Motif ID: Six6

Z-value: 1.958


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_729397580.251.3e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_117797660 25.866 ENSMUST00000106331.1
6030468B19Rik
RIKEN cDNA 6030468B19 gene
chr4_+_134864536 24.451 ENSMUST00000030627.7
Rhd
Rh blood group, D antigen
chr17_+_48247759 20.754 ENSMUST00000048065.5
Trem3
triggering receptor expressed on myeloid cells 3
chr6_-_41314700 19.804 ENSMUST00000064324.5
Try5
trypsin 5
chr17_-_28560704 19.646 ENSMUST00000114785.1
ENSMUST00000025062.3
Clps

colipase, pancreatic

chr16_-_36408349 19.384 ENSMUST00000023619.6
Stfa2
stefin A2
chr6_+_41458923 18.455 ENSMUST00000031910.7
Prss1
protease, serine, 1 (trypsin 1)
chr16_-_16863975 16.485 ENSMUST00000100136.3
Igll1
immunoglobulin lambda-like polypeptide 1
chr8_+_57455898 15.983 ENSMUST00000034023.3
Scrg1
scrapie responsive gene 1
chr3_+_108364882 15.011 ENSMUST00000090563.5
Mybphl
myosin binding protein H-like
chr11_-_102365111 14.509 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr17_+_40811089 12.858 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr7_+_131032061 11.106 ENSMUST00000084509.3
Dmbt1
deleted in malignant brain tumors 1
chr15_+_79895017 10.315 ENSMUST00000023054.7
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr2_+_131491764 9.997 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr19_+_58759700 9.511 ENSMUST00000026081.3
Pnliprp2
pancreatic lipase-related protein 2
chr7_-_119459266 7.760 ENSMUST00000033255.5
Gp2
glycoprotein 2 (zymogen granule membrane)
chr7_-_100855403 7.567 ENSMUST00000156855.1
Relt
RELT tumor necrosis factor receptor
chr1_+_139454747 7.487 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr17_+_43568641 7.392 ENSMUST00000169694.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr2_+_31245801 7.314 ENSMUST00000000199.7
Ncs1
neuronal calcium sensor 1
chr17_+_43568269 7.245 ENSMUST00000024706.5
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr17_+_43568475 7.022 ENSMUST00000167418.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr17_+_43568096 6.967 ENSMUST00000167214.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr5_+_122206792 6.877 ENSMUST00000145854.1
Hvcn1
hydrogen voltage-gated channel 1
chr7_+_128062657 6.773 ENSMUST00000120355.1
ENSMUST00000106240.2
ENSMUST00000098015.3
Itgam


integrin alpha M


chr16_+_32756336 6.344 ENSMUST00000135753.1
Muc4
mucin 4
chr3_-_75270073 5.882 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr2_+_127336152 5.570 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr5_-_148371525 5.414 ENSMUST00000138596.1
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr7_+_128062635 5.391 ENSMUST00000064821.7
ENSMUST00000106242.3
Itgam

integrin alpha M

chr1_+_174158722 5.160 ENSMUST00000068403.3
Olfr420
olfactory receptor 420
chrX_-_142966709 5.062 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr6_-_40951826 4.852 ENSMUST00000073642.5
Gm4744
predicted gene 4744
chr19_+_4154606 4.831 ENSMUST00000061086.8
Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chrX_-_73659724 4.642 ENSMUST00000114473.1
ENSMUST00000002087.7
Pnck

pregnancy upregulated non-ubiquitously expressed CaM kinase

chr7_-_14123042 4.544 ENSMUST00000098809.2
Sult2a3
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr5_+_21543525 4.521 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr18_+_62180119 4.509 ENSMUST00000067743.1
Gm9949
predicted gene 9949
chr13_-_66852017 4.504 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr9_+_108991902 4.500 ENSMUST00000147989.1
ENSMUST00000051873.8
Pfkfb4

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

chr3_+_124321031 4.484 ENSMUST00000058994.4
Tram1l1
translocation associated membrane protein 1-like 1
chr7_+_128062698 4.395 ENSMUST00000119696.1
Itgam
integrin alpha M
chr5_+_122210134 4.378 ENSMUST00000100747.2
Hvcn1
hydrogen voltage-gated channel 1
chr13_-_66851513 4.266 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr6_+_123123313 4.196 ENSMUST00000041779.6
Clec4a2
C-type lectin domain family 4, member a2
chr6_+_123123423 4.173 ENSMUST00000032248.7
Clec4a2
C-type lectin domain family 4, member a2
chr7_+_81114799 4.082 ENSMUST00000026820.4
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr2_+_30281043 3.858 ENSMUST00000143119.2
RP23-395P6.9
RP23-395P6.9
chr5_+_77016023 3.851 ENSMUST00000031161.4
ENSMUST00000117880.1
1700023E05Rik

RIKEN cDNA 1700023E05 gene

chr12_-_113422730 3.799 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu

chr11_+_98412461 3.712 ENSMUST00000058295.5
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr10_+_128238034 3.666 ENSMUST00000105245.2
Timeless
timeless circadian clock 1
chr17_+_35241746 3.564 ENSMUST00000068056.5
ENSMUST00000174757.1
Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr16_+_32735886 3.430 ENSMUST00000132475.1
ENSMUST00000096106.3
Muc4

mucin 4

chr15_+_98571004 3.404 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr7_-_98178254 3.357 ENSMUST00000040971.7
Capn5
calpain 5
chr4_+_11758147 3.247 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr5_+_140607334 3.245 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_+_35241838 3.238 ENSMUST00000173731.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr3_+_87376381 3.229 ENSMUST00000163661.1
ENSMUST00000072480.2
ENSMUST00000167200.1
Fcrl1


Fc receptor-like 1


chr6_+_120093348 3.147 ENSMUST00000112711.2
Ninj2
ninjurin 2
chr13_-_49248146 3.141 ENSMUST00000119721.1
ENSMUST00000058196.6
Susd3

sushi domain containing 3

chr7_+_43437073 2.962 ENSMUST00000070518.2
Nkg7
natural killer cell group 7 sequence
chr19_-_11660516 2.927 ENSMUST00000135994.1
ENSMUST00000121793.1
ENSMUST00000069681.3
Plac1l


placenta-specific 1-like


chr9_+_106222598 2.913 ENSMUST00000062241.9
Tlr9
toll-like receptor 9
chr8_+_69832633 2.772 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4

pre B cell leukemia homeobox 4

chr7_+_46847128 2.756 ENSMUST00000005051.4
Ldha
lactate dehydrogenase A
chr13_-_56178864 2.725 ENSMUST00000169652.1
Tifab
TRAF-interacting protein with forkhead-associated domain, family member B
chr4_-_42853888 2.680 ENSMUST00000107979.1
Gm12429
predicted gene 12429
chr2_+_106693185 2.601 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr8_+_21734490 2.577 ENSMUST00000080533.5
Defa24
defensin, alpha, 24
chr3_+_92316705 2.500 ENSMUST00000061038.2
Sprr2b
small proline-rich protein 2B
chr1_-_165708088 2.497 ENSMUST00000040357.8
ENSMUST00000097474.3
Rcsd1

RCSD domain containing 1

chr6_-_50382831 2.494 ENSMUST00000114468.2
Osbpl3
oxysterol binding protein-like 3
chr16_+_23290464 2.453 ENSMUST00000115335.1
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr18_+_35553401 2.453 ENSMUST00000181664.1
Snhg4
small nucleolar RNA host gene 4 (non-protein coding)
chr10_-_86732409 2.438 ENSMUST00000070435.4
Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr11_+_106276715 2.415 ENSMUST00000044462.3
Tcam1
testicular cell adhesion molecule 1
chr6_+_48537560 2.363 ENSMUST00000040361.5
Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr5_-_108795352 2.343 ENSMUST00000004943.1
Tmed11
transmembrane emp24 protein transport domain containing
chr17_+_57279094 2.341 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
Vav1


vav 1 oncogene


chr3_-_37724321 2.328 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr7_+_19577287 2.310 ENSMUST00000108453.1
Zfp296
zinc finger protein 296
chr15_-_74763567 2.271 ENSMUST00000040404.6
Ly6d
lymphocyte antigen 6 complex, locus D
chr15_-_82244716 2.158 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr12_+_105705970 2.146 ENSMUST00000040876.5
Ak7
adenylate kinase 7
chr16_-_90810365 2.125 ENSMUST00000140920.1
Urb1
URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
chr1_-_65123108 2.090 ENSMUST00000050047.3
ENSMUST00000148020.1
D630023F18Rik

RIKEN cDNA D630023F18 gene

chr3_-_101287879 2.088 ENSMUST00000152321.1
Cd2
CD2 antigen
chr5_+_25246775 2.087 ENSMUST00000144971.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr6_-_52218686 2.087 ENSMUST00000134367.2
Hoxa7
homeobox A7
chr11_-_6230127 2.047 ENSMUST00000004505.2
Npc1l1
NPC1-like 1
chr7_+_43950614 2.031 ENSMUST00000072204.4
Klk1b8
kallikrein 1-related peptidase b8
chr3_-_101287897 2.003 ENSMUST00000029456.4
Cd2
CD2 antigen
chr11_-_8973266 1.952 ENSMUST00000154153.1
Pkd1l1
polycystic kidney disease 1 like 1
chr15_-_63902936 1.919 ENSMUST00000063530.6
Gsdmc4
gasdermin C4
chr19_+_11407652 1.914 ENSMUST00000072729.3
Ms4a4c
membrane-spanning 4-domains, subfamily A, member 4C
chr3_+_130068390 1.908 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chrX_+_159627265 1.898 ENSMUST00000112456.2
Sh3kbp1
SH3-domain kinase binding protein 1
chr19_-_32196393 1.831 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr10_-_81627797 1.827 ENSMUST00000042923.8
Sirt6
sirtuin 6
chr13_+_112800878 1.774 ENSMUST00000016144.4
Ppap2a
phosphatidic acid phosphatase type 2A
chr1_+_165485168 1.683 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
Adcy10


adenylate cyclase 10


chr7_+_66839726 1.672 ENSMUST00000098382.3
Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr17_+_17316078 1.665 ENSMUST00000105311.3
Gm6712
predicted gene 6712
chr9_-_119341390 1.632 ENSMUST00000139870.1
Myd88
myeloid differentiation primary response gene 88
chr15_+_82252397 1.615 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr1_-_128359610 1.579 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr14_+_58893465 1.501 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr1_-_165634451 1.497 ENSMUST00000111435.2
ENSMUST00000068705.7
Mpzl1

myelin protein zero-like 1

chrX_-_74373260 1.494 ENSMUST00000073067.4
ENSMUST00000037967.5
Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr11_+_115564434 1.481 ENSMUST00000021085.4
Nup85
nucleoporin 85
chr9_-_114564315 1.474 ENSMUST00000111816.2
Trim71
tripartite motif-containing 71
chr2_-_114175321 1.416 ENSMUST00000043160.6
Aqr
aquarius
chr5_+_121204477 1.410 ENSMUST00000031617.9
Rpl6
ribosomal protein L6
chr11_-_69837781 1.384 ENSMUST00000108634.2
Nlgn2
neuroligin 2
chr13_+_94083490 1.368 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr11_-_46166397 1.363 ENSMUST00000020679.2
Nipal4
NIPA-like domain containing 4
chr4_+_129906205 1.353 ENSMUST00000145196.1
ENSMUST00000141731.1
ENSMUST00000129149.1
E330017L17Rik


RIKEN cDNA E330017L17 gene


chr1_-_23922283 1.347 ENSMUST00000027339.7
Smap1
small ArfGAP 1
chr4_+_5644084 1.347 ENSMUST00000054857.6
Fam110b
family with sequence similarity 110, member B
chr8_-_106573461 1.325 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr8_+_69822429 1.231 ENSMUST00000164890.1
ENSMUST00000034325.4
Lpar2

lysophosphatidic acid receptor 2

chr6_-_57844493 1.216 ENSMUST00000081186.3
Vmn1r21
vomeronasal 1 receptor 21
chr12_-_87443800 1.188 ENSMUST00000162961.1
Alkbh1
alkB, alkylation repair homolog 1 (E. coli)
chrX_-_7947763 1.179 ENSMUST00000154244.1
Hdac6
histone deacetylase 6
chr5_+_139211934 1.174 ENSMUST00000148772.1
ENSMUST00000110882.1
Sun1

Sad1 and UNC84 domain containing 1

chr18_-_88927447 1.162 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr4_-_120951664 1.140 ENSMUST00000106280.1
Zfp69
zinc finger protein 69
chr13_+_100124850 1.116 ENSMUST00000022147.8
ENSMUST00000091321.5
ENSMUST00000143937.1
Smn1


survival motor neuron 1


chr19_-_53589067 1.100 ENSMUST00000095978.3
Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr7_-_101903783 1.096 ENSMUST00000106969.1
Tomt
transmembrane O-methyltransferase
chr18_+_74216118 1.071 ENSMUST00000025444.6
Cxxc1
CXXC finger 1 (PHD domain)
chr2_-_110950923 1.050 ENSMUST00000099623.3
Ano3
anoctamin 3
chr7_-_42578588 1.033 ENSMUST00000179470.1
Gm21028
predicted gene, 21028
chr8_+_40423786 1.014 ENSMUST00000049389.4
ENSMUST00000128166.1
ENSMUST00000167766.1
Zdhhc2


zinc finger, DHHC domain containing 2


chr19_-_11336107 1.011 ENSMUST00000056035.2
ENSMUST00000067532.4
Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr2_-_114175274 1.002 ENSMUST00000102543.4
Aqr
aquarius
chr1_+_171682004 0.999 ENSMUST00000015499.7
ENSMUST00000068584.5
Cd48

CD48 antigen

chr16_-_19515634 0.982 ENSMUST00000054606.1
Olfr167
olfactory receptor 167
chr16_+_11203375 0.968 ENSMUST00000181526.1
2610020C07Rik
RIKEN cDNA 2610020C07 gene
chrX_-_7947553 0.950 ENSMUST00000133349.1
Hdac6
histone deacetylase 6
chr10_-_97726755 0.930 ENSMUST00000166373.1
C030005K15Rik
RIKEN cDNA C030005K15 gene
chr4_+_42318334 0.925 ENSMUST00000178192.1
Gm21598
predicted gene, 21598
chr11_+_60353324 0.910 ENSMUST00000070805.6
ENSMUST00000094140.2
ENSMUST00000108723.2
ENSMUST00000108722.4
Lrrc48



leucine rich repeat containing 48



chr8_+_85026833 0.875 ENSMUST00000047281.8
2310036O22Rik
RIKEN cDNA 2310036O22 gene
chrX_-_105929397 0.822 ENSMUST00000113573.1
ENSMUST00000130980.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr1_+_40266578 0.816 ENSMUST00000114795.1
Il1r1
interleukin 1 receptor, type I
chr3_-_95133989 0.811 ENSMUST00000172572.2
ENSMUST00000173462.2
Scnm1

sodium channel modifier 1

chr11_+_101987050 0.781 ENSMUST00000010985.7
1700006E09Rik
RIKEN cDNA 1700006E09 gene
chr4_-_88676924 0.779 ENSMUST00000105148.1
Gm13280
predicted gene 13280
chr3_-_158016419 0.778 ENSMUST00000127778.1
Srsf11
serine/arginine-rich splicing factor 11
chr19_+_25672408 0.777 ENSMUST00000053068.5
Dmrt2
doublesex and mab-3 related transcription factor 2
chr11_-_87826023 0.772 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr16_+_10835046 0.759 ENSMUST00000037913.8
Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr2_-_127482499 0.733 ENSMUST00000088538.5
Kcnip3
Kv channel interacting protein 3, calsenilin
chr18_+_32815383 0.720 ENSMUST00000025237.3
Tslp
thymic stromal lymphopoietin
chr2_-_13271268 0.707 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr8_-_94918012 0.686 ENSMUST00000077955.5
Ccdc102a
coiled-coil domain containing 102A
chr6_+_57002300 0.682 ENSMUST00000079669.4
Vmn1r6
vomeronasal 1 receptor 6
chr6_+_129397297 0.664 ENSMUST00000032262.7
Clec1b
C-type lectin domain family 1, member b
chr1_-_118982551 0.642 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chr15_-_63869297 0.622 ENSMUST00000089894.5
Gsdmc3
gasdermin C3
chr12_+_87954475 0.620 ENSMUST00000181843.1
ENSMUST00000180706.1
ENSMUST00000181394.1
ENSMUST00000110145.4
ENSMUST00000181326.1
ENSMUST00000181300.1
Gm2042





predicted gene 2042





chr10_+_24595623 0.602 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr4_+_102986343 0.595 ENSMUST00000030248.5
ENSMUST00000125417.1
Tctex1d1

Tctex1 domain containing 1

chrX_-_7947848 0.590 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
Hdac6


histone deacetylase 6


chr2_-_13271419 0.584 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr12_-_103989917 0.575 ENSMUST00000151709.2
ENSMUST00000176246.1
ENSMUST00000074693.7
Serpina11


serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11


chr15_+_55557575 0.560 ENSMUST00000170046.1
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr19_-_4625612 0.536 ENSMUST00000025823.3
Rce1
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chr5_+_117319258 0.529 ENSMUST00000111967.1
Vsig10
V-set and immunoglobulin domain containing 10
chr11_-_83592981 0.523 ENSMUST00000019071.3
Ccl6
chemokine (C-C motif) ligand 6
chr14_+_55510445 0.505 ENSMUST00000165262.1
ENSMUST00000074225.4
Cpne6

copine VI

chr7_+_82611777 0.493 ENSMUST00000172784.1
Adamtsl3
ADAMTS-like 3
chr7_-_118243564 0.490 ENSMUST00000179047.1
ENSMUST00000032891.8
Smg1

SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)

chr2_-_119029359 0.482 ENSMUST00000110833.1
Ccdc32
coiled-coil domain containing 32
chrX_-_74373218 0.476 ENSMUST00000178691.1
ENSMUST00000114146.1
Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr9_+_98422961 0.469 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr8_+_21134610 0.438 ENSMUST00000098898.4
Gm15284
predicted gene 15284
chr4_+_156013835 0.402 ENSMUST00000030952.5
Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
chr1_+_60746358 0.320 ENSMUST00000027165.2
Cd28
CD28 antigen
chrX_-_12673540 0.319 ENSMUST00000060108.6
1810030O07Rik
RIKEN cDNA 1810030O07 gene
chr7_+_123123870 0.307 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr14_+_70555900 0.303 ENSMUST00000163060.1
Hr
hairless
chr12_-_103989950 0.265 ENSMUST00000120251.2
Serpina11
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr8_+_31150307 0.265 ENSMUST00000098842.2
Tti2
TELO2 interacting protein 2
chr4_+_150148905 0.236 ENSMUST00000059893.7
Slc2a7
solute carrier family 2 (facilitated glucose transporter), member 7
chr8_-_86885222 0.193 ENSMUST00000034074.7
N4bp1
NEDD4 binding protein 1
chr2_+_86074715 0.190 ENSMUST00000164985.1
Olfr1036
olfactory receptor 1036
chr11_-_4849345 0.189 ENSMUST00000053079.6
ENSMUST00000109910.2
Nf2

neurofibromatosis 2

chr1_+_60909148 0.187 ENSMUST00000097720.3
Ctla4
cytotoxic T-lymphocyte-associated protein 4
chr5_-_129879038 0.186 ENSMUST00000026617.6
Phkg1
phosphorylase kinase gamma 1
chr17_-_62606679 0.180 ENSMUST00000163332.1
Efna5
ephrin A5
chrX_+_169685191 0.160 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr19_+_8764934 0.156 ENSMUST00000184663.1
Nxf1
nuclear RNA export factor 1
chr5_-_23616528 0.147 ENSMUST00000088392.4
Srpk2
serine/arginine-rich protein specific kinase 2
chr11_-_99230998 0.143 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr5_+_140419248 0.118 ENSMUST00000100507.3
Eif3b
eukaryotic translation initiation factor 3, subunit B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 28.6 GO:0034441 plasma lipoprotein oxidation(GO:0034441)
3.0 20.8 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
2.9 37.3 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
2.4 16.6 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
1.6 9.8 GO:0002838 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
1.6 7.8 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
1.5 7.5 GO:0051661 maintenance of centrosome location(GO:0051661)
1.5 2.9 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
1.4 10.0 GO:0046208 spermine catabolic process(GO:0046208)
1.3 3.8 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
1.2 3.7 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
1.1 3.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
1.0 11.3 GO:0071294 cellular response to zinc ion(GO:0071294)
1.0 6.8 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.9 15.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.9 2.7 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.8 4.1 GO:0015855 purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.7 3.7 GO:0044849 estrous cycle(GO:0044849)
0.7 10.3 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.7 2.7 GO:0007356 thorax and anterior abdomen determination(GO:0007356)
0.7 5.4 GO:1903826 arginine transmembrane transport(GO:1903826)
0.7 2.0 GO:0003127 detection of nodal flow(GO:0003127) detection of endogenous stimulus(GO:0009726)
0.6 3.2 GO:0007386 compartment pattern specification(GO:0007386)
0.6 2.5 GO:1990743 protein sialylation(GO:1990743)
0.6 1.8 GO:1905564 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) positive regulation of vascular endothelial cell proliferation(GO:1905564) histone H3-K9 deacetylation(GO:1990619)
0.6 11.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.6 4.5 GO:0048539 bone marrow development(GO:0048539)
0.6 9.5 GO:0019377 galactolipid metabolic process(GO:0019374) glycolipid catabolic process(GO:0019377)
0.5 14.5 GO:0014823 response to activity(GO:0014823)
0.5 4.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.5 2.8 GO:0019659 fermentation(GO:0006113) L(+)-lactate biosynthetic process from pyruvate(GO:0019246) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.4 18.5 GO:0032094 response to food(GO:0032094)
0.4 16.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.4 1.6 GO:2000338 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.3 4.1 GO:2000484 positive regulation of interleukin-8 secretion(GO:2000484)
0.3 2.5 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.3 1.2 GO:0002101 tRNA wobble cytosine modification(GO:0002101) oxidative single-stranded DNA demethylation(GO:0035552)
0.3 40.0 GO:0007586 digestion(GO:0007586)
0.3 1.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 2.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.2 0.8 GO:0010286 heat acclimation(GO:0010286)
0.2 1.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 0.8 GO:0061055 myotome development(GO:0061055)
0.2 5.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 2.1 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.2 0.6 GO:0060032 notochord regression(GO:0060032)
0.2 1.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 0.5 GO:0033189 response to vitamin A(GO:0033189)
0.2 1.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 1.1 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 0.8 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.6 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 2.3 GO:0035634 response to stilbenoid(GO:0035634)
0.1 0.5 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 1.8 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 8.0 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 24.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 1.6 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 2.8 GO:0042246 tissue regeneration(GO:0042246)
0.1 2.3 GO:0045954 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.1 2.5 GO:0002437 inflammatory response to antigenic stimulus(GO:0002437)
0.1 2.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 7.3 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.1 1.4 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 1.3 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 1.9 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 1.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.5 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.2 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.5 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.1 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.0 4.8 GO:0018210 peptidyl-threonine modification(GO:0018210)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:1903978 regulation of microglial cell activation(GO:1903978)
0.0 0.7 GO:0030220 platelet formation(GO:0030220)
0.0 4.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 1.1 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 0.7 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 1.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0035330 Schwann cell proliferation(GO:0014010) regulation of hippo signaling(GO:0035330)
0.0 1.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.5 GO:0002548 monocyte chemotaxis(GO:0002548)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.8 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 0.1 GO:0033364 mast cell secretory granule organization(GO:0033364)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 11.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
1.5 7.5 GO:0036449 microtubule minus-end(GO:0036449)
1.3 28.6 GO:0034362 low-density lipoprotein particle(GO:0034362)
1.1 20.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.0 2.9 GO:0036019 endolysosome(GO:0036019)
0.7 9.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.6 15.0 GO:0005859 muscle myosin complex(GO:0005859)
0.4 4.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.4 9.8 GO:0031528 microvillus membrane(GO:0031528)
0.4 7.3 GO:0031045 dense core granule(GO:0031045)
0.4 16.6 GO:0008305 integrin complex(GO:0008305)
0.3 7.0 GO:0000346 transcription export complex(GO:0000346)
0.3 3.7 GO:0043219 lateral loop(GO:0043219)
0.3 2.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.2 1.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.2 2.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 14.5 GO:0014704 intercalated disc(GO:0014704)
0.2 2.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.5 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.1 1.4 GO:0098936 intrinsic component of postsynaptic membrane(GO:0098936) integral component of postsynaptic membrane(GO:0099055) intrinsic component of synaptic membrane(GO:0099240) integral component of synaptic membrane(GO:0099699)
0.1 2.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 2.8 GO:0001741 XY body(GO:0001741)
0.1 5.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.7 GO:0045178 basal part of cell(GO:0045178)
0.1 10.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 3.1 GO:0030139 endocytic vesicle(GO:0030139)
0.1 1.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 16.9 GO:0031965 nuclear membrane(GO:0031965)
0.1 2.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.6 GO:0097542 ciliary tip(GO:0097542)
0.0 2.6 GO:0016235 aggresome(GO:0016235)
0.0 2.0 GO:0031526 brush border membrane(GO:0031526)
0.0 10.0 GO:0044306 neuron projection terminus(GO:0044306)
0.0 1.2 GO:0001533 cornified envelope(GO:0001533)
0.0 1.4 GO:0031672 A band(GO:0031672)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 2.0 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 1.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.6 GO:0042555 MCM complex(GO:0042555) MCM core complex(GO:0097373)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 34.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.6 GO:0000776 kinetochore(GO:0000776)
0.0 0.6 GO:0001772 immunological synapse(GO:0001772)
0.0 63.1 GO:0005576 extracellular region(GO:0005576)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 10.0 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
2.9 28.6 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
2.6 10.3 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
2.4 9.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
2.4 16.6 GO:0001851 complement component C3b binding(GO:0001851)
2.3 11.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
1.7 20.8 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
1.4 4.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
1.4 6.8 GO:0030621 U4 snRNA binding(GO:0030621)
1.2 3.7 GO:0001042 RNA polymerase I core binding(GO:0001042)
1.2 37.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
1.1 3.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
1.1 3.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.8 20.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.8 15.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.8 5.4 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.7 14.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.7 2.7 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.6 4.5 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.6 9.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.6 1.8 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.6 4.0 GO:0045322 unmethylated CpG binding(GO:0045322)
0.5 2.1 GO:0004127 cytidylate kinase activity(GO:0004127)
0.5 4.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.5 2.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.4 1.6 GO:0070976 TIR domain binding(GO:0070976)
0.4 5.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 1.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.4 1.8 GO:0033188 ceramide phosphoethanolamine synthase activity(GO:0002950) sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.4 1.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206) L-dopa O-methyltransferase activity(GO:0102084)
0.3 2.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 2.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.3 0.8 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.2 8.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 1.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.2 1.4 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 19.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 12.8 GO:0003823 antigen binding(GO:0003823)
0.2 8.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 43.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.5 GO:0035198 miRNA binding(GO:0035198)
0.1 4.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 7.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 2.0 GO:0031489 myosin V binding(GO:0031489)
0.1 2.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 1.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229) intracellular chloride channel activity(GO:0061778)
0.0 0.8 GO:0043495 protein membrane anchor(GO:0043495)
0.0 1.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.5 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 1.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 1.7 GO:0030145 manganese ion binding(GO:0030145)
0.0 17.5 GO:0008047 enzyme activator activity(GO:0008047)
0.0 6.0 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 4.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 2.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.3 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.7 GO:0015459 potassium channel regulator activity(GO:0015459)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 28.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.5 16.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 3.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 3.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 27.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 7.3 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 2.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 10.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 10.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 4.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 2.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.8 PID_P73PATHWAY p73 transcription factor network
0.0 0.2 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 24.9 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6 18.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.6 10.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.5 19.6 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.4 9.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.4 12.9 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.3 4.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.3 2.7 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.2 5.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 21.0 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.2 14.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 9.5 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.2 3.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 2.8 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 3.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.2 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 4.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.9 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.1 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 2.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 2.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.9 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 2.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.8 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.9 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.2 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)