Motif ID: Runx1

Z-value: 1.233


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Runx1mm10_v2_chr16_-_92826004_928260800.875.0e-12Click!


Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_87793470 15.266 ENSMUST00000020779.4
Mpo
myeloperoxidase
chr11_+_87793722 14.449 ENSMUST00000143021.2
Mpo
myeloperoxidase
chr16_-_92826004 13.225 ENSMUST00000023673.7
Runx1
runt related transcription factor 1
chr2_-_28084877 10.645 ENSMUST00000028179.8
ENSMUST00000117486.1
ENSMUST00000135472.1
Fcnb


ficolin B


chr4_-_46404224 10.134 ENSMUST00000107764.2
Hemgn
hemogen
chr15_-_103255433 8.501 ENSMUST00000075192.6
Nfe2
nuclear factor, erythroid derived 2
chr3_-_59101810 7.258 ENSMUST00000085040.4
Gpr171
G protein-coupled receptor 171
chr1_+_40515362 6.964 ENSMUST00000027237.5
Il18rap
interleukin 18 receptor accessory protein
chr5_-_107726017 6.869 ENSMUST00000159263.2
Gfi1
growth factor independent 1
chr2_+_164948219 6.758 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr13_-_113100971 6.431 ENSMUST00000023897.5
Gzma
granzyme A
chr7_+_143005046 6.018 ENSMUST00000009396.6
Tspan32
tetraspanin 32
chr7_-_127137807 5.843 ENSMUST00000049931.5
Spn
sialophorin
chr14_+_56042123 5.783 ENSMUST00000015576.4
Mcpt2
mast cell protease 2
chr7_+_44572370 5.629 ENSMUST00000002274.8
Napsa
napsin A aspartic peptidase
chr7_+_24370255 5.488 ENSMUST00000171904.1
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr13_+_76579670 5.307 ENSMUST00000126960.1
ENSMUST00000109583.2
Mctp1

multiple C2 domains, transmembrane 1

chr15_-_66801577 5.246 ENSMUST00000168589.1
Sla
src-like adaptor
chr2_+_172393900 5.104 ENSMUST00000109136.2
Cass4
Cas scaffolding protein family member 4
chr17_+_31208049 4.997 ENSMUST00000173776.1
Ubash3a
ubiquitin associated and SH3 domain containing, A
chrX_-_8090442 4.336 ENSMUST00000033505.6
Was
Wiskott-Aldrich syndrome homolog (human)
chr18_-_35649349 4.317 ENSMUST00000025211.4
Mzb1
marginal zone B and B1 cell-specific protein 1
chr2_-_58160495 4.286 ENSMUST00000028175.6
Cytip
cytohesin 1 interacting protein
chr4_+_135120640 3.892 ENSMUST00000056977.7
Runx3
runt related transcription factor 3
chr3_+_103860265 3.888 ENSMUST00000029433.7
Ptpn22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr8_+_105690906 3.794 ENSMUST00000062574.6
Rltpr
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr17_+_47596061 3.620 ENSMUST00000182539.1
Ccnd3
cyclin D3
chr17_+_12119274 3.253 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr7_-_43533171 3.194 ENSMUST00000004728.5
ENSMUST00000039861.5
Cd33

CD33 antigen

chr2_-_26021679 3.070 ENSMUST00000036509.7
Ubac1
ubiquitin associated domain containing 1
chr11_-_83649349 3.032 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chrX_-_57338598 3.006 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr4_-_133872997 2.966 ENSMUST00000137486.2
Rps6ka1
ribosomal protein S6 kinase polypeptide 1
chr2_-_26021532 2.961 ENSMUST00000136750.1
Ubac1
ubiquitin associated domain containing 1
chr12_+_85686648 2.952 ENSMUST00000040536.5
Batf
basic leucine zipper transcription factor, ATF-like
chr14_-_56262233 2.875 ENSMUST00000015581.4
Gzmb
granzyme B
chr7_-_25132473 2.842 ENSMUST00000108418.4
ENSMUST00000108415.3
ENSMUST00000098679.3
ENSMUST00000175774.2
ENSMUST00000108417.3
ENSMUST00000108416.3
ENSMUST00000108414.1
ENSMUST00000108413.1
ENSMUST00000176408.1
Pou2f2








POU domain, class 2, transcription factor 2








chr11_+_69966896 2.687 ENSMUST00000151515.1
Cldn7
claudin 7
chr8_-_11008458 2.671 ENSMUST00000040514.6
Irs2
insulin receptor substrate 2
chr3_+_96181151 2.538 ENSMUST00000035371.8
Sv2a
synaptic vesicle glycoprotein 2 a
chr17_+_33638056 2.482 ENSMUST00000052079.7
Pram1
PML-RAR alpha-regulated adaptor molecule 1
chr13_+_76579681 2.411 ENSMUST00000109589.2
Mctp1
multiple C2 domains, transmembrane 1
chr6_-_136941494 2.385 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr15_-_9529868 2.375 ENSMUST00000003981.4
Il7r
interleukin 7 receptor
chr11_-_79530569 2.345 ENSMUST00000103236.3
ENSMUST00000170799.1
ENSMUST00000170422.2
Evi2a

Evi2b
ecotropic viral integration site 2a

ecotropic viral integration site 2b
chrX_+_159697308 2.336 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chr14_+_70774304 2.246 ENSMUST00000022698.7
Dok2
docking protein 2
chr18_-_62179948 2.235 ENSMUST00000053640.3
Adrb2
adrenergic receptor, beta 2
chr6_-_136941694 2.231 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_153938218 2.230 ENSMUST00000109757.1
Bpifb4
BPI fold containing family B, member 4
chr15_-_34356421 2.194 ENSMUST00000179647.1
9430069I07Rik
RIKEN cDNA 9430069I07 gene
chr11_-_69895523 2.095 ENSMUST00000001631.6
Acap1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr2_-_119760295 2.076 ENSMUST00000082130.6
ENSMUST00000028759.6
Ltk

leukocyte tyrosine kinase

chr15_-_98607611 2.065 ENSMUST00000096224.4
Adcy6
adenylate cyclase 6
chr10_+_118441044 2.048 ENSMUST00000068592.3
Ifng
interferon gamma
chr2_-_73485733 2.000 ENSMUST00000102680.1
Wipf1
WAS/WASL interacting protein family, member 1
chr11_-_4594750 1.955 ENSMUST00000109943.3
Mtmr3
myotubularin related protein 3
chr7_-_133709051 1.941 ENSMUST00000124759.1
ENSMUST00000106144.1
Uros

uroporphyrinogen III synthase

chr7_-_115824699 1.936 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr16_-_58718724 1.862 ENSMUST00000089318.3
Gpr15
G protein-coupled receptor 15
chr4_-_129573637 1.812 ENSMUST00000102596.1
Lck
lymphocyte protein tyrosine kinase
chr4_-_70410422 1.784 ENSMUST00000144099.1
Cdk5rap2
CDK5 regulatory subunit associated protein 2
chr2_-_73486456 1.725 ENSMUST00000141264.1
Wipf1
WAS/WASL interacting protein family, member 1
chr7_-_25675047 1.687 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
Tmem91


transmembrane protein 91


chr18_+_62180119 1.684 ENSMUST00000067743.1
Gm9949
predicted gene 9949
chr15_+_9436028 1.576 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr11_-_101095367 1.540 ENSMUST00000019447.8
Psmc3ip
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
chr12_-_112860886 1.513 ENSMUST00000021729.7
Gpr132
G protein-coupled receptor 132
chr5_+_139406387 1.483 ENSMUST00000052176.8
C130050O18Rik
RIKEN cDNA C130050O18 gene
chr17_+_75178797 1.479 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr3_-_96814518 1.464 ENSMUST00000047702.7
Cd160
CD160 antigen
chr15_-_97844254 1.443 ENSMUST00000119670.1
ENSMUST00000116409.2
Hdac7

histone deacetylase 7

chr15_-_97844164 1.430 ENSMUST00000120683.1
Hdac7
histone deacetylase 7
chr7_-_133708958 1.380 ENSMUST00000106146.1
Uros
uroporphyrinogen III synthase
chr7_+_126584937 1.340 ENSMUST00000039522.6
Apobr
apolipoprotein B receptor
chr17_+_75178911 1.287 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr10_-_40302186 1.284 ENSMUST00000099945.4
Amd1
S-adenosylmethionine decarboxylase 1
chr1_+_171388954 1.278 ENSMUST00000056449.8
Arhgap30
Rho GTPase activating protein 30
chr7_-_133709069 1.268 ENSMUST00000106145.3
Uros
uroporphyrinogen III synthase
chr8_+_109705549 1.266 ENSMUST00000034163.8
Zfp821
zinc finger protein 821
chr2_-_32741016 1.243 ENSMUST00000009695.2
6330409D20Rik
RIKEN cDNA 6330409D20 gene
chr2_+_153918391 1.238 ENSMUST00000109760.1
Bpifb3
BPI fold containing family B, member 3
chr5_+_140607334 1.233 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_-_48034842 1.227 ENSMUST00000039026.7
Apln
apelin
chr8_+_94667082 1.202 ENSMUST00000109527.4
Arl2bp
ADP-ribosylation factor-like 2 binding protein
chr1_-_138175126 1.171 ENSMUST00000183301.1
Ptprc
protein tyrosine phosphatase, receptor type, C
chr19_+_5568002 1.160 ENSMUST00000096318.3
Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr1_-_138175283 1.141 ENSMUST00000182755.1
ENSMUST00000183262.1
ENSMUST00000027645.7
ENSMUST00000112036.2
ENSMUST00000182283.1
Ptprc




protein tyrosine phosphatase, receptor type, C




chr5_+_48242549 1.124 ENSMUST00000172493.1
Slit2
slit homolog 2 (Drosophila)
chr9_-_32928928 1.115 ENSMUST00000185169.1
RP24-308I2.1
RP24-308I2.1
chrX_+_56786527 1.100 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr1_-_138175238 1.092 ENSMUST00000182536.1
Ptprc
protein tyrosine phosphatase, receptor type, C
chr4_-_41275091 1.085 ENSMUST00000030143.6
ENSMUST00000108068.1
Ubap2

ubiquitin-associated protein 2

chr2_+_172393794 1.072 ENSMUST00000099061.2
ENSMUST00000103073.2
Cass4

Cas scaffolding protein family member 4

chr3_-_86142684 1.043 ENSMUST00000029722.6
Rps3a1
ribosomal protein S3A1
chr15_+_80711292 1.010 ENSMUST00000067689.7
Tnrc6b
trinucleotide repeat containing 6b
chr16_-_95586585 0.927 ENSMUST00000077773.6
Erg
avian erythroblastosis virus E-26 (v-ets) oncogene related
chr16_+_18877037 0.912 ENSMUST00000120532.1
ENSMUST00000004222.7
Hira

histone cell cycle regulation defective homolog A (S. cerevisiae)

chr11_-_110168073 0.873 ENSMUST00000044850.3
Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr10_-_95673451 0.868 ENSMUST00000099328.1
Anapc15-ps
anaphase prompoting complex C subunit 15, pseudogene
chr9_-_107770945 0.851 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chr11_-_100121558 0.830 ENSMUST00000007275.2
Krt13
keratin 13
chr15_-_78493607 0.828 ENSMUST00000163494.1
Il2rb
interleukin 2 receptor, beta chain
chr4_-_6990774 0.826 ENSMUST00000039987.3
Tox
thymocyte selection-associated high mobility group box
chr1_-_161788489 0.820 ENSMUST00000000834.2
Fasl
Fas ligand (TNF superfamily, member 6)
chr6_+_136518820 0.816 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr4_+_133176336 0.751 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chr1_+_160044564 0.720 ENSMUST00000168359.1
4930523C07Rik
RIKEN cDNA 4930523C07 gene
chr4_-_152038568 0.715 ENSMUST00000030792.1
Tas1r1
taste receptor, type 1, member 1
chrX_-_12160355 0.669 ENSMUST00000043441.6
Bcor
BCL6 interacting corepressor
chr1_-_164935522 0.589 ENSMUST00000027860.7
Xcl1
chemokine (C motif) ligand 1
chr16_+_32271468 0.573 ENSMUST00000093183.3
Smco1
single-pass membrane protein with coiled-coil domains 1
chr6_-_38637220 0.555 ENSMUST00000096030.3
Klrg2
killer cell lectin-like receptor subfamily G, member 2
chr10_-_127288999 0.541 ENSMUST00000119078.1
Mbd6
methyl-CpG binding domain protein 6
chr14_-_121915774 0.506 ENSMUST00000055475.7
Gpr18
G protein-coupled receptor 18
chr1_+_172956768 0.477 ENSMUST00000038432.4
Olfr16
olfactory receptor 16
chr9_+_113812547 0.449 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr7_-_132852606 0.447 ENSMUST00000120425.1
Mettl10
methyltransferase like 10
chr9_+_108479849 0.414 ENSMUST00000065014.4
Lamb2
laminin, beta 2
chr12_+_116077720 0.413 ENSMUST00000011315.3
Vipr2
vasoactive intestinal peptide receptor 2
chr5_+_87808082 0.405 ENSMUST00000072539.5
ENSMUST00000113279.1
ENSMUST00000101057.3
Csn1s2b


casein alpha s2-like B


chr10_-_127288851 0.399 ENSMUST00000156208.1
ENSMUST00000026476.6
Mbd6

methyl-CpG binding domain protein 6

chr2_-_20943413 0.398 ENSMUST00000140230.1
Arhgap21
Rho GTPase activating protein 21
chr1_+_36307727 0.335 ENSMUST00000126413.1
Arid5a
AT rich interactive domain 5A (MRF1-like)
chr2_+_37516618 0.328 ENSMUST00000065441.6
Gpr21
G protein-coupled receptor 21
chr11_+_75531690 0.301 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
Slc43a2



solute carrier family 43, member 2



chrX_-_20950597 0.287 ENSMUST00000009550.7
Elk1
ELK1, member of ETS oncogene family
chr9_-_66514567 0.281 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr19_+_4214238 0.263 ENSMUST00000046506.6
Clcf1
cardiotrophin-like cytokine factor 1
chr12_-_34528844 0.258 ENSMUST00000110819.2
Hdac9
histone deacetylase 9
chr14_+_56017964 0.237 ENSMUST00000022836.4
Mcpt1
mast cell protease 1
chr10_-_14718191 0.221 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr15_+_62037986 0.217 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr2_+_86041317 0.209 ENSMUST00000111589.1
Olfr1033
olfactory receptor 1033
chr2_-_71367749 0.203 ENSMUST00000151937.1
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr3_-_88378699 0.193 ENSMUST00000098956.2
Bglap2
bone gamma-carboxyglutamate protein 2
chr1_-_174118014 0.184 ENSMUST00000063030.3
Olfr231
olfactory receptor 231
chr16_+_91391721 0.184 ENSMUST00000160764.1
Gm21970
predicted gene 21970
chr11_+_77686155 0.179 ENSMUST00000100802.4
ENSMUST00000181023.1
Nufip2

nuclear fragile X mental retardation protein interacting protein 2

chr17_-_44814649 0.176 ENSMUST00000113571.3
Runx2
runt related transcription factor 2
chr16_+_25801907 0.159 ENSMUST00000040231.6
ENSMUST00000115306.1
ENSMUST00000115304.1
ENSMUST00000115305.1
Trp63



transformation related protein 63



chr11_+_75532127 0.152 ENSMUST00000127226.1
Slc43a2
solute carrier family 43, member 2
chr19_-_8839181 0.149 ENSMUST00000096259.4
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr17_-_44814604 0.145 ENSMUST00000160673.1
Runx2
runt related transcription factor 2
chr16_-_38433145 0.145 ENSMUST00000002926.6
Pla1a
phospholipase A1 member A
chr1_+_60746358 0.138 ENSMUST00000027165.2
Cd28
CD28 antigen
chr2_+_35691893 0.134 ENSMUST00000065001.5
Dab2ip
disabled 2 interacting protein
chr15_+_62178175 0.114 ENSMUST00000182476.1
Pvt1
plasmacytoma variant translocation 1
chr1_+_36307745 0.103 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
Arid5a





AT rich interactive domain 5A (MRF1-like)





chr6_-_83070225 0.079 ENSMUST00000174674.1
ENSMUST00000089641.3
Tlx2

T cell leukemia, homeobox 2

chr12_+_95692212 0.078 ENSMUST00000057324.3
Flrt2
fibronectin leucine rich transmembrane protein 2
chr3_-_107760221 0.078 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr14_-_20618339 0.077 ENSMUST00000035340.7
Usp54
ubiquitin specific peptidase 54
chr7_-_132852657 0.067 ENSMUST00000033257.8
Mettl10
methyltransferase like 10
chr19_+_5050807 0.061 ENSMUST00000025818.6
Rin1
Ras and Rab interactor 1
chr4_+_102991784 0.060 ENSMUST00000140654.1
ENSMUST00000169211.1
Tctex1d1

Tctex1 domain containing 1

chr15_-_38519227 0.050 ENSMUST00000110328.1
ENSMUST00000110329.1
ENSMUST00000065308.5
Azin1


antizyme inhibitor 1


chrX_-_50942710 0.049 ENSMUST00000060650.5
Frmd7
FERM domain containing 7
chr4_+_65124174 0.048 ENSMUST00000084501.3
Pappa
pregnancy-associated plasma protein A
chr18_+_37411674 0.042 ENSMUST00000051126.2
Pcdhb10
protocadherin beta 10
chr11_-_72215592 0.037 ENSMUST00000021157.8
Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr2_+_32629467 0.037 ENSMUST00000068271.4
Ak1
adenylate kinase 1
chr15_-_102722120 0.025 ENSMUST00000171838.1
Calcoco1
calcium binding and coiled coil domain 1
chr11_-_102218923 0.023 ENSMUST00000131254.1
Hdac5
histone deacetylase 5
chr17_-_36958533 0.019 ENSMUST00000172518.1
Znrd1
zinc ribbon domain containing, 1
chr15_-_102722150 0.018 ENSMUST00000023818.3
Calcoco1
calcium binding and coiled coil domain 1
chr3_+_103058302 0.005 ENSMUST00000029445.6
Nras
neuroblastoma ras oncogene
chr11_-_52282564 0.002 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.9 29.7 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
4.4 13.2 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
2.7 10.6 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
2.3 6.8 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
1.9 5.8 GO:0002884 regulation of type IV hypersensitivity(GO:0001807) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) negative regulation of hypersensitivity(GO:0002884) T cell aggregation(GO:0070489)
1.5 7.7 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
1.5 4.5 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
1.4 6.9 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
1.1 4.6 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.7 4.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.7 8.5 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.7 2.0 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.6 6.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.6 6.4 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071) negative regulation of nuclease activity(GO:0032074)
0.6 4.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.6 2.9 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.6 2.2 GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure(GO:0002025)
0.5 7.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.5 1.5 GO:0051466 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.5 2.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 5.5 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.4 1.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.4 1.1 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.3 2.1 GO:0035811 negative regulation of urine volume(GO:0035811)
0.3 2.7 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.3 3.0 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.3 1.8 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.3 2.5 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.3 3.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.2 5.0 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.2 1.2 GO:0007386 compartment pattern specification(GO:0007386)
0.2 0.4 GO:2000556 regulation of T-helper 1 cell cytokine production(GO:2000554) positive regulation of T-helper 1 cell cytokine production(GO:2000556)
0.2 3.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 0.8 GO:0071352 interleukin-2-mediated signaling pathway(GO:0038110) cellular response to interleukin-2(GO:0071352)
0.2 0.4 GO:0072244 metanephric glomerular epithelium development(GO:0072244)
0.2 3.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 3.0 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.2 2.5 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.2 1.8 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.2 1.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.5 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.2 0.7 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.2 0.8 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.2 0.2 GO:0060197 cloacal septation(GO:0060197)
0.2 2.1 GO:0043129 surfactant homeostasis(GO:0043129)
0.2 0.9 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 3.9 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 2.7 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 0.7 GO:0050917 sensory perception of umami taste(GO:0050917)
0.1 3.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 2.8 GO:0048305 immunoglobulin secretion(GO:0048305)
0.1 1.9 GO:0072678 T cell migration(GO:0072678)
0.1 2.8 GO:0010714 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.1 0.4 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.2 GO:0015810 aspartate transport(GO:0015810)
0.1 0.4 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.0 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 9.1 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.1 2.6 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 2.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:1903969 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.5 GO:0098664 serotonin receptor signaling pathway(GO:0007210) G-protein coupled serotonin receptor signaling pathway(GO:0098664)
0.0 1.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.8 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 1.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.3 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 1.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 1.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0046641 positive regulation of alpha-beta T cell proliferation(GO:0046641)
0.0 0.0 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 3.3 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 2.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.7 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 29.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.5 6.0 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
0.9 2.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.8 10.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.7 2.9 GO:0044194 cytolytic granule(GO:0044194)
0.5 5.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.4 5.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 4.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 3.6 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.4 GO:0005608 laminin-3 complex(GO:0005608)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 13.2 GO:0005604 basement membrane(GO:0005604)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.3 GO:0034362 low-density lipoprotein particle(GO:0034362) chylomicron(GO:0042627)
0.1 0.3 GO:0097059 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.1 1.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.1 6.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.5 GO:0030027 lamellipodium(GO:0030027)
0.1 2.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.9 GO:0010369 chromocenter(GO:0010369)
0.0 8.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.2 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.1 GO:0005768 endosome(GO:0005768)
0.0 3.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 4.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 4.6 GO:0005925 focal adhesion(GO:0005925)
0.0 2.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 3.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 4.3 GO:0005938 cell cortex(GO:0005938)
0.0 3.7 GO:0012506 vesicle membrane(GO:0012506)
0.0 3.0 GO:0005819 spindle(GO:0005819)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.2 GO:0005922 connexin complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
1.2 10.6 GO:0033691 sialic acid binding(GO:0033691)
0.9 8.9 GO:0004498 calcidiol 1-monooxygenase activity(GO:0004498)
0.8 4.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.7 2.8 GO:0050436 microfibril binding(GO:0050436)
0.6 7.0 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.6 4.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.6 2.2 GO:0031711 beta-adrenergic receptor activity(GO:0004939) bradykinin receptor binding(GO:0031711)
0.5 7.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.5 29.7 GO:0004601 peroxidase activity(GO:0004601)
0.4 1.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 1.8 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 2.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 13.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 6.8 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.3 0.8 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.2 2.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) phosphatidylinositol-3,5-bisphosphate phosphatase activity(GO:0106018)
0.2 1.3 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.2 1.3 GO:0019808 polyamine binding(GO:0019808)
0.2 8.7 GO:0050699 WW domain binding(GO:0050699)
0.2 2.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 3.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 5.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 3.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.1 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.1 3.2 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.4 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 3.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 1.5 GO:0050692 DBD domain binding(GO:0050692)
0.1 3.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 6.4 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.3 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.1 0.7 GO:0008527 taste receptor activity(GO:0008527)
0.1 3.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 4.3 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 0.8 GO:0005123 death receptor binding(GO:0005123)
0.1 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 1.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.2 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 1.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 6.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0019969 interleukin-10 receptor activity(GO:0004920) interleukin-10 binding(GO:0019969)
0.0 2.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 2.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.4 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 2.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 34.0 PID_IL23_PATHWAY IL23-mediated signaling events
0.5 5.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 16.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 14.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 6.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 6.4 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 2.7 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.1 2.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 7.3 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.1 5.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.2 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.1 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 2.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 6.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 0.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 4.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.0 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 4.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 5.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 5.8 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 2.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 2.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.0 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.7 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.1 3.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.3 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 3.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 3.3 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.9 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 8.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.2 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 4.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 1.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.3 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.1 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 2.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.1 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events