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GSE58827: Dynamics of the Mouse Liver

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Results for Sox7

Z-value: 0.56

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Transcription factors associated with Sox7

Gene Symbol Gene ID Gene Info
Sox7
ENSMUSG00000063060.5 SRY (sex determining region Y)-box 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox7mm10_v2_chr14_+_63943666_63943687-0.316.5e-02Click!

Activity profile of Sox7 motif

Sorted Z-values of Sox7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_14446570 6.53 ENSMUST00000063509.4
2810007J24Rik
RIKEN cDNA 2810007J24 gene
chr7_-_14446651 6.20 ENSMUST00000125941.1
2810007J24Rik
RIKEN cDNA 2810007J24 gene
chr3_+_146597077 2.25 ENSMUST00000029837.7
ENSMUST00000121133.1
Uox
urate oxidase
chr7_+_100022099 2.23 ENSMUST00000144808.1
Chrdl2
chordin-like 2
chr14_+_66140919 2.15 ENSMUST00000022620.9
Chrna2
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
chr11_-_46389509 1.76 ENSMUST00000020664.6
Itk
IL2 inducible T cell kinase
chr18_+_12741324 1.65 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr
calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
chr11_-_46389471 1.61 ENSMUST00000109237.2
Itk
IL2 inducible T cell kinase
chr1_-_136960427 1.55 ENSMUST00000027649.7
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr3_-_146596588 1.48 ENSMUST00000029836.4
Dnase2b
deoxyribonuclease II beta
chr2_-_120314141 1.34 ENSMUST00000054651.7
Pla2g4f
phospholipase A2, group IVF
chr9_+_50575273 1.25 ENSMUST00000059081.6
ENSMUST00000180021.1
Il18
interleukin 18
chr11_-_46389454 1.22 ENSMUST00000101306.3
Itk
IL2 inducible T cell kinase
chr19_+_26623419 1.13 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_15055274 1.11 ENSMUST00000069870.3
Arl5b
ADP-ribosylation factor-like 5B
chr12_-_75735729 1.10 ENSMUST00000021450.4
Sgpp1
sphingosine-1-phosphate phosphatase 1
chr1_+_140443101 0.94 ENSMUST00000145077.1
Kcnt2
potassium channel, subfamily T, member 2
chr7_-_48643801 0.93 ENSMUST00000094383.1
Mrgprb3
MAS-related GPR, member B3
chr2_+_38511643 0.90 ENSMUST00000054234.3
ENSMUST00000112902.1
ENSMUST00000112895.1
Nek6
NIMA (never in mitosis gene a)-related expressed kinase 6
chr7_-_99182681 0.83 ENSMUST00000033001.4
Dgat2
diacylglycerol O-acyltransferase 2
chr14_+_64652524 0.77 ENSMUST00000100473.4
Kif13b
kinesin family member 13B
chr3_+_60006743 0.75 ENSMUST00000169794.1
Aadacl2
arylacetamide deacetylase-like 2
chr5_-_107875035 0.68 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5
ecotropic viral integration site 5
chr2_-_6130117 0.63 ENSMUST00000126551.1
ENSMUST00000054254.5
ENSMUST00000114942.2
Proser2
proline and serine rich 2
chr17_+_34325658 0.63 ENSMUST00000050325.8
H2-Eb2
histocompatibility 2, class II antigen E beta2
chrX_-_48513518 0.62 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
chr1_+_107361929 0.57 ENSMUST00000027566.2
Serpinb11
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
chr6_+_48684544 0.52 ENSMUST00000118802.1
Gimap4
GTPase, IMAP family member 4
chr6_+_48684570 0.49 ENSMUST00000067506.7
ENSMUST00000119575.1
ENSMUST00000114527.2
ENSMUST00000121957.1
ENSMUST00000090070.5
Gimap4
GTPase, IMAP family member 4
chrX_-_37168829 0.47 ENSMUST00000046557.5
Akap14
A kinase (PRKA) anchor protein 14
chr5_+_8893677 0.44 ENSMUST00000003717.8
Abcb4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr10_-_100397072 0.43 ENSMUST00000167995.1
Gm4781
predicted gene 4781
chr3_-_19264959 0.41 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chrX_+_103422010 0.38 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr6_-_90036841 0.37 ENSMUST00000073415.1
Vmn1r48
vomeronasal 1 receptor 48
chr8_+_106935720 0.33 ENSMUST00000047425.3
Sntb2
syntrophin, basic 2
chr14_+_53469756 0.31 ENSMUST00000103643.2
Trav8-1
T cell receptor alpha variable 8-1
chr7_+_78578830 0.27 ENSMUST00000064591.4
Gm9885
predicted gene 9885
chr7_-_7247328 0.26 ENSMUST00000170922.1
Vmn2r29
vomeronasal 2, receptor 29
chr2_+_93452796 0.24 ENSMUST00000099693.2
ENSMUST00000162565.1
ENSMUST00000163052.1
Gm10804
predicted gene 10804
chr12_-_20900867 0.22 ENSMUST00000079237.5
Zfp125
zinc finger protein 125
chr2_+_19344317 0.21 ENSMUST00000141289.1
4930447M23Rik
RIKEN cDNA 4930447M23 gene
chr16_+_8637674 0.20 ENSMUST00000023396.9
Pmm2
phosphomannomutase 2
chr6_-_123533406 0.19 ENSMUST00000163607.1
Vmn2r21
vomeronasal 2, receptor 21
chr7_+_45514581 0.19 ENSMUST00000151506.1
ENSMUST00000085331.5
ENSMUST00000126061.1
Tulp2
tubby-like protein 2
chr9_+_38773088 0.18 ENSMUST00000062124.3
Olfr921
olfactory receptor 921
chr17_+_50239202 0.17 ENSMUST00000180996.1
AY702103
cDNA sequence AY702103
chr13_-_4150628 0.16 ENSMUST00000110704.2
ENSMUST00000021635.7
Akr1c18
aldo-keto reductase family 1, member C18
chr10_-_79614012 0.15 ENSMUST00000059699.7
ENSMUST00000178228.1
C2cd4c
C2 calcium-dependent domain containing 4C
chr9_-_101198999 0.14 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr6_-_123418061 0.14 ENSMUST00000172199.1
Vmn2r20
vomeronasal 2, receptor 20
chr7_-_8383238 0.13 ENSMUST00000166499.1
Vmn2r44
vomeronasal 2, receptor 44
chr2_+_37065746 0.12 ENSMUST00000120505.1
Olfr360
olfactory receptor 360
chr2_+_86297817 0.11 ENSMUST00000054746.2
Olfr1052
olfactory receptor 1052
chr1_+_169929929 0.11 ENSMUST00000175731.1
1700084C01Rik
RIKEN cDNA 1700084C01 gene
chr7_+_43609907 0.10 ENSMUST00000116324.2
Zfp819
zinc finger protein 819
chr9_-_35648193 0.09 ENSMUST00000178236.1
Gm17365
predicted gene, 17365
chr10_-_107912134 0.09 ENSMUST00000165341.3
Otogl
otogelin-like
chr10_+_31248140 0.06 ENSMUST00000050717.8
Gm5422
predicted pseudogene 5422
chr9_+_123767211 0.04 ENSMUST00000166236.1
ENSMUST00000111454.2
ENSMUST00000168910.1
Ccr9
chemokine (C-C motif) receptor 9
chr2_+_150190393 0.04 ENSMUST00000109929.2
Gm14139
predicted gene 14139
chr7_+_16721929 0.03 ENSMUST00000001984.3
Ceacam9
carcinoembryonic antigen-related cell adhesion molecule 9
chr7_-_25718976 0.01 ENSMUST00000002683.2
Ccdc97
coiled-coil domain containing 97
chr3_-_30140407 0.00 ENSMUST00000108271.3
Mecom
MDS1 and EVI1 complex locus
chr7_-_7819867 0.00 ENSMUST00000169683.1
Vmn2r35
vomeronasal 2, receptor 35

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.3 1.1 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.3 4.6 GO:0001865 NK T cell differentiation(GO:0001865)
0.2 1.5 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 2.2 GO:0046415 urate metabolic process(GO:0046415)
0.1 1.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 2.1 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 0.8 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.1 1.3 GO:0071236 cellular response to antibiotic(GO:0071236)
0.1 0.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 2.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.4 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 0.2 GO:0009753 sesquiterpenoid metabolic process(GO:0006714) response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 1.7 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 2.2 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.9 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 0.0 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.4 GO:0019236 response to pheromone(GO:0019236)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.1 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.8 GO:0033270 paranode region of axon(GO:0033270)
0.0 4.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.3 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.3 2.2 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.3 0.8 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.1 1.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.6 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 2.2 GO:0042166 acetylcholine binding(GO:0042166)
0.1 0.4 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 4.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.2 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.0 0.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 1.5 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.4 GO:0016503 pheromone receptor activity(GO:0016503)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 4.6 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.1 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.8 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.7 PID AURORA B PATHWAY Aurora B signaling
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 2.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.3 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 1.5 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis