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GSE58827: Dynamics of the Mouse Liver

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Results for Six3_Six1_Six2

Z-value: 0.62

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Transcription factors associated with Six3_Six1_Six2

Gene Symbol Gene ID Gene Info
ENSMUSG00000038805.9 sine oculis-related homeobox 3
ENSMUSG00000051367.8 sine oculis-related homeobox 1
ENSMUSG00000024134.10 sine oculis-related homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85621017_85621031-0.372.5e-02Click!
Six1mm10_v2_chr12_-_73047179_73047179-0.134.7e-01Click!
Six2mm10_v2_chr17_-_85688252_85688275-0.067.1e-01Click!

Activity profile of Six3_Six1_Six2 motif

Sorted Z-values of Six3_Six1_Six2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_117797660 4.63 ENSMUST00000106331.1
RIKEN cDNA 6030468B19 gene
chr3_+_108364882 2.39 ENSMUST00000090563.5
myosin binding protein H-like
chr6_+_122391379 2.20 ENSMUST00000043553.3
RIKEN cDNA 1700063H04 gene
chrX_-_142966709 1.94 ENSMUST00000041317.2
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr4_+_129906205 1.77 ENSMUST00000145196.1
ENSMUST00000141731.1
ENSMUST00000129149.1
RIKEN cDNA E330017L17 gene
chr3_+_130068390 1.40 ENSMUST00000076703.6
predicted gene 9396
chr1_-_65123108 1.35 ENSMUST00000050047.3
ENSMUST00000148020.1
RIKEN cDNA D630023F18 gene
chr17_-_53539411 1.23 ENSMUST00000056198.3
protein phosphatase 2C-like domain containing 1
chr3_-_37724321 1.12 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
predicted gene 5148
chr2_+_31245801 1.08 ENSMUST00000000199.7
neuronal calcium sensor 1
chr10_-_128180265 0.97 ENSMUST00000099139.1
RNA binding motif, single stranded interacting protein 2
chr17_+_40811089 0.92 ENSMUST00000024721.7
Rhesus blood group-associated A glycoprotein
chr4_+_134864536 0.85 ENSMUST00000030627.7
Rh blood group, D antigen
chr6_+_123123423 0.79 ENSMUST00000032248.7
C-type lectin domain family 4, member a2
chr6_+_123123313 0.78 ENSMUST00000041779.6
C-type lectin domain family 4, member a2
chr7_+_43690418 0.77 ENSMUST00000056329.6
kallikrein related-peptidase 14
chr2_+_131491764 0.71 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
spermine oxidase
chrX_-_74373218 0.68 ENSMUST00000178691.1
ENSMUST00000114146.1
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr2_+_106693185 0.63 ENSMUST00000111063.1
metallophosphoesterase domain containing 2
chr14_+_55765956 0.62 ENSMUST00000057569.3
leukotriene B4 receptor 1
chr7_-_100855403 0.61 ENSMUST00000156855.1
RELT tumor necrosis factor receptor
chr8_+_69832633 0.61 ENSMUST00000131637.2
ENSMUST00000081503.6
pre B cell leukemia homeobox 4
chr9_+_32393963 0.59 ENSMUST00000172015.1
potassium inwardly-rectifying channel, subfamily J, member 1
chr1_+_139454747 0.59 ENSMUST00000053364.8
ENSMUST00000097554.3
asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr19_-_23075853 0.58 ENSMUST00000181623.1
RIKEN cDNA C330002G04 gene
chr8_-_106573461 0.56 ENSMUST00000073722.5
predicted pseudogene 10073
chr9_+_98422961 0.48 ENSMUST00000052068.9
retinol binding protein 1, cellular
chr2_+_127336152 0.48 ENSMUST00000028846.6
dual specificity phosphatase 2
chr3_-_40509737 0.48 ENSMUST00000179966.1
RIKEN cDNA 1700017G19 gene
chrX_+_38772671 0.48 ENSMUST00000050744.5
RIKEN cDNA 6030498E09 gene
chr14_+_58893465 0.46 ENSMUST00000079960.1
ribosomal protein L13, pseudogene 3
chr10_-_81627797 0.46 ENSMUST00000042923.8
sirtuin 6
chr15_-_82244716 0.46 ENSMUST00000089155.4
ENSMUST00000089157.3
centromere protein M
chr7_-_30232186 0.45 ENSMUST00000006254.5
tubulin folding cofactor B
chr4_-_60582152 0.45 ENSMUST00000098047.2
major urinary protein 10
chrX_-_74373260 0.44 ENSMUST00000073067.4
ENSMUST00000037967.5
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr8_+_57455898 0.44 ENSMUST00000034023.3
scrapie responsive gene 1
chr1_+_136467958 0.41 ENSMUST00000047817.6
kinesin family member 14
chr4_-_61303802 0.40 ENSMUST00000125461.1
major urinary protein 14
chr17_+_35241838 0.39 ENSMUST00000173731.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chrX_-_167102059 0.38 ENSMUST00000146929.1
predicted gene 15232
chr17_+_35241746 0.36 ENSMUST00000068056.5
ENSMUST00000174757.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr19_+_46341118 0.36 ENSMUST00000128041.1
transmembrane protein 180
chr7_-_101903783 0.34 ENSMUST00000106969.1
transmembrane O-methyltransferase
chr5_+_140607334 0.29 ENSMUST00000031555.1
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr13_+_104229366 0.29 ENSMUST00000022227.6
centromere protein K
chr7_+_30231884 0.28 ENSMUST00000019882.9
polymerase (RNA) II (DNA directed) polypeptide I
chr17_-_40914350 0.28 ENSMUST00000166343.1
glycine-N-acyltransferase-like 3
chr8_+_84831522 0.27 ENSMUST00000036734.5
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr7_+_30232310 0.27 ENSMUST00000108193.1
ENSMUST00000108192.1
polymerase (RNA) II (DNA directed) polypeptide I
chr9_+_65141154 0.27 ENSMUST00000034961.4
immunoglobulin superfamily, DCC subclass, member 3
chr17_+_56717759 0.24 ENSMUST00000002452.6
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr8_-_4275886 0.24 ENSMUST00000003029.7
translocase of inner mitochondrial membrane 44
chr7_-_80115294 0.23 ENSMUST00000107384.3
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr2_-_152540094 0.22 ENSMUST00000060598.3
defensin beta 29
chr3_-_92827239 0.22 ENSMUST00000072363.4
keratinocyte expressed, proline-rich
chr4_-_60421933 0.21 ENSMUST00000107506.2
ENSMUST00000122381.1
ENSMUST00000118759.1
ENSMUST00000122177.1
major urinary protein 9
chr6_-_52218686 0.20 ENSMUST00000134367.2
homeobox A7
chr4_+_11758147 0.19 ENSMUST00000029871.5
ENSMUST00000108303.1
cadherin 17
chr4_-_43030440 0.18 ENSMUST00000135660.1
stomatin (Epb7.2)-like 2
chr6_+_38534823 0.17 ENSMUST00000019833.4
RIKEN cDNA 1110001J03 gene
chr2_-_119029392 0.16 ENSMUST00000036470.7
ENSMUST00000110834.1
coiled-coil domain containing 32
chr12_+_84773262 0.16 ENSMUST00000021667.5
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr8_-_22653406 0.16 ENSMUST00000033938.5
polymerase (DNA directed), beta
chr16_-_60605226 0.15 ENSMUST00000068860.6
Eph receptor A6
chr10_+_23949516 0.15 ENSMUST00000045152.4
trace amine-associated receptor 3
chr5_+_21543525 0.15 ENSMUST00000035651.4
leucine rich repeat containing 17
chr16_+_11203375 0.14 ENSMUST00000181526.1
RIKEN cDNA 2610020C07 gene
chr5_+_104046869 0.13 ENSMUST00000031250.7
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr2_-_119029359 0.13 ENSMUST00000110833.1
coiled-coil domain containing 32
chr19_-_44135816 0.13 ENSMUST00000026218.5
CWF19-like 1, cell cycle control (S. pombe)
chrX_+_31117674 0.13 ENSMUST00000179532.1
predicted gene, 21447
chr11_-_87826023 0.12 ENSMUST00000103177.3
lactoperoxidase
chr10_+_70868633 0.12 ENSMUST00000058942.5
RIKEN cDNA 4930533K18 gene
chr16_-_45724600 0.12 ENSMUST00000096057.4
transgelin 3
chr2_+_86297817 0.11 ENSMUST00000054746.2
olfactory receptor 1052
chr11_-_99230998 0.11 ENSMUST00000103133.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr7_+_30977043 0.10 ENSMUST00000058093.4
family with sequence similarity 187, member B
chr16_-_18235074 0.10 ENSMUST00000076957.5
zinc finger, DHHC domain containing 8
chr7_+_15750134 0.09 ENSMUST00000173455.1
oocyte specific homeobox 5
chr19_+_8764934 0.09 ENSMUST00000184663.1
nuclear RNA export factor 1
chr6_+_90269106 0.09 ENSMUST00000058039.2
vomeronasal 1 receptor 54
chr7_+_15750377 0.09 ENSMUST00000098802.3
ENSMUST00000173053.1
oocyte specific homeobox 5
chr10_+_100488289 0.09 ENSMUST00000164751.1
centrosomal protein 290
chr7_-_141168671 0.09 ENSMUST00000106033.3
ribonuclease/angiogenin inhibitor 1
chr7_+_14659733 0.08 ENSMUST00000069740.7
ENSMUST00000183424.1
predicted gene 4745
chr2_-_13271419 0.08 ENSMUST00000028059.2
Ras suppressor protein 1
chr4_-_116651644 0.08 ENSMUST00000030455.8
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr11_-_9039585 0.07 ENSMUST00000043377.5
Sad1 and UNC84 domain containing 3
chr14_+_57798182 0.07 ENSMUST00000111269.1
Sin3-associated polypeptide 18
chrX_-_33702349 0.07 ENSMUST00000105117.2
predicted gene 2933
chr4_-_63605126 0.07 ENSMUST00000136620.1
predicted gene 11213
chrX_+_31336454 0.06 ENSMUST00000180197.1
predicted gene 2784
chr2_-_13271268 0.06 ENSMUST00000137670.1
ENSMUST00000114791.2
Ras suppressor protein 1
chr16_-_11203259 0.06 ENSMUST00000119953.1
ribosomal L1 domain containing 1
chr9_-_35790101 0.05 ENSMUST00000034619.1
RIKEN cDNA D730048I06 gene
chr7_-_104893626 0.05 ENSMUST00000081116.1
olfactory receptor 666
chr1_+_165485168 0.05 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
adenylate cyclase 10
chr11_+_101987050 0.05 ENSMUST00000010985.7
RIKEN cDNA 1700006E09 gene
chr2_+_117249725 0.05 ENSMUST00000028825.4
family with sequence similarity 98, member B
chr5_-_106926245 0.05 ENSMUST00000117588.1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr17_-_36951636 0.05 ENSMUST00000040402.7
ENSMUST00000174711.1
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr7_-_103771594 0.04 ENSMUST00000080910.1
olfactory receptor 69
chrX_+_169685191 0.04 ENSMUST00000112104.1
ENSMUST00000112107.1
midline 1
chrX_+_32047829 0.04 ENSMUST00000178747.1
predicted gene, 21645
chr15_-_67113909 0.04 ENSMUST00000092640.5
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr14_+_57798156 0.03 ENSMUST00000128764.1
Sin3-associated polypeptide 18
chrX_-_33956540 0.03 ENSMUST00000179466.1
predicted gene 2964
chrX_+_32894625 0.03 ENSMUST00000179069.1
predicted gene, 21657
chr18_+_62180119 0.03 ENSMUST00000067743.1
predicted gene 9949
chrX_-_34161499 0.03 ENSMUST00000178219.1
predicted gene, 21681
chr15_+_82252397 0.03 ENSMUST00000136948.1
RIKEN cDNA 1500009C09 gene
chr15_+_38661904 0.03 ENSMUST00000022904.6
ATPase, H+ transporting, lysosomal V1 subunit C1
chr7_-_24724237 0.02 ENSMUST00000081657.4
predicted gene 4763
chr1_-_119504736 0.02 ENSMUST00000004565.8
v-ral simian leukemia viral oncogene homolog B (ras related)
chrX_+_33657172 0.00 ENSMUST00000177912.1
predicted gene 2927
chr1_-_118982551 0.00 ENSMUST00000159678.1
GLI-Kruppel family member GLI2
chrX_-_111536325 0.00 ENSMUST00000156639.1
ribosomal protein S6 kinase polypeptide 6
chr2_-_76868375 0.00 ENSMUST00000149616.1
ENSMUST00000152185.1
ENSMUST00000130915.1
ENSMUST00000155365.1
ENSMUST00000128071.1
titin
chr7_-_48499270 0.00 ENSMUST00000098433.3
MAS-related GPR, member X2

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 0.2 GO:1904464 regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773)
0.2 0.6 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.2 0.5 GO:0033189 response to vitamin A(GO:0033189)
0.2 0.5 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 2.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.4 GO:0033624 negative regulation of integrin activation(GO:0033624)
0.1 0.6 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.8 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.7 GO:0046208 spermine catabolic process(GO:0046208)
0.1 0.6 GO:1901979 renal sodium ion absorption(GO:0070294) regulation of inward rectifier potassium channel activity(GO:1901979)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:0090297 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.8 GO:0007320 insemination(GO:0007320)
0.1 0.3 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.2 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.0 0.1 GO:0046032 ADP catabolic process(GO:0046032)
0.0 0.3 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.3 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.0 0.1 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0036449 microtubule minus-end(GO:0036449)
0.1 2.4 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.8 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 1.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.2 1.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.6 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 0.5 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.2 0.8 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 2.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 1.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.5 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.6 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 1.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels