO:0035617 stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 1.7 GO:0061857 endoplasmic reticulum stress-induced pre-emptive quality control(GO:0061857)
0.3 1.0 GO:0060300 regulation of cytokine activity(GO:0060300)
0.3 2.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 2.3 GO:0099004 calmodulin dependent kinase signaling pathway(GO:0099004)
0.2 22.7 GO:0070988 demethylation(GO:0070988)
0.2 29.9 GO:0008203 cholesterol metabolic process(GO:0008203)
0.2 0.8 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 0.4 GO:2000449 regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449)
0.2 1.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 0.5 GO:2000642 negative regulation of cytoplasmic transport(GO:1903650) negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 0.6 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 0.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 5.0 GO:0002021 response to dietary excess(GO:0002021)
0.1 0.7 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 1.7 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.1 1.1 GO:0008228 opsonization(GO:0008228)
0.1 0.4 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 1.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.4 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 1.0 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 1.0 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.1 2.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.5 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.7 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.1 0.3 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 1.8 GO:0070986 left/right axis specification(GO:0070986)
0.1 1.4 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.6 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 1.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.1 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.6 GO:1905516 positive regulation of fertilization(GO:1905516) positive regulation of acrosome reaction(GO:2000344)
0.1 0.5 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.2 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.6 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.1 0.6 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.4 GO:0030242 autophagy of peroxisome(GO:0030242) peroxisome disassembly(GO:1905683)
0.1 0.2 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:1902172 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.0 6.6 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.8 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.2 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560) negative regulation of phospholipase C activity(GO:1900275)
0.0 0.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.4 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.7 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.2 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.5 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.0 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 1.9 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945) negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 1.0 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.6 GO:0001845 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.4 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.4 GO:0009409 response to cold(GO:0009409)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 36.6 GO:0042589 zymogen granule membrane(GO:0042589)
1.9 28.7 GO:0042588 zymogen granule(GO:0042588)
0.5 2.3 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.3 1.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 1.7 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 2.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 0.6 GO:0097447 dendritic tree(GO:0097447)
0.1 0.9 GO:0005927 muscle tendon junction(GO:0005927)
0.1 1.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.7 GO:0008091 spectrin(GO:0008091)
0.1 0.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.8 GO:0035253 ciliary rootlet(GO:0035253)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 12.2 GO:0072562 blood microparticle(GO:0072562)
0.1 2.5 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0097342 ripoptosome(GO:0097342)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 2.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 3.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 17.5 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 1.8 GO:0005882 intermediate filament(GO:0005882)
0.0 120.1 GO:0005615 extracellular space(GO:0005615)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 3.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0000791 euchromatin(GO:0000791)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.6 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 75.1 GO:0004556 alpha-amylase activity(GO:0004556)
2.9 22.9 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
2.4 36.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.3 8.0 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.7 3.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.5 2.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.5 1.4 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.3 1.8 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 0.6 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 2.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 0.8 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 28.7 GO:0008083 growth factor activity(GO:0008083)
0.2 54.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 1.0 GO:0031493 nucleosomal histone binding(GO:0031493)
0.2 0.5 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.5 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 0.7 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 1.7 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.0 GO:0036122 BMP binding(GO:0036122)
0.1 0.4 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.1 1.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 4.8 GO:0030507 spectrin binding(GO:0030507)
0.1 1.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.2 GO:0001587 Gq/11-coupled serotonin receptor activity(GO:0001587)
0.1 0.6 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 3.0 GO:0070888 E-box binding(GO:0070888)
0.0 2.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.8 GO:0051400 BH domain binding(GO:0051400)
0.0 0.2 GO:0004875 complement receptor activity(GO:0004875)
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0051748 UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451)
0.0 0.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.9 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 0.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 3.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 34.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 4.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.2 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.0 0.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 2.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 35.2 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.3 12.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.2 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 2.7 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.8 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.0 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.8 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.2 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 0.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.4 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.2 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules