Motif ID: Sox4

Z-value: 1.471


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_289537130.711.5e-06Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103853199 16.949 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chrX_+_73639414 16.806 ENSMUST00000019701.8
Dusp9
dual specificity phosphatase 9
chr4_+_115057683 13.518 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr9_-_103480328 11.389 ENSMUST00000124310.2
Bfsp2
beaded filament structural protein 2, phakinin
chr15_+_102296256 9.382 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr5_+_115908644 9.103 ENSMUST00000141101.1
Cit
citron
chr15_-_79285502 8.699 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr7_+_45216671 8.317 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr7_+_100493795 8.135 ENSMUST00000129324.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr7_-_100514800 8.059 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr15_-_79285470 7.902 ENSMUST00000170955.1
Baiap2l2
BAI1-associated protein 2-like 2
chr13_+_117220584 7.831 ENSMUST00000022242.7
Emb
embigin
chr7_+_100494044 7.515 ENSMUST00000153287.1
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr12_+_24831583 7.390 ENSMUST00000110942.3
ENSMUST00000078902.6
Mboat2

membrane bound O-acyltransferase domain containing 2

chr5_-_122050102 7.090 ENSMUST00000154139.1
Cux2
cut-like homeobox 2
chr10_-_116473875 5.908 ENSMUST00000068233.4
Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr19_+_34922351 5.838 ENSMUST00000087341.5
Kif20b
kinesin family member 20B
chr17_+_12119274 5.776 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chrX_+_164090187 5.457 ENSMUST00000015545.3
Tmem27
transmembrane protein 27
chr19_-_46327121 5.407 ENSMUST00000041391.4
ENSMUST00000096029.5
Psd

pleckstrin and Sec7 domain containing

chr12_+_24708984 4.905 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr8_-_4259257 4.775 ENSMUST00000053252.7
Ctxn1
cortexin 1
chrX_+_159840463 4.754 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr16_+_17146937 4.736 ENSMUST00000115706.1
ENSMUST00000069064.4
Ydjc

YdjC homolog (bacterial)

chr15_-_36879816 4.551 ENSMUST00000100713.2
Gm10384
predicted gene 10384
chr18_-_15063560 4.423 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr3_+_131110350 4.390 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
Lef1


lymphoid enhancer binding factor 1


chr3_-_50443603 4.209 ENSMUST00000029297.4
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr17_-_79355082 4.040 ENSMUST00000068958.7
Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr12_-_54986363 3.950 ENSMUST00000173433.1
ENSMUST00000173803.1
Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr3_+_8509477 3.808 ENSMUST00000029002.7
Stmn2
stathmin-like 2
chr18_+_82554463 3.708 ENSMUST00000062446.7
ENSMUST00000102812.4
ENSMUST00000075372.5
ENSMUST00000080658.4
ENSMUST00000152071.1
ENSMUST00000114674.3
ENSMUST00000142850.1
ENSMUST00000133193.1
ENSMUST00000123251.1
ENSMUST00000153478.1
ENSMUST00000132369.1
Mbp










myelin basic protein










chr9_-_111057235 3.662 ENSMUST00000111888.1
Ccrl2
chemokine (C-C motif) receptor-like 2
chr17_+_75005523 3.631 ENSMUST00000001927.5
Ltbp1
latent transforming growth factor beta binding protein 1
chr11_+_54314896 3.579 ENSMUST00000072178.4
ENSMUST00000101211.2
ENSMUST00000101213.2
Acsl6


acyl-CoA synthetase long-chain family member 6


chr5_+_44100442 3.539 ENSMUST00000072800.4
Gm16401
predicted gene 16401
chr18_+_56707725 3.418 ENSMUST00000025486.8
Lmnb1
lamin B1
chr11_+_69846610 3.293 ENSMUST00000152566.1
ENSMUST00000108633.2
Plscr3

phospholipid scramblase 3

chr5_-_131538687 3.218 ENSMUST00000161374.1
Auts2
autism susceptibility candidate 2
chr11_+_69846665 3.102 ENSMUST00000019605.2
Plscr3
phospholipid scramblase 3
chr12_-_54986328 2.932 ENSMUST00000038926.6
Baz1a
bromodomain adjacent to zinc finger domain 1A
chrX_-_145505175 2.910 ENSMUST00000143610.1
Amot
angiomotin
chr6_+_17065129 2.813 ENSMUST00000115467.4
ENSMUST00000154266.2
ENSMUST00000076654.7
Tes


testis derived transcript


chr13_-_97747399 2.767 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_+_69846374 2.759 ENSMUST00000108632.1
Plscr3
phospholipid scramblase 3
chr8_-_11635745 2.726 ENSMUST00000033905.5
ENSMUST00000169782.1
Ankrd10

ankyrin repeat domain 10

chr16_-_91044473 2.597 ENSMUST00000118522.1
Paxbp1
PAX3 and PAX7 binding protein 1
chr1_+_135729147 2.544 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr4_+_127021311 2.525 ENSMUST00000030623.7
Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr13_-_97747373 2.491 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_+_54314960 2.377 ENSMUST00000064690.3
ENSMUST00000108899.1
Acsl6

acyl-CoA synthetase long-chain family member 6

chrX_-_145505136 2.299 ENSMUST00000112835.1
Amot
angiomotin
chr17_-_68004075 2.143 ENSMUST00000024840.5
Arhgap28
Rho GTPase activating protein 28
chr11_-_98625661 2.098 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr6_-_16898441 2.095 ENSMUST00000031533.7
Tfec
transcription factor EC
chr18_-_36766198 2.089 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr6_-_47594967 2.051 ENSMUST00000081721.6
ENSMUST00000114618.1
ENSMUST00000114616.1
Ezh2


enhancer of zeste homolog 2 (Drosophila)


chr15_-_79254737 2.045 ENSMUST00000039752.3
Slc16a8
solute carrier family 16 (monocarboxylic acid transporters), member 8
chr6_-_99726392 2.041 ENSMUST00000032152.8
ENSMUST00000101120.4
ENSMUST00000008273.6
Prok2


prokineticin 2


chr5_+_25246775 1.926 ENSMUST00000144971.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr7_+_99466004 1.868 ENSMUST00000037359.2
Klhl35
kelch-like 35
chr11_+_101442298 1.814 ENSMUST00000077856.6
Rpl27
ribosomal protein L27
chr17_-_35704574 1.692 ENSMUST00000117301.1
ENSMUST00000134995.1
Ddr1

discoidin domain receptor family, member 1

chr9_-_32541589 1.682 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr11_+_101442440 1.602 ENSMUST00000107249.1
Rpl27
ribosomal protein L27
chr5_+_19907502 1.601 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr11_-_106159902 1.576 ENSMUST00000064545.4
Limd2
LIM domain containing 2
chr3_-_95133989 1.561 ENSMUST00000172572.2
ENSMUST00000173462.2
Scnm1

sodium channel modifier 1

chr6_+_4903298 1.532 ENSMUST00000035813.2
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr5_+_25247344 1.514 ENSMUST00000114950.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr18_-_62756275 1.328 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr2_-_143862933 1.324 ENSMUST00000099296.3
Bfsp1
beaded filament structural protein 1, in lens-CP94
chr11_+_70432627 1.300 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
Arrb2






arrestin, beta 2






chrX_+_71556874 1.286 ENSMUST00000123100.1
Hmgb3
high mobility group box 3
chr4_+_136286061 1.263 ENSMUST00000069195.4
ENSMUST00000130658.1
Zfp46

zinc finger protein 46

chr14_+_54936456 1.255 ENSMUST00000037814.6
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr11_-_106160101 1.198 ENSMUST00000045923.3
Limd2
LIM domain containing 2
chr1_-_153487639 1.184 ENSMUST00000042141.5
Dhx9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr2_-_26910569 1.118 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22


mediator complex subunit 22


chr1_-_55027473 1.105 ENSMUST00000027127.7
Sf3b1
splicing factor 3b, subunit 1
chr4_-_129742275 1.099 ENSMUST00000066257.5
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
chr17_-_27622785 1.041 ENSMUST00000176458.1
ENSMUST00000114886.1
Nudt3

nudix (nucleotide diphosphate linked moiety X)-type motif 3

chr4_+_150148905 0.990 ENSMUST00000059893.7
Slc2a7
solute carrier family 2 (facilitated glucose transporter), member 7
chr16_+_84834901 0.948 ENSMUST00000114184.1
Gabpa
GA repeat binding protein, alpha
chrX_+_133850980 0.927 ENSMUST00000033602.8
Tnmd
tenomodulin
chr11_+_121237216 0.888 ENSMUST00000103015.3
Narf
nuclear prelamin A recognition factor
chr17_-_35697971 0.878 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr2_-_165898951 0.877 ENSMUST00000136842.1
Zmynd8
zinc finger, MYND-type containing 8
chr6_-_38875965 0.870 ENSMUST00000160360.1
Hipk2
homeodomain interacting protein kinase 2
chr1_-_36557517 0.830 ENSMUST00000114990.1
ENSMUST00000128104.1
ENSMUST00000027295.4
Sema4c


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C


chr16_+_20516962 0.815 ENSMUST00000003318.5
Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr16_+_17070220 0.785 ENSMUST00000141959.1
Ypel1
yippee-like 1 (Drosophila)
chr13_-_54749849 0.699 ENSMUST00000135343.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr1_+_153665274 0.680 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chrX_-_10117597 0.658 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
Srpx


sushi-repeat-containing protein


chr12_-_112673944 0.610 ENSMUST00000130342.1
Akt1
thymoma viral proto-oncogene 1
chr11_-_114066174 0.551 ENSMUST00000041627.7
Sdk2
sidekick homolog 2 (chicken)
chr11_-_85139939 0.491 ENSMUST00000108075.2
Usp32
ubiquitin specific peptidase 32
chr16_+_20517000 0.490 ENSMUST00000171572.1
Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr4_+_83417715 0.476 ENSMUST00000030206.3
ENSMUST00000071544.4
Snapc3

small nuclear RNA activating complex, polypeptide 3

chr12_-_112674193 0.453 ENSMUST00000001780.3
Akt1
thymoma viral proto-oncogene 1
chr8_+_81856324 0.434 ENSMUST00000109851.2
Inpp4b
inositol polyphosphate-4-phosphatase, type II
chr2_+_32570858 0.432 ENSMUST00000140592.1
ENSMUST00000028151.6
Dpm2

dolichol-phosphate (beta-D) mannosyltransferase 2

chr5_+_20702129 0.393 ENSMUST00000101556.4
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_-_116473418 0.365 ENSMUST00000087965.4
ENSMUST00000164271.1
Kcnmb4

potassium large conductance calcium-activated channel, subfamily M, beta member 4

chr18_+_37496997 0.343 ENSMUST00000059571.5
Pcdhb19
protocadherin beta 19
chr11_-_115813621 0.339 ENSMUST00000041684.4
ENSMUST00000156812.1
Caskin2

CASK-interacting protein 2

chr3_+_89164790 0.320 ENSMUST00000121212.2
ENSMUST00000152205.1
ENSMUST00000090927.5
ENSMUST00000148265.1
ENSMUST00000121931.1
Clk2




CDC-like kinase 2




chr17_-_35704000 0.317 ENSMUST00000097333.3
ENSMUST00000003628.6
Ddr1

discoidin domain receptor family, member 1

chr1_-_93101854 0.269 ENSMUST00000171796.1
ENSMUST00000171556.1
Kif1a

kinesin family member 1A

chr11_-_78497734 0.242 ENSMUST00000061174.6
Sarm1
sterile alpha and HEAT/Armadillo motif containing 1
chr5_-_24445254 0.233 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr1_-_93101825 0.230 ENSMUST00000112958.2
Kif1a
kinesin family member 1A
chr17_+_68837062 0.183 ENSMUST00000178545.1
Tmem200c
transmembrane protein 200C
chr12_-_79296266 0.149 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr5_-_114380459 0.139 ENSMUST00000001125.5
Kctd10
potassium channel tetramerisation domain containing 10
chr5_-_114380505 0.117 ENSMUST00000102581.4
Kctd10
potassium channel tetramerisation domain containing 10
chr16_+_84835070 0.108 ENSMUST00000009120.7
Gabpa
GA repeat binding protein, alpha
chr1_+_174430430 0.081 ENSMUST00000053178.4
Olfr414
olfactory receptor 414
chr6_-_39557830 0.076 ENSMUST00000036877.3
ENSMUST00000154149.1
Dennd2a

DENN/MADD domain containing 2A

chr5_-_24445166 0.030 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr18_+_37300799 0.030 ENSMUST00000051754.1
Pcdhb3
protocadherin beta 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0060217 hemangioblast cell differentiation(GO:0060217)
2.7 8.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
2.1 16.9 GO:0015671 oxygen transport(GO:0015671)
1.9 5.8 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
1.3 5.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
1.2 3.7 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
1.1 3.4 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.1 4.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
1.1 3.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.0 6.0 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
1.0 3.8 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.9 15.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.8 9.9 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.7 16.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.7 12.7 GO:0070307 lens fiber cell development(GO:0070307)
0.7 2.1 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.7 2.0 GO:0060983 epicardium-derived cardiac vascular smooth muscle cell differentiation(GO:0060983)
0.6 5.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.6 6.3 GO:0005513 detection of calcium ion(GO:0005513)
0.6 9.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.5 16.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.5 2.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 3.4 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.4 1.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.4 9.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.4 1.5 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.4 2.5 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.3 1.0 GO:0071544 diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.3 9.2 GO:0017121 phospholipid scrambling(GO:0017121)
0.3 4.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.3 8.3 GO:0048368 lateral mesoderm development(GO:0048368)
0.3 6.8 GO:0007614 short-term memory(GO:0007614)
0.3 1.1 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.3 4.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 1.1 GO:0060709 glycogen cell differentiation involved in embryonic placenta development(GO:0060709)
0.3 1.3 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.2 1.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 2.6 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.2 2.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 2.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 4.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 1.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 5.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 0.9 GO:1903756 regulation of postsynaptic density protein 95 clustering(GO:1902897) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 0.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 2.1 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.1 1.1 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.1 3.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.9 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 1.3 GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953)
0.1 1.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 14.0 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.1 0.7 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.5 GO:0009301 snRNA transcription(GO:0009301)
0.0 6.9 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 3.7 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.8 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 2.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.5 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.5 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 4.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.1 GO:0001825 blastocyst formation(GO:0001825)
0.0 0.6 GO:0010842 retina layer formation(GO:0010842)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0033193 Lsd1/2 complex(GO:0033193)
2.8 8.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.1 16.9 GO:0005833 hemoglobin complex(GO:0005833)
1.7 6.9 GO:0008623 CHRAC(GO:0008623)
1.4 16.6 GO:0071439 clathrin complex(GO:0071439)
1.2 3.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
1.0 4.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.6 4.3 GO:0005638 lamin filament(GO:0005638)
0.6 5.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.5 3.7 GO:0033269 internode region of axon(GO:0033269)
0.4 5.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.4 4.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.3 2.5 GO:0042382 paraspeckles(GO:0042382)
0.3 1.5 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 1.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 9.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 2.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 9.4 GO:0072686 mitotic spindle(GO:0072686)
0.1 12.7 GO:0005882 intermediate filament(GO:0005882)
0.1 5.2 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 2.1 GO:0045120 pronucleus(GO:0045120)
0.1 1.1 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 5.9 GO:0097540 sperm flagellum(GO:0036126) axonemal central pair(GO:0097540) axonemal outer doublet(GO:0097545) A axonemal microtubule(GO:0097649) B axonemal microtubule(GO:0097650) 9+2 motile cilium(GO:0097729) C1 axonemal microtubule(GO:1990719) C2 axonemal microtubule(GO:1990720)
0.1 6.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 5.5 GO:0031526 brush border membrane(GO:0031526)
0.1 11.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 6.1 GO:0030139 endocytic vesicle(GO:0030139)
0.0 2.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 11.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.1 GO:0016592 mediator complex(GO:0016592) core mediator complex(GO:0070847)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.8 GO:0030027 lamellipodium(GO:0030027)
0.0 7.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.7 GO:0005776 autophagosome(GO:0005776)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 16.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.2 7.4 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
1.2 15.7 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.1 16.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.0 5.2 GO:0043532 angiostatin binding(GO:0043532)
1.0 4.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 3.6 GO:0050436 microfibril binding(GO:0050436)
0.8 5.5 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.7 4.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 4.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.6 12.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.4 1.2 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.4 8.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 9.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 2.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 6.0 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.3 2.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3 2.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 5.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 2.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 13.5 GO:0070888 E-box binding(GO:0070888)
0.2 3.7 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.2 6.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 4.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 1.0 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.2 5.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 3.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 5.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.4 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 0.4 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 3.4 GO:0043274 phospholipase binding(GO:0043274)
0.1 9.1 GO:0097110 scaffold protein binding(GO:0097110)
0.1 1.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.1 0.9 GO:0046790 virion binding(GO:0046790)
0.1 8.1 GO:0051082 unfolded protein binding(GO:0051082)
0.1 2.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907) G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.0 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 3.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.9 GO:0005521 lamin binding(GO:0005521)
0.0 0.9 GO:0070577 lysine-acetylated histone binding(GO:0070577) acetylation-dependent protein binding(GO:0140033)
0.0 13.6 GO:0005543 phospholipid binding(GO:0005543)
0.0 4.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 4.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 3.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 4.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 6.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 16.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 9.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 4.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.3 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 3.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 4.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 4.8 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 4.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.2 4.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 6.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 8.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 5.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 6.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 5.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 6.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 11.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 4.8 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.1 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.0 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 3.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 3.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 3.4 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.1 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 2.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane