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GSE58827: Dynamics of the Mouse Liver

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Results for Nr2f6

Z-value: 1.05

Motif logo

Transcription factors associated with Nr2f6

Gene Symbol Gene ID Gene Info
ENSMUSG00000002393.8 nuclear receptor subfamily 2, group F, member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr2f6mm10_v2_chr8_-_71381907_71381977-0.634.4e-05Click!

Activity profile of Nr2f6 motif

Sorted Z-values of Nr2f6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_33794008 9.17 ENSMUST00000115044.1
mucin 13, epithelial transmembrane
chr16_+_33794345 9.16 ENSMUST00000023520.6
mucin 13, epithelial transmembrane
chr10_-_79788924 9.09 ENSMUST00000020573.6
protease, serine 57
chr5_+_76840597 7.85 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
RIKEN cDNA C530008M17 gene
chr2_+_155611175 7.07 ENSMUST00000092995.5
myosin, heavy chain 7B, cardiac muscle, beta
chr19_+_10001669 6.70 ENSMUST00000121418.1
RAB3A interacting protein (rabin3)-like 1
chr11_+_32283511 6.40 ENSMUST00000093209.3
hemoglobin alpha, adult chain 1
chr5_-_137741601 5.36 ENSMUST00000119498.1
ENSMUST00000061789.7
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chr11_-_33513736 5.09 ENSMUST00000102815.3
RAN binding protein 17
chr11_+_116198853 4.82 ENSMUST00000021130.6
TEN1 telomerase capping complex subunit
chr19_+_47228804 4.51 ENSMUST00000111807.3
neuralized homolog 1A (Drosophila)
chr11_+_58379036 4.45 ENSMUST00000013787.4
ENSMUST00000108826.2
LY6/PLAUR domain containing 8
chr1_+_135799833 4.16 ENSMUST00000148201.1
troponin I, skeletal, slow 1
chr2_+_24336846 3.84 ENSMUST00000114487.2
interleukin 1 receptor antagonist
chr3_-_89418287 3.61 ENSMUST00000029679.3
CDC28 protein kinase 1b
chr1_+_172499948 3.56 ENSMUST00000111230.1
transgelin 2
chr7_+_98494222 3.52 ENSMUST00000165205.1
leucine rich repeat containing 32
chr9_+_110344185 3.46 ENSMUST00000142100.1
SREBF chaperone
chr2_-_164743182 3.41 ENSMUST00000103096.3
WAP four-disulfide core domain 3
chr18_+_21072329 3.40 ENSMUST00000082235.4
meprin 1 beta
chr4_+_140906344 3.40 ENSMUST00000030765.6
peptidyl arginine deiminase, type II
chr11_-_33513626 3.31 ENSMUST00000037522.7
RAN binding protein 17
chr2_+_164805082 3.28 ENSMUST00000052107.4
zinc finger SWIM-type containing 3
chr7_+_43427622 3.20 ENSMUST00000177164.2
lens intrinsic membrane protein 2
chr1_+_91145103 3.16 ENSMUST00000094698.1
RNA binding motif protein 44
chr13_+_112288451 3.08 ENSMUST00000022275.6
ENSMUST00000056047.7
ENSMUST00000165593.1
ankyrin repeat domain 55
chr2_+_25242929 3.04 ENSMUST00000114355.1
ENSMUST00000060818.1
ring finger protein 208
chr1_+_63176818 2.94 ENSMUST00000129339.1
eukaryotic translation elongation factor 1 beta 2
chrX_+_101449078 2.94 ENSMUST00000033674.5
integrin beta 1 binding protein 2
chr17_+_47672720 2.89 ENSMUST00000152724.1
ubiquitin specific peptidase 49
chr1_+_74409376 2.87 ENSMUST00000027366.6
villin 1
chr8_+_117095854 2.77 ENSMUST00000034308.8
ENSMUST00000167370.1
ENSMUST00000176860.1
beta-carotene 15,15'-monooxygenase
chr10_-_93589621 2.69 ENSMUST00000020203.6
small nuclear ribonucleoprotein polypeptide F
chr8_+_71469186 2.68 ENSMUST00000124745.1
ENSMUST00000138892.1
ENSMUST00000147642.1
DET1 and DDB1 associated 1
chr13_-_24761861 2.59 ENSMUST00000006898.3
ENSMUST00000110382.2
geminin
chr13_-_59769751 2.49 ENSMUST00000057115.6
iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
chr13_+_112288516 2.47 ENSMUST00000168684.1
ankyrin repeat domain 55
chr18_-_70472429 2.43 ENSMUST00000067556.3
RIKEN cDNA 4930503L19 gene
chr2_+_25242227 2.34 ENSMUST00000154498.1
ring finger protein 208
chr2_+_91082362 2.33 ENSMUST00000169852.1
spleen focus forming virus (SFFV) proviral integration oncogene
chr5_+_114003833 2.27 ENSMUST00000086599.4
D-amino acid oxidase
chr10_-_35711891 2.25 ENSMUST00000080898.2
S-adenosylmethionine decarboxylase 2
chr5_+_114004781 2.19 ENSMUST00000161610.1
D-amino acid oxidase
chr15_-_95528702 2.16 ENSMUST00000166170.1
NEL-like 2
chr2_+_75832168 2.15 ENSMUST00000047232.7
ENSMUST00000111952.2
alkylglycerone phosphate synthase
chr19_-_10001625 2.15 ENSMUST00000117346.1
bestrophin 1
chr1_-_120270253 2.12 ENSMUST00000112639.1
STEAP family member 3
chr5_+_31698050 2.02 ENSMUST00000114507.3
ENSMUST00000063813.4
ENSMUST00000071531.5
ENSMUST00000131995.1
brain and reproductive organ-expressed protein
chr6_+_125145235 1.94 ENSMUST00000119527.1
ENSMUST00000088276.6
ENSMUST00000051171.7
ENSMUST00000117675.1
intermediate filament family orphan 1
chr14_-_70176787 1.93 ENSMUST00000153735.1
PDZ and LIM domain 2
chr7_-_19950729 1.92 ENSMUST00000043440.6
immunoglobulin superfamily, member 23
chr5_+_31697960 1.90 ENSMUST00000114515.2
brain and reproductive organ-expressed protein
chr10_-_13324160 1.85 ENSMUST00000105545.4
phosphatase and actin regulator 2
chr2_-_119229885 1.85 ENSMUST00000076084.5
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr11_+_4986824 1.81 ENSMUST00000009234.9
ENSMUST00000109897.1
adaptor protein complex AP-1, beta 1 subunit
chr2_+_158028687 1.79 ENSMUST00000109518.1
ENSMUST00000029180.7
regulation of nuclear pre-mRNA domain containing 1B
chr11_+_101442298 1.79 ENSMUST00000077856.6
ribosomal protein L27
chr1_+_171388954 1.76 ENSMUST00000056449.8
Rho GTPase activating protein 30
chr10_-_80102653 1.71 ENSMUST00000042771.7
strawberry notch homolog 2 (Drosophila)
chr4_+_132564051 1.71 ENSMUST00000070690.7
platelet-activating factor receptor
chr2_-_158028423 1.67 ENSMUST00000029179.4
TELO2 interacting protein 1
chr5_+_31697665 1.66 ENSMUST00000080598.7
brain and reproductive organ-expressed protein
chr17_+_48264270 1.66 ENSMUST00000059873.7
ENSMUST00000154335.1
ENSMUST00000136272.1
ENSMUST00000125426.1
ENSMUST00000153420.1
triggering receptor expressed on myeloid cells-like 4
chr6_+_85431970 1.61 ENSMUST00000045693.7
SET and MYND domain containing 5
chr11_+_101442440 1.60 ENSMUST00000107249.1
ribosomal protein L27
chr12_-_55080098 1.59 ENSMUST00000021406.5
RIKEN cDNA 2700097O09 gene
chr1_+_74506044 1.58 ENSMUST00000087215.5
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr5_+_117120120 1.55 ENSMUST00000111978.1
TAO kinase 3
chr6_+_6248659 1.51 ENSMUST00000181633.1
ENSMUST00000176283.1
ENSMUST00000175814.1
ENSMUST00000181192.1
predicted gene 20619
chr1_-_120271074 1.50 ENSMUST00000112641.1
STEAP family member 3
chr7_-_28598140 1.47 ENSMUST00000040531.8
ENSMUST00000108283.1
sterile alpha motif domain containing 4B
p21 protein (Cdc42/Rac)-activated kinase 4
chr10_+_93589413 1.46 ENSMUST00000181835.1
RIKEN cDNA 4933408J17 gene
chr5_+_135187251 1.44 ENSMUST00000002825.5
bromodomain adjacent to zinc finger domain, 1B
chr4_-_137048695 1.42 ENSMUST00000049583.7
zinc finger and BTB domain containing 40
chr10_-_22731918 1.42 ENSMUST00000095794.3
TATA box binding protein-like 1
chr17_+_49615104 1.41 ENSMUST00000162854.1
kinesin family member 6
chr7_-_98119482 1.40 ENSMUST00000138627.1
ENSMUST00000107127.1
ENSMUST00000107128.1
myosin VIIA
chr2_+_158028481 1.39 ENSMUST00000103123.3
regulation of nuclear pre-mRNA domain containing 1B
chr2_-_119229849 1.39 ENSMUST00000110820.2
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr4_+_129461581 1.38 ENSMUST00000048162.8
ENSMUST00000138013.1
BSD domain containing 1
chr3_+_4211716 1.35 ENSMUST00000170943.1
predicted gene 8775
chr19_+_45998131 1.34 ENSMUST00000181820.1
RIKEN cDNA 4930505N22 gene
chr10_-_13324250 1.32 ENSMUST00000105543.1
phosphatase and actin regulator 2
chr1_+_136683375 1.30 ENSMUST00000181524.1
predicted gene, 19705
chr18_+_70472660 1.29 ENSMUST00000174118.1
StAR-related lipid transfer (START) domain containing 6
chr8_+_11713259 1.28 ENSMUST00000134409.1
RIKEN cDNA 1700128E19 gene
chr9_+_118506226 1.28 ENSMUST00000084820.4
golgi autoantigen, golgin subfamily a, 4
chr7_-_19715395 1.25 ENSMUST00000032555.9
ENSMUST00000093552.5
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr5_-_31697598 1.23 ENSMUST00000031018.7
ribokinase
chr2_-_59160644 1.17 ENSMUST00000077687.5
coiled-coil domain containing 148
chr2_-_32775330 1.14 ENSMUST00000161089.1
ENSMUST00000066478.2
ENSMUST00000161950.1
tetratricopeptide repeat domain 16
chr2_+_158794807 1.14 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr10_-_119240006 1.12 ENSMUST00000020315.6
cullin associated and neddylation disassociated 1
chr3_-_95133989 1.11 ENSMUST00000172572.2
ENSMUST00000173462.2
sodium channel modifier 1
chr9_+_108460518 1.08 ENSMUST00000061209.5
coiled-coil domain containing 71
chr2_+_158028733 1.07 ENSMUST00000152452.1
regulation of nuclear pre-mRNA domain containing 1B
chr4_+_110397661 1.02 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
ATP/GTP binding protein-like 4
chr4_+_110397764 1.01 ENSMUST00000097920.2
ENSMUST00000080744.6
ATP/GTP binding protein-like 4
chr18_+_70472559 0.99 ENSMUST00000168249.2
StAR-related lipid transfer (START) domain containing 6
chr10_+_128303322 0.96 ENSMUST00000005825.6
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr3_-_8923796 0.93 ENSMUST00000042148.5
mitochondrial ribosomal protein S28
chr11_-_118093702 0.92 ENSMUST00000018719.3
dynein, axonemal, heavy chain 17
chr16_+_92612755 0.91 ENSMUST00000180989.1
predicted gene, 26626
chr10_-_14705459 0.90 ENSMUST00000149485.1
ENSMUST00000154132.1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_-_83156393 0.89 ENSMUST00000153148.1
ENSMUST00000125894.1
WD repeat domain 54
chr11_+_115475645 0.87 ENSMUST00000035240.6
armadillo repeat containing 7
chr7_+_45897429 0.85 ENSMUST00000140243.1
transmembrane protein 143
chr18_+_70472406 0.84 ENSMUST00000114959.2
StAR-related lipid transfer (START) domain containing 6
chr11_-_94782500 0.79 ENSMUST00000162809.2
transmembrane protein 92
chr18_+_63708689 0.77 ENSMUST00000072726.5
WD repeat domain 7
chr2_+_180710117 0.76 ENSMUST00000029090.2
GID complex subunit 8 homolog (S. cerevisiae)
chr19_-_45998479 0.76 ENSMUST00000045396.7
RIKEN cDNA 9130011E15 gene
chr19_-_47536997 0.76 ENSMUST00000182808.1
ENSMUST00000049369.9
oligonucleotide/oligosaccharide-binding fold containing 1
chr2_-_32775584 0.71 ENSMUST00000161430.1
tetratricopeptide repeat domain 16
chr6_+_84008540 0.69 ENSMUST00000113821.1
ENSMUST00000113823.1
dysferlin
chr11_-_99244058 0.68 ENSMUST00000103132.3
ENSMUST00000038214.6
keratin 222
chr9_-_109746089 0.66 ENSMUST00000071917.3
F-box and WD-40 domain protein 26
chr10_+_128747850 0.64 ENSMUST00000163377.2
within bgcn homolog (Drosophila)
chr16_-_4624984 0.64 ENSMUST00000014445.6
presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
chr4_-_117682233 0.63 ENSMUST00000102687.3
DNA methyltransferase 1-associated protein 1
chr4_-_130174691 0.63 ENSMUST00000132545.2
ENSMUST00000175992.1
ENSMUST00000105999.2
tubulointerstitial nephritis antigen-like 1
chr18_+_70472621 0.60 ENSMUST00000164223.1
StAR-related lipid transfer (START) domain containing 6
chr11_-_75439489 0.59 ENSMUST00000043696.2
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr2_+_153345809 0.59 ENSMUST00000109790.1
additional sex combs like 1
chr5_+_150018675 0.58 ENSMUST00000065745.3
ENSMUST00000110496.1
relaxin/insulin-like family peptide receptor 2
chr13_-_55571118 0.58 ENSMUST00000021957.6
family with sequence similarity 193, member B
chr11_-_97352016 0.58 ENSMUST00000093942.4
G protein-coupled receptor 179
chr11_-_75439551 0.57 ENSMUST00000128330.1
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr11_-_83592981 0.55 ENSMUST00000019071.3
chemokine (C-C motif) ligand 6
chr9_+_108392820 0.55 ENSMUST00000035234.4
RIKEN cDNA 1700102P08 gene
chr9_-_44767792 0.51 ENSMUST00000034607.9
archain 1
chr11_-_94782703 0.51 ENSMUST00000100554.1
transmembrane protein 92
chr15_-_81871883 0.51 ENSMUST00000023117.8
PHD finger protein 5A
chr14_+_57798182 0.49 ENSMUST00000111269.1
Sin3-associated polypeptide 18
chrX_-_148615153 0.49 ENSMUST00000112755.2
predicted gene 8334
chr5_+_134176358 0.49 ENSMUST00000180674.1
RIKEN cDNA B230377A18 gene
chr6_-_116716888 0.47 ENSMUST00000056623.6
transmembrane protein 72
chr7_-_89941196 0.46 ENSMUST00000117354.1
lethal, Chr 7, Rinchik 6
chr9_+_21002737 0.43 ENSMUST00000003386.5
mitochondrial ribosomal protein L4
chr12_-_57197311 0.41 ENSMUST00000044634.5
solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
chr3_+_95134088 0.41 ENSMUST00000066386.5
LysM, putative peptidoglycan-binding, domain containing 1
chr4_+_85205120 0.40 ENSMUST00000107188.3
SH3-domain GRB2-like 2
chr14_+_57798620 0.39 ENSMUST00000111268.1
Sin3-associated polypeptide 18
chr9_+_104547267 0.36 ENSMUST00000098443.2
copine IV
chr7_-_89941084 0.36 ENSMUST00000075010.4
ENSMUST00000153470.1
lethal, Chr 7, Rinchik 6
chr2_+_71719417 0.36 ENSMUST00000079720.5
predicted gene 1631
chr2_-_180709985 0.34 ENSMUST00000103057.1
ENSMUST00000103055.1
death inducer-obliterator 1
chr7_+_31059342 0.33 ENSMUST00000039775.7
leucine-rich repeat LGI family, member 4
chr12_+_74288735 0.32 ENSMUST00000095617.1
RIKEN cDNA 1700086L19 gene
chr8_+_66511732 0.29 ENSMUST00000002025.3
transketolase-like 2
chr16_+_44139821 0.27 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr7_+_141078188 0.26 ENSMUST00000106039.2
plakophilin 3
chr15_+_86214431 0.26 ENSMUST00000063414.8
TBC1 domain family, member 22a
chr13_-_73328442 0.24 ENSMUST00000022097.5
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr17_-_34850162 0.24 ENSMUST00000046022.9
superkiller viralicidic activity 2-like (S. cerevisiae)
chr1_-_74284636 0.18 ENSMUST00000178235.1
ENSMUST00000006462.7
angio-associated migratory protein
chr6_+_84008915 0.17 ENSMUST00000168387.1
dysferlin
chr12_-_104751900 0.17 ENSMUST00000041987.6
dicer 1, ribonuclease type III
chr17_-_35132050 0.13 ENSMUST00000025249.6
apolipoprotein M
chr5_-_31202215 0.12 ENSMUST00000176245.1
ENSMUST00000177310.1
ENSMUST00000114590.1
zinc finger protein 513
chr17_-_23586214 0.11 ENSMUST00000115516.3
zinc finger protein 13
chr2_-_164200076 0.11 ENSMUST00000063251.2
WAP four-disulfide core domain 15A
chr12_-_93929102 0.08 ENSMUST00000180321.1
predicted gene 9726
chr2_-_26237368 0.08 ENSMUST00000036187.8
quiescin Q6 sulfhydryl oxidase 2
chr14_+_57798156 0.07 ENSMUST00000128764.1
Sin3-associated polypeptide 18
chr11_-_84870812 0.07 ENSMUST00000168434.1
gametogenetin binding protein 2
chr17_+_30954679 0.06 ENSMUST00000066981.5
ENSMUST00000066554.6
ENSMUST00000114555.1
uromodulin-like 1
chr14_+_57798637 0.06 ENSMUST00000111267.1
Sin3-associated polypeptide 18
chrX_+_6415736 0.05 ENSMUST00000143641.3
shroom family member 4
chr15_+_89532816 0.05 ENSMUST00000167173.1
SH3/ankyrin domain gene 3
chr4_-_118409219 0.03 ENSMUST00000075406.5
seizure threshold 2
chr6_+_114403666 0.02 ENSMUST00000161650.1
histamine receptor H1
chr6_-_137649211 0.01 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
epidermal growth factor receptor pathway substrate 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2f6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0036088 D-serine catabolic process(GO:0036088) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
1.1 18.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.8 3.4 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.8 3.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.8 2.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.7 3.6 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
0.7 2.9 GO:1902896 terminal web assembly(GO:1902896)
0.6 2.9 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.5 2.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.5 4.6 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.4 2.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.4 1.7 GO:1904306 regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.4 4.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.4 2.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.4 1.4 GO:0046075 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.3 1.7 GO:0071105 response to interleukin-11(GO:0071105)
0.3 2.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 1.2 GO:0006014 D-ribose metabolic process(GO:0006014)
0.3 1.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 3.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 6.4 GO:0035634 response to stilbenoid(GO:0035634)
0.2 4.2 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 4.8 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.2 0.5 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.9 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.6 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 1.2 GO:0010757 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) negative regulation of plasminogen activation(GO:0010757)
0.1 3.5 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.4 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.1 0.1 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.1 2.1 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 8.4 GO:0006611 protein export from nucleus(GO:0006611)
0.1 2.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 1.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 5.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 2.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 3.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 1.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 3.4 GO:1901998 toxin transport(GO:1901998)
0.1 1.1 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 2.9 GO:0006414 translational elongation(GO:0006414)
0.1 4.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.1 2.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0032290 peripheral nervous system myelin formation(GO:0032290) regulation of enamel mineralization(GO:0070173)
0.0 0.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 3.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 5.4 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0010726 positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.0 1.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.2 GO:0043928 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.0 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.6 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)
0.0 3.2 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.0 2.7 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032434)
0.0 0.9 GO:0003341 cilium movement(GO:0003341)
0.0 0.3 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
1.3 6.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.5 2.7 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.5 7.1 GO:0097512 cardiac myofibril(GO:0097512)
0.5 2.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.5 4.8 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.3 4.2 GO:0005861 troponin complex(GO:0005861)
0.3 1.0 GO:0031251 PAN complex(GO:0031251)
0.2 0.2 GO:0055087 Ski complex(GO:0055087)
0.2 1.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.2 1.4 GO:0002139 stereocilia coupling link(GO:0002139)
0.2 3.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 1.7 GO:0031931 TORC1 complex(GO:0031931)
0.1 2.9 GO:0032433 filopodium tip(GO:0032433)
0.1 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.0 GO:0061574 ASAP complex(GO:0061574)
0.1 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 4.5 GO:0097440 apical dendrite(GO:0097440)
0.1 3.6 GO:0005771 multivesicular body(GO:0005771)
0.1 8.4 GO:0005643 nuclear pore(GO:0005643)
0.1 1.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 0.9 GO:0016342 catenin complex(GO:0016342)
0.1 0.9 GO:0036157 outer dynein arm(GO:0036157)
0.1 3.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 3.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.3 GO:0005914 spot adherens junction(GO:0005914)
0.0 1.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 3.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 13.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.6 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 0.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 4.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 4.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.9 GO:0030018 Z disc(GO:0030018)
0.0 0.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0070578 RISC-loading complex(GO:0070578)
0.0 2.0 GO:0005814 centriole(GO:0005814)
0.0 1.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.8 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 2.2 GO:0043204 perikaryon(GO:0043204)
0.0 1.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.4 GO:0031720 haptoglobin binding(GO:0031720)
1.3 3.8 GO:0045353 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
1.1 4.5 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.9 3.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.8 8.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.7 3.4 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.5 3.6 GO:0052851 ferric-chelate reductase activity(GO:0000293) cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.4 2.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.3 1.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.3 2.3 GO:0019808 polyamine binding(GO:0019808)
0.2 1.2 GO:0015288 porin activity(GO:0015288)
0.1 3.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 6.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 4.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 2.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 4.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 6.0 GO:0045182 translation regulator activity(GO:0045182)
0.1 1.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 5.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.9 GO:0051525 NFAT protein binding(GO:0051525)
0.1 2.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 2.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 11.4 GO:0008201 heparin binding(GO:0008201)
0.1 9.4 GO:0003774 motor activity(GO:0003774)
0.1 1.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 4.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.2 GO:0070883 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) pre-miRNA binding(GO:0070883)
0.0 2.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 2.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 2.2 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 1.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.4 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 18.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 3.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 3.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 18.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 2.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 2.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 5.9 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 3.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 4.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.6 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 6.3 REACTOME TRANSLATION Genes involved in Translation
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 3.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives