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GSE58827: Dynamics of the Mouse Liver

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Results for Srf

Z-value: 1.00

Motif logo

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Transcription factors associated with Srf

Gene Symbol Gene ID Gene Info
Srf
ENSMUSG00000015605.5 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_465561880.363.0e-02Click!

Activity profile of Srf motif

Sorted Z-values of Srf motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_142661305 11.89 ENSMUST00000105936.1
Igf2
insulin-like growth factor 2
chr2_-_114052804 9.75 ENSMUST00000090269.6
Actc1
actin, alpha, cardiac muscle 1
chr8_-_123894736 8.13 ENSMUST00000034453.4
Acta1
actin, alpha 1, skeletal muscle
chr7_-_142661858 6.08 ENSMUST00000145896.2
Igf2
insulin-like growth factor 2
chr4_+_46039202 5.27 ENSMUST00000156200.1
Tmod1
tropomodulin 1
chrX_+_101449078 4.71 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2
chr7_+_19411086 3.72 ENSMUST00000003643.1
Ckm
creatine kinase, muscle
chr11_-_94973447 3.63 ENSMUST00000100551.4
ENSMUST00000152042.1
Sgca
sarcoglycan, alpha (dystrophin-associated glycoprotein)
chr8_+_15057646 3.43 ENSMUST00000033842.3
Myom2
myomesin 2
chr6_-_83536215 3.28 ENSMUST00000075161.5
Actg2
actin, gamma 2, smooth muscle, enteric
chr10_-_111997204 3.19 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr9_+_110763646 3.17 ENSMUST00000079784.7
Myl3
myosin, light polypeptide 3
chr4_-_119190005 2.82 ENSMUST00000138395.1
ENSMUST00000156746.1
Ermap
erythroblast membrane-associated protein
chr2_+_127336152 2.78 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr14_-_34588654 2.76 ENSMUST00000022328.6
ENSMUST00000064098.6
ENSMUST00000022327.5
ENSMUST00000022330.7
Ldb3
LIM domain binding 3
chr4_+_43957401 2.69 ENSMUST00000030202.7
Glipr2
GLI pathogenesis-related 2
chr2_+_154548888 2.64 ENSMUST00000045116.4
ENSMUST00000109709.3
1700003F12Rik
RIKEN cDNA 1700003F12 gene
chr10_+_45335751 2.58 ENSMUST00000095715.3
Bves
blood vessel epicardial substance
chr14_-_54966570 2.43 ENSMUST00000124930.1
ENSMUST00000134256.1
ENSMUST00000081857.6
ENSMUST00000145322.1
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr17_-_57194170 2.17 ENSMUST00000005976.6
Tnfsf14
tumor necrosis factor (ligand) superfamily, member 14
chr4_+_43957678 2.08 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chr2_+_156775409 2.00 ENSMUST00000088552.6
Myl9
myosin, light polypeptide 9, regulatory
chr2_+_164940742 1.85 ENSMUST00000137626.1
Mmp9
matrix metallopeptidase 9
chr5_-_24329556 1.65 ENSMUST00000115098.2
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr6_-_40951826 1.65 ENSMUST00000073642.5
Gm4744
predicted gene 4744
chr4_-_63403330 1.64 ENSMUST00000035724.4
Akna
AT-hook transcription factor
chr1_-_43163891 1.63 ENSMUST00000008280.7
Fhl2
four and a half LIM domains 2
chr2_-_152415044 1.61 ENSMUST00000099207.3
Zcchc3
zinc finger, CCHC domain containing 3
chr14_-_34588607 1.57 ENSMUST00000090040.4
Ldb3
LIM domain binding 3
chr11_-_120348513 1.44 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr11_-_120348475 1.38 ENSMUST00000062147.7
ENSMUST00000128055.1
Actg1
actin, gamma, cytoplasmic 1
chr3_+_131112785 1.38 ENSMUST00000098611.3
Lef1
lymphoid enhancer binding factor 1
chr19_+_53529100 1.33 ENSMUST00000038287.6
Dusp5
dual specificity phosphatase 5
chr10_+_4266323 1.23 ENSMUST00000045730.5
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr5_-_112896350 1.18 ENSMUST00000086617.4
Myo18b
myosin XVIIIb
chr14_-_19585135 1.18 ENSMUST00000170694.1
Gm2237
predicted gene 2237
chr1_+_74409376 1.16 ENSMUST00000027366.6
Vil1
villin 1
chr12_-_32953772 1.16 ENSMUST00000180391.1
ENSMUST00000181670.1
4933406C10Rik
RIKEN cDNA 4933406C10 gene
chr1_-_127677923 1.15 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr1_-_33757711 1.06 ENSMUST00000044691.7
Bag2
BCL2-associated athanogene 2
chr10_+_79988584 1.04 ENSMUST00000004784.4
ENSMUST00000105374.1
Cnn2
calponin 2
chr10_+_33083476 1.03 ENSMUST00000095762.4
Trdn
triadin
chr18_+_34861200 0.96 ENSMUST00000165033.1
Egr1
early growth response 1
chr4_+_148000722 0.94 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr2_+_150786735 0.93 ENSMUST00000045441.7
Pygb
brain glycogen phosphorylase
chr19_-_5912771 0.92 ENSMUST00000118623.1
Dpf2
D4, zinc and double PHD fingers family 2
chr11_-_120348091 0.91 ENSMUST00000106215.4
Actg1
actin, gamma, cytoplasmic 1
chr7_+_128246812 0.86 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr7_+_128246953 0.83 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr2_+_125068118 0.83 ENSMUST00000070353.3
Slc24a5
solute carrier family 24, member 5
chr11_-_5898771 0.82 ENSMUST00000102921.3
Myl7
myosin, light polypeptide 7, regulatory
chr4_+_132351768 0.82 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr4_-_132351636 0.76 ENSMUST00000105951.1
Rcc1
regulator of chromosome condensation 1
chr19_-_5912834 0.76 ENSMUST00000136983.1
Dpf2
D4, zinc and double PHD fingers family 2
chr11_+_101330605 0.73 ENSMUST00000103105.3
Aoc3
amine oxidase, copper containing 3
chr17_+_7925990 0.72 ENSMUST00000036370.7
Tagap
T cell activation Rho GTPase activating protein
chr11_-_99493112 0.71 ENSMUST00000006969.7
Krt23
keratin 23
chr1_+_63176818 0.71 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr6_-_97179100 0.69 ENSMUST00000095664.3
Tmf1
TATA element modulatory factor 1
chr4_+_120615816 0.68 ENSMUST00000148457.1
Gm12860
predicted gene 12860
chr13_+_23746734 0.66 ENSMUST00000099703.2
Hist1h2bb
histone cluster 1, H2bb
chr2_-_91649785 0.65 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr10_+_67537861 0.61 ENSMUST00000048289.7
ENSMUST00000105438.2
ENSMUST00000130933.1
ENSMUST00000146986.1
Egr2
early growth response 2
chr11_-_120731944 0.61 ENSMUST00000154565.1
ENSMUST00000026148.2
Cbr2
carbonyl reductase 2
chr4_-_155056784 0.58 ENSMUST00000131173.2
Plch2
phospholipase C, eta 2
chr5_+_90367204 0.54 ENSMUST00000068250.3
Gm9958
predicted gene 9958
chr8_+_47675362 0.52 ENSMUST00000098781.2
AA386476
expressed sequence AA386476
chr3_+_68468162 0.52 ENSMUST00000182532.1
Schip1
schwannomin interacting protein 1
chr9_+_53537021 0.51 ENSMUST00000035850.7
Npat
nuclear protein in the AT region
chr3_-_152266320 0.51 ENSMUST00000046045.8
Nexn
nexilin
chr11_+_77462325 0.51 ENSMUST00000102493.1
Coro6
coronin 6
chr7_+_101896817 0.49 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr5_+_24413406 0.46 ENSMUST00000049346.5
Asic3
acid-sensing (proton-gated) ion channel 3
chr7_-_102210120 0.45 ENSMUST00000070165.5
Nup98
nucleoporin 98
chr8_+_54550324 0.45 ENSMUST00000033918.2
Asb5
ankyrin repeat and SOCs box-containing 5
chr17_+_5941280 0.45 ENSMUST00000146009.1
ENSMUST00000115791.2
ENSMUST00000080283.6
Synj2
synaptojanin 2
chr6_+_87373357 0.43 ENSMUST00000032128.4
Gkn2
gastrokine 2
chr9_-_66514567 0.42 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr5_+_103754154 0.42 ENSMUST00000054979.3
Aff1
AF4/FMR2 family, member 1
chr2_-_60881360 0.41 ENSMUST00000164147.1
ENSMUST00000112509.1
Rbms1
RNA binding motif, single stranded interacting protein 1
chr7_+_101896340 0.41 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15
anaphase prompoting complex C subunit 15
chr16_-_4880284 0.38 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr17_-_73399289 0.36 ENSMUST00000095208.3
Capn13
calpain 13
chr19_+_5447692 0.36 ENSMUST00000025850.5
Fosl1
fos-like antigen 1
chrX_+_11311934 0.36 ENSMUST00000178979.1
Gm14484
predicted gene 14484
chr3_+_106113229 0.33 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia
chitinase, acidic
chr17_+_23803179 0.31 ENSMUST00000088621.4
Srrm2
serine/arginine repetitive matrix 2
chr11_+_101331069 0.31 ENSMUST00000017316.6
Aoc3
amine oxidase, copper containing 3
chr12_+_86678685 0.31 ENSMUST00000021681.3
Vash1
vasohibin 1
chr3_-_95891929 0.29 ENSMUST00000171519.1
BC028528
cDNA sequence BC028528
chr12_-_40199315 0.29 ENSMUST00000095760.2
Lsmem1
leucine-rich single-pass membrane protein 1
chr2_+_127208358 0.28 ENSMUST00000103220.3
Snrnp200
small nuclear ribonucleoprotein 200 (U5)
chr7_-_44997221 0.27 ENSMUST00000152341.1
Bcl2l12
BCL2-like 12 (proline rich)
chr13_+_109260481 0.26 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr5_+_98180866 0.25 ENSMUST00000112959.1
Prdm8
PR domain containing 8
chr14_+_53640701 0.25 ENSMUST00000179267.2
Trav14-2
T cell receptor alpha variable 14-2
chr3_-_19311269 0.24 ENSMUST00000099195.3
Pde7a
phosphodiesterase 7A
chr2_-_127521358 0.23 ENSMUST00000028850.8
ENSMUST00000103215.4
Kcnip3
Kv channel interacting protein 3, calsenilin
chr2_+_31759932 0.21 ENSMUST00000028190.6
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr2_-_13271419 0.19 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr12_-_103355967 0.19 ENSMUST00000021617.7
Asb2
ankyrin repeat and SOCS box-containing 2
chr2_-_13271268 0.18 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1
Ras suppressor protein 1
chr3_-_95891938 0.18 ENSMUST00000036360.6
ENSMUST00000090476.3
BC028528
cDNA sequence BC028528
chr12_+_85473883 0.18 ENSMUST00000021674.6
Fos
FBJ osteosarcoma oncogene
chr4_+_19280850 0.17 ENSMUST00000102999.1
Cngb3
cyclic nucleotide gated channel beta 3
chr2_-_60673654 0.17 ENSMUST00000059888.8
ENSMUST00000154764.1
Itgb6
integrin beta 6
chr8_-_47675130 0.15 ENSMUST00000080353.2
Ing2
inhibitor of growth family, member 2
chr4_-_122886044 0.15 ENSMUST00000106255.1
ENSMUST00000106257.3
Cap1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr17_-_46153517 0.15 ENSMUST00000171172.1
Mad2l1bp
MAD2L1 binding protein
chr15_-_77842133 0.15 ENSMUST00000016771.6
Myh9
myosin, heavy polypeptide 9, non-muscle
chrX_-_166518567 0.14 ENSMUST00000112187.1
Tceanc
transcription elongation factor A (SII) N-terminal and central domain containing
chr7_+_17972124 0.14 ENSMUST00000094799.2
Ceacam11
carcinoembryonic antigen-related cell adhesion molecule 11
chr15_+_11000716 0.13 ENSMUST00000117100.1
ENSMUST00000022851.7
Slc45a2
solute carrier family 45, member 2
chrX_-_79434418 0.13 ENSMUST00000179788.1
Chdc2
calponin homology domain containing 2
chr13_+_64432479 0.13 ENSMUST00000021939.6
Cdk20
cyclin-dependent kinase 20
chr16_+_11313812 0.12 ENSMUST00000023140.5
Tnfrsf17
tumor necrosis factor receptor superfamily, member 17
chr14_-_6108665 0.12 ENSMUST00000165193.1
Gm3468
predicted gene 3468
chr9_-_58313189 0.10 ENSMUST00000061799.8
Loxl1
lysyl oxidase-like 1
chr14_+_20929416 0.10 ENSMUST00000022369.7
Vcl
vinculin
chr7_-_19310035 0.06 ENSMUST00000003640.2
Fosb
FBJ osteosarcoma oncogene B
chr7_+_19131686 0.05 ENSMUST00000165913.1
Fbxo46
F-box protein 46
chr17_-_27204357 0.05 ENSMUST00000055117.7
Lemd2
LEM domain containing 2
chr7_-_44997535 0.03 ENSMUST00000124232.1
ENSMUST00000003290.4
Bcl2l12
BCL2-like 12 (proline rich)
chr7_+_18009881 0.03 ENSMUST00000108488.1
ENSMUST00000081703.6
Ceacam13
carcinoembryonic antigen-related cell adhesion molecule 13
chr2_-_17996924 0.03 ENSMUST00000105001.2
H2afb1
H2A histone family, member B1
chr14_+_3049285 0.01 ENSMUST00000166494.1
Gm2897
predicted gene 2897

Network of associatons between targets according to the STRING database.

First level regulatory network of Srf

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 18.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.7 23.1 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.7 2.2 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.6 1.9 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.5 1.6 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.4 2.6 GO:0060931 sinoatrial node cell development(GO:0060931)
0.4 1.7 GO:1902303 negative regulation of potassium ion export(GO:1902303)
0.3 1.0 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.3 1.0 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.3 1.4 GO:0071899 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.3 3.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.3 3.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.3 1.0 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.3 1.2 GO:1902896 terminal web assembly(GO:1902896)
0.2 0.9 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.2 0.7 GO:2000845 positive regulation of androgen secretion(GO:2000836) positive regulation of testosterone secretion(GO:2000845)
0.2 1.7 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 0.8 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.2 0.6 GO:0021666 rhombomere formation(GO:0021594) rhombomere 3 formation(GO:0021660) rhombomere 5 morphogenesis(GO:0021664) rhombomere 5 formation(GO:0021666)
0.2 0.5 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.1 0.1 GO:1903918 regulation of actin filament severing(GO:1903918) negative regulation of actin filament severing(GO:1903919)
0.1 7.7 GO:0045214 sarcomere organization(GO:0045214)
0.1 1.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.6 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 1.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.3 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 3.2 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 2.8 GO:0001706 endoderm formation(GO:0001706)
0.1 0.9 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 3.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 3.7 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.1 1.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.1 0.4 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.9 GO:0044247 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.2 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.3 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.1 GO:0015766 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.3 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.5 GO:0001553 luteinization(GO:0001553)
0.0 0.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 1.7 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.1 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.3 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.0 0.8 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.7 GO:0006414 translational elongation(GO:0006414)
0.0 0.2 GO:0035994 response to muscle stretch(GO:0035994)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.4 3.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 1.0 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.3 13.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 5.7 GO:0005859 muscle myosin complex(GO:0005859)
0.2 3.7 GO:0043034 costamere(GO:0043034)
0.2 0.5 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 2.2 GO:0016460 myosin II complex(GO:0016460)
0.1 1.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 23.6 GO:0031674 I band(GO:0031674)
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.9 GO:0042629 mast cell granule(GO:0042629)
0.1 0.5 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 0.8 GO:0031672 A band(GO:0031672)
0.1 0.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 1.2 GO:0032433 filopodium tip(GO:0032433)
0.1 1.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.7 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 2.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 4.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 19.0 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.7 GO:0004111 creatine kinase activity(GO:0004111)
0.5 18.0 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.4 2.3 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.3 1.0 GO:0052594 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.3 7.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 5.3 GO:0005523 tropomyosin binding(GO:0005523)
0.3 1.7 GO:1902282 phosphorelay sensor kinase activity(GO:0000155) voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.3 4.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 0.9 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.2 1.7 GO:0048495 Roundabout binding(GO:0048495)
0.2 1.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.2 0.6 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 1.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 11.8 GO:0017022 myosin binding(GO:0017022)
0.1 0.8 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 1.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 2.6 GO:0030552 cAMP binding(GO:0030552)
0.1 1.9 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.4 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 4.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0015154 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 2.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 17.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 7.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 8.3 PID RHOA PATHWAY RhoA signaling pathway
0.1 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 1.9 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 3.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.4 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 18.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 10.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 5.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 3.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation