Motif ID: Nkx6-2

Z-value: 1.288


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.115.3e-01Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_142661858 14.315 ENSMUST00000145896.2
Igf2
insulin-like growth factor 2
chr7_-_142661305 13.799 ENSMUST00000105936.1
Igf2
insulin-like growth factor 2
chr18_-_74207771 9.831 ENSMUST00000040188.8
ENSMUST00000177604.1
Ska1

spindle and kinetochore associated complex subunit 1

chr9_-_123678782 9.428 ENSMUST00000170591.1
ENSMUST00000171647.1
Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr17_-_48432723 8.965 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr9_-_123678873 8.165 ENSMUST00000040960.6
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr18_+_34840575 7.237 ENSMUST00000043484.7
Reep2
receptor accessory protein 2
chr16_-_22161450 6.982 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr5_+_66676098 6.574 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr14_+_27000362 6.501 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chr19_+_58728887 6.420 ENSMUST00000048644.5
Pnliprp1
pancreatic lipase related protein 1
chr9_+_65890237 6.307 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr10_+_115817247 6.050 ENSMUST00000035563.7
ENSMUST00000080630.3
ENSMUST00000179196.1
Tspan8


tetraspanin 8


chr4_-_117182623 6.001 ENSMUST00000065896.2
Kif2c
kinesin family member 2C
chr17_-_29888570 5.917 ENSMUST00000171691.1
Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr7_-_4397705 5.798 ENSMUST00000108590.2
Gp6
glycoprotein 6 (platelet)
chr9_+_96258697 5.252 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr10_+_37139558 5.042 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr12_+_117843873 4.925 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr6_-_102464667 4.691 ENSMUST00000032159.6
Cntn3
contactin 3
chr1_-_126830632 4.572 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr9_+_96259246 3.775 ENSMUST00000179065.1
ENSMUST00000165768.2
Tfdp2

transcription factor Dp 2

chr4_-_147642496 3.704 ENSMUST00000133006.1
ENSMUST00000037565.7
ENSMUST00000105720.1
2610305D13Rik


RIKEN cDNA 2610305D13 gene


chr4_-_3938354 3.648 ENSMUST00000003369.3
Plag1
pleiomorphic adenoma gene 1
chr19_-_33787452 3.547 ENSMUST00000178735.1
ENSMUST00000148137.1
Gm5097

predicted gene 5097

chr5_+_110839973 3.538 ENSMUST00000066160.1
Chek2
checkpoint kinase 2
chr4_+_140701466 3.488 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chrX_-_59568068 3.115 ENSMUST00000119833.1
ENSMUST00000131319.1
Fgf13

fibroblast growth factor 13

chr13_+_109926832 2.975 ENSMUST00000117420.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr8_+_93810832 2.964 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr5_+_65863563 2.908 ENSMUST00000031106.4
Rhoh
ras homolog gene family, member H
chr8_+_21025545 2.877 ENSMUST00000076754.2
Defa21
defensin, alpha, 21
chr19_+_8802486 2.839 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr16_+_44394771 2.797 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chrX_+_153139941 2.795 ENSMUST00000039720.4
ENSMUST00000144175.2
Rragb

Ras-related GTP binding B

chr4_+_147553277 2.631 ENSMUST00000139784.1
ENSMUST00000143885.1
ENSMUST00000081742.6
Gm13154


predicted gene 13154


chr17_+_35861343 2.595 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr1_+_63176818 2.593 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr2_-_125625065 2.483 ENSMUST00000089776.2
Cep152
centrosomal protein 152
chr17_+_35861318 2.475 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr8_-_62123106 2.422 ENSMUST00000034052.6
ENSMUST00000034054.7
Anxa10

annexin A10

chr4_+_127172866 2.355 ENSMUST00000106094.2
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr1_+_170308802 2.340 ENSMUST00000056991.5
1700015E13Rik
RIKEN cDNA 1700015E13 gene
chr5_-_110839757 2.331 ENSMUST00000056937.5
Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr3_-_17230976 2.312 ENSMUST00000177874.1
Gm5283
predicted gene 5283
chr7_+_28788955 2.297 ENSMUST00000059857.7
Rinl
Ras and Rab interactor-like
chrX_+_75382384 2.249 ENSMUST00000033541.4
Fundc2
FUN14 domain containing 2
chr17_+_82539258 2.229 ENSMUST00000097278.3
Gm6594
predicted pseudogene 6594
chr17_-_78684262 2.222 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr8_+_21162277 2.163 ENSMUST00000098897.1
Defa22
defensin, alpha, 22
chr9_-_35558522 2.143 ENSMUST00000034612.5
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr8_+_21565368 2.140 ENSMUST00000084040.2
Gm14850
predicted gene 14850
chr11_+_20543307 2.085 ENSMUST00000093292.4
Sertad2
SERTA domain containing 2
chr5_-_122821298 2.072 ENSMUST00000086216.4
Anapc5
anaphase-promoting complex subunit 5
chr11_+_23256566 2.065 ENSMUST00000136235.1
Xpo1
exportin 1, CRM1 homolog (yeast)
chr14_+_51129055 2.058 ENSMUST00000095923.3
Rnase6
ribonuclease, RNase A family, 6
chrX_-_59567348 2.043 ENSMUST00000124402.1
Fgf13
fibroblast growth factor 13
chr15_-_81104999 2.019 ENSMUST00000109579.2
Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr11_+_46810792 1.927 ENSMUST00000068877.6
Timd4
T cell immunoglobulin and mucin domain containing 4
chr1_-_126830786 1.884 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr5_-_110839575 1.858 ENSMUST00000145318.1
Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr4_+_150927918 1.853 ENSMUST00000139826.1
ENSMUST00000116257.1
Tnfrsf9

tumor necrosis factor receptor superfamily, member 9

chr18_+_68337504 1.827 ENSMUST00000172148.1
Mc5r
melanocortin 5 receptor
chr8_-_105568298 1.809 ENSMUST00000005849.5
Agrp
agouti related protein
chr11_+_105092194 1.738 ENSMUST00000021029.5
Efcab3
EF-hand calcium binding domain 3
chr5_-_20951769 1.688 ENSMUST00000036489.5
Rsbn1l
round spermatid basic protein 1-like
chr4_+_146097312 1.669 ENSMUST00000105730.1
ENSMUST00000091878.5
Gm13051

predicted gene 13051

chr4_-_136835843 1.662 ENSMUST00000105846.2
ENSMUST00000059287.7
ENSMUST00000105845.2
Ephb2


Eph receptor B2


chr10_-_37138863 1.647 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr2_-_33087169 1.634 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr7_+_25228687 1.621 ENSMUST00000169914.1
9130221H12Rik
RIKEN cDNA 9130221H12 gene
chr11_-_17953861 1.540 ENSMUST00000076661.6
Etaa1
Ewing's tumor-associated antigen 1
chr5_+_19907502 1.533 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr15_+_99006056 1.523 ENSMUST00000079818.3
Gm8973
predicted gene 8973
chr6_+_125552948 1.522 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr8_-_65129317 1.519 ENSMUST00000098713.3
BC030870
cDNA sequence BC030870
chr5_-_131308076 1.475 ENSMUST00000160609.1
Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr12_-_46818749 1.448 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr5_+_25246775 1.405 ENSMUST00000144971.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr2_+_62664279 1.400 ENSMUST00000028257.2
Gca
grancalcin
chr8_+_21427456 1.372 ENSMUST00000095424.4
Gm21498
predicted gene, 21498
chr7_+_142831227 1.253 ENSMUST00000097935.2
Gm6471
predicted gene 6471
chr11_-_87826023 1.239 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr11_-_107348130 1.229 ENSMUST00000134763.1
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr18_-_43477764 1.201 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr1_+_66321708 1.189 ENSMUST00000114013.1
Map2
microtubule-associated protein 2
chr6_-_13839916 1.188 ENSMUST00000060442.7
Gpr85
G protein-coupled receptor 85
chr3_+_10088173 1.175 ENSMUST00000061419.7
Gm9833
predicted gene 9833
chr16_+_96467606 1.171 ENSMUST00000061739.8
Pcp4
Purkinje cell protein 4
chr2_+_69861562 1.171 ENSMUST00000090852.4
ENSMUST00000166411.1
Ssb

Sjogren syndrome antigen B

chr18_-_31911903 1.164 ENSMUST00000054984.6
Sft2d3
SFT2 domain containing 3
chr8_+_25720054 1.161 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr6_-_87533219 1.136 ENSMUST00000113637.2
ENSMUST00000071024.6
Arhgap25

Rho GTPase activating protein 25

chr1_+_66322102 1.131 ENSMUST00000123647.1
Map2
microtubule-associated protein 2
chr4_+_147361303 1.113 ENSMUST00000133078.1
ENSMUST00000154154.1
Gm13145

predicted gene 13145

chr2_-_45117349 1.108 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr8_+_21665797 1.106 ENSMUST00000075268.4
Gm15315
predicted gene 15315
chr4_-_146909590 1.047 ENSMUST00000049821.3
Gm21411
predicted gene, 21411
chr8_-_107439585 1.046 ENSMUST00000077208.4
Rps26-ps1
ribosomal protein S26, pseudogene 1
chr5_+_75152274 1.029 ENSMUST00000000476.8
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr2_+_3114220 1.019 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr2_+_157367594 1.011 ENSMUST00000081202.5
Manbal
mannosidase, beta A, lysosomal-like
chr19_-_14597983 0.974 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr3_+_83055516 0.968 ENSMUST00000150268.1
ENSMUST00000122128.1
Plrg1

pleiotropic regulator 1, PRL1 homolog (Arabidopsis)

chr4_+_109343029 0.953 ENSMUST00000030281.5
Eps15
epidermal growth factor receptor pathway substrate 15
chr19_-_14598031 0.951 ENSMUST00000167776.2
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr6_-_119963733 0.950 ENSMUST00000161512.2
Wnk1
WNK lysine deficient protein kinase 1
chrX_+_134059315 0.939 ENSMUST00000144483.1
Cstf2
cleavage stimulation factor, 3' pre-RNA subunit 2
chr2_+_163694015 0.925 ENSMUST00000109400.2
Pkig
protein kinase inhibitor, gamma
chr4_+_3940747 0.909 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr2_-_33086366 0.903 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr16_-_76403673 0.889 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr1_-_135585314 0.856 ENSMUST00000040599.8
ENSMUST00000067414.6
Nav1

neuron navigator 1

chr3_+_68572245 0.855 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr15_+_18818895 0.846 ENSMUST00000166873.2
Cdh10
cadherin 10
chr3_+_107291215 0.844 ENSMUST00000029502.7
Slc16a4
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr4_+_147305674 0.823 ENSMUST00000148762.3
Gm13151
predicted gene 13151
chr6_+_127149389 0.811 ENSMUST00000180811.1
9330179D12Rik
RIKEN cDNA 9330179D12 gene
chr9_-_22117123 0.692 ENSMUST00000013966.6
Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr18_-_63387124 0.684 ENSMUST00000047480.6
ENSMUST00000046860.5
Piezo2

piezo-type mechanosensitive ion channel component 2

chr12_-_80760541 0.625 ENSMUST00000073251.6
Ccdc177
coiled-coil domain containing 177
chr18_+_6332587 0.613 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr4_+_146502027 0.610 ENSMUST00000105735.2
Gm13247
predicted gene 13247
chr15_+_34453285 0.594 ENSMUST00000060894.7
BC030476
cDNA sequence BC030476
chr3_+_19894855 0.585 ENSMUST00000059704.4
4632415L05Rik
RIKEN cDNA 4632415L05 gene
chr10_+_26822560 0.521 ENSMUST00000135866.1
Arhgap18
Rho GTPase activating protein 18
chr15_-_13173607 0.518 ENSMUST00000036439.4
Cdh6
cadherin 6
chr7_+_39588931 0.502 ENSMUST00000178791.1
ENSMUST00000098511.3
Gm2058

predicted gene 2058

chr3_+_96221111 0.501 ENSMUST00000090781.6
Hist2h2be
histone cluster 2, H2be
chr1_-_64121456 0.500 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7

Kruppel-like factor 7 (ubiquitous)

chr9_-_119719032 0.481 ENSMUST00000084787.5
Scn10a
sodium channel, voltage-gated, type X, alpha
chr11_+_115933282 0.472 ENSMUST00000140991.1
Sap30bp
SAP30 binding protein
chr1_-_9944103 0.468 ENSMUST00000182498.1
ENSMUST00000182742.1
ENSMUST00000182580.1
Snhg6


small nucleolar RNA host gene (non-protein coding) 6


chr10_+_19621992 0.458 ENSMUST00000036564.7
Il22ra2
interleukin 22 receptor, alpha 2
chr9_-_113708209 0.456 ENSMUST00000111861.3
ENSMUST00000035086.6
Pdcd6ip

programmed cell death 6 interacting protein

chr4_+_148558422 0.452 ENSMUST00000017408.7
ENSMUST00000076022.6
Exosc10

exosome component 10

chr11_+_100859492 0.430 ENSMUST00000107356.1
Stat5a
signal transducer and activator of transcription 5A
chr2_-_174346712 0.427 ENSMUST00000168292.1
Gm20721
predicted gene, 20721
chr11_+_67321638 0.422 ENSMUST00000108684.1
Myh13
myosin, heavy polypeptide 13, skeletal muscle
chr4_-_133756769 0.402 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr10_+_79910856 0.384 ENSMUST00000181321.1
Gm26602
predicted gene, 26602
chr5_-_131307848 0.376 ENSMUST00000086023.5
Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr18_+_4993795 0.334 ENSMUST00000153016.1
Svil
supervillin
chr4_-_147702553 0.325 ENSMUST00000117638.1
Zfp534
zinc finger protein 534
chr11_-_115933464 0.320 ENSMUST00000021097.3
Recql5
RecQ protein-like 5
chr3_+_3634145 0.313 ENSMUST00000108394.1
Hnf4g
hepatocyte nuclear factor 4, gamma
chr2_+_69219971 0.310 ENSMUST00000005364.5
ENSMUST00000112317.2
G6pc2

glucose-6-phosphatase, catalytic, 2

chr3_+_69222412 0.279 ENSMUST00000183126.1
Arl14
ADP-ribosylation factor-like 14
chr1_+_34005872 0.275 ENSMUST00000182296.1
Dst
dystonin
chr3_+_106113229 0.274 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr13_-_27513206 0.248 ENSMUST00000018389.3
ENSMUST00000110350.1
Prl8a8

prolactin family 8, subfamily a, member 81

chr19_-_33517776 0.245 ENSMUST00000112511.3
ENSMUST00000143522.1
Lipo4

lipase, member O4

chr1_-_185329331 0.231 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr5_+_140419248 0.216 ENSMUST00000100507.3
Eif3b
eukaryotic translation initiation factor 3, subunit B
chr13_+_44121167 0.215 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chrX_-_75382615 0.213 ENSMUST00000147349.1
F8
coagulation factor VIII
chr11_-_4440745 0.205 ENSMUST00000109948.1
Hormad2
HORMA domain containing 2
chr16_-_16829276 0.180 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chr5_+_123142187 0.177 ENSMUST00000174836.1
ENSMUST00000163030.2
Setd1b

SET domain containing 1B

chr11_+_100859351 0.177 ENSMUST00000004145.7
ENSMUST00000133036.1
Stat5a

signal transducer and activator of transcription 5A

chr7_+_45062429 0.173 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip



nitric oxide synthase interacting protein



chr5_+_20702129 0.163 ENSMUST00000101556.4
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_+_43515513 0.162 ENSMUST00000167522.1
ENSMUST00000144558.1
ENSMUST00000076939.6
C1qtnf7


C1q and tumor necrosis factor related protein 7


chr11_-_109995743 0.162 ENSMUST00000106669.2
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr5_-_137142413 0.144 ENSMUST00000160533.1
Muc3
mucin 3, intestinal
chr4_+_146971976 0.135 ENSMUST00000146688.2
Gm13150
predicted gene 13150
chr18_-_42899294 0.133 ENSMUST00000117687.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr11_-_109995775 0.128 ENSMUST00000020948.8
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr2_-_177267036 0.115 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr11_+_98863610 0.107 ENSMUST00000142414.1
ENSMUST00000037480.8
Wipf2

WAS/WASL interacting protein family, member 2

chrX_-_43274786 0.105 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr10_-_127311740 0.075 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chrX_-_112405822 0.012 ENSMUST00000124335.1
Satl1
spermidine/spermine N1-acetyl transferase-like 1
chr13_+_41148796 0.011 ENSMUST00000141292.1
Sycp2l
synaptonemal complex protein 2-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 28.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.6 17.6 GO:0035524 proline transmembrane transport(GO:0035524)
1.5 9.0 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.2 7.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
1.2 6.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.2 3.5 GO:0098763 mitotic cell cycle phase(GO:0098763)
1.1 6.6 GO:0007412 axon target recognition(GO:0007412)
0.8 5.9 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.7 5.2 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.7 6.5 GO:0030916 otic vesicle formation(GO:0030916)
0.6 4.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.6 3.5 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.5 1.9 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.4 2.5 GO:0098535 de novo centriole assembly(GO:0097742) de novo centriole assembly involved in multi-ciliated epithelial cell differentiation(GO:0098535)
0.3 1.0 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.3 2.0 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.3 1.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 5.8 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.3 2.8 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.3 2.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.9 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.2 3.0 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.7 GO:0099550 trans-synaptic signaling, modulating synaptic transmission(GO:0099550)
0.2 1.0 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2 1.1 GO:1902748 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 1.4 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.2 1.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 3.6 GO:0060736 prostate gland growth(GO:0060736)
0.2 1.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 0.5 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 0.6 GO:0060376 positive regulation of mast cell differentiation(GO:0060376)
0.1 1.2 GO:0099004 calmodulin dependent kinase signaling pathway(GO:0099004)
0.1 0.5 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 12.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 6.1 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 0.4 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 0.3 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.9 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 1.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 9.1 GO:0051028 mRNA transport(GO:0051028)
0.1 2.6 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 3.0 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 0.5 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.1 1.6 GO:0051764 actin crosslink formation(GO:0051764)
0.1 2.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.9 GO:0001553 luteinization(GO:0001553)
0.0 2.6 GO:0045471 response to ethanol(GO:0045471)
0.0 0.7 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 2.9 GO:0045576 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) mast cell activation(GO:0045576)
0.0 6.0 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.7 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 1.8 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 1.5 GO:0000422 autophagy of mitochondrion(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 1.2 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.5 GO:0001889 liver development(GO:0001889)
0.0 2.1 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 1.4 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 3.1 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.6 2.8 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.5 1.6 GO:0042585 germinal vesicle(GO:0042585)
0.5 5.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 2.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 2.5 GO:0098536 deuterosome(GO:0098536)
0.3 0.9 GO:0071920 cleavage body(GO:0071920)
0.3 3.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.3 5.1 GO:0005652 nuclear lamina(GO:0005652)
0.3 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.3 2.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 2.1 GO:0005642 annulate lamellae(GO:0005642)
0.2 6.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.2 GO:0005883 neurofilament(GO:0005883)
0.1 2.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.5 GO:0044299 C-fiber(GO:0044299)
0.1 2.1 GO:0033391 chromatoid body(GO:0033391)
0.1 7.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 6.8 GO:1904115 axon cytoplasm(GO:1904115)
0.1 5.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 2.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 5.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 3.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.4 GO:0001772 immunological synapse(GO:0001772)
0.1 1.5 GO:0071162 nuclear replication fork(GO:0043596) CMG complex(GO:0071162)
0.0 0.9 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 9.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.5 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834) GTPase complex(GO:1905360)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.6 GO:0001650 fibrillar center(GO:0001650)
0.0 5.7 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 28.1 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
1.6 6.6 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
1.6 17.6 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.5 9.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.5 5.8 GO:0038064 collagen receptor activity(GO:0038064)
0.4 3.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3 1.8 GO:0004977 melanocortin receptor activity(GO:0004977)
0.3 6.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 2.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 7.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 1.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 2.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 1.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 6.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 0.5 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 2.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 2.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 2.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 4.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 1.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 3.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.1 1.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 5.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.9 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 1.5 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 1.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.7 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.3 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 1.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 3.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 2.4 GO:0001540 amyloid-beta binding(GO:0001540)
0.0 0.1 GO:0004825 methionine-tRNA ligase activity(GO:0004825)
0.0 6.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 10.1 GO:0008017 microtubule binding(GO:0008017)
0.0 1.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 2.9 GO:0019210 kinase inhibitor activity(GO:0019210)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 3.4 GO:0004540 ribonuclease activity(GO:0004540)
0.0 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.6 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.5 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 1.2 GO:0004601 peroxidase activity(GO:0004601)
0.0 6.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 11.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.4 GO:0005178 integrin binding(GO:0005178)
0.0 4.3 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.7 GO:0031593 polyubiquitin modification-dependent protein binding(GO:0031593)
0.0 0.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 21.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 3.0 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 6.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 1.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 6.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.1 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 8.3 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.5 PID_ATM_PATHWAY ATM pathway
0.1 1.7 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 2.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.0 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 2.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.9 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 28.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 3.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 6.0 REACTOME_KINESINS Genes involved in Kinesins
0.2 2.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 13.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.1 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.1 1.0 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 1.5 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 3.0 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.9 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 3.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 7.0 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 4.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.8 REACTOME_TRANSLATION Genes involved in Translation
0.0 1.4 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.2 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation