Motif ID: Pou3f4

Z-value: 1.494


Transcription factors associated with Pou3f4:

Gene SymbolEntrez IDGene Name
Pou3f4 ENSMUSG00000056854.3 Pou3f4



Activity profile for motif Pou3f4.

activity profile for motif Pou3f4


Sorted Z-values histogram for motif Pou3f4

Sorted Z-values for motif Pou3f4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_79285502 23.252 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr8_+_80494032 17.885 ENSMUST00000063359.6
Gypa
glycophorin A
chr1_-_132390301 15.869 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr6_-_102464667 12.846 ENSMUST00000032159.6
Cntn3
contactin 3
chr15_-_79285470 12.777 ENSMUST00000170955.1
Baiap2l2
BAI1-associated protein 2-like 2
chr11_+_24078111 12.557 ENSMUST00000109516.1
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr6_+_34412334 11.963 ENSMUST00000007449.8
Akr1b7
aldo-keto reductase family 1, member B7
chr8_-_71725696 9.632 ENSMUST00000153800.1
ENSMUST00000146100.1
Fcho1

FCH domain only 1

chr8_-_85365317 9.404 ENSMUST00000034133.7
Mylk3
myosin light chain kinase 3
chr8_-_85365341 9.301 ENSMUST00000121972.1
Mylk3
myosin light chain kinase 3
chr4_+_134510999 7.759 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chr3_+_68869563 7.703 ENSMUST00000054551.2
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr14_-_47411666 7.131 ENSMUST00000111778.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr7_-_143460989 6.685 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr2_+_85136355 6.025 ENSMUST00000057019.7
Aplnr
apelin receptor
chr1_-_89933290 5.720 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr6_+_124830217 5.674 ENSMUST00000131847.1
ENSMUST00000151674.1
Cdca3

cell division cycle associated 3

chr9_+_96259246 5.390 ENSMUST00000179065.1
ENSMUST00000165768.2
Tfdp2

transcription factor Dp 2

chr3_-_14778452 5.276 ENSMUST00000094365.4
Car1
carbonic anhydrase 1
chr15_+_79690869 5.251 ENSMUST00000046463.8
Gtpbp1
GTP binding protein 1
chr9_+_96258697 5.199 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chrX_+_106920618 5.173 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chrX_-_150814265 4.964 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chr2_+_109280738 4.948 ENSMUST00000028527.7
Kif18a
kinesin family member 18A
chr3_-_116253467 4.844 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr13_-_90905321 4.722 ENSMUST00000109541.3
Atp6ap1l
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr6_-_36811361 4.299 ENSMUST00000101534.1
Ptn
pleiotrophin
chr18_+_60774675 4.291 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chr10_-_76110956 4.180 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr18_+_60774510 4.075 ENSMUST00000025511.3
Rps14
ribosomal protein S14
chr8_+_12984246 3.877 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
Mcf2l


mcf.2 transforming sequence-like


chr15_-_9140374 3.757 ENSMUST00000096482.3
ENSMUST00000110585.2
Skp2

S-phase kinase-associated protein 2 (p45)

chr17_+_40115358 3.754 ENSMUST00000061746.7
Gm7148
predicted gene 7148
chr1_-_38898084 3.696 ENSMUST00000027249.6
Chst10
carbohydrate sulfotransferase 10
chr6_-_129913166 3.682 ENSMUST00000169901.2
ENSMUST00000167079.2
ENSMUST00000014683.6
Klra5


killer cell lectin-like receptor, subfamily A, member 5


chr17_-_50094277 3.409 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chr1_-_126830632 3.258 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr16_-_4003750 3.244 ENSMUST00000171658.1
ENSMUST00000171762.1
Slx4

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

chr1_-_44061936 3.190 ENSMUST00000168641.1
Gm8251
predicted gene 8251
chr9_+_124102110 3.183 ENSMUST00000168841.1
ENSMUST00000055918.6
Ccr2

chemokine (C-C motif) receptor 2

chr17_-_24073479 3.145 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr10_-_127189981 3.137 ENSMUST00000019611.7
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr9_+_14784638 2.979 ENSMUST00000034405.4
Mre11a
meiotic recombination 11 homolog A (S. cerevisiae)
chrX_+_96455359 2.950 ENSMUST00000033553.7
Heph
hephaestin
chr9_+_124101944 2.866 ENSMUST00000171719.1
Ccr2
chemokine (C-C motif) receptor 2
chr8_+_83997613 2.837 ENSMUST00000095228.3
Samd1
sterile alpha motif domain containing 1
chr4_+_100776664 2.769 ENSMUST00000030257.8
ENSMUST00000097955.2
Cachd1

cache domain containing 1

chr9_-_96437434 2.653 ENSMUST00000070500.2
BC043934
cDNA sequence BC043934
chr6_+_129350237 2.637 ENSMUST00000065289.4
Clec12a
C-type lectin domain family 12, member a
chr6_+_34354119 2.588 ENSMUST00000038406.6
Akr1b8
aldo-keto reductase family 1, member B8
chr13_+_49544443 2.588 ENSMUST00000177948.1
ENSMUST00000021820.6
Aspn

asporin

chr10_-_19014549 2.580 ENSMUST00000146388.1
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr8_+_93810832 2.579 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr9_+_14784660 2.540 ENSMUST00000115632.3
ENSMUST00000147305.1
Mre11a

meiotic recombination 11 homolog A (S. cerevisiae)

chr4_+_41569775 2.446 ENSMUST00000102963.3
Dnaic1
dynein, axonemal, intermediate chain 1
chrX_-_164258186 2.385 ENSMUST00000112265.2
Bmx
BMX non-receptor tyrosine kinase
chr6_+_34384218 2.303 ENSMUST00000038383.7
ENSMUST00000115051.1
Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr4_-_117891994 2.228 ENSMUST00000030265.3
Dph2
DPH2 homolog (S. cerevisiae)
chr17_-_47016956 2.202 ENSMUST00000165525.1
Gm16494
predicted gene 16494
chr16_-_29946499 2.156 ENSMUST00000181968.1
Gm26569
predicted gene, 26569
chr10_+_7667503 2.151 ENSMUST00000040135.8
Nup43
nucleoporin 43
chr5_-_111761697 2.055 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr3_+_102734496 2.003 ENSMUST00000029451.5
Tspan2
tetraspanin 2
chr5_+_62813823 1.986 ENSMUST00000170704.1
Gm17384
predicted gene, 17384
chr17_+_17316078 1.972 ENSMUST00000105311.3
Gm6712
predicted gene 6712
chr3_-_17230976 1.936 ENSMUST00000177874.1
Gm5283
predicted gene 5283
chr2_+_25180737 1.887 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr3_+_136670076 1.758 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr7_+_113765998 1.640 ENSMUST00000046687.9
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr17_-_58991343 1.614 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr3_+_105973711 1.537 ENSMUST00000000573.2
Ovgp1
oviductal glycoprotein 1
chr11_-_99244058 1.522 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222

keratin 222

chr19_+_55741810 1.491 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr12_-_84194007 1.422 ENSMUST00000110294.1
Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr8_+_10006656 1.417 ENSMUST00000033892.7
Tnfsf13b
tumor necrosis factor (ligand) superfamily, member 13b
chr8_-_65129317 1.409 ENSMUST00000098713.3
BC030870
cDNA sequence BC030870
chr2_+_85979312 1.378 ENSMUST00000170610.1
Olfr1030
olfactory receptor 1030
chr18_+_22345089 1.376 ENSMUST00000120223.1
ENSMUST00000097655.3
Asxl3

additional sex combs like 3 (Drosophila)

chr9_+_113812547 1.352 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr6_-_99028874 1.335 ENSMUST00000154163.2
Foxp1
forkhead box P1
chr7_+_110061702 1.307 ENSMUST00000084727.3
ENSMUST00000169638.2
Zfp143

zinc finger protein 143

chr6_-_145210791 1.281 ENSMUST00000111728.1
ENSMUST00000060797.7
Casc1

cancer susceptibility candidate 1

chr18_+_44104407 1.241 ENSMUST00000081271.5
Spink12
serine peptidase inhibitor, Kazal type 11
chr7_+_92741603 1.202 ENSMUST00000032879.7
Rab30
RAB30, member RAS oncogene family
chr12_-_54695885 1.197 ENSMUST00000067272.8
Eapp
E2F-associated phosphoprotein
chr6_-_56704673 1.188 ENSMUST00000170382.2
Lsm5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr4_+_8690399 1.148 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr4_+_15881255 1.139 ENSMUST00000029876.1
Calb1
calbindin 1
chr4_+_136423524 1.123 ENSMUST00000088677.4
ENSMUST00000121571.1
ENSMUST00000117699.1
Htr1d


5-hydroxytryptamine (serotonin) receptor 1D


chr11_+_62847111 1.119 ENSMUST00000150989.1
ENSMUST00000176577.1
Fbxw10

F-box and WD-40 domain protein 10

chr3_+_68572245 1.076 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr6_-_113719880 1.070 ENSMUST00000064993.5
Ghrl
ghrelin
chr1_-_126830786 1.013 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr4_+_109343029 1.010 ENSMUST00000030281.5
Eps15
epidermal growth factor receptor pathway substrate 15
chr4_+_6365650 0.967 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
Sdcbp




syndecan binding protein




chr15_-_81190720 0.956 ENSMUST00000131235.1
ENSMUST00000134469.1
ENSMUST00000149582.1
Mkl1


MKL (megakaryoblastic leukemia)/myocardin-like 1


chr18_+_37320374 0.954 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chr2_-_72813665 0.951 ENSMUST00000136807.1
ENSMUST00000148327.1
6430710C18Rik

RIKEN cDNA 6430710C18 gene

chr2_-_176319494 0.925 ENSMUST00000108961.3
Gm11009
predicted gene 11009
chr1_+_159737510 0.919 ENSMUST00000111669.3
Tnr
tenascin R
chrX_+_20662898 0.910 ENSMUST00000001989.8
Uba1
ubiquitin-like modifier activating enzyme 1
chr16_+_94425083 0.901 ENSMUST00000141176.1
Ttc3
tetratricopeptide repeat domain 3
chr7_-_126792469 0.892 ENSMUST00000032936.6
Ppp4c
protein phosphatase 4, catalytic subunit
chr1_+_66321708 0.891 ENSMUST00000114013.1
Map2
microtubule-associated protein 2
chrX_+_164162167 0.863 ENSMUST00000131543.1
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr2_+_110721587 0.843 ENSMUST00000111017.2
Muc15
mucin 15
chr9_-_40346290 0.833 ENSMUST00000121357.1
Gramd1b
GRAM domain containing 1B
chr17_-_21908092 0.808 ENSMUST00000106026.2
2210404O09Rik
RIKEN cDNA 2210404O09 gene
chr13_+_93304799 0.772 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr11_+_67171095 0.758 ENSMUST00000018641.7
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr11_+_67171027 0.744 ENSMUST00000170159.1
Myh2
myosin, heavy polypeptide 2, skeletal muscle, adult
chr1_-_133661318 0.741 ENSMUST00000027736.6
ENSMUST00000179598.1
Zc3h11a
Zbed6
zinc finger CCCH type containing 11A
zinc finger, BED domain containing 6
chrX_-_163761323 0.734 ENSMUST00000059320.2
Rnf138rt1
ring finger protein 138, retrogene 1
chr11_+_62847062 0.731 ENSMUST00000036085.4
Fbxw10
F-box and WD-40 domain protein 10
chr16_-_22439570 0.677 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr11_-_74724670 0.658 ENSMUST00000021091.8
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr13_+_104287855 0.651 ENSMUST00000065766.6
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr11_+_102885160 0.645 ENSMUST00000100369.3
Fam187a
family with sequence similarity 187, member A
chr16_+_38562806 0.627 ENSMUST00000171687.1
ENSMUST00000002924.8
Tmem39a

transmembrane protein 39a

chr14_+_53757356 0.618 ENSMUST00000180380.1
Trav13-4-dv7
T cell receptor alpha variable 13-4-DV7
chr18_+_37504264 0.604 ENSMUST00000052179.6
Pcdhb20
protocadherin beta 20
chr15_+_18818895 0.597 ENSMUST00000166873.2
Cdh10
cadherin 10
chr8_-_60954726 0.596 ENSMUST00000110302.1
Clcn3
chloride channel 3
chr15_-_98831498 0.591 ENSMUST00000168846.1
Prkag1
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr3_+_106034661 0.538 ENSMUST00000170669.2
Gm4540
predicted gene 4540
chr8_+_11758329 0.475 ENSMUST00000074856.6
ENSMUST00000098938.2
Arhgef7

Rho guanine nucleotide exchange factor (GEF7)

chr18_+_33794915 0.474 ENSMUST00000179138.1
2410004N09Rik
RIKEN cDNA 2410004N09 gene
chr12_+_5411641 0.466 ENSMUST00000163627.1
2810032G03Rik
RIKEN cDNA 2810032G03 gene
chr19_+_4081565 0.460 ENSMUST00000159593.1
Cabp2
calcium binding protein 2
chr1_-_156718989 0.446 ENSMUST00000122424.1
Fam20b
family with sequence similarity 20, member B
chr1_-_166002591 0.439 ENSMUST00000111429.4
ENSMUST00000176800.1
Pou2f1

POU domain, class 2, transcription factor 1

chr16_+_25801907 0.437 ENSMUST00000040231.6
ENSMUST00000115306.1
ENSMUST00000115304.1
ENSMUST00000115305.1
Trp63



transformation related protein 63



chr2_-_80129458 0.433 ENSMUST00000102653.1
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr10_+_3119841 0.430 ENSMUST00000095874.2
9230019H11Rik
RIKEN cDNA 9230019H11 gene
chr15_-_57265126 0.427 ENSMUST00000137764.1
ENSMUST00000022995.6
Slc22a22

solute carrier family 22 (organic cation transporter), member 22

chr13_-_22102764 0.418 ENSMUST00000075055.2
Vmn1r189
vomeronasal 1 receptor 189
chr12_-_54695829 0.410 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
Eapp



E2F-associated phosphoprotein



chr2_+_176711933 0.408 ENSMUST00000108983.2
Gm14305
predicted gene 14305
chr1_-_179745185 0.402 ENSMUST00000131716.1
Gm1305
predicted gene 1305
chr7_+_24507006 0.383 ENSMUST00000176880.1
Zfp428
zinc finger protein 428
chr8_+_60983437 0.359 ENSMUST00000052189.3
B230317F23Rik
RIKEN cDNA B230317F23 gene
chr16_-_22439719 0.355 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr2_+_28192971 0.351 ENSMUST00000113920.1
Olfm1
olfactomedin 1
chr18_+_36939178 0.347 ENSMUST00000115662.2
Pcdha2
protocadherin alpha 2
chr2_+_28193093 0.317 ENSMUST00000100244.3
Olfm1
olfactomedin 1
chr5_+_137350371 0.313 ENSMUST00000166239.1
ENSMUST00000111054.1
Ephb4

Eph receptor B4

chr2_-_80128834 0.308 ENSMUST00000102654.4
ENSMUST00000102655.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr9_-_26802563 0.256 ENSMUST00000162252.1
Glb1l2
galactosidase, beta 1-like 2
chr7_-_12818837 0.249 ENSMUST00000121215.1
ENSMUST00000108546.1
ENSMUST00000072222.7
Zfp329


zinc finger protein 329


chr10_-_28986280 0.234 ENSMUST00000152363.1
ENSMUST00000015663.6
2310057J18Rik

RIKEN cDNA 2310057J18 gene

chr4_+_154964117 0.222 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr11_-_69795930 0.205 ENSMUST00000045971.8
Chrnb1
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chr5_-_137786681 0.197 ENSMUST00000132726.1
Mepce
methylphosphate capping enzyme
chr11_+_71749914 0.177 ENSMUST00000150531.1
Wscd1
WSC domain containing 1
chr2_+_177004553 0.153 ENSMUST00000126358.1
Gm14419
predicted gene 14419
chr4_+_52607204 0.139 ENSMUST00000107671.1
4930547C10Rik
RIKEN cDNA 4930547C10 gene
chr19_+_55741884 0.130 ENSMUST00000111658.3
ENSMUST00000111654.1
Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chrX_-_88115632 0.119 ENSMUST00000113966.1
ENSMUST00000113964.1
Il1rapl1

interleukin 1 receptor accessory protein-like 1

chr11_+_73350839 0.108 ENSMUST00000120137.1
Olfr20
olfactory receptor 20
chr9_-_58202281 0.102 ENSMUST00000163897.1
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr9_+_49055574 0.094 ENSMUST00000034803.8
Zw10
zw10 kinetochore protein
chr10_-_39122277 0.081 ENSMUST00000136546.1
Fam229b
family with sequence similarity 229, member B
chr2_+_173737492 0.076 ENSMUST00000067530.4
Vapb
vesicle-associated membrane protein, associated protein B and C
chr2_-_175133322 0.071 ENSMUST00000099029.3
Gm14399
predicted gene 14399
chr2_-_175327598 0.053 ENSMUST00000109050.2
Gm4631
predicted gene 4631
chr5_-_137786651 0.040 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr1_-_144567667 0.029 ENSMUST00000184008.1
Rgs21
regulator of G-protein signalling 21
chr1_-_156718894 0.007 ENSMUST00000086153.6
Fam20b
family with sequence similarity 20, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.6 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
3.1 18.7 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
2.2 17.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
2.0 6.0 GO:1902567 immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
1.6 36.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
1.5 6.0 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
1.2 4.8 GO:0061743 motor learning(GO:0061743)
1.1 5.5 GO:0031860 telomeric 3' overhang formation(GO:0031860)
1.1 3.2 GO:1904431 positive regulation of t-circle formation(GO:1904431)
1.1 4.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.9 2.6 GO:0006714 sesquiterpenoid metabolic process(GO:0006714)
0.9 2.6 GO:0070429 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.8 6.7 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.7 5.7 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.6 5.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.6 1.8 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.6 3.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.6 2.2 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.5 2.6 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.4 1.5 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.4 8.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 1.1 GO:1905564 positive regulation of cortisol secretion(GO:0051464) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306) positive regulation of vascular endothelial cell proliferation(GO:1905564)
0.4 1.4 GO:0031296 B cell costimulation(GO:0031296)
0.3 10.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 0.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 3.8 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.3 1.1 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 2.0 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.3 1.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 16.2 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.2 9.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 0.9 GO:0015827 tryptophan transport(GO:0015827)
0.2 0.6 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.2 4.9 GO:0072520 seminiferous tubule development(GO:0072520)
0.2 1.0 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.2 1.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 1.0 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.2 1.6 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.2 1.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 0.7 GO:0051660 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660)
0.2 1.9 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.2 2.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 4.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.1 2.4 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 0.4 GO:0060197 cloacal septation(GO:0060197)
0.1 1.1 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.1 1.3 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 5.3 GO:0046039 GTP metabolic process(GO:0046039)
0.1 1.5 GO:0001778 plasma membrane repair(GO:0001778)
0.1 1.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 5.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.4 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.1 3.7 GO:0007616 long-term memory(GO:0007616)
0.1 2.3 GO:0042572 retinol metabolic process(GO:0042572)
0.1 2.7 GO:0006825 copper ion transport(GO:0006825)
0.1 2.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 0.5 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 0.3 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 7.8 GO:0007051 spindle organization(GO:0007051)
0.0 1.1 GO:0001553 luteinization(GO:0001553)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.3 GO:0048661 positive regulation of smooth muscle cell proliferation(GO:0048661)
0.0 4.7 GO:0051301 cell division(GO:0051301)
0.0 0.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 1.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.1 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.4 GO:0001913 T cell mediated cytotoxicity(GO:0001913)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 36.0 GO:0071439 clathrin complex(GO:0071439)
0.9 5.5 GO:0030870 Mre11 complex(GO:0030870)
0.7 5.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.6 3.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.5 1.5 GO:0030312 external encapsulating structure(GO:0030312)
0.5 1.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 5.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.4 7.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 0.9 GO:0072534 perineuronal net(GO:0072534)
0.3 1.8 GO:0005955 calcineurin complex(GO:0005955)
0.2 1.1 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.2 0.9 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.2 2.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 1.5 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 1.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 1.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 8.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.7 GO:0000235 astral microtubule(GO:0000235)
0.1 10.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 0.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 7.8 GO:0000922 spindle pole(GO:0000922)
0.1 0.5 GO:0000322 storage vacuole(GO:0000322)
0.0 8.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 16.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0042581 specific granule(GO:0042581)
0.0 4.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 8.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.9 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.7 GO:0000346 transcription export complex(GO:0000346)
0.0 4.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 4.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.8 GO:0036157 outer dynein arm(GO:0036157)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 3.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.7 GO:0030016 myofibril(GO:0030016)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 18.7 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.0 6.0 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
1.9 16.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.4 4.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.8 8.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.7 5.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.7 5.3 GO:0004064 arylesterase activity(GO:0004064)
0.6 3.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.6 9.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.4 6.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.4 5.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 1.5 GO:0004568 chitinase activity(GO:0004568)
0.4 2.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.4 1.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.3 4.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.3 2.9 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.3 1.8 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 5.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 2.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 3.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 0.9 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.6 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.1 GO:0005499 vitamin D binding(GO:0005499)
0.1 1.0 GO:0045545 syndecan binding(GO:0045545)
0.1 2.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.9 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 3.1 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.7 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 1.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 36.0 GO:0005543 phospholipid binding(GO:0005543)
0.1 6.7 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.9 GO:0046625 sphingolipid binding(GO:0046625)
0.1 3.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.9 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 2.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 3.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.4 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 4.7 GO:0003774 motor activity(GO:0003774)
0.0 2.6 GO:0005518 collagen binding(GO:0005518)
0.0 16.3 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.6 GO:0016208 AMP binding(GO:0016208)
0.0 2.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 1.0 GO:0031593 polyubiquitin modification-dependent protein binding(GO:0031593)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 5.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.7 GO:0001540 amyloid-beta binding(GO:0001540)
0.0 5.0 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 4.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 2.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.2 7.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 7.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 5.5 PID_BARD1_PATHWAY BARD1 signaling events
0.1 10.6 PID_E2F_PATHWAY E2F transcription factor network
0.1 4.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.6 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 1.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.5 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.8 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 5.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.3 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 2.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.0 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.4 5.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.3 5.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 4.9 REACTOME_KINESINS Genes involved in Kinesins
0.2 8.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.1 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.1 2.9 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 3.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.1 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.6 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 1.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 5.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.0 2.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 3.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 1.0 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 2.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism