Motif ID: Prdm1

Z-value: 1.384


Transcription factors associated with Prdm1:

Gene SymbolEntrez IDGene Name
Prdm1 ENSMUSG00000038151.6 Prdm1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prdm1mm10_v2_chr10_-_44458715_44458751-0.564.1e-04Click!


Activity profile for motif Prdm1.

activity profile for motif Prdm1


Sorted Z-values histogram for motif Prdm1

Sorted Z-values for motif Prdm1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prdm1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_77729091 11.016 ENSMUST00000109775.2
Apol9b
apolipoprotein L 9b
chr8_+_70083509 8.705 ENSMUST00000007738.9
Hapln4
hyaluronan and proteoglycan link protein 4
chr6_-_55175019 7.781 ENSMUST00000003569.5
Inmt
indolethylamine N-methyltransferase
chr11_-_5950018 7.419 ENSMUST00000102920.3
Gck
glucokinase
chr5_+_30921825 7.084 ENSMUST00000117435.1
Khk
ketohexokinase
chr5_+_30921867 6.775 ENSMUST00000123885.1
Khk
ketohexokinase
chr5_+_30921556 6.671 ENSMUST00000031053.8
Khk
ketohexokinase
chr4_-_42756543 6.271 ENSMUST00000102957.3
Ccl19
chemokine (C-C motif) ligand 19
chr1_-_139608282 5.889 ENSMUST00000170441.2
Cfhr3
complement factor H-related 3
chr19_-_11050500 5.391 ENSMUST00000099676.4
AW112010
expressed sequence AW112010
chr4_+_42629719 5.372 ENSMUST00000166898.2
Gm2564
predicted gene 2564
chr16_+_43363855 4.554 ENSMUST00000156367.1
Zbtb20
zinc finger and BTB domain containing 20
chr19_+_44203265 4.333 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr7_-_29248375 4.070 ENSMUST00000032808.4
2200002D01Rik
RIKEN cDNA 2200002D01 gene
chr2_-_126783416 3.928 ENSMUST00000130356.1
ENSMUST00000028842.2
Usp50

ubiquitin specific peptidase 50

chr5_-_105239533 3.773 ENSMUST00000065588.6
Gbp10
guanylate-binding protein 10
chr3_-_113574758 3.726 ENSMUST00000106540.1
Amy1
amylase 1, salivary
chr9_-_106476372 3.567 ENSMUST00000123555.1
ENSMUST00000125850.1
Parp3

poly (ADP-ribose) polymerase family, member 3

chr10_-_109009055 3.530 ENSMUST00000156979.1
Syt1
synaptotagmin I
chr11_+_75468040 3.395 ENSMUST00000043598.7
ENSMUST00000108435.1
Tlcd2

TLC domain containing 2

chr3_+_122895072 3.299 ENSMUST00000023820.5
Fabp2
fatty acid binding protein 2, intestinal
chr9_-_106476590 3.294 ENSMUST00000112479.2
Parp3
poly (ADP-ribose) polymerase family, member 3
chr16_+_43364145 3.291 ENSMUST00000148775.1
Zbtb20
zinc finger and BTB domain containing 20
chr9_-_106476104 3.184 ENSMUST00000156426.1
Parp3
poly (ADP-ribose) polymerase family, member 3
chr14_+_41105359 3.154 ENSMUST00000047286.6
Mat1a
methionine adenosyltransferase I, alpha
chr8_-_84800344 3.116 ENSMUST00000099070.3
Nfix
nuclear factor I/X
chr4_-_96591555 3.025 ENSMUST00000055693.8
Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr11_-_73324616 3.017 ENSMUST00000021119.2
Aspa
aspartoacylase
chr8_-_84800024 3.014 ENSMUST00000126806.1
ENSMUST00000076715.6
Nfix

nuclear factor I/X

chr16_-_24393588 2.989 ENSMUST00000181640.1
1110054M08Rik
RIKEN cDNA 1110054M08 gene
chr17_+_37193889 2.978 ENSMUST00000038844.6
Ubd
ubiquitin D
chr4_-_108071327 2.952 ENSMUST00000106701.1
Scp2
sterol carrier protein 2, liver
chr15_-_89379246 2.928 ENSMUST00000049968.7
Odf3b
outer dense fiber of sperm tails 3B
chr5_+_114923234 2.851 ENSMUST00000031540.4
ENSMUST00000112143.3
Oasl1

2'-5' oligoadenylate synthetase-like 1

chr4_-_148152059 2.793 ENSMUST00000056965.5
ENSMUST00000168503.1
ENSMUST00000152098.1
Fbxo6


F-box protein 6


chr15_+_25843264 2.761 ENSMUST00000022881.7
Fam134b
family with sequence similarity 134, member B
chr2_+_43555321 2.745 ENSMUST00000028223.2
Kynu
kynureninase (L-kynurenine hydrolase)
chr10_-_95324072 2.741 ENSMUST00000053594.5
Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
chr10_+_116301374 2.735 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr9_-_107668967 2.696 ENSMUST00000177567.1
Slc38a3
solute carrier family 38, member 3
chr15_+_66891477 2.691 ENSMUST00000118823.1
Wisp1
WNT1 inducible signaling pathway protein 1
chr8_+_94525067 2.690 ENSMUST00000098489.4
Nlrc5
NLR family, CARD domain containing 5
chr10_-_75797528 2.536 ENSMUST00000120177.1
Gstt1
glutathione S-transferase, theta 1
chr3_-_101604580 2.529 ENSMUST00000036493.6
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_-_106759727 2.529 ENSMUST00000010049.4
Kdsr
3-ketodihydrosphingosine reductase
chr2_+_116067213 2.521 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr19_-_11081088 2.495 ENSMUST00000025636.6
Ms4a8a
membrane-spanning 4-domains, subfamily A, member 8A
chr14_-_26066961 2.491 ENSMUST00000100818.5
Tmem254c
transmembrane protein 254c
chr3_-_108044801 2.477 ENSMUST00000178808.1
ENSMUST00000106670.1
ENSMUST00000029489.8
Gstm4


glutathione S-transferase, mu 4


chr15_+_66891320 2.454 ENSMUST00000005255.2
Wisp1
WNT1 inducible signaling pathway protein 1
chr2_+_43555342 2.449 ENSMUST00000112826.1
ENSMUST00000050511.6
Kynu

kynureninase (L-kynurenine hydrolase)

chr19_+_34640871 2.403 ENSMUST00000102824.3
Ifit1
interferon-induced protein with tetratricopeptide repeats 1
chr11_+_103103051 2.388 ENSMUST00000152971.1
Acbd4
acyl-Coenzyme A binding domain containing 4
chr4_+_42255767 2.385 ENSMUST00000178864.1
Ccl21b
chemokine (C-C motif) ligand 21B (leucine)
chr9_-_44802951 2.341 ENSMUST00000044694.6
Ttc36
tetratricopeptide repeat domain 36
chr13_+_33004528 2.321 ENSMUST00000006391.4
Serpinb9
serine (or cysteine) peptidase inhibitor, clade B, member 9
chr13_-_12464925 2.278 ENSMUST00000124888.1
Lgals8
lectin, galactose binding, soluble 8
chr13_+_74639866 2.277 ENSMUST00000169114.1
Erap1
endoplasmic reticulum aminopeptidase 1
chr13_+_23839401 2.243 ENSMUST00000039721.7
ENSMUST00000166467.1
Slc17a3

solute carrier family 17 (sodium phosphate), member 3

chr6_+_117168535 2.224 ENSMUST00000112866.1
ENSMUST00000112871.1
ENSMUST00000073043.4
Cxcl12


chemokine (C-X-C motif) ligand 12


chr14_-_25927250 2.222 ENSMUST00000100811.5
Tmem254a
transmembrane protein 254a
chr7_-_141435327 2.197 ENSMUST00000138865.1
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr11_-_53859187 2.177 ENSMUST00000117316.1
ENSMUST00000120776.1
ENSMUST00000121435.1
Gm12216


predicted gene 12216


chr4_-_42773993 2.176 ENSMUST00000095114.4
Ccl21a
chemokine (C-C motif) ligand 21A (serine)
chr1_-_172590463 2.160 ENSMUST00000065679.6
Slamf8
SLAM family member 8
chr3_+_145758674 2.156 ENSMUST00000029845.8
Ddah1
dimethylarginine dimethylaminohydrolase 1
chr10_-_75797728 2.139 ENSMUST00000139724.1
Gstt1
glutathione S-transferase, theta 1
chr8_+_127064022 2.110 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr2_+_69135799 2.049 ENSMUST00000041865.7
Nostrin
nitric oxide synthase trafficker
chr10_-_78352323 2.033 ENSMUST00000001240.5
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr15_+_32920723 2.030 ENSMUST00000022871.5
Sdc2
syndecan 2
chr10_-_78351711 2.028 ENSMUST00000105390.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr8_+_127064107 1.984 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr14_-_16249154 1.983 ENSMUST00000148121.1
ENSMUST00000112624.1
Oxsm

3-oxoacyl-ACP synthase, mitochondrial

chr11_-_77894096 1.976 ENSMUST00000017597.4
Pipox
pipecolic acid oxidase
chr5_+_92137896 1.963 ENSMUST00000031355.6
Uso1
USO1 vesicle docking factor
chr1_-_184845838 1.941 ENSMUST00000068725.3
Marc2
mitochondrial amidoxime reducing component 2
chr3_+_81932601 1.852 ENSMUST00000029649.2
Ctso
cathepsin O
chr11_+_70459940 1.843 ENSMUST00000147289.1
ENSMUST00000126105.1
Zmynd15

zinc finger, MYND-type containing 15

chr16_+_97536079 1.841 ENSMUST00000024112.7
Mx2
myxovirus (influenza virus) resistance 2
chr9_-_45204083 1.838 ENSMUST00000034599.8
Tmprss4
transmembrane protease, serine 4
chr18_-_12879973 1.836 ENSMUST00000119512.1
Osbpl1a
oxysterol binding protein-like 1A
chr17_-_12916345 1.824 ENSMUST00000079121.3
Mrpl18
mitochondrial ribosomal protein L18
chr17_-_34187219 1.787 ENSMUST00000173831.1
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr15_+_44787746 1.777 ENSMUST00000181839.1
2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr15_+_99392948 1.749 ENSMUST00000161250.1
ENSMUST00000160635.1
ENSMUST00000161778.1
Tmbim6


transmembrane BAX inhibitor motif containing 6


chr8_+_22283441 1.727 ENSMUST00000077194.1
Tpte
transmembrane phosphatase with tensin homology
chr18_+_84851338 1.716 ENSMUST00000160180.1
Cyb5
cytochrome b-5
chr7_-_5413145 1.689 ENSMUST00000108569.2
Vmn1r58
vomeronasal 1 receptor 58
chr9_-_78322357 1.667 ENSMUST00000095071.4
Gm8074
predicted gene 8074
chrX_+_161717055 1.666 ENSMUST00000112338.1
Rai2
retinoic acid induced 2
chr17_+_33919332 1.665 ENSMUST00000025161.7
Tapbp
TAP binding protein
chr1_-_140183283 1.655 ENSMUST00000111977.1
Cfh
complement component factor h
chr10_+_81574699 1.653 ENSMUST00000131794.1
ENSMUST00000136341.1
Tle2

transducin-like enhancer of split 2, homolog of Drosophila E(spl)

chr16_-_35871544 1.650 ENSMUST00000042665.8
Parp14
poly (ADP-ribose) polymerase family, member 14
chr17_+_84956718 1.637 ENSMUST00000112305.3
Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
chr2_-_101621033 1.637 ENSMUST00000090513.4
B230118H07Rik
RIKEN cDNA B230118H07 gene
chr10_-_78352053 1.633 ENSMUST00000105388.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr9_-_98955302 1.618 ENSMUST00000181706.1
Foxl2os
forkhead box L2 opposite strand transcript
chr1_+_153899937 1.596 ENSMUST00000086199.5
Glul
glutamate-ammonia ligase (glutamine synthetase)
chr16_+_24393350 1.582 ENSMUST00000038053.6
Lpp
LIM domain containing preferred translocation partner in lipoma
chr5_+_63649335 1.560 ENSMUST00000159584.1
3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr7_+_30184160 1.556 ENSMUST00000098594.2
Cox7a1
cytochrome c oxidase subunit VIIa 1
chr9_-_106891401 1.547 ENSMUST00000069036.7
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr16_+_11008898 1.544 ENSMUST00000180624.1
Gm4262
predicted gene 4262
chr14_-_45477856 1.524 ENSMUST00000141424.1
Fermt2
fermitin family homolog 2 (Drosophila)
chr2_+_97467657 1.517 ENSMUST00000059049.7
Lrrc4c
leucine rich repeat containing 4C
chr8_-_94434259 1.516 ENSMUST00000180445.1
9330175E14Rik
RIKEN cDNA 9330175E14 gene
chr14_-_101640434 1.506 ENSMUST00000168587.1
Commd6
COMM domain containing 6
chr5_-_93206489 1.484 ENSMUST00000058550.8
Ccni
cyclin I
chr6_+_114648811 1.466 ENSMUST00000182510.1
Atg7
autophagy related 7
chr8_+_88697022 1.454 ENSMUST00000043526.8
Cyld
cylindromatosis (turban tumor syndrome)
chr2_+_76675265 1.448 ENSMUST00000111920.1
Plekha3
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
chr14_+_16249259 1.440 ENSMUST00000022310.6
Ngly1
N-glycanase 1
chr17_-_25785533 1.391 ENSMUST00000140738.1
ENSMUST00000145053.1
ENSMUST00000138759.1
ENSMUST00000133071.1
ENSMUST00000077938.3
Haghl




hydroxyacylglutathione hydrolase-like




chr11_+_120677226 1.386 ENSMUST00000129644.2
ENSMUST00000151160.1
Aspscr1

alveolar soft part sarcoma chromosome region, candidate 1 (human)

chr16_-_30267524 1.382 ENSMUST00000064856.7
Cpn2
carboxypeptidase N, polypeptide 2
chr9_-_106891965 1.375 ENSMUST00000159283.1
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr4_-_84546284 1.370 ENSMUST00000177040.1
Bnc2
basonuclin 2
chr12_+_37241633 1.356 ENSMUST00000049874.7
Agmo
alkylglycerol monooxygenase
chr14_-_101640670 1.349 ENSMUST00000100339.2
Commd6
COMM domain containing 6
chr11_+_49076584 1.339 ENSMUST00000109202.1
Ifi47
interferon gamma inducible protein 47
chr10_+_4710119 1.330 ENSMUST00000105588.1
ENSMUST00000105589.1
Esr1

estrogen receptor 1 (alpha)

chr17_-_35895920 1.325 ENSMUST00000059740.8
2310061I04Rik
RIKEN cDNA 2310061I04 gene
chr10_+_128322443 1.300 ENSMUST00000026446.2
Cnpy2
canopy 2 homolog (zebrafish)
chr8_-_94434142 1.294 ENSMUST00000180612.1
9330175E14Rik
RIKEN cDNA 9330175E14 gene
chr10_-_78351690 1.289 ENSMUST00000166360.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr9_-_29963112 1.280 ENSMUST00000075069.4
Ntm
neurotrimin
chr1_-_184033998 1.268 ENSMUST00000050306.5
1700056E22Rik
RIKEN cDNA 1700056E22 gene
chr3_-_86548268 1.251 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr1_+_139501692 1.247 ENSMUST00000027615.5
F13b
coagulation factor XIII, beta subunit
chr3_-_88425094 1.247 ENSMUST00000168755.1
ENSMUST00000057935.6
Slc25a44

solute carrier family 25, member 44

chr4_-_45489794 1.239 ENSMUST00000146236.1
Shb
src homology 2 domain-containing transforming protein B
chr12_-_72664759 1.239 ENSMUST00000021512.9
Dhrs7
dehydrogenase/reductase (SDR family) member 7
chr4_-_63745055 1.237 ENSMUST00000062246.6
Tnfsf15
tumor necrosis factor (ligand) superfamily, member 15
chr15_-_76243401 1.224 ENSMUST00000165738.1
ENSMUST00000075689.6
Parp10

poly (ADP-ribose) polymerase family, member 10

chr5_-_135962275 1.212 ENSMUST00000054895.3
Srcrb4d
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr2_+_164332740 1.212 ENSMUST00000017148.7
Svs5
seminal vesicle secretory protein 5
chr7_+_131371138 1.201 ENSMUST00000075610.6
Pstk
phosphoseryl-tRNA kinase
chr17_-_32034493 1.195 ENSMUST00000002145.5
Hsf2bp
heat shock transcription factor 2 binding protein
chr3_+_142701067 1.185 ENSMUST00000044392.4
Ccbl2
cysteine conjugate-beta lyase 2
chr8_-_45410539 1.181 ENSMUST00000034056.4
ENSMUST00000167106.1
Tlr3

toll-like receptor 3

chr9_+_38718263 1.174 ENSMUST00000001544.5
ENSMUST00000118144.1
Vwa5a

von Willebrand factor A domain containing 5A

chr3_-_7613427 1.165 ENSMUST00000168269.2
Il7
interleukin 7
chr7_-_27166413 1.162 ENSMUST00000108382.1
Egln2
EGL nine homolog 2 (C. elegans)
chr10_-_78352212 1.120 ENSMUST00000146899.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr3_-_65392579 1.113 ENSMUST00000029414.5
Ssr3
signal sequence receptor, gamma
chr13_-_18031616 1.104 ENSMUST00000099736.2
Vdac3-ps1
voltage-dependent anion channel 3, pseudogene 1
chr4_-_148151646 1.089 ENSMUST00000132083.1
Fbxo6
F-box protein 6
chrX_-_74023908 1.084 ENSMUST00000033769.8
ENSMUST00000114352.1
ENSMUST00000068286.5
ENSMUST00000114360.3
ENSMUST00000114354.3
Irak1




interleukin-1 receptor-associated kinase 1




chr1_-_78196832 1.082 ENSMUST00000004994.9
Pax3
paired box gene 3
chr6_-_39118211 1.068 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr8_-_93363676 1.059 ENSMUST00000145041.1
Ces1h
carboxylesterase 1H
chr4_-_52497244 1.056 ENSMUST00000114578.4
Vma21-ps
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene
chr7_+_100706623 1.049 ENSMUST00000107042.1
Fam168a
family with sequence similarity 168, member A
chr15_-_103340085 1.025 ENSMUST00000168828.1
Zfp385a
zinc finger protein 385A
chr13_-_92483996 1.025 ENSMUST00000040106.7
Fam151b
family with sequence similarity 151, member B
chr4_+_141115660 1.019 ENSMUST00000181450.1
4921514A10Rik
RIKEN cDNA 4921514A10 gene
chr17_+_24895116 1.016 ENSMUST00000043907.7
Mrps34
mitochondrial ribosomal protein S34
chr8_-_129065488 1.014 ENSMUST00000125112.1
ENSMUST00000108747.2
ENSMUST00000095158.4
Ccdc7


coiled-coil domain containing 7


chr3_+_142701044 1.012 ENSMUST00000106218.1
Ccbl2
cysteine conjugate-beta lyase 2
chr18_-_66022580 1.007 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr3_+_106482427 0.993 ENSMUST00000029508.4
Dennd2d
DENN/MADD domain containing 2D
chr2_-_51973219 0.988 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr11_+_72301613 0.980 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
Xaf1


XIAP associated factor 1


chr8_+_46739745 0.965 ENSMUST00000034041.7
Irf2
interferon regulatory factor 2
chr1_-_78197112 0.960 ENSMUST00000087086.6
Pax3
paired box gene 3
chr7_-_45136102 0.958 ENSMUST00000125500.1
Flt3l
FMS-like tyrosine kinase 3 ligand
chr1_+_184034381 0.947 ENSMUST00000048655.7
Dusp10
dual specificity phosphatase 10
chr10_-_75517856 0.938 ENSMUST00000123505.1
ENSMUST00000147269.1
ENSMUST00000118936.1
Gucd1


guanylyl cyclase domain containing 1


chr13_+_30974204 0.931 ENSMUST00000070258.2
Gm5447
predicted gene 5447
chr1_+_181150926 0.919 ENSMUST00000134115.1
ENSMUST00000111059.1
Cnih4

cornichon homolog 4 (Drosophila)

chr4_-_72200833 0.917 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chr12_+_8208107 0.917 ENSMUST00000037383.5
ENSMUST00000169104.1
1110057K04Rik

RIKEN cDNA 1110057K04 gene

chr2_-_90904827 0.915 ENSMUST00000005647.3
Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr10_-_116950366 0.914 ENSMUST00000020375.6
Rab3ip
RAB3A interacting protein
chr3_-_98564038 0.908 ENSMUST00000058728.5
Gm10681
predicted gene 10681
chr14_+_64652524 0.902 ENSMUST00000100473.4
Kif13b
kinesin family member 13B
chr1_+_6730135 0.893 ENSMUST00000155921.1
St18
suppression of tumorigenicity 18
chr14_+_122534305 0.888 ENSMUST00000154206.1
ENSMUST00000038374.6
ENSMUST00000135578.1
Pcca


propionyl-Coenzyme A carboxylase, alpha polypeptide


chr5_+_28165690 0.888 ENSMUST00000036177.7
En2
engrailed 2
chr1_+_132008285 0.880 ENSMUST00000146432.1
Elk4
ELK4, member of ETS oncogene family
chr1_-_67038824 0.864 ENSMUST00000119559.1
ENSMUST00000149996.1
ENSMUST00000027149.5
ENSMUST00000113979.3
Lancl1



LanC (bacterial lantibiotic synthetase component C)-like 1



chr6_+_71373400 0.853 ENSMUST00000066747.7
ENSMUST00000172321.1
Cd8a

CD8 antigen, alpha chain

chr6_-_125231772 0.852 ENSMUST00000043422.7
Tapbpl
TAP binding protein-like
chr5_-_93206428 0.850 ENSMUST00000144514.1
Ccni
cyclin I
chr17_-_66519666 0.850 ENSMUST00000167962.1
ENSMUST00000070538.4
Rab12

RAB12, member RAS oncogene family

chr12_+_37242030 0.838 ENSMUST00000160390.1
Agmo
alkylglycerol monooxygenase
chr4_+_150236816 0.837 ENSMUST00000080926.6
Eno1
enolase 1, alpha non-neuron
chr7_-_45136391 0.837 ENSMUST00000146760.1
Flt3l
FMS-like tyrosine kinase 3 ligand
chr7_-_45136056 0.830 ENSMUST00000130628.1
Flt3l
FMS-like tyrosine kinase 3 ligand
chr6_-_129451906 0.824 ENSMUST00000037481.7
Clec1a
C-type lectin domain family 1, member a
chr1_+_180942500 0.823 ENSMUST00000159436.1
Tmem63a
transmembrane protein 63a
chr6_+_147042755 0.819 ENSMUST00000036111.7
Mrps35
mitochondrial ribosomal protein S35
chr12_+_37241729 0.813 ENSMUST00000160768.1
Agmo
alkylglycerol monooxygenase
chr1_+_6730051 0.797 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18



suppression of tumorigenicity 18



chr1_-_130887408 0.795 ENSMUST00000121040.1
Il24
interleukin 24
chr11_-_70459957 0.793 ENSMUST00000019064.2
Cxcl16
chemokine (C-X-C motif) ligand 16
chr8_-_83332416 0.787 ENSMUST00000177594.1
ENSMUST00000053902.3
Elmod2

ELMO/CED-12 domain containing 2

chr17_-_24895047 0.783 ENSMUST00000119848.1
ENSMUST00000121542.1
Eme2

essential meiotic endonuclease 1 homolog 2 (S. pombe)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 20.5 GO:0006001 fructose catabolic process(GO:0006001) response to sucrose(GO:0009744) response to disaccharide(GO:0034285) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
3.3 10.0 GO:1990166 protein localization to site of double-strand break(GO:1990166)
2.7 8.2 GO:2000547 regulation of dendritic cell dendrite assembly(GO:2000547)
1.7 5.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
1.6 4.7 GO:0018900 dichloromethane metabolic process(GO:0018900)
1.5 7.4 GO:0034287 detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
1.1 4.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
1.0 2.9 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.9 2.7 GO:0006867 asparagine transport(GO:0006867) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) regulation of glutamine transport(GO:2000485)
0.9 0.9 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.8 3.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.7 3.0 GO:1901373 lipid hydroperoxide transport(GO:1901373)
0.7 2.9 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.7 4.1 GO:0003383 apical constriction(GO:0003383)
0.7 2.0 GO:0006553 lysine metabolic process(GO:0006553)
0.6 2.5 GO:1903416 response to glycoside(GO:1903416)
0.6 1.8 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.6 2.3 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.6 1.7 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.6 2.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.5 1.6 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.5 3.0 GO:0006083 acetate metabolic process(GO:0006083)
0.5 2.0 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.5 1.5 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157) nucleus disassembly(GO:1905690)
0.4 3.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.4 1.3 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.4 1.3 GO:0043181 vacuolar sequestering(GO:0043181)
0.4 2.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 1.5 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.3 1.7 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 1.0 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.3 1.0 GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.3 6.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 2.7 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.3 3.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 3.5 GO:0005513 detection of calcium ion(GO:0005513)
0.3 2.5 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.3 0.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.3 2.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.3 1.6 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.3 5.3 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.3 1.3 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.3 2.0 GO:0060594 mammary gland specification(GO:0060594)
0.2 0.7 GO:0000963 mitochondrial RNA processing(GO:0000963) RNA 5'-end processing(GO:0000966)
0.2 1.2 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.2 1.9 GO:0042126 nitrate metabolic process(GO:0042126)
0.2 1.2 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.2 5.1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
0.2 2.2 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.2 3.0 GO:0070842 aggresome assembly(GO:0070842)
0.2 2.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 3.0 GO:0046485 ether lipid metabolic process(GO:0046485)
0.2 1.7 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.2 1.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.2 0.7 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 7.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 11.8 GO:0071346 cellular response to interferon-gamma(GO:0071346)
0.2 0.7 GO:0070268 cornification(GO:0070268)
0.2 0.5 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.2 2.2 GO:0015747 urate transport(GO:0015747)
0.2 1.7 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 0.8 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.2 0.9 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.2 2.0 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 1.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 1.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.4 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.1 1.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 2.5 GO:0046519 sphingoid metabolic process(GO:0046519)
0.1 0.6 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.1 0.5 GO:0009992 cellular water homeostasis(GO:0009992)
0.1 1.2 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194) negative regulation of oogenesis(GO:1905880)
0.1 2.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.9 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.1 0.5 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.1 0.5 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.1 0.4 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.1 0.4 GO:2000864 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721) estradiol secretion(GO:0035938) regulation of estradiol secretion(GO:2000864)
0.1 0.4 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 7.8 GO:0009308 amine metabolic process(GO:0009308)
0.1 3.3 GO:0050892 intestinal absorption(GO:0050892)
0.1 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.3 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.1 0.5 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.3 GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 1.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.6 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 0.4 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 2.6 GO:0035456 response to interferon-beta(GO:0035456)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 0.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.3 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.0 GO:1990403 embryonic brain development(GO:1990403)
0.1 0.8 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.4 GO:0003374 dynamin family protein polymerization involved in membrane fission(GO:0003373) dynamin family protein polymerization involved in mitochondrial fission(GO:0003374)
0.0 1.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.3 GO:0048861 histone H3-K27 acetylation(GO:0043974) leukemia inhibitory factor signaling pathway(GO:0048861) regulation of histone H3-K27 acetylation(GO:1901674)
0.0 1.4 GO:0003416 endochondral bone growth(GO:0003416)
0.0 1.2 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 0.8 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.6 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.9 GO:2000811 negative regulation of anoikis(GO:2000811)
0.0 8.1 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.1 GO:1903969 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.0 0.7 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.9 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.8 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.7 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.6 GO:0045116 protein neddylation(GO:0045116)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 2.0 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.3 GO:0043368 positive T cell selection(GO:0043368)
0.0 2.8 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.0 1.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.8 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 2.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:1900116 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.3 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.1 GO:0042697 menopause(GO:0042697)
0.0 1.7 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 2.0 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 1.5 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0097500 receptor localization to non-motile cilium(GO:0097500)
0.0 0.9 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.0 0.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.5 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 0.7 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 6.9 GO:0001501 skeletal system development(GO:0001501)
0.0 0.7 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0033269 internode region of axon(GO:0033269)
0.5 7.4 GO:0045180 basal cortex(GO:0045180)
0.4 2.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 2.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 3.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 9.9 GO:0090734 site of double-strand break(GO:0035861) site of DNA damage(GO:0090734)
0.2 3.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 3.3 GO:0045179 apical cortex(GO:0045179)
0.2 1.7 GO:0042825 TAP complex(GO:0042825)
0.2 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 3.5 GO:0031045 dense core granule(GO:0031045)
0.2 0.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 0.8 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 2.1 GO:0097542 ciliary tip(GO:0097542)
0.1 0.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 2.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.4 GO:0005840 ribosome(GO:0005840)
0.1 1.3 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.9 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 1.6 GO:0097386 glial cell projection(GO:0097386)
0.1 0.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.5 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.0 1.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.9 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.5 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 0.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 1.5 GO:0031941 filamentous actin(GO:0031941)
0.0 1.1 GO:0005811 lipid droplet(GO:0005811)
0.0 1.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 3.9 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.3 GO:0060076 excitatory synapse(GO:0060076)
0.0 0.1 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 1.7 GO:0032993 protein-DNA complex(GO:0032993)
0.0 6.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.7 GO:0043209 myelin sheath(GO:0043209)
0.0 0.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.4 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 20.5 GO:0004454 ketohexokinase activity(GO:0004454) triokinase activity(GO:0050354) fructose-1-phosphate aldolase activity(GO:0061609)
1.6 6.3 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
1.6 4.7 GO:0019120 hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
1.3 5.2 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
1.1 10.0 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
1.1 4.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
1.0 3.0 GO:0019807 aspartoacylase activity(GO:0019807)
1.0 3.0 GO:0050479 glyceryl-ether monooxygenase activity(GO:0050479)
0.9 2.7 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.9 3.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.8 3.2 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.7 3.0 GO:0050632 propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632)
0.6 1.9 GO:0008940 nitrate reductase activity(GO:0008940)
0.6 7.8 GO:0008172 S-methyltransferase activity(GO:0008172)
0.5 3.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.5 1.6 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.5 2.0 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.5 2.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.5 3.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 1.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 8.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 7.4 GO:0005536 glucose binding(GO:0005536)
0.4 13.0 GO:0008009 chemokine activity(GO:0008009)
0.3 8.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 2.2 GO:0019534 efflux transmembrane transporter activity(GO:0015562) toxin transporter activity(GO:0019534)
0.3 1.3 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.3 0.9 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.3 1.7 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 4.8 GO:0070628 proteasome binding(GO:0070628)
0.3 2.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3 2.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 2.5 GO:1990239 steroid hormone binding(GO:1990239)
0.2 1.7 GO:0046978 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.2 1.7 GO:0001851 complement component C3b binding(GO:0001851)
0.2 3.9 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 5.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 2.7 GO:0070513 death domain binding(GO:0070513)
0.2 2.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.8 GO:0008147 structural constituent of bone(GO:0008147)
0.2 1.5 GO:0019779 Atg8 activating enzyme activity(GO:0019779)
0.2 1.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.2 2.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 5.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 1.8 GO:0008097 5S rRNA binding(GO:0008097)
0.1 1.4 GO:0004462 hydroxyacylglutathione hydrolase activity(GO:0004416) lactoylglutathione lyase activity(GO:0004462)
0.1 0.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 1.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.7 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 2.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.5 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 5.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.5 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 1.7 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 0.2 GO:0042007 interleukin-18 binding(GO:0042007)
0.1 0.3 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 2.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 2.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 1.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.0 GO:0005537 mannose binding(GO:0005537)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.6 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0071208 histone pre-mRNA DCP binding(GO:0071208) U7 snRNA binding(GO:0071209)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 1.6 GO:0030145 manganese ion binding(GO:0030145)
0.0 5.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.9 GO:0008083 growth factor activity(GO:0008083)
0.0 0.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 1.4 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 1.2 GO:0001784 phosphotyrosine residue binding(GO:0001784)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 2.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.2 GO:0000049 tRNA binding(GO:0000049)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 3.7 GO:0061660 Atg12 activating enzyme activity(GO:0019778) Atg8-specific protease activity(GO:0019786) Atg12 conjugating enzyme activity(GO:0061651) Atg12 ligase activity(GO:0061660)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.4 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 1.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 1.0 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0102991 myristoyl-CoA hydrolase activity(GO:0102991)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 1.7 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 8.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 2.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.7 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 3.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 2.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 2.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 1.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.0 PID_ARF_3PATHWAY Arf1 pathway
0.1 4.1 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 1.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 7.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.0 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.3 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.6 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.4 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 1.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 5.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.4 7.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.3 3.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 7.2 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2 9.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 8.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 4.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 4.1 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.0 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 2.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.1 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 1.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 1.2 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 23.6 REACTOME_METABOLISM_OF_CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 4.6 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 3.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.7 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 1.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.0 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 2.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 2.1 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 2.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.7 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.5 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport