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GSE58827: Dynamics of the Mouse Liver

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Results for Spib

Z-value: 2.80

Motif logo

Transcription factors associated with Spib

Gene Symbol Gene ID Gene Info
ENSMUSG00000008193.7 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Spibmm10_v2_chr7_-_44532064_445320780.812.3e-09Click!

Activity profile of Spib motif

Sorted Z-values of Spib motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_80000292 24.32 ENSMUST00000088735.3
olfactomedin 4
chrX_-_7964166 23.13 ENSMUST00000128449.1
GATA binding protein 1
chr17_+_48232755 17.08 ENSMUST00000113251.3
ENSMUST00000048782.6
triggering receptor expressed on myeloid cells 1
chr15_-_66812593 14.79 ENSMUST00000100572.3
src-like adaptor
chr1_+_174172738 14.52 ENSMUST00000027817.7
spectrin alpha, erythrocytic 1
chr11_-_17008647 14.24 ENSMUST00000102881.3
pleckstrin
chr7_-_100856289 14.13 ENSMUST00000139604.1
RELT tumor necrosis factor receptor
chr11_+_11685909 13.18 ENSMUST00000065433.5
IKAROS family zinc finger 1
chr1_+_171767123 12.76 ENSMUST00000015460.4
signaling lymphocytic activation molecule family member 1
chr9_+_56089962 12.39 ENSMUST00000059206.7
proline-serine-threonine phosphatase-interacting protein 1
chr5_-_134229581 12.18 ENSMUST00000111275.1
ENSMUST00000016094.6
ENSMUST00000144086.1
neutrophil cytosolic factor 1
chr5_+_149265035 11.42 ENSMUST00000130144.1
ENSMUST00000071130.3
arachidonate 5-lipoxygenase activating protein
chr7_-_126704736 11.16 ENSMUST00000131415.1
coronin, actin binding protein 1A
chr2_+_25423234 10.96 ENSMUST00000134259.1
ENSMUST00000100320.4
fucosyltransferase 7
chr2_-_181691771 10.90 ENSMUST00000108778.1
ENSMUST00000165416.1
regulator of G-protein signaling 19
chr2_-_165400398 10.26 ENSMUST00000029213.4
osteoclast stimulatory transmembrane protein
chr8_+_72189613 10.20 ENSMUST00000072097.6
hematopoietic SH2 domain containing
chr16_-_22657182 10.09 ENSMUST00000023578.7
diacylglycerol kinase, gamma
chr15_-_78305603 9.85 ENSMUST00000096356.3
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr13_+_30749226 9.77 ENSMUST00000021784.2
ENSMUST00000110307.1
interferon regulatory factor 4
chr12_-_32208470 9.50 ENSMUST00000085469.5
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr13_-_23465872 9.22 ENSMUST00000041674.7
butyrophilin, subfamily 1, member A1
chr1_-_170927567 9.16 ENSMUST00000046322.7
ENSMUST00000159171.1
Fc receptor-like A
chr3_-_105932664 9.14 ENSMUST00000098758.2
RIKEN cDNA I830077J02 gene
chr6_-_136941694 9.12 ENSMUST00000032344.5
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_24345282 9.02 ENSMUST00000114485.2
interleukin 1 receptor antagonist
chr7_+_99535439 9.00 ENSMUST00000098266.2
ENSMUST00000179755.1
arrestin, beta 1
chr9_-_66919646 8.88 ENSMUST00000041139.7
RAB8B, member RAS oncogene family
chr7_+_43408187 8.84 ENSMUST00000005592.6
sialic acid binding Ig-like lectin G
chr16_-_22657165 8.68 ENSMUST00000089925.3
diacylglycerol kinase, gamma
chr7_-_126704522 8.62 ENSMUST00000135087.1
coronin, actin binding protein 1A
chr2_+_24345305 8.54 ENSMUST00000114482.1
interleukin 1 receptor antagonist
chr13_-_113100971 8.37 ENSMUST00000023897.5
granzyme A
chr1_-_170927540 8.30 ENSMUST00000162136.1
ENSMUST00000162887.1
Fc receptor-like A
chr13_+_104228929 8.20 ENSMUST00000070761.3
centromere protein K
chr10_-_6980376 8.15 ENSMUST00000105617.1
interaction protein for cytohesin exchange factors 1
chr17_+_34604262 8.11 ENSMUST00000174041.1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr7_-_45239041 8.00 ENSMUST00000131290.1
CD37 antigen
chr12_-_32208609 7.99 ENSMUST00000053215.7
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr4_-_116123618 7.95 ENSMUST00000102704.3
ENSMUST00000102705.3
RAD54 like (S. cerevisiae)
chr7_-_45238794 7.86 ENSMUST00000098461.1
ENSMUST00000107797.1
CD37 antigen
chr7_-_126704179 7.68 ENSMUST00000106364.1
coronin, actin binding protein 1A
chr19_+_6084983 7.67 ENSMUST00000025704.2
cell division cycle associated 5
chrX_+_20703906 7.61 ENSMUST00000033383.2
ubiquitin specific peptidase 11
chr10_+_130322845 7.50 ENSMUST00000042586.8
thymocyte expressed, positive selection associated 1
chr1_-_38664947 7.23 ENSMUST00000039827.7
ENSMUST00000027250.7
AF4/FMR2 family, member 3
chr2_-_181693810 7.21 ENSMUST00000108776.1
ENSMUST00000108771.1
ENSMUST00000108779.1
ENSMUST00000108769.1
ENSMUST00000108772.1
ENSMUST00000002532.2
regulator of G-protein signaling 19
chr19_+_4154606 7.20 ENSMUST00000061086.8
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr15_+_78325990 7.05 ENSMUST00000096355.3
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr11_-_34783850 6.96 ENSMUST00000093193.5
ENSMUST00000101365.2
dedicator of cyto-kinesis 2
chr7_-_45239108 6.95 ENSMUST00000033063.6
CD37 antigen
chr5_+_134676490 6.95 ENSMUST00000100641.2
predicted gene 10369
chr2_+_36216749 6.94 ENSMUST00000147012.1
ENSMUST00000122948.1
predicted gene 13431
chr17_+_57279094 6.92 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
vav 1 oncogene
chr10_+_81257277 6.85 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
megakaryocyte-associated tyrosine kinase
chr6_-_136941494 6.67 ENSMUST00000111892.1
Rho, GDP dissociation inhibitor (GDI) beta
chr15_+_103453782 6.61 ENSMUST00000047405.7
NCK associated protein 1 like
chr6_+_38918969 6.57 ENSMUST00000003017.6
thromboxane A synthase 1, platelet
chr5_+_118560719 6.56 ENSMUST00000100816.4
mediator complex subunit 13-like
chr2_+_22774081 6.54 ENSMUST00000014290.8
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr2_+_91650116 6.47 ENSMUST00000111331.2
Rho GTPase activating protein 1
chr6_+_60944472 6.43 ENSMUST00000129603.1
multimerin 1
chr13_+_20794119 6.27 ENSMUST00000021757.3
acyloxyacyl hydrolase
chr15_-_78572754 6.20 ENSMUST00000043214.6
RAS-related C3 botulinum substrate 2
chr8_+_79028317 6.14 ENSMUST00000087927.4
ENSMUST00000098614.2
zinc finger protein 827
chr13_-_23465895 6.12 ENSMUST00000110434.1
butyrophilin, subfamily 1, member A1
chrX_+_159708593 6.07 ENSMUST00000080394.6
SH3-domain kinase binding protein 1
chr15_-_83033294 6.03 ENSMUST00000100377.4
Nfat activating molecule with ITAM motif 1
chr3_+_83766300 6.02 ENSMUST00000029625.7
secreted frizzled-related protein 2
chr1_-_171059390 5.95 ENSMUST00000164044.1
ENSMUST00000169017.1
Fc receptor, IgG, low affinity III
chr1_-_173333503 5.91 ENSMUST00000038227.4
Duffy blood group, chemokine receptor
chr6_+_129350237 5.91 ENSMUST00000065289.4
C-type lectin domain family 12, member a
chr1_-_45503282 5.89 ENSMUST00000086430.4
collagen, type V, alpha 2
chr2_+_156840966 5.87 ENSMUST00000109564.1
TGFB-induced factor homeobox 2
chr12_-_78980758 5.87 ENSMUST00000174072.1
transmembrane protein 229B
chr11_+_70130329 5.82 ENSMUST00000041550.5
ENSMUST00000165951.1
macrophage galactose N-acetyl-galactosamine specific lectin 2
chr7_-_80387935 5.66 ENSMUST00000080932.6
feline sarcoma oncogene
chr2_+_43748802 5.62 ENSMUST00000112824.1
ENSMUST00000055776.7
Rho GTPase activating protein 15
chr15_-_36608959 5.62 ENSMUST00000001809.8
poly(A) binding protein, cytoplasmic 1
chr17_+_7925990 5.59 ENSMUST00000036370.7
T cell activation Rho GTPase activating protein
chr17_+_35049966 5.54 ENSMUST00000007257.9
chloride intracellular channel 1
chr10_-_62508097 5.52 ENSMUST00000159020.1
serglycin
chr7_-_3720382 5.48 ENSMUST00000078451.6
paired Ig-like receptor B
chr16_-_89960815 5.47 ENSMUST00000002588.3
T cell lymphoma invasion and metastasis 1
chr4_+_140701466 5.38 ENSMUST00000038893.5
ENSMUST00000138808.1
regulator of chromosome condensation 2
chr11_-_103344651 5.32 ENSMUST00000041385.7
Rho GTPase activating protein 27
chr3_+_99253754 5.30 ENSMUST00000029462.5
T-box 15
chr6_-_124733067 5.22 ENSMUST00000173647.1
protein tyrosine phosphatase, non-receptor type 6
chr2_+_91650169 5.18 ENSMUST00000090614.4
Rho GTPase activating protein 1
chr2_+_120463566 4.95 ENSMUST00000028749.7
ENSMUST00000110721.1
calpain 3
chr8_-_88636117 4.93 ENSMUST00000034087.7
sorting nexin 20
chr15_-_9529868 4.92 ENSMUST00000003981.4
interleukin 7 receptor
chr2_+_24386604 4.90 ENSMUST00000166388.1
pleckstrin and Sec7 domain containing 4
chr17_-_67950908 4.86 ENSMUST00000164647.1
Rho GTPase activating protein 28
chr14_+_67745229 4.83 ENSMUST00000111095.2
gonadotropin releasing hormone 1
chr15_-_81045467 4.81 ENSMUST00000135047.1
MKL (megakaryoblastic leukemia)/myocardin-like 1
chr2_-_39005574 4.74 ENSMUST00000080861.5
ribosomal protein L35
chr11_+_46454957 4.73 ENSMUST00000109229.1
hepatitis A virus cellular receptor 2
chr5_-_116024475 4.65 ENSMUST00000111999.1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr11_+_46454921 4.56 ENSMUST00000020668.8
hepatitis A virus cellular receptor 2
chr9_+_124101944 4.55 ENSMUST00000171719.1
chemokine (C-C motif) receptor 2
chr16_-_36642742 4.55 ENSMUST00000135280.1
CD86 antigen
chr4_+_130913264 4.50 ENSMUST00000156225.1
ENSMUST00000156742.1
lysosomal-associated protein transmembrane 5
chr9_+_106203108 4.48 ENSMUST00000024047.5
twinfilin, actin-binding protein, homolog 2 (Drosophila)
chr2_-_93046053 4.45 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
PR domain containing 11
chr16_-_92826004 4.43 ENSMUST00000023673.7
runt related transcription factor 1
chr1_+_87620306 4.41 ENSMUST00000169754.1
inositol polyphosphate-5-phosphatase D
chr9_+_124102110 4.39 ENSMUST00000168841.1
ENSMUST00000055918.6
chemokine (C-C motif) receptor 2
chr5_-_38876693 4.37 ENSMUST00000169819.1
ENSMUST00000171633.1
cytokine-dependent hematopoietic cell linker
chr1_+_87620334 4.36 ENSMUST00000042275.8
ENSMUST00000168783.1
inositol polyphosphate-5-phosphatase D
chr11_+_46810792 4.27 ENSMUST00000068877.6
T cell immunoglobulin and mucin domain containing 4
chr13_+_23544052 4.26 ENSMUST00000075558.2
histone cluster 1, H3f
chr19_+_12846773 4.25 ENSMUST00000164001.1
predicted pseudogene 5244
chr15_+_58510037 4.22 ENSMUST00000161028.1
fer-1-like 6 (C. elegans)
chr3_-_59210881 4.17 ENSMUST00000040622.1
purinergic receptor P2Y, G-protein coupled 13
chr3_-_101029543 4.16 ENSMUST00000147399.2
CD101 antigen
chr3_-_95142346 4.13 ENSMUST00000013851.3
tumor necrosis factor, alpha-induced protein 8-like 2
chr7_-_29232478 4.12 ENSMUST00000085818.4
potassium inwardly-rectifying channel, subfamily K, member 6
chr5_+_86071734 4.10 ENSMUST00000031171.7
signal transducing adaptor family member 1
chr7_-_3898120 4.09 ENSMUST00000070639.7
predicted gene 14548
chrX_+_166344692 3.99 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
glycoprotein m6b
chr4_-_92191749 3.98 ENSMUST00000123179.1
predicted gene 12666
chr4_+_119195496 3.90 ENSMUST00000097908.3
coiled-coil domain containing 23
chr8_+_10006656 3.89 ENSMUST00000033892.7
tumor necrosis factor (ligand) superfamily, member 13b
chr1_-_149961230 3.81 ENSMUST00000070200.8
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr19_+_6399857 3.80 ENSMUST00000146601.1
ENSMUST00000150713.1
RAS, guanyl releasing protein 2
chr5_+_81021202 3.75 ENSMUST00000117253.1
ENSMUST00000120128.1
latrophilin 3
chr8_+_94745590 3.73 ENSMUST00000034231.3
chemokine (C-C motif) ligand 22
chr4_+_119195279 3.59 ENSMUST00000030395.2
coiled-coil domain containing 23
chr7_-_126463100 3.53 ENSMUST00000032974.6
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr1_-_171234290 3.53 ENSMUST00000079957.6
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_-_99483645 3.52 ENSMUST00000107096.1
ENSMUST00000032998.6
ribosomal protein S3
chr4_+_130913120 3.51 ENSMUST00000151698.1
lysosomal-associated protein transmembrane 5
chr2_+_91096744 3.51 ENSMUST00000132741.2
spleen focus forming virus (SFFV) proviral integration oncogene
chr4_+_119195353 3.47 ENSMUST00000106345.2
coiled-coil domain containing 23
chr1_-_173227229 3.45 ENSMUST00000049706.5
Fc receptor, IgE, high affinity I, alpha polypeptide
chr9_+_106222598 3.45 ENSMUST00000062241.9
toll-like receptor 9
chr2_-_105399286 3.42 ENSMUST00000006128.6
reticulocalbin 1
chr16_-_36666067 3.41 ENSMUST00000089620.4
CD86 antigen
chr2_-_91649785 3.33 ENSMUST00000111333.1
zinc finger protein 408
chr14_-_51988829 3.31 ENSMUST00000181008.1
predicted gene, 16617
chrX_-_48454152 3.31 ENSMUST00000114958.1
E74-like factor 4 (ets domain transcription factor)
chr5_-_116024452 3.30 ENSMUST00000031486.7
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr13_+_5861489 3.28 ENSMUST00000000080.6
Kruppel-like factor 6
chr11_-_69323768 3.27 ENSMUST00000092973.5
centrobin, centrosomal BRCA2 interacting protein
chr3_-_87263518 3.23 ENSMUST00000090986.4
Fc receptor-like S, scavenger receptor
chr11_+_68432112 3.14 ENSMUST00000021283.7
phosphoinositide-3-kinase, regulatory subunit 5, p101
chr10_+_80265035 3.10 ENSMUST00000092305.5
DAZ associated protein 1
chr7_-_127286385 3.07 ENSMUST00000172206.2
predicted gene, 17511
chr4_+_115839192 3.07 ENSMUST00000019677.5
ENSMUST00000144427.1
ENSMUST00000106513.3
ENSMUST00000130819.1
ENSMUST00000151203.1
ENSMUST00000140315.1
MAP kinase-interacting serine/threonine kinase 1
chr18_+_75000469 3.06 ENSMUST00000079716.5
ribosomal protein L17
chr3_-_87263703 3.04 ENSMUST00000146512.1
Fc receptor-like S, scavenger receptor
chr10_+_81393610 3.04 ENSMUST00000118206.1
RIKEN cDNA 2210404O07 gene
chr13_-_13393592 2.96 ENSMUST00000021738.8
G protein-coupled receptor 137B
chr2_-_91649751 2.95 ENSMUST00000099714.3
zinc finger protein 408
chr11_+_87737530 2.93 ENSMUST00000093955.5
suppressor of Ty 4A
chr1_+_171682004 2.92 ENSMUST00000015499.7
ENSMUST00000068584.5
CD48 antigen
chr11_+_120458093 2.88 ENSMUST00000058370.7
ENSMUST00000175970.1
ENSMUST00000176120.1
coiled-coil domain containing 137
chrX_-_136085206 2.81 ENSMUST00000138878.1
ENSMUST00000080929.6
nuclear RNA export factor 3
chr2_+_164074122 2.77 ENSMUST00000018353.7
serine/threonine kinase 4
chr7_-_3845050 2.76 ENSMUST00000108615.3
ENSMUST00000119469.1
paired-Ig-like receptor A2
chrX_+_42149288 2.73 ENSMUST00000115073.2
ENSMUST00000115072.1
stromal antigen 2
chr2_-_26640230 2.69 ENSMUST00000181621.1
ENSMUST00000180659.1
small nucleolar RNA host gene (non-protein coding) 7
chr2_+_112265809 2.69 ENSMUST00000110991.2
solute carrier family 12, member 6
chr19_+_10605625 2.67 ENSMUST00000025649.8
damage specific DNA binding protein 1
chr17_-_35516780 2.61 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
transcription factor 19
chr4_+_109343029 2.60 ENSMUST00000030281.5
epidermal growth factor receptor pathway substrate 15
chr7_-_81345189 2.53 ENSMUST00000080813.4
ribosomal protein S17
chr15_+_39745926 2.53 ENSMUST00000022913.4
dentrocyte expressed seven transmembrane protein
chr8_+_121127827 2.51 ENSMUST00000181609.1
forkhead box L1
chr8_+_120488416 2.51 ENSMUST00000034279.9
genetic suppressor element 1
chr2_+_121358591 2.48 ENSMUST00000000317.6
ENSMUST00000129130.1
creatine kinase, mitochondrial 1, ubiquitous
chr4_+_133176336 2.46 ENSMUST00000105912.1
WAS protein family, member 2
chrX_+_42149534 2.43 ENSMUST00000127618.1
stromal antigen 2
chr12_+_98268626 2.42 ENSMUST00000075072.4
G-protein coupled receptor 65
chr16_+_36934976 2.35 ENSMUST00000023531.8
hematopoietic cell specific Lyn substrate 1
chr9_+_21526144 2.32 ENSMUST00000086361.5
ENSMUST00000179459.1
ENSMUST00000173769.2
cDNA sequence AB124611
chr7_-_47008397 2.29 ENSMUST00000061639.7
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr7_-_19118357 2.29 ENSMUST00000141380.1
predicted gene 4969
chr18_+_15832772 2.28 ENSMUST00000079733.5
predicted gene 10036
chr13_-_78199757 2.27 ENSMUST00000091458.6
nuclear receptor subfamily 2, group F, member 1
chr6_-_34955903 2.27 ENSMUST00000147169.1
RIKEN cDNA 2010107G12 gene
chr7_-_127208423 2.24 ENSMUST00000120705.1
TBC1 domain family, member 10b
chr19_+_6399746 2.22 ENSMUST00000113468.1
RAS, guanyl releasing protein 2
chr13_+_102693522 2.21 ENSMUST00000022124.3
ENSMUST00000171267.1
ENSMUST00000167144.1
ENSMUST00000170878.1
CD180 antigen
chr3_-_146839365 2.17 ENSMUST00000084614.3
predicted gene 10288
chr4_+_124714776 2.10 ENSMUST00000030734.4
splicing factor 3a, subunit 3
chr3_-_123672321 2.08 ENSMUST00000172537.1
ENSMUST00000029602.6
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr17_-_13052280 2.04 ENSMUST00000091648.2
G protein-coupled receptor 31, D17Leh66b region
chr3_-_90052463 2.03 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
ubiquitin associated protein 2-like
chr8_-_106573461 2.03 ENSMUST00000073722.5
predicted pseudogene 10073
chr14_+_60378242 2.00 ENSMUST00000022561.6
APC membrane recruitment 2
chr11_-_77188968 2.00 ENSMUST00000108400.1
EF-hand calcium binding domain 5
chr15_-_99705490 1.92 ENSMUST00000163472.2
predicted gene, 17349
chr4_+_62663620 1.91 ENSMUST00000126338.1
regulator of G-protein signaling 3
chr5_-_25498702 1.89 ENSMUST00000173073.1
ENSMUST00000045291.7
lysine (K)-specific methyltransferase 2C
chr8_+_94923687 1.87 ENSMUST00000153448.1
ENSMUST00000074570.3
ENSMUST00000166802.1
G protein-coupled receptor 114
chr6_+_122952515 1.85 ENSMUST00000117173.1
ENSMUST00000088468.4
C-type lectin domain family 4, member a3
chrX_-_94123359 1.80 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
zinc finger protein X-linked
chr7_-_45896656 1.78 ENSMUST00000120299.1
synaptogyrin 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Spib

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.1 GO:0030221 basophil differentiation(GO:0030221)
6.6 19.7 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
4.6 27.5 GO:0032796 uropod organization(GO:0032796)
4.4 13.2 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
4.1 12.2 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
3.5 17.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
3.3 9.8 GO:0042231 interleukin-10 biosynthetic process(GO:0042091) interleukin-13 biosynthetic process(GO:0042231) regulation of interleukin-10 biosynthetic process(GO:0045074) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
3.2 32.1 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
3.2 12.8 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
3.0 8.9 GO:2000458 immune complex clearance by monocytes and macrophages(GO:0002436) astrocyte chemotaxis(GO:0035700) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) negative regulation of eosinophil activation(GO:1902567) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
2.9 11.4 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
2.8 14.2 GO:0070560 negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560)
2.8 17.1 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
2.7 10.9 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
2.7 8.0 GO:0002644 negative regulation of tolerance induction(GO:0002644)
2.6 7.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
2.5 7.5 GO:0010387 COP9 signalosome assembly(GO:0010387)
2.5 17.5 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
2.2 8.8 GO:0045659 negative regulation of neutrophil differentiation(GO:0045659)
2.0 10.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
2.0 6.0 GO:2000040 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
2.0 15.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
1.9 11.7 GO:0032439 endosome localization(GO:0032439) negative regulation of vacuolar transport(GO:1903336)
1.8 5.5 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
1.7 6.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.6 4.9 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315)
1.6 6.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.5 9.0 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
1.5 4.4 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
1.5 5.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.4 5.5 GO:0033373 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
1.4 4.1 GO:1903972 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
1.3 6.7 GO:0033277 abortive mitotic cell cycle(GO:0033277)
1.2 3.5 GO:0051659 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
1.2 3.5 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
1.1 3.4 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
1.1 3.4 GO:0032741 positive regulation of interleukin-18 production(GO:0032741) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
1.1 5.6 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.1 8.9 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
1.1 6.5 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.0 14.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
1.0 11.0 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
1.0 3.9 GO:0031296 B cell costimulation(GO:0031296)
0.9 8.4 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.9 5.4 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.9 6.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.8 4.8 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.8 4.8 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.8 4.7 GO:0001866 NK T cell proliferation(GO:0001866)
0.8 2.3 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.8 6.2 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.7 6.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.7 3.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.7 2.8 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.7 4.1 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.7 2.7 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.6 3.8 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.6 2.5 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.6 6.9 GO:0035878 nail development(GO:0035878)
0.6 4.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.6 2.3 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.6 1.7 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.6 4.5 GO:0032532 regulation of microvillus length(GO:0032532)
0.5 5.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.5 4.0 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.5 18.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.5 3.3 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.5 25.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 5.5 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.4 4.7 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.4 2.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.3 1.7 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.3 2.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.3 14.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.3 1.4 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.3 2.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 1.9 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.3 0.9 GO:2000793 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) cell proliferation involved in heart valve development(GO:2000793)
0.3 7.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 5.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 1.6 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.3 2.6 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.3 5.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 0.7 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 1.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 2.0 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 2.9 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.2 2.8 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 6.9 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.2 4.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.2 3.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 13.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 4.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 1.5 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.2 0.8 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.2 3.1 GO:0009651 response to salt stress(GO:0009651)
0.1 2.5 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 2.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.8 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 3.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.8 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 7.2 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.1 3.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.1 0.8 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 0.9 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.5 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.1 0.4 GO:0043686 co-translational protein modification(GO:0043686)
0.1 3.7 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.1 3.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.9 GO:0086023 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.1 5.3 GO:0048701 embryonic cranial skeleton morphogenesis(GO:0048701)
0.1 6.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 5.5 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 3.1 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 2.4 GO:0010447 response to acidic pH(GO:0010447)
0.1 0.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 3.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 0.5 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.1 0.9 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 1.5 GO:0060746 parental behavior(GO:0060746)
0.1 0.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) germline stem cell asymmetric division(GO:0098728)
0.1 1.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 0.5 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.1 0.2 GO:1901301 pulmonary artery morphogenesis(GO:0061156) regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 7.2 GO:0000910 cytokinesis(GO:0000910)
0.0 0.5 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 6.3 GO:1903509 liposaccharide metabolic process(GO:1903509)
0.0 4.2 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 14.0 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.2 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 5.0 GO:0016579 protein deubiquitination(GO:0016579)
0.0 7.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 7.1 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.0 0.6 GO:0043586 tongue development(GO:0043586)
0.0 0.1 GO:0014735 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) regulation of muscle atrophy(GO:0014735)
0.0 4.8 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 1.5 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 2.0 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 3.1 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.0 0.1 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.1 GO:0071910 determination of pancreatic left/right asymmetry(GO:0035469) determination of liver left/right asymmetry(GO:0071910)
0.0 0.3 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 20.6 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
2.4 14.5 GO:0032437 cuticular plate(GO:0032437)
2.0 5.9 GO:0005588 collagen type V trimer(GO:0005588)
1.9 11.7 GO:0097443 sorting endosome(GO:0097443)
1.5 12.4 GO:0005826 actomyosin contractile ring(GO:0005826)
1.5 24.3 GO:0042581 specific granule(GO:0042581)
1.2 27.5 GO:0032426 stereocilium tip(GO:0032426)
1.1 12.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.9 2.8 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.9 3.4 GO:0036019 endolysosome(GO:0036019)
0.9 7.7 GO:0008278 cohesin complex(GO:0008278)
0.8 13.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.7 6.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.7 9.1 GO:0031209 SCAR complex(GO:0031209)
0.7 6.5 GO:0042101 T cell receptor complex(GO:0042101)
0.6 4.8 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.6 3.5 GO:0031673 H zone(GO:0031673)
0.5 5.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.5 5.5 GO:0042629 mast cell granule(GO:0042629)
0.5 9.0 GO:0031143 pseudopodium(GO:0031143)
0.5 5.5 GO:0060091 kinocilium(GO:0060091)
0.5 27.1 GO:0001772 immunological synapse(GO:0001772)
0.5 8.9 GO:0051286 cell tip(GO:0051286)
0.4 5.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.4 2.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 1.3 GO:0097450 astrocyte end-foot(GO:0097450)
0.3 7.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 4.5 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.3 9.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 3.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 24.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 11.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 5.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 2.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.2 3.8 GO:0042588 zymogen granule(GO:0042588)
0.2 6.9 GO:0008180 COP9 signalosome(GO:0008180)
0.1 17.9 GO:0032587 ruffle membrane(GO:0032587)
0.1 5.1 GO:0016592 mediator complex(GO:0016592)
0.1 9.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.5 GO:0032420 stereocilium(GO:0032420)
0.1 19.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 4.9 GO:0000786 nucleosome(GO:0000786)
0.1 0.8 GO:0033503 HULC complex(GO:0033503)
0.1 9.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 4.9 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.8 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.9 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 5.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 31.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.1 1.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 10.9 GO:0005884 actin filament(GO:0005884)
0.1 9.4 GO:0000776 kinetochore(GO:0000776)
0.1 3.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 6.3 GO:0005604 basement membrane(GO:0005604)
0.0 2.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 6.2 GO:0001650 fibrillar center(GO:0001650)
0.0 11.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 1.9 GO:0005844 polysome(GO:0005844)
0.0 15.5 GO:0005911 cell-cell junction(GO:0005911)
0.0 1.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.1 GO:0005814 centriole(GO:0005814)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507) COPII vesicle coat(GO:0030127)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.8 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.6 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
3.8 11.4 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
3.0 9.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
3.0 8.9 GO:0035717 chemokine (C-C motif) ligand 7 binding(GO:0035717)
2.0 15.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.8 11.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
1.7 7.0 GO:0019767 IgE receptor activity(GO:0019767)
1.6 17.5 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
1.5 8.8 GO:0051425 PTB domain binding(GO:0051425)
1.4 23.1 GO:0008301 DNA binding, bending(GO:0008301)
1.4 4.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.4 12.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.3 18.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
1.2 27.5 GO:0032036 myosin heavy chain binding(GO:0032036)
1.2 3.5 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
1.1 8.9 GO:0030911 TPR domain binding(GO:0030911)
0.8 6.7 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.8 2.3 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.7 4.2 GO:0004111 creatine kinase activity(GO:0004111)
0.7 6.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.7 7.9 GO:0036310 annealing helicase activity(GO:0036310)
0.6 20.3 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.6 19.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 2.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.5 3.4 GO:0045322 unmethylated CpG binding(GO:0045322)
0.5 21.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 3.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.4 14.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 3.8 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.4 14.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 3.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 18.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 7.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 1.0 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.3 4.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 4.9 GO:0031432 titin binding(GO:0031432)
0.3 4.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 3.5 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.3 3.5 GO:0051525 NFAT protein binding(GO:0051525)
0.3 1.7 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.3 4.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 12.7 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2 5.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 0.8 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.2 21.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 2.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 17.1 GO:0097110 scaffold protein binding(GO:0097110)
0.2 0.9 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 2.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 4.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 5.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 4.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 4.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 5.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 4.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.3 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.1 3.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 37.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 18.3 GO:0019903 protein phosphatase binding(GO:0019903)
0.1 2.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 4.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 4.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 4.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 32.0 GO:0045296 cadherin binding(GO:0045296)
0.1 7.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 3.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 5.5 GO:0005518 collagen binding(GO:0005518)
0.1 2.8 GO:0032452 histone demethylase activity(GO:0032452)
0.1 6.6 GO:0020037 heme binding(GO:0020037)
0.0 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 1.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 2.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 4.9 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 2.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 6.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 2.3 GO:0003823 antigen binding(GO:0003823)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 4.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 4.5 GO:0008168 methyltransferase activity(GO:0008168)
0.0 3.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171)
0.0 2.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.8 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 3.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 3.9 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 1.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.0 6.7 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.1 PID IL5 PATHWAY IL5-mediated signaling events
0.8 39.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.4 8.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 14.7 PID IL1 PATHWAY IL1-mediated signaling events
0.4 30.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 34.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.4 21.4 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.3 24.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.3 4.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.3 11.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 21.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 5.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 9.8 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 13.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 7.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.2 8.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.2 9.7 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 4.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 7.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.6 PID RHOA PATHWAY RhoA signaling pathway
0.1 5.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 9.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.9 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 5.2 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 0.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 3.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 6.4 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.5 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 8.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
1.0 12.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.8 14.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.8 3.8 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.7 3.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.6 30.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.6 24.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.6 4.8 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.5 7.9 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5 5.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.5 6.7 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.5 6.5 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.5 9.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.4 4.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.4 7.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.3 4.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.3 4.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.3 14.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 15.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.3 5.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.3 3.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.3 18.0 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.3 2.4 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 51.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 20.5 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.3 18.1 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.2 6.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 7.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2 17.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 6.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 17.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 7.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 7.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 9.5 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 16.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 5.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.0 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 6.6 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.1 0.7 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 0.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 4.2 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.1 2.1 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 7.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 2.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway