Motif ID: Spic

Z-value: 3.093


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_886830250.931.2e-16Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_106167564 37.333 ENSMUST00000063062.8
Chi3l3
chitinase 3-like 3
chrX_-_7964166 33.575 ENSMUST00000128449.1
Gata1
GATA binding protein 1
chr11_+_87793470 29.816 ENSMUST00000020779.4
Mpo
myeloperoxidase
chr11_+_87793722 28.516 ENSMUST00000143021.2
Mpo
myeloperoxidase
chr10_+_79879614 25.076 ENSMUST00000006679.8
Prtn3
proteinase 3
chr14_+_80000292 23.886 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr9_+_7558429 19.795 ENSMUST00000018765.2
Mmp8
matrix metallopeptidase 8
chr1_-_144775419 18.012 ENSMUST00000027603.3
Rgs18
regulator of G-protein signaling 18
chr8_+_70373541 17.238 ENSMUST00000003659.7
Comp
cartilage oligomeric matrix protein
chr7_-_122132844 16.162 ENSMUST00000106469.1
ENSMUST00000063587.6
ENSMUST00000106468.1
ENSMUST00000130149.1
ENSMUST00000098068.3
Palb2




partner and localizer of BRCA2




chr7_-_100856289 15.467 ENSMUST00000139604.1
Relt
RELT tumor necrosis factor receptor
chrX_-_49788204 14.905 ENSMUST00000114893.1
Igsf1
immunoglobulin superfamily, member 1
chr1_+_40084764 14.672 ENSMUST00000027243.7
Il1r2
interleukin 1 receptor, type II
chrX_+_8271133 14.562 ENSMUST00000127103.1
ENSMUST00000115591.1
Slc38a5

solute carrier family 38, member 5

chr11_+_98907801 14.005 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr11_+_32276400 13.871 ENSMUST00000020531.2
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr16_-_75909272 13.097 ENSMUST00000114239.2
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1
chr19_+_6084983 12.748 ENSMUST00000025704.2
Cdca5
cell division cycle associated 5
chr7_-_126704736 12.451 ENSMUST00000131415.1
Coro1a
coronin, actin binding protein 1A
chr7_+_43408187 12.134 ENSMUST00000005592.6
Siglecg
sialic acid binding Ig-like lectin G
chrX_+_8271381 11.906 ENSMUST00000033512.4
Slc38a5
solute carrier family 38, member 5
chr13_-_110357136 11.899 ENSMUST00000058806.5
Gapt
Grb2-binding adaptor, transmembrane
chr7_-_126704522 11.375 ENSMUST00000135087.1
Coro1a
coronin, actin binding protein 1A
chr9_+_56089962 10.978 ENSMUST00000059206.7
Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
chr5_-_138170992 10.931 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr2_+_152847993 10.605 ENSMUST00000028969.8
Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr11_-_102469839 10.603 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr2_+_152847961 10.423 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr7_+_28982832 10.396 ENSMUST00000085835.6
Map4k1
mitogen-activated protein kinase kinase kinase kinase 1
chr5_-_138171248 10.298 ENSMUST00000153867.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr7_-_126704179 10.264 ENSMUST00000106364.1
Coro1a
coronin, actin binding protein 1A
chr7_+_128062657 10.194 ENSMUST00000120355.1
ENSMUST00000106240.2
ENSMUST00000098015.3
Itgam


integrin alpha M


chr7_-_127042420 10.070 ENSMUST00000032915.6
Kif22
kinesin family member 22
chr15_+_78244781 9.938 ENSMUST00000096357.5
ENSMUST00000133618.1
Ncf4

neutrophil cytosolic factor 4

chr11_+_120948480 9.852 ENSMUST00000070653.6
Slc16a3
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr5_+_149265035 9.765 ENSMUST00000130144.1
ENSMUST00000071130.3
Alox5ap

arachidonate 5-lipoxygenase activating protein

chr7_-_4725082 9.444 ENSMUST00000086363.4
ENSMUST00000086364.4
Tmem150b

transmembrane protein 150B

chr5_-_138171216 9.267 ENSMUST00000147920.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr5_-_134229581 9.226 ENSMUST00000111275.1
ENSMUST00000016094.6
ENSMUST00000144086.1
Ncf1


neutrophil cytosolic factor 1


chr10_+_83722865 9.212 ENSMUST00000150459.1
1500009L16Rik
RIKEN cDNA 1500009L16 gene
chr14_+_55765956 9.085 ENSMUST00000057569.3
Ltb4r1
leukotriene B4 receptor 1
chr13_+_30749226 8.850 ENSMUST00000021784.2
ENSMUST00000110307.1
Irf4

interferon regulatory factor 4

chr6_-_136941694 8.725 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr5_-_116024452 8.657 ENSMUST00000031486.7
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr10_+_75943020 8.655 ENSMUST00000121151.1
Vpreb3
pre-B lymphocyte gene 3
chr3_-_105932664 8.585 ENSMUST00000098758.2
I830077J02Rik
RIKEN cDNA I830077J02 gene
chr10_-_117282262 8.515 ENSMUST00000092163.7
Lyz2
lysozyme 2
chr10_+_115817247 8.482 ENSMUST00000035563.7
ENSMUST00000080630.3
ENSMUST00000179196.1
Tspan8


tetraspanin 8


chr2_-_165400398 8.355 ENSMUST00000029213.4
Ocstamp
osteoclast stimulatory transmembrane protein
chr7_+_142460834 8.089 ENSMUST00000018963.4
ENSMUST00000105967.1
Lsp1

lymphocyte specific 1

chr3_+_103832562 7.905 ENSMUST00000062945.5
Bcl2l15
BCLl2-like 15
chr4_+_44300876 7.902 ENSMUST00000045607.5
Melk
maternal embryonic leucine zipper kinase
chr5_-_116024475 7.899 ENSMUST00000111999.1
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr7_-_45239041 7.895 ENSMUST00000131290.1
Cd37
CD37 antigen
chr7_+_128062698 7.819 ENSMUST00000119696.1
Itgam
integrin alpha M
chr7_-_45238794 7.747 ENSMUST00000098461.1
ENSMUST00000107797.1
Cd37

CD37 antigen

chr7_+_142460809 7.678 ENSMUST00000105968.1
Lsp1
lymphocyte specific 1
chr8_+_84701430 7.662 ENSMUST00000037165.4
Lyl1
lymphoblastomic leukemia 1
chr9_-_114781986 7.616 ENSMUST00000035009.8
ENSMUST00000084867.7
Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr10_-_30655859 7.615 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr17_+_7925990 7.581 ENSMUST00000036370.7
Tagap
T cell activation Rho GTPase activating protein
chr11_-_79523760 7.323 ENSMUST00000179322.1
Evi2b
ecotropic viral integration site 2b
chr17_+_34604262 7.311 ENSMUST00000174041.1
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr4_-_133874682 7.070 ENSMUST00000168974.2
Rps6ka1
ribosomal protein S6 kinase polypeptide 1
chr11_-_17008647 7.028 ENSMUST00000102881.3
Plek
pleckstrin
chrX_+_20703906 7.018 ENSMUST00000033383.2
Usp11
ubiquitin specific peptidase 11
chr2_+_22774081 6.947 ENSMUST00000014290.8
Apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr15_-_78305603 6.946 ENSMUST00000096356.3
Csf2rb2
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr7_-_45239108 6.926 ENSMUST00000033063.6
Cd37
CD37 antigen
chr8_-_122432924 6.866 ENSMUST00000017604.8
Cyba
cytochrome b-245, alpha polypeptide
chr1_+_87620334 6.616 ENSMUST00000042275.8
ENSMUST00000168783.1
Inpp5d

inositol polyphosphate-5-phosphatase D

chr2_+_24345282 6.616 ENSMUST00000114485.2
Il1rn
interleukin 1 receptor antagonist
chr1_+_87620306 6.399 ENSMUST00000169754.1
Inpp5d
inositol polyphosphate-5-phosphatase D
chr6_-_136941887 6.367 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_24345305 6.333 ENSMUST00000114482.1
Il1rn
interleukin 1 receptor antagonist
chr7_-_134232125 6.320 ENSMUST00000127524.1
Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr2_+_156840966 6.303 ENSMUST00000109564.1
Tgif2
TGFB-induced factor homeobox 2
chr7_-_134232005 6.293 ENSMUST00000134504.1
Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr17_+_57279094 6.162 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
Vav1


vav 1 oncogene


chr11_-_115133981 6.151 ENSMUST00000106561.1
ENSMUST00000051264.7
ENSMUST00000106562.2
Cd300lf


CD300 antigen like family member F


chr17_-_6655939 6.128 ENSMUST00000179554.1
Dynlt1f
dynein light chain Tctex-type 1F
chr19_+_53529100 6.076 ENSMUST00000038287.6
Dusp5
dual specificity phosphatase 5
chr4_+_11758147 6.012 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr17_-_6317474 5.986 ENSMUST00000169415.1
Dynlt1a
dynein light chain Tctex-type 1A
chr2_+_164805082 5.955 ENSMUST00000052107.4
Zswim3
zinc finger SWIM-type containing 3
chr5_+_34999111 5.923 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr2_+_43748802 5.873 ENSMUST00000112824.1
ENSMUST00000055776.7
Arhgap15

Rho GTPase activating protein 15

chr9_-_20644726 5.819 ENSMUST00000148631.1
ENSMUST00000131128.1
ENSMUST00000151861.1
ENSMUST00000131343.1
ENSMUST00000086458.3
Fbxl12




F-box and leucine-rich repeat protein 12




chr5_+_4192367 5.702 ENSMUST00000177258.1
Gm9897
predicted gene 9897
chr5_+_34999046 5.687 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr8_+_117498272 5.648 ENSMUST00000081232.7
Plcg2
phospholipase C, gamma 2
chr10_+_130322845 5.635 ENSMUST00000042586.8
Tespa1
thymocyte expressed, positive selection associated 1
chr6_-_136941494 5.591 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_36216749 5.482 ENSMUST00000147012.1
ENSMUST00000122948.1
Gm13431

predicted gene 13431

chr12_-_32208470 5.432 ENSMUST00000085469.5
Pik3cg
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_120463566 5.420 ENSMUST00000028749.7
ENSMUST00000110721.1
Capn3

calpain 3

chr5_-_3893907 5.408 ENSMUST00000117463.1
ENSMUST00000044746.4
Mterf

mitochondrial transcription termination factor

chr4_+_130913264 5.392 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr14_+_116925516 5.387 ENSMUST00000125435.1
Gpc6
glypican 6
chr1_-_171234290 5.162 ENSMUST00000079957.6
Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_-_19271797 5.152 ENSMUST00000032561.8
Vasp
vasodilator-stimulated phosphoprotein
chr1_-_170927567 5.136 ENSMUST00000046322.7
ENSMUST00000159171.1
Fcrla

Fc receptor-like A

chr3_-_67463828 5.091 ENSMUST00000058981.2
Lxn
latexin
chr12_-_11265768 5.031 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr14_+_57524734 5.029 ENSMUST00000089494.4
Il17d
interleukin 17D
chr1_-_149961230 5.025 ENSMUST00000070200.8
Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr19_+_4154606 4.994 ENSMUST00000061086.8
Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr2_+_91650116 4.991 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr15_+_103453782 4.931 ENSMUST00000047405.7
Nckap1l
NCK associated protein 1 like
chr7_+_28440927 4.898 ENSMUST00000078845.6
Gmfg
glia maturation factor, gamma
chr1_+_152807877 4.803 ENSMUST00000027754.6
Ncf2
neutrophil cytosolic factor 2
chrX_-_136085206 4.800 ENSMUST00000138878.1
ENSMUST00000080929.6
Nxf3

nuclear RNA export factor 3

chr1_-_20820213 4.717 ENSMUST00000053266.9
Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr12_-_78980758 4.704 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr15_-_66812593 4.699 ENSMUST00000100572.3
Sla
src-like adaptor
chr7_+_126584937 4.655 ENSMUST00000039522.6
Apobr
apolipoprotein B receptor
chr3_-_101029543 4.619 ENSMUST00000147399.2
Cd101
CD101 antigen
chr17_+_47594629 4.606 ENSMUST00000182846.1
Ccnd3
cyclin D3
chr6_-_124733067 4.601 ENSMUST00000173647.1
Ptpn6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_170927540 4.586 ENSMUST00000162136.1
ENSMUST00000162887.1
Fcrla

Fc receptor-like A

chr12_-_32208609 4.585 ENSMUST00000053215.7
Pik3cg
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_164074122 4.570 ENSMUST00000018353.7
Stk4
serine/threonine kinase 4
chr2_-_105399286 4.545 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr6_+_123229843 4.524 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
Clec4n


C-type lectin domain family 4, member n


chr17_+_29360923 4.498 ENSMUST00000024810.6
Fgd2
FYVE, RhoGEF and PH domain containing 2
chr9_-_77045788 4.496 ENSMUST00000034911.6
Tinag
tubulointerstitial nephritis antigen
chr9_+_109875541 4.472 ENSMUST00000094324.3
Cdc25a
cell division cycle 25A
chr11_+_70505244 4.439 ENSMUST00000019063.2
Tm4sf5
transmembrane 4 superfamily member 5
chr3_+_88621102 4.424 ENSMUST00000029694.7
ENSMUST00000176804.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr4_+_115839192 4.385 ENSMUST00000019677.5
ENSMUST00000144427.1
ENSMUST00000106513.3
ENSMUST00000130819.1
ENSMUST00000151203.1
ENSMUST00000140315.1
Mknk1





MAP kinase-interacting serine/threonine kinase 1





chr17_-_33955658 4.367 ENSMUST00000174609.2
ENSMUST00000008812.7
Rps18

ribosomal protein S18

chr4_+_130913120 4.254 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr2_+_91650169 4.231 ENSMUST00000090614.4
Arhgap1
Rho GTPase activating protein 1
chr13_-_97137877 4.206 ENSMUST00000073456.7
Nsa2
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr3_+_87376381 4.203 ENSMUST00000163661.1
ENSMUST00000072480.2
ENSMUST00000167200.1
Fcrl1


Fc receptor-like 1


chr6_+_5725639 4.123 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr5_-_99978914 4.003 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
Hnrnpd




heterogeneous nuclear ribonucleoprotein D




chr17_+_48316141 4.001 ENSMUST00000049614.6
B430306N03Rik
RIKEN cDNA B430306N03 gene
chr9_+_106222598 3.995 ENSMUST00000062241.9
Tlr9
toll-like receptor 9
chr11_+_69914179 3.993 ENSMUST00000057884.5
Gps2
G protein pathway suppressor 2
chr13_-_49309217 3.956 ENSMUST00000110087.2
Fgd3
FYVE, RhoGEF and PH domain containing 3
chr4_+_140701466 3.905 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr3_+_109123104 3.893 ENSMUST00000029477.6
Slc25a24
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
chr4_-_41314877 3.893 ENSMUST00000030145.8
Dcaf12
DDB1 and CUL4 associated factor 12
chr5_+_34999070 3.881 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr3_+_105904377 3.861 ENSMUST00000000574.1
Adora3
adenosine A3 receptor
chr2_+_119112793 3.839 ENSMUST00000140939.1
ENSMUST00000028795.3
Rad51

RAD51 homolog

chr12_+_98268626 3.771 ENSMUST00000075072.4
Gpr65
G-protein coupled receptor 65
chr11_+_70130329 3.756 ENSMUST00000041550.5
ENSMUST00000165951.1
Mgl2

macrophage galactose N-acetyl-galactosamine specific lectin 2

chr1_-_33669745 3.756 ENSMUST00000027312.9
Prim2
DNA primase, p58 subunit
chr1_-_37496095 3.714 ENSMUST00000148047.1
ENSMUST00000143636.1
Mgat4a

mannoside acetylglucosaminyltransferase 4, isoenzyme A

chr7_-_35396708 3.671 ENSMUST00000154597.1
ENSMUST00000032704.5
C230052I12Rik

RIKEN cDNA C230052I12 gene

chr17_+_6601671 3.664 ENSMUST00000092966.4
Dynlt1c
dynein light chain Tctex-type 1C
chr6_-_67376147 3.604 ENSMUST00000018485.3
Il12rb2
interleukin 12 receptor, beta 2
chr18_+_67562387 3.570 ENSMUST00000163749.1
Gm17669
predicted gene, 17669
chr7_-_104369782 3.560 ENSMUST00000164410.1
Trim30b
tripartite motif-containing 30B
chr9_+_108508005 3.557 ENSMUST00000006838.8
ENSMUST00000134939.1
Qars

glutaminyl-tRNA synthetase

chr1_+_179546303 3.527 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr5_-_38876693 3.498 ENSMUST00000169819.1
ENSMUST00000171633.1
Clnk

cytokine-dependent hematopoietic cell linker

chr1_-_52232296 3.477 ENSMUST00000114512.1
Gls
glutaminase
chr7_-_19604444 3.469 ENSMUST00000086041.5
Clasrp
CLK4-associating serine/arginine rich protein
chr19_+_4878671 3.437 ENSMUST00000006632.7
Zdhhc24
zinc finger, DHHC domain containing 24
chr3_+_24333046 3.376 ENSMUST00000077389.6
Gm7536
predicted gene 7536
chr5_-_137116177 3.350 ENSMUST00000054384.5
ENSMUST00000152207.1
Trim56

tripartite motif-containing 56

chr4_-_117891994 3.268 ENSMUST00000030265.3
Dph2
DPH2 homolog (S. cerevisiae)
chr1_+_191325912 3.265 ENSMUST00000027940.5
Tmem206
transmembrane protein 206
chr16_+_91406235 3.249 ENSMUST00000023691.5
Il10rb
interleukin 10 receptor, beta
chr8_+_94923687 3.191 ENSMUST00000153448.1
ENSMUST00000074570.3
ENSMUST00000166802.1
Gpr114


G protein-coupled receptor 114


chr8_-_70897407 3.178 ENSMUST00000054220.8
Rpl18a
ribosomal protein L18A
chr2_-_91649785 3.123 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr11_-_69323768 3.104 ENSMUST00000092973.5
Cntrob
centrobin, centrosomal BRCA2 interacting protein
chr5_+_108065742 3.084 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
Mtf2


metal response element binding transcription factor 2


chr5_+_86071734 3.064 ENSMUST00000031171.7
Stap1
signal transducing adaptor family member 1
chr14_+_30479565 3.055 ENSMUST00000022535.7
Dcp1a
DCP1 decapping enzyme homolog A (S. cerevisiae)
chr7_+_131032061 3.037 ENSMUST00000084509.3
Dmbt1
deleted in malignant brain tumors 1
chr12_-_24493656 2.971 ENSMUST00000073088.2
Gm16372
predicted pseudogene 16372
chr1_+_136683375 2.964 ENSMUST00000181524.1
Gm19705
predicted gene, 19705
chr12_+_77238093 2.948 ENSMUST00000177595.1
ENSMUST00000171770.2
Fut8

fucosyltransferase 8

chr1_-_171059390 2.935 ENSMUST00000164044.1
ENSMUST00000169017.1
Fcgr3

Fc receptor, IgG, low affinity III

chr7_-_100964371 2.916 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr17_+_35135463 2.885 ENSMUST00000173535.1
ENSMUST00000173952.1
Bag6

BCL2-associated athanogene 6

chr10_-_89443888 2.871 ENSMUST00000099374.2
ENSMUST00000105298.1
Gas2l3

growth arrest-specific 2 like 3

chr11_+_120458093 2.843 ENSMUST00000058370.7
ENSMUST00000175970.1
ENSMUST00000176120.1
Ccdc137


coiled-coil domain containing 137


chr16_-_36642742 2.823 ENSMUST00000135280.1
Cd86
CD86 antigen
chr11_-_98400453 2.804 ENSMUST00000090827.5
Pgap3
post-GPI attachment to proteins 3
chr10_-_44458687 2.768 ENSMUST00000105490.2
Prdm1
PR domain containing 1, with ZNF domain
chr15_+_39745926 2.766 ENSMUST00000022913.4
Dcstamp
dentrocyte expressed seven transmembrane protein
chr19_-_56389877 2.751 ENSMUST00000166203.1
ENSMUST00000167239.1
ENSMUST00000040711.8
ENSMUST00000095947.4
ENSMUST00000073536.6
Nrap




nebulin-related anchoring protein




chr10_-_80102653 2.728 ENSMUST00000042771.7
Sbno2
strawberry notch homolog 2 (Drosophila)
chr7_+_28540863 2.710 ENSMUST00000119180.2
Sycn
syncollin
chr2_-_91649751 2.705 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chr8_+_94666722 2.667 ENSMUST00000034228.8
Arl2bp
ADP-ribosylation factor-like 2 binding protein
chr19_-_40994133 2.643 ENSMUST00000117695.1
Blnk
B cell linker
chr2_-_84670727 2.633 ENSMUST00000117299.2
2700094K13Rik
RIKEN cDNA 2700094K13 gene
chr11_-_98400393 2.631 ENSMUST00000128897.1
Pgap3
post-GPI attachment to proteins 3
chr1_-_150164943 2.621 ENSMUST00000181308.1
Gm26687
predicted gene, 26687
chr2_-_167492826 2.608 ENSMUST00000109211.2
ENSMUST00000057627.9
Spata2

spermatogenesis associated 2

chr11_-_102880981 2.589 ENSMUST00000107060.1
Eftud2
elongation factor Tu GTP binding domain containing 2
chr6_+_137410721 2.549 ENSMUST00000167002.1
Ptpro
protein tyrosine phosphatase, receptor type, O
chr2_-_93046053 2.531 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
Prdm11


PR domain containing 11



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
19.4 58.3 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
11.2 33.6 GO:0030221 basophil differentiation(GO:0030221)
5.7 34.1 GO:0032796 uropod organization(GO:0032796)
5.5 27.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
5.0 25.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
4.2 12.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of protein localization to chromatin(GO:1905634)
3.5 14.0 GO:0006742 NADP catabolic process(GO:0006742)
3.4 34.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.3 13.0 GO:0045659 negative regulation of neutrophil differentiation(GO:0045659)
3.1 15.5 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
2.9 8.8 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) interleukin-13 biosynthetic process(GO:0042231) regulation of interleukin-10 biosynthetic process(GO:0045074) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
2.8 11.1 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
2.6 20.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
2.6 18.0 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
2.5 7.6 GO:0002337 B-1a B cell differentiation(GO:0002337)
2.4 9.8 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
2.4 9.5 GO:0001805 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
2.3 6.9 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
2.3 22.6 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
2.1 6.2 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
2.0 6.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
2.0 4.0 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
2.0 9.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
1.9 5.6 GO:0010387 COP9 signalosome assembly(GO:0010387)
1.8 5.4 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) G1 to G0 transition involved in cell differentiation(GO:0070315)
1.7 6.9 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
1.7 13.9 GO:0015671 oxygen transport(GO:0015671)
1.7 8.6 GO:0061857 endoplasmic reticulum stress-induced pre-emptive quality control(GO:0061857)
1.7 5.1 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
1.6 4.9 GO:0071846 actin filament debranching(GO:0071846)
1.6 4.7 GO:0072717 cellular response to actinomycin D(GO:0072717)
1.5 9.2 GO:0032439 endosome localization(GO:0032439)
1.5 26.5 GO:0015816 glycine transport(GO:0015816)
1.4 10.0 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
1.4 7.0 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920) protein secretion by platelet(GO:0070560) negative regulation of phospholipase C activity(GO:1900275)
1.4 4.2 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
1.4 15.3 GO:0035878 nail development(GO:0035878)
1.4 4.1 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
1.3 4.0 GO:1905663 regulation of telomerase RNA reverse transcriptase activity(GO:1905661) positive regulation of telomerase RNA reverse transcriptase activity(GO:1905663)
1.2 4.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
1.2 3.5 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
1.2 3.5 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
1.2 5.8 GO:0033277 abortive mitotic cell cycle(GO:0033277)
1.2 6.9 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.1 4.6 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
1.1 5.6 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
1.1 7.7 GO:0001955 blood vessel maturation(GO:0001955)
1.0 3.1 GO:1903969 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
1.0 5.1 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
1.0 3.0 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
1.0 18.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.0 9.9 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.9 2.8 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.9 2.7 GO:0032240 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.9 1.8 GO:0042494 detection of bacterial lipoprotein(GO:0042494)
0.9 8.7 GO:0051025 negative regulation of immunoglobulin secretion(GO:0051025)
0.8 5.0 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.8 3.3 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.8 17.5 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.8 7.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.8 3.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.7 2.9 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.7 5.0 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.7 4.0 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.6 7.6 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.6 1.9 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.6 8.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.6 1.8 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.6 3.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.6 4.4 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.5 13.1 GO:0030574 collagen catabolic process(GO:0030574)
0.5 2.7 GO:0072675 osteoclast fusion(GO:0072675)
0.5 13.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.5 1.6 GO:2000556 regulation of T-helper 1 cell cytokine production(GO:2000554) positive regulation of T-helper 1 cell cytokine production(GO:2000556)
0.5 4.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.5 2.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.5 1.9 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.5 0.9 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.5 2.3 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.5 7.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.5 1.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.4 2.2 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.4 3.1 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.4 3.9 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.4 0.9 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 2.5 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.4 1.3 GO:1902559 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.4 0.8 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.4 6.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.4 22.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 10.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.4 9.9 GO:0045730 respiratory burst(GO:0045730)
0.4 10.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.4 3.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.4 4.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 12.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.4 2.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.4 1.4 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.3 1.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 1.0 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.3 1.0 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.3 0.7 GO:0035420 negative regulation of toll-like receptor 2 signaling pathway(GO:0034136) activation of MAPK activity involved in innate immune response(GO:0035419) MAPK cascade involved in innate immune response(GO:0035420)
0.3 1.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.3 1.6 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.3 0.9 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
0.3 1.5 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.3 3.9 GO:0015866 ADP transport(GO:0015866)
0.3 1.5 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.3 6.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.3 1.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.3 1.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.3 1.7 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.3 1.9 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 0.8 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.3 1.5 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.3 4.8 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.3 3.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.2 4.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 17.2 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.2 5.1 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.2 1.7 GO:1904867 protein localization to nuclear body(GO:1903405) positive regulation of establishment of protein localization to telomere(GO:1904851) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.2 2.1 GO:0051014 actin filament severing(GO:0051014)
0.2 5.0 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.2 1.4 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.2 2.4 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.2 0.2 GO:0045359 positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.2 3.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 1.7 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.2 4.0 GO:0009651 response to salt stress(GO:0009651)
0.2 3.8 GO:0010447 response to acidic pH(GO:0010447)
0.2 0.7 GO:0007000 nucleolus organization(GO:0007000)
0.2 4.5 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 0.2 GO:0061738 late endosomal microautophagy(GO:0061738)
0.2 4.2 GO:0043486 histone exchange(GO:0043486)
0.2 0.5 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.2 15.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.2 4.9 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.2 1.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 1.8 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.2 8.5 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 1.6 GO:0035330 regulation of hippo signaling(GO:0035330)
0.1 4.7 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.1 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 6.1 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.1 3.3 GO:0051764 actin filament network formation(GO:0051639) actin crosslink formation(GO:0051764)
0.1 1.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.6 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
0.1 1.7 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.1 0.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 5.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.5 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 1.0 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 3.2 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.1 2.5 GO:0034508 centromere complex assembly(GO:0034508)
0.1 1.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.2 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 0.7 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.1 11.7 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 1.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.1 2.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 4.0 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 1.5 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 3.7 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.1 0.3 GO:1903984 TRAIL-activated apoptotic signaling pathway(GO:0036462) regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) negative regulation of metalloendopeptidase activity(GO:1904684)
0.1 1.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 1.2 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 4.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 1.0 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 2.6 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.1 1.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.7 GO:0003283 atrial septum development(GO:0003283)
0.1 3.6 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.1 1.2 GO:0050832 defense response to fungus(GO:0050832)
0.1 8.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 4.9 GO:0051289 protein homotetramerization(GO:0051289)
0.0 6.3 GO:0000910 cytokinesis(GO:0000910)
0.0 0.7 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 6.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.6 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.3 GO:0051013 microtubule severing(GO:0051013)
0.0 4.8 GO:0051607 defense response to virus(GO:0051607)
0.0 0.4 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.5 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.9 GO:0031529 ruffle organization(GO:0031529)
0.0 0.5 GO:0006298 mismatch repair(GO:0006298)
0.0 0.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 2.2 GO:0016579 protein deubiquitination(GO:0016579)
0.0 1.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.6 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 1.2 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.5 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 1.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 5.1 GO:0006935 chemotaxis(GO:0006935)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.6 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 58.3 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
2.9 11.5 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
2.8 30.8 GO:0043020 NADPH oxidase complex(GO:0043020)
2.6 21.0 GO:0005818 aster(GO:0005818)
2.5 25.4 GO:0042581 specific granule(GO:0042581)
2.1 2.1 GO:0070820 tertiary granule(GO:0070820)
1.7 13.9 GO:0005833 hemoglobin complex(GO:0005833)
1.6 4.8 GO:0042272 nuclear RNA export factor complex(GO:0042272)
1.5 9.2 GO:0097443 sorting endosome(GO:0097443)
1.5 34.1 GO:0032426 stereocilium tip(GO:0032426)
1.4 8.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.4 12.7 GO:0008278 cohesin complex(GO:0008278)
1.4 4.1 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
1.4 11.0 GO:0005826 actomyosin contractile ring(GO:0005826)
1.2 8.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
1.1 3.3 GO:0032127 dense core granule membrane(GO:0032127)
1.0 4.0 GO:0036019 endolysosome(GO:0036019)
0.8 4.1 GO:1990745 EARP complex(GO:1990745)
0.8 3.0 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.8 3.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.7 5.6 GO:0008180 COP9 signalosome(GO:0008180)
0.7 29.0 GO:0008305 integrin complex(GO:0008305)
0.6 5.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 6.9 GO:0042101 T cell receptor complex(GO:0042101)
0.5 30.2 GO:0042555 MCM complex(GO:0042555) MCM core complex(GO:0097373)
0.5 19.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.5 2.1 GO:0032021 NELF complex(GO:0032021)
0.5 1.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.5 15.3 GO:0051233 spindle midzone(GO:0051233)
0.5 2.8 GO:0005927 muscle tendon junction(GO:0005927)
0.4 20.7 GO:0001772 immunological synapse(GO:0001772)
0.4 12.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.4 4.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 1.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.3 13.4 GO:0097440 apical dendrite(GO:0097440)
0.3 4.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 38.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 3.0 GO:0005642 annulate lamellae(GO:0005642)
0.2 12.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 8.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 6.1 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.2 4.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 2.9 GO:0031209 SCAR complex(GO:0031209)
0.2 1.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 2.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.2 14.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 3.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 2.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 1.0 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 0.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.2 5.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.4 GO:0070985 TFIIK complex(GO:0070985)
0.1 3.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 68.6 GO:0031012 extracellular matrix(GO:0031012)
0.1 7.0 GO:0005871 kinesin complex(GO:0005871)
0.1 1.7 GO:0031011 Ino80 complex(GO:0031011)
0.1 6.9 GO:0042629 mast cell granule(GO:0042629)
0.1 4.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 3.7 GO:0090734 site of double-strand break(GO:0035861) site of DNA damage(GO:0090734)
0.1 14.2 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 5.4 GO:0030315 T-tubule(GO:0030315)
0.1 3.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 3.9 GO:0002102 podosome(GO:0002102)
0.1 4.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.7 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 3.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.6 GO:0034709 methylosome(GO:0034709)
0.1 1.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 1.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 19.1 GO:0031965 nuclear membrane(GO:0031965)
0.1 5.7 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 0.2 GO:0055087 Ski complex(GO:0055087)
0.1 1.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.3 GO:0030175 filopodium(GO:0030175)
0.1 2.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.0 GO:0090725 peripheral region of growth cone(GO:0090725)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 2.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.8 GO:0042588 zymogen granule(GO:0042588)
0.0 57.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.1 GO:0001726 ruffle(GO:0001726)
0.0 1.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 4.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 5.3 GO:0001650 fibrillar center(GO:0001650)
0.0 3.1 GO:0000932 P-body(GO:0000932)
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.5 GO:0000776 kinetochore(GO:0000776)
0.0 6.7 GO:0005911 cell-cell junction(GO:0005911)
0.0 0.6 GO:0008021 synaptic vesicle(GO:0008021)
0.0 3.2 GO:0005938 cell cortex(GO:0005938)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.5 GO:0005581 collagen trimer(GO:0005581)
0.0 8.1 GO:0009986 cell surface(GO:0009986)
0.0 0.5 GO:0016592 mediator complex(GO:0016592) core mediator complex(GO:0070847)
0.0 1.0 GO:0005903 brush border(GO:0005903)
0.0 0.4 GO:0005776 autophagosome(GO:0005776)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.7 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
4.3 12.9 GO:0045352 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
3.3 9.8 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
2.7 24.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
2.6 20.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.6 18.0 GO:0001851 complement component C3b binding(GO:0001851)
2.3 21.0 GO:0061676 importin-alpha family protein binding(GO:0061676)
2.3 9.1 GO:0004974 leukotriene receptor activity(GO:0004974)
2.2 13.0 GO:0051425 PTB domain binding(GO:0051425)
2.2 17.2 GO:0005499 vitamin D binding(GO:0005499)
2.1 10.6 GO:0070051 fibrinogen binding(GO:0070051)
2.1 6.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
2.0 6.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
1.9 26.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
1.7 13.9 GO:0005344 oxygen transporter activity(GO:0005344)
1.7 14.9 GO:0034711 inhibin binding(GO:0034711)
1.5 34.1 GO:0032036 myosin heavy chain binding(GO:0032036)
1.5 33.6 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
1.5 1.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
1.4 9.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.4 6.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.3 5.2 GO:0019767 IgE receptor activity(GO:0019767)
1.0 3.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.0 4.0 GO:0003721 telomerase RNA reverse transcriptase activity(GO:0003721)
1.0 2.9 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.9 10.0 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.9 7.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.9 54.4 GO:0004601 peroxidase activity(GO:0004601)
0.8 2.5 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.8 4.7 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.7 29.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.7 10.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.7 5.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.7 5.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.6 8.5 GO:0003796 lysozyme activity(GO:0003796)
0.6 3.5 GO:0004359 glutaminase activity(GO:0004359)
0.6 2.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.6 5.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.5 3.8 GO:0000150 recombinase activity(GO:0000150)
0.5 8.6 GO:0015643 toxic substance binding(GO:0015643)
0.5 3.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.5 4.0 GO:0051434 BH3 domain binding(GO:0051434)
0.5 4.9 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.5 15.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.5 3.7 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.5 3.2 GO:0019969 interleukin-10 receptor activity(GO:0004920) interleukin-10 binding(GO:0019969)
0.5 2.3 GO:0016936 galactoside binding(GO:0016936)
0.4 12.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.4 4.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.4 1.3 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.4 4.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.4 6.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 6.4 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.4 5.2 GO:0005522 profilin binding(GO:0005522)
0.4 1.2 GO:0070290 phospholipase D activity(GO:0004630) N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.4 24.9 GO:0001784 phosphotyrosine residue binding(GO:0001784)
0.4 3.0 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.4 7.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 5.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 3.5 GO:0071253 connexin binding(GO:0071253)
0.3 1.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 5.4 GO:0031432 titin binding(GO:0031432)
0.3 17.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 6.0 GO:0017166 vinculin binding(GO:0017166)
0.3 3.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 3.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 3.9 GO:0015217 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.3 1.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.3 1.7 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.3 12.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 1.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.2 2.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 1.9 GO:0016531 copper chaperone activity(GO:0016531) cuprous ion binding(GO:1903136)
0.2 4.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 7.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 2.9 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 0.7 GO:0038075 MAP kinase activity involved in innate immune response(GO:0038075)
0.2 0.6 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.2 22.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 0.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.2 7.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 0.8 GO:0089720 caspase binding(GO:0089720)
0.2 8.8 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.2 0.8 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 1.5 GO:0003964 RNA-directed DNA polymerase activity(GO:0003964)
0.1 1.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 2.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 5.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.9 GO:0004498 calcidiol 1-monooxygenase activity(GO:0004498)
0.1 4.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 40.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.8 GO:0043394 proteoglycan binding(GO:0043394)
0.1 1.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 3.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 4.5 GO:0003899 DNA-directed 5'-3' RNA polymerase activity(GO:0003899)
0.1 3.0 GO:0070840 dynein complex binding(GO:0070840)
0.1 7.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 4.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 4.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.1 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.1 1.6 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 0.9 GO:0043142 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 1.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 0.6 GO:0000293 ferric-chelate reductase activity(GO:0000293) cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 8.5 GO:0005178 integrin binding(GO:0005178)
0.1 2.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 7.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.6 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 23.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.3 GO:0008143 poly(A) binding(GO:0008143)
0.1 8.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 4.4 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 11.2 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 4.7 GO:0004386 helicase activity(GO:0004386)
0.1 0.5 GO:0051400 BH domain binding(GO:0051400)
0.1 2.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.3 GO:0140034 methylated histone binding(GO:0035064) methylation-dependent protein binding(GO:0140034)
0.1 3.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 3.1 GO:0019894 kinesin binding(GO:0019894)
0.0 26.7 GO:0003779 actin binding(GO:0003779)
0.0 1.5 GO:0071949 FAD binding(GO:0071949)
0.0 2.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 13.0 GO:0045296 cadherin binding(GO:0045296)
0.0 4.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 1.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 1.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0032183 SUMO binding(GO:0032183)
0.0 3.1 GO:0051087 chaperone binding(GO:0051087)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 5.8 GO:0005125 cytokine activity(GO:0005125)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.0 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.5 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.2 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding(GO:0070530)
0.0 0.0 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.8 GO:0003729 mRNA binding(GO:0003729)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 59.3 PID_IL23_PATHWAY IL23-mediated signaling events
1.1 53.8 PID_ATR_PATHWAY ATR signaling pathway
0.9 29.0 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.8 12.5 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.6 24.5 PID_EPO_PATHWAY EPO signaling pathway
0.5 15.9 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5 16.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.5 20.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 15.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 32.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.4 15.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.4 15.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.4 10.0 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.3 17.6 PID_LKB1_PATHWAY LKB1 signaling events
0.3 24.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.3 15.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.3 3.6 PID_IL27_PATHWAY IL27-mediated signaling events
0.2 5.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 4.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.2 22.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 8.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 4.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 10.7 SIG_CHEMOTAXIS Genes related to chemotaxis
0.2 2.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.2 8.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.2 2.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 4.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 5.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 26.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 9.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 0.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 5.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 4.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 1.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 8.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 5.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.7 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 2.0 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 4.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 35.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.5 4.5 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.3 14.0 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.0 17.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.8 11.0 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.8 12.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.7 9.9 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 16.2 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.6 26.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 28.5 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.5 2.8 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.4 5.8 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.4 16.8 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.4 5.8 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.4 11.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.4 3.8 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.4 4.4 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 7.0 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.3 9.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.3 16.8 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.3 8.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 4.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.3 7.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.3 2.6 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.3 53.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 7.4 REACTOME_KINESINS Genes involved in Kinesins
0.3 4.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 14.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 3.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 30.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 6.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 16.0 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.2 3.5 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 12.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 2.6 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 6.3 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 4.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 4.7 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 7.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 5.4 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 4.2 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 31.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 5.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.6 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 5.2 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 0.6 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 2.9 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 7.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 9.1 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.0 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 3.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 6.3 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM Genes involved in Integration of energy metabolism
0.1 6.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 0.9 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.1 1.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 6.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 3.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 4.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 1.7 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.7 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation