Motif ID: Spib

Z-value: 2.804


Transcription factors associated with Spib:

Gene SymbolEntrez IDGene Name
Spib ENSMUSG00000008193.7 Spib

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spibmm10_v2_chr7_-_44532064_445320780.812.3e-09Click!


Activity profile for motif Spib.

activity profile for motif Spib


Sorted Z-values histogram for motif Spib

Sorted Z-values for motif Spib



Network of associatons between targets according to the STRING database.



First level regulatory network of Spib

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_80000292 24.318 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chrX_-_7964166 23.129 ENSMUST00000128449.1
Gata1
GATA binding protein 1
chr17_+_48232755 17.081 ENSMUST00000113251.3
ENSMUST00000048782.6
Trem1

triggering receptor expressed on myeloid cells 1

chr15_-_66812593 14.794 ENSMUST00000100572.3
Sla
src-like adaptor
chr1_+_174172738 14.516 ENSMUST00000027817.7
Spta1
spectrin alpha, erythrocytic 1
chr11_-_17008647 14.238 ENSMUST00000102881.3
Plek
pleckstrin
chr7_-_100856289 14.130 ENSMUST00000139604.1
Relt
RELT tumor necrosis factor receptor
chr11_+_11685909 13.176 ENSMUST00000065433.5
Ikzf1
IKAROS family zinc finger 1
chr1_+_171767123 12.756 ENSMUST00000015460.4
Slamf1
signaling lymphocytic activation molecule family member 1
chr9_+_56089962 12.385 ENSMUST00000059206.7
Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
chr5_-_134229581 12.182 ENSMUST00000111275.1
ENSMUST00000016094.6
ENSMUST00000144086.1
Ncf1


neutrophil cytosolic factor 1


chr5_+_149265035 11.421 ENSMUST00000130144.1
ENSMUST00000071130.3
Alox5ap

arachidonate 5-lipoxygenase activating protein

chr7_-_126704736 11.156 ENSMUST00000131415.1
Coro1a
coronin, actin binding protein 1A
chr2_+_25423234 10.959 ENSMUST00000134259.1
ENSMUST00000100320.4
Fut7

fucosyltransferase 7

chr2_-_181691771 10.896 ENSMUST00000108778.1
ENSMUST00000165416.1
Rgs19

regulator of G-protein signaling 19

chr2_-_165400398 10.261 ENSMUST00000029213.4
Ocstamp
osteoclast stimulatory transmembrane protein
chr8_+_72189613 10.197 ENSMUST00000072097.6
Hsh2d
hematopoietic SH2 domain containing
chr16_-_22657182 10.090 ENSMUST00000023578.7
Dgkg
diacylglycerol kinase, gamma
chr15_-_78305603 9.854 ENSMUST00000096356.3
Csf2rb2
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr13_+_30749226 9.771 ENSMUST00000021784.2
ENSMUST00000110307.1
Irf4

interferon regulatory factor 4

chr12_-_32208470 9.502 ENSMUST00000085469.5
Pik3cg
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr13_-_23465872 9.221 ENSMUST00000041674.7
Btn1a1
butyrophilin, subfamily 1, member A1
chr1_-_170927567 9.160 ENSMUST00000046322.7
ENSMUST00000159171.1
Fcrla

Fc receptor-like A

chr3_-_105932664 9.144 ENSMUST00000098758.2
I830077J02Rik
RIKEN cDNA I830077J02 gene
chr6_-_136941694 9.122 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_24345282 9.021 ENSMUST00000114485.2
Il1rn
interleukin 1 receptor antagonist
chr7_+_99535439 9.001 ENSMUST00000098266.2
ENSMUST00000179755.1
Arrb1

arrestin, beta 1

chr9_-_66919646 8.876 ENSMUST00000041139.7
Rab8b
RAB8B, member RAS oncogene family
chr7_+_43408187 8.840 ENSMUST00000005592.6
Siglecg
sialic acid binding Ig-like lectin G
chr16_-_22657165 8.679 ENSMUST00000089925.3
Dgkg
diacylglycerol kinase, gamma
chr7_-_126704522 8.625 ENSMUST00000135087.1
Coro1a
coronin, actin binding protein 1A
chr2_+_24345305 8.540 ENSMUST00000114482.1
Il1rn
interleukin 1 receptor antagonist
chr13_-_113100971 8.372 ENSMUST00000023897.5
Gzma
granzyme A
chr1_-_170927540 8.297 ENSMUST00000162136.1
ENSMUST00000162887.1
Fcrla

Fc receptor-like A

chr13_+_104228929 8.198 ENSMUST00000070761.3
Cenpk
centromere protein K
chr10_-_6980376 8.151 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr17_+_34604262 8.114 ENSMUST00000174041.1
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr7_-_45239041 8.000 ENSMUST00000131290.1
Cd37
CD37 antigen
chr12_-_32208609 7.990 ENSMUST00000053215.7
Pik3cg
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr4_-_116123618 7.946 ENSMUST00000102704.3
ENSMUST00000102705.3
Rad54l

RAD54 like (S. cerevisiae)

chr7_-_45238794 7.855 ENSMUST00000098461.1
ENSMUST00000107797.1
Cd37

CD37 antigen

chr7_-_126704179 7.678 ENSMUST00000106364.1
Coro1a
coronin, actin binding protein 1A
chr19_+_6084983 7.674 ENSMUST00000025704.2
Cdca5
cell division cycle associated 5
chrX_+_20703906 7.605 ENSMUST00000033383.2
Usp11
ubiquitin specific peptidase 11
chr10_+_130322845 7.503 ENSMUST00000042586.8
Tespa1
thymocyte expressed, positive selection associated 1
chr1_-_38664947 7.230 ENSMUST00000039827.7
ENSMUST00000027250.7
Aff3

AF4/FMR2 family, member 3

chr2_-_181693810 7.211 ENSMUST00000108776.1
ENSMUST00000108771.1
ENSMUST00000108779.1
ENSMUST00000108769.1
ENSMUST00000108772.1
ENSMUST00000002532.2
Rgs19





regulator of G-protein signaling 19





chr19_+_4154606 7.200 ENSMUST00000061086.8
Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr15_+_78325990 7.053 ENSMUST00000096355.3
Csf2rb
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr11_-_34783850 6.961 ENSMUST00000093193.5
ENSMUST00000101365.2
Dock2

dedicator of cyto-kinesis 2

chr7_-_45239108 6.949 ENSMUST00000033063.6
Cd37
CD37 antigen
chr5_+_134676490 6.947 ENSMUST00000100641.2
Gm10369
predicted gene 10369
chr2_+_36216749 6.938 ENSMUST00000147012.1
ENSMUST00000122948.1
Gm13431

predicted gene 13431

chr17_+_57279094 6.921 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
Vav1


vav 1 oncogene


chr10_+_81257277 6.855 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
Matk


megakaryocyte-associated tyrosine kinase


chr6_-_136941494 6.666 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr15_+_103453782 6.606 ENSMUST00000047405.7
Nckap1l
NCK associated protein 1 like
chr6_+_38918969 6.566 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr5_+_118560719 6.564 ENSMUST00000100816.4
Med13l
mediator complex subunit 13-like
chr2_+_22774081 6.544 ENSMUST00000014290.8
Apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr2_+_91650116 6.473 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr6_+_60944472 6.429 ENSMUST00000129603.1
Mmrn1
multimerin 1
chr13_+_20794119 6.271 ENSMUST00000021757.3
Aoah
acyloxyacyl hydrolase
chr15_-_78572754 6.204 ENSMUST00000043214.6
Rac2
RAS-related C3 botulinum substrate 2
chr8_+_79028317 6.142 ENSMUST00000087927.4
ENSMUST00000098614.2
Zfp827

zinc finger protein 827

chr13_-_23465895 6.119 ENSMUST00000110434.1
Btn1a1
butyrophilin, subfamily 1, member A1
chrX_+_159708593 6.066 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr15_-_83033294 6.031 ENSMUST00000100377.4
Nfam1
Nfat activating molecule with ITAM motif 1
chr3_+_83766300 6.023 ENSMUST00000029625.7
Sfrp2
secreted frizzled-related protein 2
chr1_-_171059390 5.954 ENSMUST00000164044.1
ENSMUST00000169017.1
Fcgr3

Fc receptor, IgG, low affinity III

chr1_-_173333503 5.914 ENSMUST00000038227.4
Darc
Duffy blood group, chemokine receptor
chr6_+_129350237 5.908 ENSMUST00000065289.4
Clec12a
C-type lectin domain family 12, member a
chr1_-_45503282 5.888 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr2_+_156840966 5.870 ENSMUST00000109564.1
Tgif2
TGFB-induced factor homeobox 2
chr12_-_78980758 5.868 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr11_+_70130329 5.817 ENSMUST00000041550.5
ENSMUST00000165951.1
Mgl2

macrophage galactose N-acetyl-galactosamine specific lectin 2

chr7_-_80387935 5.658 ENSMUST00000080932.6
Fes
feline sarcoma oncogene
chr2_+_43748802 5.619 ENSMUST00000112824.1
ENSMUST00000055776.7
Arhgap15

Rho GTPase activating protein 15

chr15_-_36608959 5.615 ENSMUST00000001809.8
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr17_+_7925990 5.590 ENSMUST00000036370.7
Tagap
T cell activation Rho GTPase activating protein
chr17_+_35049966 5.541 ENSMUST00000007257.9
Clic1
chloride intracellular channel 1
chr10_-_62508097 5.520 ENSMUST00000159020.1
Srgn
serglycin
chr7_-_3720382 5.481 ENSMUST00000078451.6
Pirb
paired Ig-like receptor B
chr16_-_89960815 5.473 ENSMUST00000002588.3
Tiam1
T cell lymphoma invasion and metastasis 1
chr4_+_140701466 5.381 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr11_-_103344651 5.325 ENSMUST00000041385.7
Arhgap27
Rho GTPase activating protein 27
chr3_+_99253754 5.304 ENSMUST00000029462.5
Tbx15
T-box 15
chr6_-_124733067 5.218 ENSMUST00000173647.1
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr2_+_91650169 5.177 ENSMUST00000090614.4
Arhgap1
Rho GTPase activating protein 1
chr2_+_120463566 4.949 ENSMUST00000028749.7
ENSMUST00000110721.1
Capn3

calpain 3

chr8_-_88636117 4.930 ENSMUST00000034087.7
Snx20
sorting nexin 20
chr15_-_9529868 4.921 ENSMUST00000003981.4
Il7r
interleukin 7 receptor
chr2_+_24386604 4.897 ENSMUST00000166388.1
Psd4
pleckstrin and Sec7 domain containing 4
chr17_-_67950908 4.857 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr14_+_67745229 4.834 ENSMUST00000111095.2
Gnrh1
gonadotropin releasing hormone 1
chr15_-_81045467 4.812 ENSMUST00000135047.1
Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr2_-_39005574 4.741 ENSMUST00000080861.5
Rpl35
ribosomal protein L35
chr11_+_46454957 4.727 ENSMUST00000109229.1
Havcr2
hepatitis A virus cellular receptor 2
chr5_-_116024475 4.650 ENSMUST00000111999.1
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr11_+_46454921 4.559 ENSMUST00000020668.8
Havcr2
hepatitis A virus cellular receptor 2
chr9_+_124101944 4.552 ENSMUST00000171719.1
Ccr2
chemokine (C-C motif) receptor 2
chr16_-_36642742 4.547 ENSMUST00000135280.1
Cd86
CD86 antigen
chr4_+_130913264 4.496 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr9_+_106203108 4.476 ENSMUST00000024047.5
Twf2
twinfilin, actin-binding protein, homolog 2 (Drosophila)
chr2_-_93046053 4.447 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
Prdm11


PR domain containing 11


chr16_-_92826004 4.429 ENSMUST00000023673.7
Runx1
runt related transcription factor 1
chr1_+_87620306 4.406 ENSMUST00000169754.1
Inpp5d
inositol polyphosphate-5-phosphatase D
chr9_+_124102110 4.391 ENSMUST00000168841.1
ENSMUST00000055918.6
Ccr2

chemokine (C-C motif) receptor 2

chr5_-_38876693 4.370 ENSMUST00000169819.1
ENSMUST00000171633.1
Clnk

cytokine-dependent hematopoietic cell linker

chr1_+_87620334 4.364 ENSMUST00000042275.8
ENSMUST00000168783.1
Inpp5d

inositol polyphosphate-5-phosphatase D

chr11_+_46810792 4.271 ENSMUST00000068877.6
Timd4
T cell immunoglobulin and mucin domain containing 4
chr13_+_23544052 4.260 ENSMUST00000075558.2
Hist1h3f
histone cluster 1, H3f
chr19_+_12846773 4.252 ENSMUST00000164001.1
Gm5244
predicted pseudogene 5244
chr15_+_58510037 4.220 ENSMUST00000161028.1
Fer1l6
fer-1-like 6 (C. elegans)
chr3_-_59210881 4.167 ENSMUST00000040622.1
P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr3_-_101029543 4.163 ENSMUST00000147399.2
Cd101
CD101 antigen
chr3_-_95142346 4.128 ENSMUST00000013851.3
Tnfaip8l2
tumor necrosis factor, alpha-induced protein 8-like 2
chr7_-_29232478 4.115 ENSMUST00000085818.4
Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
chr5_+_86071734 4.104 ENSMUST00000031171.7
Stap1
signal transducing adaptor family member 1
chr7_-_3898120 4.093 ENSMUST00000070639.7
Gm14548
predicted gene 14548
chrX_+_166344692 3.987 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chr4_-_92191749 3.976 ENSMUST00000123179.1
Gm12666
predicted gene 12666
chr4_+_119195496 3.900 ENSMUST00000097908.3
Ccdc23
coiled-coil domain containing 23
chr8_+_10006656 3.889 ENSMUST00000033892.7
Tnfsf13b
tumor necrosis factor (ligand) superfamily, member 13b
chr1_-_149961230 3.813 ENSMUST00000070200.8
Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr19_+_6399857 3.804 ENSMUST00000146601.1
ENSMUST00000150713.1
Rasgrp2

RAS, guanyl releasing protein 2

chr5_+_81021202 3.753 ENSMUST00000117253.1
ENSMUST00000120128.1
Lphn3

latrophilin 3

chr8_+_94745590 3.726 ENSMUST00000034231.3
Ccl22
chemokine (C-C motif) ligand 22
chr4_+_119195279 3.587 ENSMUST00000030395.2
Ccdc23
coiled-coil domain containing 23
chr7_-_126463100 3.531 ENSMUST00000032974.6
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr1_-_171234290 3.526 ENSMUST00000079957.6
Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_-_99483645 3.522 ENSMUST00000107096.1
ENSMUST00000032998.6
Rps3

ribosomal protein S3

chr4_+_130913120 3.514 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr2_+_91096744 3.511 ENSMUST00000132741.2
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr4_+_119195353 3.474 ENSMUST00000106345.2
Ccdc23
coiled-coil domain containing 23
chr1_-_173227229 3.446 ENSMUST00000049706.5
Fcer1a
Fc receptor, IgE, high affinity I, alpha polypeptide
chr9_+_106222598 3.446 ENSMUST00000062241.9
Tlr9
toll-like receptor 9
chr2_-_105399286 3.422 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr16_-_36666067 3.412 ENSMUST00000089620.4
Cd86
CD86 antigen
chr2_-_91649785 3.330 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr14_-_51988829 3.313 ENSMUST00000181008.1
Gm16617
predicted gene, 16617
chrX_-_48454152 3.312 ENSMUST00000114958.1
Elf4
E74-like factor 4 (ets domain transcription factor)
chr5_-_116024452 3.299 ENSMUST00000031486.7
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr13_+_5861489 3.282 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr11_-_69323768 3.272 ENSMUST00000092973.5
Cntrob
centrobin, centrosomal BRCA2 interacting protein
chr3_-_87263518 3.234 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr11_+_68432112 3.142 ENSMUST00000021283.7
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5, p101
chr10_+_80265035 3.096 ENSMUST00000092305.5
Dazap1
DAZ associated protein 1
chr7_-_127286385 3.074 ENSMUST00000172206.2
Gm17511
predicted gene, 17511
chr4_+_115839192 3.066 ENSMUST00000019677.5
ENSMUST00000144427.1
ENSMUST00000106513.3
ENSMUST00000130819.1
ENSMUST00000151203.1
ENSMUST00000140315.1
Mknk1





MAP kinase-interacting serine/threonine kinase 1





chr18_+_75000469 3.060 ENSMUST00000079716.5
Rpl17
ribosomal protein L17
chr3_-_87263703 3.041 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr10_+_81393610 3.037 ENSMUST00000118206.1
2210404O07Rik
RIKEN cDNA 2210404O07 gene
chr13_-_13393592 2.958 ENSMUST00000021738.8
Gpr137b
G protein-coupled receptor 137B
chr2_-_91649751 2.946 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chr11_+_87737530 2.934 ENSMUST00000093955.5
Supt4a
suppressor of Ty 4A
chr1_+_171682004 2.918 ENSMUST00000015499.7
ENSMUST00000068584.5
Cd48

CD48 antigen

chr11_+_120458093 2.879 ENSMUST00000058370.7
ENSMUST00000175970.1
ENSMUST00000176120.1
Ccdc137


coiled-coil domain containing 137


chrX_-_136085206 2.812 ENSMUST00000138878.1
ENSMUST00000080929.6
Nxf3

nuclear RNA export factor 3

chr2_+_164074122 2.775 ENSMUST00000018353.7
Stk4
serine/threonine kinase 4
chr7_-_3845050 2.762 ENSMUST00000108615.3
ENSMUST00000119469.1
Pira2

paired-Ig-like receptor A2

chrX_+_42149288 2.728 ENSMUST00000115073.2
ENSMUST00000115072.1
Stag2

stromal antigen 2

chr2_-_26640230 2.694 ENSMUST00000181621.1
ENSMUST00000180659.1
Snhg7

small nucleolar RNA host gene (non-protein coding) 7

chr2_+_112265809 2.688 ENSMUST00000110991.2
Slc12a6
solute carrier family 12, member 6
chr19_+_10605625 2.672 ENSMUST00000025649.8
Ddb1
damage specific DNA binding protein 1
chr17_-_35516780 2.609 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr4_+_109343029 2.604 ENSMUST00000030281.5
Eps15
epidermal growth factor receptor pathway substrate 15
chr7_-_81345189 2.533 ENSMUST00000080813.4
Rps17
ribosomal protein S17
chr15_+_39745926 2.530 ENSMUST00000022913.4
Dcstamp
dentrocyte expressed seven transmembrane protein
chr8_+_121127827 2.515 ENSMUST00000181609.1
Foxl1
forkhead box L1
chr8_+_120488416 2.510 ENSMUST00000034279.9
Gse1
genetic suppressor element 1
chr2_+_121358591 2.478 ENSMUST00000000317.6
ENSMUST00000129130.1
Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr4_+_133176336 2.460 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chrX_+_42149534 2.426 ENSMUST00000127618.1
Stag2
stromal antigen 2
chr12_+_98268626 2.422 ENSMUST00000075072.4
Gpr65
G-protein coupled receptor 65
chr16_+_36934976 2.351 ENSMUST00000023531.8
Hcls1
hematopoietic cell specific Lyn substrate 1
chr9_+_21526144 2.323 ENSMUST00000086361.5
ENSMUST00000179459.1
ENSMUST00000173769.2
AB124611


cDNA sequence AB124611


chr7_-_47008397 2.286 ENSMUST00000061639.7
Spty2d1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr7_-_19118357 2.286 ENSMUST00000141380.1
Gm4969
predicted gene 4969
chr18_+_15832772 2.284 ENSMUST00000079733.5
Gm10036
predicted gene 10036
chr13_-_78199757 2.275 ENSMUST00000091458.6
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr6_-_34955903 2.268 ENSMUST00000147169.1
2010107G12Rik
RIKEN cDNA 2010107G12 gene
chr7_-_127208423 2.240 ENSMUST00000120705.1
Tbc1d10b
TBC1 domain family, member 10b
chr19_+_6399746 2.218 ENSMUST00000113468.1
Rasgrp2
RAS, guanyl releasing protein 2
chr13_+_102693522 2.211 ENSMUST00000022124.3
ENSMUST00000171267.1
ENSMUST00000167144.1
ENSMUST00000170878.1
Cd180



CD180 antigen



chr3_-_146839365 2.172 ENSMUST00000084614.3
Gm10288
predicted gene 10288
chr4_+_124714776 2.096 ENSMUST00000030734.4
Sf3a3
splicing factor 3a, subunit 3
chr3_-_123672321 2.084 ENSMUST00000172537.1
ENSMUST00000029602.6
Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr17_-_13052280 2.036 ENSMUST00000091648.2
Gpr31b
G protein-coupled receptor 31, D17Leh66b region
chr3_-_90052463 2.030 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr8_-_106573461 2.027 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr14_+_60378242 1.998 ENSMUST00000022561.6
Amer2
APC membrane recruitment 2
chr11_-_77188968 1.995 ENSMUST00000108400.1
Efcab5
EF-hand calcium binding domain 5
chr15_-_99705490 1.925 ENSMUST00000163472.2
Gm17349
predicted gene, 17349
chr4_+_62663620 1.914 ENSMUST00000126338.1
Rgs3
regulator of G-protein signaling 3
chr5_-_25498702 1.894 ENSMUST00000173073.1
ENSMUST00000045291.7
Kmt2c

lysine (K)-specific methyltransferase 2C

chr8_+_94923687 1.870 ENSMUST00000153448.1
ENSMUST00000074570.3
ENSMUST00000166802.1
Gpr114


G protein-coupled receptor 114


chr6_+_122952515 1.847 ENSMUST00000117173.1
ENSMUST00000088468.4
Clec4a3

C-type lectin domain family 4, member a3

chrX_-_94123359 1.800 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
Zfx


zinc finger protein X-linked


chr7_-_45896656 1.777 ENSMUST00000120299.1
Syngr4
synaptogyrin 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.1 GO:0030221 basophil differentiation(GO:0030221)
6.6 19.7 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
4.6 27.5 GO:0032796 uropod organization(GO:0032796)
4.4 13.2 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
4.1 12.2 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
3.5 17.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
3.3 9.8 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) interleukin-13 biosynthetic process(GO:0042231) regulation of interleukin-10 biosynthetic process(GO:0045074) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
3.2 32.1 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
3.2 12.8 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
3.0 8.9 GO:1902567 immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
2.9 11.4 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
2.8 14.2 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560) negative regulation of phospholipase C activity(GO:1900275)
2.8 17.1 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
2.7 10.9 GO:0001805 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
2.7 8.0 GO:0002644 negative regulation of tolerance induction(GO:0002644)
2.6 7.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of protein localization to chromatin(GO:1905634)
2.5 7.5 GO:0010387 COP9 signalosome assembly(GO:0010387)
2.5 17.5 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
2.2 8.8 GO:0045659 negative regulation of neutrophil differentiation(GO:0045659)
2.0 10.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
2.0 6.0 GO:0061054 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
2.0 15.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
1.9 11.7 GO:0032439 endosome localization(GO:0032439)
1.8 5.5 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
1.7 6.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.6 4.9 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315)
1.6 6.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.5 9.0 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
1.5 4.4 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
1.5 5.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.4 5.5 GO:0033380 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
1.4 4.1 GO:1903969 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
1.3 6.7 GO:0033277 abortive mitotic cell cycle(GO:0033277)
1.2 6.2 GO:0071593 lymphocyte aggregation(GO:0071593)
1.2 3.5 GO:0090076 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
1.2 3.5 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
1.1 3.4 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
1.1 3.4 GO:0032741 positive regulation of interleukin-18 production(GO:0032741) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
1.1 5.6 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.1 8.9 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
1.1 6.5 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.0 14.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
1.0 11.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
1.0 3.9 GO:0031296 B cell costimulation(GO:0031296)
0.9 5.4 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.9 6.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.8 8.4 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.8 4.8 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.8 4.8 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.8 4.7 GO:0001866 NK T cell proliferation(GO:0001866)
0.8 2.3 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.7 6.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.7 3.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.7 2.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.7 4.1 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.7 2.7 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.6 3.8 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.6 2.5 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.6 6.9 GO:0035878 nail development(GO:0035878)
0.6 4.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.6 7.9 GO:0000733 DNA strand renaturation(GO:0000733)
0.6 1.7 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.6 4.5 GO:0032532 regulation of microvillus length(GO:0032532)
0.5 5.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.5 4.0 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.5 18.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.5 3.3 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.5 25.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 4.7 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.4 2.3 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.4 5.5 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.4 2.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.3 1.7 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.3 2.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.3 1.4 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.3 2.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 14.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.3 4.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.3 0.9 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) cell proliferation involved in heart valve development(GO:2000793)
0.3 5.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 1.6 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.3 2.6 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.3 5.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 0.7 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 1.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 2.0 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 2.8 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 2.9 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.2 6.9 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.2 3.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 0.9 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616)
0.2 13.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 4.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 1.5 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.2 0.8 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.2 3.1 GO:0009651 response to salt stress(GO:0009651)
0.2 0.9 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.1 14.1 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 2.5 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 2.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 1.0 GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010)
0.1 2.8 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 3.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.8 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 7.2 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.1 3.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 0.8 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 0.9 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.5 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.1 0.4 GO:0043686 co-translational protein modification(GO:0043686)
0.1 3.7 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.1 3.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 3.1 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 6.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 5.3 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.1 5.5 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 2.4 GO:0010447 response to acidic pH(GO:0010447)
0.1 0.4 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 0.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 3.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 0.9 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 1.5 GO:0060746 parental behavior(GO:0060746)
0.1 0.5 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.1 1.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 7.2 GO:0000910 cytokinesis(GO:0000910)
0.1 0.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.2 GO:0061156 pulmonary artery morphogenesis(GO:0061156) regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 6.3 GO:1903509 liposaccharide metabolic process(GO:1903509)
0.0 1.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 28.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 4.2 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 0.5 GO:0003214 cardiac left ventricle morphogenesis(GO:0003214)
0.0 0.5 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.2 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 12.0 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 5.0 GO:0016579 protein deubiquitination(GO:0016579)
0.0 4.8 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.6 GO:0043586 tongue development(GO:0043586)
0.0 0.1 GO:0014735 regulation of muscle atrophy(GO:0014735)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 2.0 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 1.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469) determination of liver left/right asymmetry(GO:0071910)
0.0 0.1 GO:0070253 negative regulation of appetite(GO:0032099) somatostatin secretion(GO:0070253)
0.0 0.3 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 1.0 GO:0008033 tRNA processing(GO:0008033)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 20.6 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
2.4 14.5 GO:0032437 cuticular plate(GO:0032437)
2.0 5.9 GO:0005588 collagen type V trimer(GO:0005588)
1.9 11.7 GO:0097443 sorting endosome(GO:0097443)
1.5 12.4 GO:0005826 actomyosin contractile ring(GO:0005826)
1.5 24.3 GO:0042581 specific granule(GO:0042581)
1.2 27.5 GO:0032426 stereocilium tip(GO:0032426)
1.1 12.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.9 2.8 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.9 3.4 GO:0036019 endolysosome(GO:0036019)
0.9 7.7 GO:0008278 cohesin complex(GO:0008278)
0.8 13.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.7 6.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.7 9.1 GO:0031209 SCAR complex(GO:0031209)
0.6 4.8 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.6 3.5 GO:0031673 H zone(GO:0031673)
0.5 6.5 GO:0042101 T cell receptor complex(GO:0042101)
0.5 5.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.5 9.0 GO:0031143 pseudopodium(GO:0031143)
0.5 5.5 GO:0097732 kinocilium(GO:0060091) 9+2 non-motile cilium(GO:0097732)
0.5 27.1 GO:0001772 immunological synapse(GO:0001772)
0.5 8.9 GO:0051286 cell tip(GO:0051286)
0.4 5.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.4 2.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.4 24.4 GO:0042629 mast cell granule(GO:0042629)
0.3 1.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.3 7.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 4.5 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.3 9.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 3.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 5.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 11.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 25.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.2 3.8 GO:0042588 zymogen granule(GO:0042588)
0.2 6.9 GO:0008180 COP9 signalosome(GO:0008180)
0.1 17.9 GO:0032587 ruffle membrane(GO:0032587)
0.1 5.1 GO:0016592 mediator complex(GO:0016592) core mediator complex(GO:0070847)
0.1 2.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 9.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.9 GO:0000786 nucleosome(GO:0000786)
0.1 0.8 GO:0033503 HULC complex(GO:0033503)
0.1 9.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 4.5 GO:0032421 stereocilium(GO:0032420) stereocilium bundle(GO:0032421)
0.1 0.8 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 4.9 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.4 GO:0140007 KICSTOR complex(GO:0140007)
0.1 14.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 5.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 24.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 9.4 GO:0000776 kinetochore(GO:0000776)
0.1 1.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 6.6 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 3.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 2.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 6.3 GO:0005604 basement membrane(GO:0005604)
0.0 2.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 6.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 3.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.9 GO:0005844 polysome(GO:0005844)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 14.2 GO:0005911 cell-cell junction(GO:0005911)
0.0 4.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 7.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.0 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.6 GO:0045352 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
3.8 11.4 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
3.0 9.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
3.0 8.9 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
2.0 15.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.8 11.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
1.7 7.0 GO:0019767 IgE receptor activity(GO:0019767)
1.6 17.5 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
1.5 8.8 GO:0051425 PTB domain binding(GO:0051425)
1.4 4.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.4 12.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.3 18.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
1.2 27.5 GO:0032036 myosin heavy chain binding(GO:0032036)
1.2 3.5 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
1.1 8.9 GO:0030911 TPR domain binding(GO:0030911)
1.1 23.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.9 14.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.8 6.7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.7 4.2 GO:0004111 creatine kinase activity(GO:0004111)
0.7 6.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 7.9 GO:0036310 annealing helicase activity(GO:0036310)
0.7 6.6 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.6 20.3 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.6 19.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 2.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.5 3.4 GO:0045322 unmethylated CpG binding(GO:0045322)
0.5 1.4 GO:0019972 interleukin-12 binding(GO:0019972)
0.5 21.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 3.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.4 14.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 3.8 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.4 2.3 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.4 3.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 18.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.0 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.3 4.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 4.9 GO:0031432 titin binding(GO:0031432)
0.3 4.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 3.5 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.3 3.5 GO:0051525 NFAT protein binding(GO:0051525)
0.3 1.7 GO:1990948 ubiquitin ligase inhibitor activity(GO:1990948)
0.3 7.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 4.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 12.7 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2 5.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 0.8 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.2 17.1 GO:0097110 scaffold protein binding(GO:0097110)
0.2 2.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 19.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 0.9 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 2.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 4.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 5.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 4.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 4.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 5.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 21.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.3 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.1 6.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 4.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 2.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 3.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 6.5 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 4.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.9 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 4.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 29.6 GO:0045296 cadherin binding(GO:0045296)
0.1 0.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 16.6 GO:0019903 protein phosphatase binding(GO:0019903)
0.1 3.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 5.5 GO:0005518 collagen binding(GO:0005518)
0.1 5.1 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 2.8 GO:0032452 histone demethylase activity(GO:0032452)
0.1 1.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 7.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 6.6 GO:0020037 heme binding(GO:0020037)
0.1 3.0 GO:0003823 antigen binding(GO:0003823)
0.1 0.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.9 GO:0001784 phosphotyrosine residue binding(GO:0001784)
0.0 7.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 4.9 GO:0005179 hormone activity(GO:0005179)
0.0 11.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.1 GO:0071949 FAD binding(GO:0071949)
0.0 6.2 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 1.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 6.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 5.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 2.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 4.5 GO:0008168 methyltransferase activity(GO:0008168)
0.0 2.8 GO:0003729 mRNA binding(GO:0003729)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171)
0.0 0.5 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 2.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 1.0 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.0 6.7 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.1 PID_IL5_PATHWAY IL5-mediated signaling events
0.8 39.0 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.4 8.2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 14.7 PID_IL1_PATHWAY IL1-mediated signaling events
0.4 30.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 34.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.4 21.4 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.3 24.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 4.8 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.3 11.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 21.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 5.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 9.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 13.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 7.9 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.2 8.7 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.2 9.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 4.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 7.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 5.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 9.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.9 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 5.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 0.7 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 3.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 6.4 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.5 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.2 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 8.9 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
1.0 12.4 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.8 14.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.8 3.8 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.7 3.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.6 30.4 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.6 24.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.6 4.8 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.5 7.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5 5.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.5 6.7 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.5 6.5 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.5 9.0 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.4 4.3 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.4 7.1 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.3 4.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.3 4.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.3 14.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 15.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.3 5.8 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.3 3.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.3 18.0 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.3 2.4 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 51.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 20.5 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.3 18.1 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.2 6.6 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 7.0 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2 17.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 6.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 17.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 7.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 7.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 9.5 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 16.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.7 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.1 5.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.0 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 6.6 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism
0.1 0.7 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 4.2 REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2
0.1 2.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 7.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.3 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.5 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 2.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway