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GSE58827: Dynamics of the Mouse Liver

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Results for Rhox11

Z-value: 0.66

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Transcription factors associated with Rhox11

Gene Symbol Gene ID Gene Info
Rhox11
ENSMUSG00000051038.9 reproductive homeobox 11

Activity profile of Rhox11 motif

Sorted Z-values of Rhox11 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_122100951 5.04 ENSMUST00000014080.6
ENSMUST00000111750.1
ENSMUST00000139213.1
ENSMUST00000111751.1
ENSMUST00000155612.1
Myl2
myosin, light polypeptide 2, regulatory, cardiac, slow
chr7_-_142699510 3.33 ENSMUST00000105934.1
Ins2
insulin II
chr3_-_123034943 2.43 ENSMUST00000029761.7
Myoz2
myozenin 2
chr7_-_28008416 1.80 ENSMUST00000180024.1
Zfp850
zinc finger protein 850
chr1_-_175688353 1.75 ENSMUST00000104984.1
Chml
choroideremia-like
chr11_-_102082464 1.66 ENSMUST00000100398.4
Mpp2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr17_+_40811089 1.65 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr11_+_70639118 1.56 ENSMUST00000055184.6
ENSMUST00000108551.2
Gp1ba
glycoprotein 1b, alpha polypeptide
chr1_+_40805578 1.54 ENSMUST00000114765.2
Tmem182
transmembrane protein 182
chr10_+_58394361 1.53 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr9_-_60838200 1.51 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr10_+_58394381 1.51 ENSMUST00000105468.1
Lims1
LIM and senescent cell antigen-like domains 1
chr4_+_126556994 1.44 ENSMUST00000147675.1
Clspn
claspin
chr6_+_78405148 1.42 ENSMUST00000023906.2
Reg2
regenerating islet-derived 2
chr4_+_126556935 1.23 ENSMUST00000048391.8
Clspn
claspin
chr7_-_119479249 1.19 ENSMUST00000033263.4
Umod
uromodulin
chr17_-_47016956 1.12 ENSMUST00000165525.1
Gm16494
predicted gene 16494
chr11_-_30198232 1.06 ENSMUST00000102838.3
Sptbn1
spectrin beta, non-erythrocytic 1
chr11_+_11487671 1.04 ENSMUST00000020410.4
4930415F15Rik
RIKEN cDNA 4930415F15 gene
chr5_+_17574268 1.01 ENSMUST00000030568.7
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr14_-_20496780 0.94 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr6_-_129660556 0.94 ENSMUST00000119533.1
ENSMUST00000145984.1
ENSMUST00000118401.1
ENSMUST00000071920.4
Klrc2
killer cell lectin-like receptor subfamily C, member 2
chr17_-_37280418 0.94 ENSMUST00000077585.2
Olfr99
olfactory receptor 99
chr18_-_60501983 0.93 ENSMUST00000042710.6
Smim3
small integral membrane protein 3
chr8_+_105827721 0.93 ENSMUST00000034365.4
Tsnaxip1
translin-associated factor X (Tsnax) interacting protein 1
chrX_-_102157065 0.92 ENSMUST00000056904.2
Ercc6l
excision repair cross-complementing rodent repair deficiency complementation group 6 like
chr5_+_43818893 0.92 ENSMUST00000101237.4
Bst1
bone marrow stromal cell antigen 1
chr5_-_139130159 0.90 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_+_17574726 0.87 ENSMUST00000169603.1
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr12_+_74288735 0.84 ENSMUST00000095617.1
1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr5_+_37735519 0.79 ENSMUST00000073554.3
Cytl1
cytokine-like 1
chr1_-_153186447 0.73 ENSMUST00000027753.6
Lamc2
laminin, gamma 2
chr9_+_86743616 0.71 ENSMUST00000036426.6
Prss35
protease, serine, 35
chr11_+_29373618 0.71 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a
coiled coil domain containing 88A
chr4_+_62480025 0.70 ENSMUST00000030088.5
ENSMUST00000107449.3
Bspry
B-box and SPRY domain containing
chr13_-_95525239 0.68 ENSMUST00000022185.8
F2rl1
coagulation factor II (thrombin) receptor-like 1
chr12_+_104101087 0.68 ENSMUST00000021495.3
Serpina5
serine (or cysteine) peptidase inhibitor, clade A, member 5
chr7_-_46795661 0.66 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr5_+_143933059 0.61 ENSMUST00000166847.1
Rsph10b
radial spoke head 10 homolog B (Chlamydomonas)
chr2_-_5862923 0.59 ENSMUST00000071016.2
Gm13199
predicted gene 13199
chr10_-_61273242 0.58 ENSMUST00000120336.1
Adamts14
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
chr15_+_25742314 0.56 ENSMUST00000135981.1
Myo10
myosin X
chr9_+_86743641 0.56 ENSMUST00000179574.1
Prss35
protease, serine, 35
chr12_-_99883429 0.54 ENSMUST00000046485.3
Efcab11
EF-hand calcium binding domain 11
chr9_-_20644726 0.53 ENSMUST00000148631.1
ENSMUST00000131128.1
ENSMUST00000151861.1
ENSMUST00000131343.1
ENSMUST00000086458.3
Fbxl12
F-box and leucine-rich repeat protein 12
chr13_-_3611064 0.51 ENSMUST00000096069.3
BC016423
cDNA sequence BC016423
chr11_-_100355383 0.49 ENSMUST00000146878.2
Hap1
huntingtin-associated protein 1
chr2_-_150362708 0.49 ENSMUST00000051153.5
3300002I08Rik
RIKEN cDNA 3300002I08 gene
chr9_-_8134294 0.48 ENSMUST00000037397.6
AK129341
cDNA sequence AK129341
chr13_-_23562369 0.42 ENSMUST00000105107.1
Hist1h3e
histone cluster 1, H3e
chr6_-_129451906 0.40 ENSMUST00000037481.7
Clec1a
C-type lectin domain family 1, member a
chr11_-_97700327 0.39 ENSMUST00000018681.7
Pcgf2
polycomb group ring finger 2
chr5_+_121220191 0.39 ENSMUST00000119892.2
ENSMUST00000042614.6
Gm15800
predicted gene 15800
chr18_+_62977854 0.35 ENSMUST00000150267.1
Napg
N-ethylmaleimide sensitive fusion protein attachment protein gamma
chr19_-_10974664 0.35 ENSMUST00000072748.6
Ms4a10
membrane-spanning 4-domains, subfamily A, member 10
chr9_-_67043709 0.34 ENSMUST00000113689.1
ENSMUST00000113684.1
Tpm1
tropomyosin 1, alpha
chr3_-_92485886 0.34 ENSMUST00000054599.7
Sprr1a
small proline-rich protein 1A
chr10_-_61273409 0.32 ENSMUST00000092486.4
Adamts14
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
chr8_-_105827190 0.32 ENSMUST00000041400.5
Ranbp10
RAN binding protein 10
chr7_+_126584937 0.31 ENSMUST00000039522.6
Apobr
apolipoprotein B receptor
chr1_+_87853264 0.31 ENSMUST00000027517.7
Dgkd
diacylglycerol kinase, delta
chr3_-_121171678 0.30 ENSMUST00000170781.1
ENSMUST00000039761.5
ENSMUST00000106467.1
ENSMUST00000106466.3
ENSMUST00000164925.2
Rwdd3
RWD domain containing 3
chr6_+_135065651 0.30 ENSMUST00000050104.7
Gprc5a
G protein-coupled receptor, family C, group 5, member A
chr15_+_36179299 0.29 ENSMUST00000047348.3
Spag1
sperm associated antigen 1
chr3_+_90603767 0.28 ENSMUST00000001046.5
ENSMUST00000107330.1
S100a4
S100 calcium binding protein A4
chr11_-_69895523 0.28 ENSMUST00000001631.6
Acap1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr5_-_114858682 0.28 ENSMUST00000066959.4
Gm9936
predicted gene 9936
chr13_+_95325195 0.26 ENSMUST00000045909.7
Zbed3
zinc finger, BED domain containing 3
chr10_+_19712587 0.26 ENSMUST00000020185.3
Il20ra
interleukin 20 receptor, alpha
chr9_-_107289847 0.26 ENSMUST00000035194.2
Mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
chr19_-_8818924 0.25 ENSMUST00000153281.1
Ttc9c
tetratricopeptide repeat domain 9C
chr12_+_76837408 0.23 ENSMUST00000041008.9
Fntb
farnesyltransferase, CAAX box, beta
chr9_-_20521375 0.23 ENSMUST00000068296.7
ENSMUST00000174462.1
Zfp266
zinc finger protein 266
chr6_-_34977999 0.19 ENSMUST00000044387.7
2010107G12Rik
RIKEN cDNA 2010107G12 gene
chr14_-_46822232 0.19 ENSMUST00000111817.1
ENSMUST00000079314.5
Gmfb
glia maturation factor, beta
chr13_+_49653297 0.17 ENSMUST00000021824.7
Nol8
nucleolar protein 8
chr11_-_5381734 0.16 ENSMUST00000172492.1
Znrf3
zinc and ring finger 3
chr7_-_14123042 0.15 ENSMUST00000098809.2
Sult2a3
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr7_+_5051515 0.15 ENSMUST00000069324.5
Zfp580
zinc finger protein 580
chr3_-_144975011 0.14 ENSMUST00000075496.4
ENSMUST00000029923.6
Clca6
chloride channel calcium activated 6
chrX_+_105079735 0.14 ENSMUST00000033577.4
Pbdc1
polysaccharide biosynthesis domain containing 1
chr11_-_97782377 0.12 ENSMUST00000128801.1
Rpl23
ribosomal protein L23
chr8_-_81014866 0.12 ENSMUST00000042724.6
Usp38
ubiquitin specific peptidase 38
chr11_-_97782409 0.12 ENSMUST00000103146.4
Rpl23
ribosomal protein L23
chr1_-_44061936 0.10 ENSMUST00000168641.1
Gm8251
predicted gene 8251
chr3_+_127791374 0.10 ENSMUST00000171621.1
Tifa
TRAF-interacting protein with forkhead-associated domain
chr3_+_68468162 0.08 ENSMUST00000182532.1
Schip1
schwannomin interacting protein 1
chr11_-_102880981 0.08 ENSMUST00000107060.1
Eftud2
elongation factor Tu GTP binding domain containing 2
chr11_-_102880925 0.08 ENSMUST00000021306.7
Eftud2
elongation factor Tu GTP binding domain containing 2
chr13_+_34924409 0.06 ENSMUST00000160279.1
4933417A18Rik
RIKEN cDNA 4933417A18 gene
chr2_-_131352857 0.06 ENSMUST00000059372.4
Rnf24
ring finger protein 24
chr10_-_59951753 0.05 ENSMUST00000020308.3
Ddit4
DNA-damage-inducible transcript 4
chr9_-_110654161 0.05 ENSMUST00000133191.1
ENSMUST00000167320.1
Nbeal2
neurobeachin-like 2
chr3_+_156561792 0.05 ENSMUST00000074015.4
Negr1
neuronal growth regulator 1
chr9_-_78489141 0.05 ENSMUST00000154207.1
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr10_+_21295979 0.03 ENSMUST00000020153.8
ENSMUST00000092674.6
Hbs1l
Hbs1-like (S. cerevisiae)
chr2_-_57113053 0.03 ENSMUST00000112627.1
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr13_-_71963713 0.03 ENSMUST00000077337.8
Irx1
Iroquois related homeobox 1 (Drosophila)
chr11_+_74082907 0.03 ENSMUST00000178159.1
Zfp616
zinc finger protein 616
chr5_+_138187485 0.03 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr1_+_180942325 0.02 ENSMUST00000161847.1
Tmem63a
transmembrane protein 63a
chr1_+_24177610 0.02 ENSMUST00000054588.8
Col9a1
collagen, type IX, alpha 1
chr7_+_46983593 0.02 ENSMUST00000070660.4
Gm9999
predicted gene 9999
chr7_-_46795881 0.01 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr7_-_119720742 0.00 ENSMUST00000033236.7
Thumpd1
THUMP domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Rhox11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) neuron projection maintenance(GO:1990535)
0.7 5.0 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.5 1.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.4 3.0 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.3 1.2 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.3 1.9 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.2 2.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 0.7 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949) positive regulation of renin secretion into blood stream(GO:1900135) positive regulation of eosinophil activation(GO:1902568)
0.2 1.7 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 1.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.3 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.1 0.5 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.1 1.6 GO:0042730 fibrinolysis(GO:0042730)
0.1 1.4 GO:0001967 suckling behavior(GO:0001967)
0.1 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.3 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.0 0.3 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.7 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.8 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.9 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 2.4 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.9 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:1902570 protein localization to nucleolus(GO:1902570)
0.0 0.0 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.9 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 1.7 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.0 GO:0051866 general adaptation syndrome(GO:0051866)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.0 GO:0097512 cardiac myofibril(GO:0097512)
0.3 1.7 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 0.7 GO:0005607 laminin-2 complex(GO:0005607)
0.2 1.1 GO:0032437 cuticular plate(GO:0032437)
0.2 0.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 3.3 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.1 0.7 GO:0031094 platelet dense tubular network(GO:0031094)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.9 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 1.7 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0042627 low-density lipoprotein particle(GO:0034362) chylomicron(GO:0042627)
0.0 2.4 GO:0030018 Z disc(GO:0030018)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0051373 FATZ binding(GO:0051373)
0.4 2.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 0.9 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.2 0.7 GO:0032190 acrosin binding(GO:0032190)
0.2 0.7 GO:0015057 thrombin receptor activity(GO:0015057)
0.2 1.2 GO:0019864 IgG binding(GO:0019864)
0.1 5.0 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.9 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.4 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 3.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 1.6 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 1.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 0.3 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.3 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.4 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 1.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.3 GO:0010857 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 0.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 3.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.7 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 2.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 5.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.6 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.9 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling