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GSE58827: Dynamics of the Mouse Liver

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Results for Pax6

Z-value: 0.40

Motif logo

Transcription factors associated with Pax6

Gene Symbol Gene ID Gene Info
ENSMUSG00000027168.15 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105668935_105668950-0.077.0e-01Click!

Activity profile of Pax6 motif

Sorted Z-values of Pax6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_26061495 4.89 ENSMUST00000005669.7
cytochrome P450, family 2, subfamily b, polypeptide 13
chr14_-_43819639 1.00 ENSMUST00000100691.3
eosinophil-associated, ribonuclease A family, member 1
chr1_+_131638306 0.66 ENSMUST00000073350.6
cathepsin E
chr17_+_25366550 0.62 ENSMUST00000069616.7
tryptase beta 2
chr13_-_23914998 0.62 ENSMUST00000021769.8
ENSMUST00000110407.2
solute carrier family 17 (sodium phosphate), member 4
chr7_-_101869012 0.60 ENSMUST00000123321.1
folate receptor 1 (adult)
chr6_-_60829826 0.42 ENSMUST00000163779.1
synuclein, alpha
chr7_-_101868667 0.42 ENSMUST00000150184.1
folate receptor 1 (adult)
chr11_-_67965631 0.41 ENSMUST00000021287.5
ENSMUST00000126766.1
WD repeat domain 16
chr17_-_6827990 0.41 ENSMUST00000181895.1
predicted gene 2885
chr11_+_104550663 0.36 ENSMUST00000018800.2
myosin, light polypeptide 4
chr7_+_5051515 0.36 ENSMUST00000069324.5
zinc finger protein 580
chr10_+_26229707 0.35 ENSMUST00000060716.5
ENSMUST00000164660.1
sterile alpha motif domain containing 3
chr7_-_103843154 0.35 ENSMUST00000063957.4
hemoglobin Z, beta-like embryonic chain
chr17_+_43568096 0.33 ENSMUST00000167214.1
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr4_-_34050077 0.33 ENSMUST00000029927.5
sperm acrosome associated 1
chr17_+_43016536 0.32 ENSMUST00000024708.4
tumor necrosis factor receptor superfamily, member 21
chr3_-_89245159 0.30 ENSMUST00000090924.6
tripartite motif-containing 46
chr3_-_98753465 0.30 ENSMUST00000094050.4
ENSMUST00000090743.6
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
chr5_+_112255813 0.29 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
crystallin, beta B1
chr15_-_78495059 0.28 ENSMUST00000089398.1
interleukin 2 receptor, beta chain
chr5_+_90903864 0.28 ENSMUST00000075433.6
chemokine (C-X-C motif) ligand 2
chr2_+_163602331 0.28 ENSMUST00000152135.1
tocopherol (alpha) transfer protein-like
chr15_+_6299781 0.28 ENSMUST00000078019.6
disabled 2, mitogen-responsive phosphoprotein
chr8_-_24948771 0.26 ENSMUST00000119720.1
ENSMUST00000121438.2
a disintegrin and metallopeptidase domain 32
chr5_-_142906702 0.26 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
actin, beta
chr8_+_105860634 0.26 ENSMUST00000008594.7
nuclear transport factor 2
chr7_+_30422389 0.25 ENSMUST00000108175.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr15_+_6299797 0.24 ENSMUST00000159046.1
ENSMUST00000161040.1
disabled 2, mitogen-responsive phosphoprotein
chr11_+_73090554 0.23 ENSMUST00000102537.3
ENSMUST00000006101.3
integrin alpha E, epithelial-associated
chr11_+_34047115 0.23 ENSMUST00000109329.1
ENSMUST00000169878.2
lymphocyte cytosolic protein 2
chr9_+_15239045 0.23 ENSMUST00000034413.6
V-set and transmembrane domain containing 5
chr11_-_95587691 0.22 ENSMUST00000000122.6
nerve growth factor receptor (TNFR superfamily, member 16)
chr6_-_118780324 0.22 ENSMUST00000112793.3
ENSMUST00000075591.6
ENSMUST00000078320.7
ENSMUST00000112790.2
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr3_-_89245005 0.22 ENSMUST00000107464.1
tripartite motif-containing 46
chr4_-_70410422 0.21 ENSMUST00000144099.1
CDK5 regulatory subunit associated protein 2
chr6_-_145048809 0.21 ENSMUST00000032402.5
branched chain aminotransferase 1, cytosolic
chrX_+_74740927 0.21 ENSMUST00000114117.1
predicted gene 6890
chr7_+_64153835 0.21 ENSMUST00000085222.5
ENSMUST00000107525.1
transient receptor potential cation channel, subfamily M, member 1
chr3_+_31902507 0.20 ENSMUST00000119310.1
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr6_+_123229843 0.20 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
C-type lectin domain family 4, member n
chr13_-_113618549 0.19 ENSMUST00000109241.3
sorting nexin 18
chr19_+_34290653 0.18 ENSMUST00000025691.5
ENSMUST00000112472.2
Fas (TNF receptor superfamily member 6)
chr7_-_44548733 0.18 ENSMUST00000145956.1
ENSMUST00000049343.8
polymerase (DNA directed), delta 1, catalytic subunit
chr9_+_92250039 0.17 ENSMUST00000093801.3
phospholipid scramblase 1
chr15_+_84669565 0.15 ENSMUST00000171460.1
proline rich 5 (renal)
chr8_-_57962564 0.15 ENSMUST00000098757.3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr7_+_12897800 0.14 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
zinc finger and SCAN domain containing 22
chr10_-_127030813 0.14 ENSMUST00000040560.4
Ts translation elongation factor, mitochondrial
chr6_-_122856151 0.14 ENSMUST00000042081.8
complement component 3a receptor 1
chr14_+_34170640 0.14 ENSMUST00000104925.3
ribosomal protein L23A, pseudogene 3
chr2_-_162661075 0.14 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
protein tyrosine phosphatase, receptor type, T
chr13_-_97760588 0.12 ENSMUST00000074072.3
predicted gene 10260
chr7_+_51511005 0.11 ENSMUST00000043944.5
anoctamin 5
chr5_+_123907175 0.11 ENSMUST00000023869.8
density-regulated protein
chr2_-_75981967 0.10 ENSMUST00000099994.3
tetratricopeptide repeat domain 30A1
chr7_+_64153916 0.10 ENSMUST00000107527.2
transient receptor potential cation channel, subfamily M, member 1
chr10_-_127189981 0.10 ENSMUST00000019611.7
Rho guanine nucleotide exchange factor (GEF) 25
chr9_+_21337828 0.10 ENSMUST00000034697.7
solute carrier family 44, member 2
chr8_+_95825353 0.10 ENSMUST00000074053.4
predicted gene 10094
chrX_-_112406779 0.10 ENSMUST00000026601.2
spermidine/spermine N1-acetyl transferase-like 1
chr5_+_149265035 0.09 ENSMUST00000130144.1
ENSMUST00000071130.3
arachidonate 5-lipoxygenase activating protein
chr4_+_155491353 0.09 ENSMUST00000165335.1
ENSMUST00000105616.3
ENSMUST00000030940.7
guanine nucleotide binding protein (G protein), beta 1
chr7_-_80901220 0.09 ENSMUST00000146402.1
ENSMUST00000026816.8
WD repeat domain 73
chr12_-_45074457 0.08 ENSMUST00000053768.6
syntaxin binding protein 6 (amisyn)
chr17_-_51832666 0.08 ENSMUST00000144331.1
special AT-rich sequence binding protein 1
chr13_+_64432479 0.08 ENSMUST00000021939.6
cyclin-dependent kinase 20
chr5_-_38480131 0.07 ENSMUST00000143758.1
ENSMUST00000067886.5
solute carrier family 2 (facilitated glucose transporter), member 9
chr19_+_34583528 0.07 ENSMUST00000102825.3
interferon-induced protein with tetratricopeptide repeats 3
chrX_+_103422010 0.07 ENSMUST00000182089.1
predicted gene, 26992
chr11_+_102268732 0.07 ENSMUST00000036467.4
ankyrin repeat and SOCS box-containing 16
chr10_-_127030789 0.07 ENSMUST00000120547.1
ENSMUST00000152054.1
Ts translation elongation factor, mitochondrial
chr11_+_67966442 0.07 ENSMUST00000021286.4
ENSMUST00000108675.1
syntaxin 8
chr6_-_88045190 0.07 ENSMUST00000113596.1
ENSMUST00000113600.3
RAB7, member RAS oncogene family
chr13_-_53377355 0.07 ENSMUST00000021920.6
serine palmitoyltransferase, long chain base subunit 1
chr15_-_101850778 0.06 ENSMUST00000023790.3
keratin 1
chr18_+_37447641 0.06 ENSMUST00000052387.3
protocadherin beta 14
chr12_+_112976471 0.06 ENSMUST00000165079.1
ENSMUST00000002880.6
BTB (POZ) domain containing 6
chr11_+_78328415 0.05 ENSMUST00000048073.8
phosphatidylinositol glycan anchor biosynthesis, class S
chr11_+_69125896 0.05 ENSMUST00000021268.2
arachidonate lipoxygenase 3
chr11_+_60699718 0.05 ENSMUST00000052346.3
lethal giant larvae homolog 1 (Drosophila)
chr9_-_62811592 0.05 ENSMUST00000034775.8
feminization 1 homolog b (C. elegans)
chr19_+_6400611 0.04 ENSMUST00000113467.1
RAS, guanyl releasing protein 2
chr6_-_124741374 0.04 ENSMUST00000004389.5
gene rich cluster, C10 gene
chr7_-_107625161 0.04 ENSMUST00000060348.2
RIKEN cDNA 5330417H12 gene
chr18_-_34373313 0.04 ENSMUST00000006027.5
receptor accessory protein 5
chr8_+_31150307 0.04 ENSMUST00000098842.2
TELO2 interacting protein 2
chr5_-_134639311 0.04 ENSMUST00000036125.8
eukaryotic translation initiation factor 4H
chr11_+_60699758 0.04 ENSMUST00000108719.3
lethal giant larvae homolog 1 (Drosophila)
chr4_+_85205417 0.04 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
SH3-domain GRB2-like 2
chr4_+_129820702 0.03 ENSMUST00000165853.1
protein tyrosine phosphatase 4a2
chr8_+_54600774 0.03 ENSMUST00000033917.6
spermatogenesis associated 4
chr17_+_34604262 0.03 ENSMUST00000174041.1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr1_-_195131536 0.03 ENSMUST00000075451.6
complement component (3b/4b) receptor 1-like
chr7_+_141228766 0.03 ENSMUST00000106027.2
PHD and ring finger domains 1
chr13_-_66905322 0.03 ENSMUST00000021993.4
ubiquinol-cytochrome c reductase binding protein
chr8_-_80880479 0.02 ENSMUST00000034150.8
growth factor receptor bound protein 2-associated protein 1
chr5_-_18360384 0.02 ENSMUST00000074694.5
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr18_-_32139570 0.02 ENSMUST00000171765.1
protein C
chr16_+_34784917 0.02 ENSMUST00000023538.8
myosin, light polypeptide kinase
chr6_-_113377376 0.02 ENSMUST00000043333.2
transcriptional adaptor 3
chr5_-_86745787 0.02 ENSMUST00000161306.1
transmembrane protease, serine 11e
chr1_+_106938953 0.02 ENSMUST00000112724.2
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
chr9_-_63602464 0.02 ENSMUST00000080527.5
ENSMUST00000042322.4
IQ motif containing H
chrX_+_36795642 0.01 ENSMUST00000016463.3
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chr7_+_97453204 0.01 ENSMUST00000050732.7
ENSMUST00000121987.1
potassium channel tetramerisation domain containing 14
chr1_-_38836090 0.01 ENSMUST00000147695.1
LON peptidase N-terminal domain and ring finger 2
chr9_+_64179289 0.01 ENSMUST00000034965.6
small nuclear RNA activating complex, polypeptide 5
chr8_-_72475212 0.01 ENSMUST00000079510.4
calcium homeostasis endoplasmic reticulum protein
chr1_+_43092588 0.01 ENSMUST00000039080.3
RIKEN cDNA 8430432A02 gene
chr11_-_115612491 0.00 ENSMUST00000106507.2
MIF4G domain containing

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.8 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.4 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)
0.1 1.0 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.1 0.5 GO:0035026 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026)
0.1 0.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 0.3 GO:1904046 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.1 0.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.1 0.2 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.2 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 0.2 GO:2000373 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 0.3 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.1 0.2 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.2 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.7 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.2 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.2 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.2 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.2 GO:0036089 cleavage furrow formation(GO:0036089)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.5 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.1 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0002461 complement receptor mediated signaling pathway(GO:0002430) tolerance induction dependent upon immune response(GO:0002461)
0.0 0.3 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.3 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.1 GO:0061724 lipophagy(GO:0061724) negative regulation of exosomal secretion(GO:1903542)
0.0 0.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.3 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.0 GO:0036343 psychomotor behavior(GO:0036343)
0.0 0.1 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.5 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.3 GO:0035841 new growing cell tip(GO:0035841)
0.1 0.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 1.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.8 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.3 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 1.0 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.3 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0098918 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 0.2 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.0 0.6 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.4 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.2 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.1 GO:0019809 spermidine binding(GO:0019809)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis