Motif ID: Stat6

Z-value: 1.126


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_127643034-0.221.9e-01Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_171767123 14.785 ENSMUST00000015460.4
Slamf1
signaling lymphocytic activation molecule family member 1
chr11_+_87793722 13.422 ENSMUST00000143021.2
Mpo
myeloperoxidase
chr11_+_87793470 12.511 ENSMUST00000020779.4
Mpo
myeloperoxidase
chr14_+_27000362 12.251 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chr4_+_120666562 9.250 ENSMUST00000094814.4
Cited4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr3_+_153844209 8.913 ENSMUST00000044089.3
Asb17
ankyrin repeat and SOCS box-containing 17
chr9_-_70421533 8.093 ENSMUST00000034742.6
Ccnb2
cyclin B2
chr17_+_48299952 7.807 ENSMUST00000170941.1
Treml2
triggering receptor expressed on myeloid cells-like 2
chr2_+_84988194 7.019 ENSMUST00000028466.5
Prg3
proteoglycan 3
chr9_+_112234257 6.904 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr1_+_107535508 5.965 ENSMUST00000182198.1
Serpinb10
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
chr1_+_134182150 5.660 ENSMUST00000156873.1
Chi3l1
chitinase 3-like 1
chr13_+_99100698 5.656 ENSMUST00000181742.1
Gm807
predicted gene 807
chr5_-_148392810 5.105 ENSMUST00000138257.1
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr7_+_127091426 4.833 ENSMUST00000056288.5
AI467606
expressed sequence AI467606
chr1_+_134182404 4.786 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
Chi3l1



chitinase 3-like 1



chr18_+_50053282 3.976 ENSMUST00000148159.2
Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr2_-_113848655 3.958 ENSMUST00000102545.1
ENSMUST00000110948.1
Arhgap11a

Rho GTPase activating protein 11A

chr3_+_103832562 3.951 ENSMUST00000062945.5
Bcl2l15
BCLl2-like 15
chr12_-_87233556 3.761 ENSMUST00000021423.7
Noxred1
NADP+ dependent oxidoreductase domain containing 1
chr14_-_56262233 3.704 ENSMUST00000015581.4
Gzmb
granzyme B
chr2_-_113848601 3.582 ENSMUST00000110949.2
Arhgap11a
Rho GTPase activating protein 11A
chr2_+_24345282 3.556 ENSMUST00000114485.2
Il1rn
interleukin 1 receptor antagonist
chr7_+_81114816 3.478 ENSMUST00000119083.1
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr9_-_49798905 3.460 ENSMUST00000114476.2
Ncam1
neural cell adhesion molecule 1
chr7_+_81114799 3.388 ENSMUST00000026820.4
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr2_+_24345305 3.320 ENSMUST00000114482.1
Il1rn
interleukin 1 receptor antagonist
chr5_+_122100951 3.245 ENSMUST00000014080.6
ENSMUST00000111750.1
ENSMUST00000139213.1
ENSMUST00000111751.1
ENSMUST00000155612.1
Myl2




myosin, light polypeptide 2, regulatory, cardiac, slow




chr1_+_130731963 3.221 ENSMUST00000039323.6
AA986860
expressed sequence AA986860
chr4_-_117125618 3.145 ENSMUST00000183310.1
Btbd19
BTB (POZ) domain containing 19
chr2_+_36216749 2.775 ENSMUST00000147012.1
ENSMUST00000122948.1
Gm13431

predicted gene 13431

chr6_+_8520008 2.774 ENSMUST00000162567.1
ENSMUST00000161217.1
Glcci1

glucocorticoid induced transcript 1

chr4_+_130308595 2.768 ENSMUST00000070532.7
Fabp3
fatty acid binding protein 3, muscle and heart
chr9_+_86743641 2.703 ENSMUST00000179574.1
Prss35
protease, serine, 35
chr9_-_49798729 2.634 ENSMUST00000166811.2
Ncam1
neural cell adhesion molecule 1
chr14_-_65425453 2.552 ENSMUST00000059339.5
Pnoc
prepronociceptin
chr18_+_68337504 2.486 ENSMUST00000172148.1
Mc5r
melanocortin 5 receptor
chr1_-_23909687 2.376 ENSMUST00000129254.1
Smap1
small ArfGAP 1
chr7_-_126800354 2.328 ENSMUST00000106348.1
Aldoa
aldolase A, fructose-bisphosphate
chr3_+_14641722 2.316 ENSMUST00000029071.8
Car13
carbonic anhydrase 13
chr7_+_126766397 2.292 ENSMUST00000032944.7
Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
chr9_+_86743616 2.274 ENSMUST00000036426.6
Prss35
protease, serine, 35
chrX_+_163911401 2.207 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr15_-_82244716 2.177 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr2_+_153943919 2.119 ENSMUST00000099181.1
Bpifb4
BPI fold containing family B, member 4
chr5_+_114786045 2.112 ENSMUST00000137519.1
Ankrd13a
ankyrin repeat domain 13a
chr7_-_126800036 1.911 ENSMUST00000133514.1
ENSMUST00000151137.1
Aldoa

aldolase A, fructose-bisphosphate

chr6_-_113600645 1.910 ENSMUST00000035870.4
Fancd2os
Fancd2 opposite strand
chr16_-_23890805 1.817 ENSMUST00000004480.3
Sst
somatostatin
chr5_-_38876693 1.809 ENSMUST00000169819.1
ENSMUST00000171633.1
Clnk

cytokine-dependent hematopoietic cell linker

chr10_-_51631458 1.691 ENSMUST00000020062.3
Gprc6a
G protein-coupled receptor, family C, group 6, member A
chr13_-_117221075 1.673 ENSMUST00000165680.1
Gm17509
predicted gene, 17509
chr14_-_104522615 1.608 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr2_-_125723387 1.573 ENSMUST00000042246.7
Shc4
SHC (Src homology 2 domain containing) family, member 4
chr11_+_68503019 1.560 ENSMUST00000102613.1
ENSMUST00000060441.6
Pik3r6

phosphoinositide-3-kinase, regulatory subunit 6

chr3_-_87263518 1.535 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr2_+_30077684 1.507 ENSMUST00000125346.1
Pkn3
protein kinase N3
chr13_-_77135416 1.491 ENSMUST00000159462.1
ENSMUST00000151524.2
Ankrd32

ankyrin repeat domain 32

chr11_-_78183551 1.462 ENSMUST00000102483.4
Rpl23a
ribosomal protein L23A
chr3_-_87263703 1.451 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr15_-_9529868 1.450 ENSMUST00000003981.4
Il7r
interleukin 7 receptor
chr11_-_69761963 1.442 ENSMUST00000102586.3
Slc35g3
solute carrier family 35, member G3
chr6_-_87533219 1.436 ENSMUST00000113637.2
ENSMUST00000071024.6
Arhgap25

Rho GTPase activating protein 25

chr2_-_73453918 1.431 ENSMUST00000102679.1
Wipf1
WAS/WASL interacting protein family, member 1
chr19_+_12846773 1.427 ENSMUST00000164001.1
Gm5244
predicted pseudogene 5244
chr19_-_50030735 1.401 ENSMUST00000071866.1
Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr12_-_15816762 1.398 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr1_-_126738167 1.393 ENSMUST00000160693.1
Nckap5
NCK-associated protein 5
chr11_+_78188422 1.383 ENSMUST00000002128.7
ENSMUST00000150941.1
Rab34

RAB34, member of RAS oncogene family

chr3_+_97032416 1.363 ENSMUST00000132256.1
ENSMUST00000072600.6
Gja5

gap junction protein, alpha 5

chr8_-_111082043 1.330 ENSMUST00000039597.7
Clec18a
C-type lectin domain family 18, member A
chr17_-_89910449 1.313 ENSMUST00000086423.4
Gm10184
predicted pseudogene 10184
chr15_+_91231578 1.288 ENSMUST00000109284.2
CN725425
cDNA sequence CN725425
chr12_+_37108533 1.255 ENSMUST00000041183.5
Meox2
mesenchyme homeobox 2
chr4_-_145315143 1.250 ENSMUST00000030339.6
Tnfrsf8
tumor necrosis factor receptor superfamily, member 8
chr1_-_125913101 1.246 ENSMUST00000161361.1
Lypd1
Ly6/Plaur domain containing 1
chr17_-_35205305 1.231 ENSMUST00000025266.5
Lta
lymphotoxin A
chr8_-_106573461 1.229 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr7_-_127286385 1.216 ENSMUST00000172206.2
Gm17511
predicted gene, 17511
chr4_+_116708624 1.157 ENSMUST00000106463.1
Ccdc163
coiled-coil domain containing 163
chr11_+_108587077 1.153 ENSMUST00000146912.2
Cep112
centrosomal protein 112
chr10_+_81070035 1.150 ENSMUST00000005057.6
Thop1
thimet oligopeptidase 1
chr4_+_116708571 1.149 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
Ccdc163



coiled-coil domain containing 163



chr2_-_14056029 1.148 ENSMUST00000074854.7
Ptpla
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr6_-_141773810 1.137 ENSMUST00000148411.1
Gm5724
predicted gene 5724
chr13_-_23683941 1.136 ENSMUST00000171127.1
Hist1h2ac
histone cluster 1, H2ac
chr10_-_19014549 1.134 ENSMUST00000146388.1
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr7_+_28350652 1.042 ENSMUST00000082134.4
Rps16
ribosomal protein S16
chr7_-_44524642 1.037 ENSMUST00000165208.2
Mybpc2
myosin binding protein C, fast-type
chr11_+_96351632 1.020 ENSMUST00000100523.5
Hoxb2
homeobox B2
chr5_+_31054766 1.013 ENSMUST00000013773.5
ENSMUST00000114646.1
Cad

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

chr4_-_138757578 1.010 ENSMUST00000030526.6
Pla2g2f
phospholipase A2, group IIF
chr19_-_7711263 1.009 ENSMUST00000025666.7
Slc22a19
solute carrier family 22 (organic anion transporter), member 19
chr2_-_14055963 0.974 ENSMUST00000091429.5
ENSMUST00000114753.1
Ptpla

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a

chr1_+_171840607 0.967 ENSMUST00000136479.1
ENSMUST00000042302.6
Cd84

CD84 antigen

chr10_-_44458687 0.952 ENSMUST00000105490.2
Prdm1
PR domain containing 1, with ZNF domain
chr10_-_100589205 0.946 ENSMUST00000054471.8
4930430F08Rik
RIKEN cDNA 4930430F08 gene
chr17_+_29090969 0.941 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr5_+_31054821 0.927 ENSMUST00000174367.1
ENSMUST00000170329.1
ENSMUST00000031049.6
Cad


carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase


chr6_+_57703051 0.922 ENSMUST00000151042.1
Lancl2
LanC (bacterial lantibiotic synthetase component C)-like 2
chr2_-_148443543 0.908 ENSMUST00000099269.3
Cd93
CD93 antigen
chr10_-_128626464 0.895 ENSMUST00000026420.5
Rps26
ribosomal protein S26
chr9_-_119093468 0.892 ENSMUST00000010804.2
Plcd1
phospholipase C, delta 1
chr3_+_90476121 0.886 ENSMUST00000001042.8
Ilf2
interleukin enhancer binding factor 2
chr7_+_66839752 0.867 ENSMUST00000107478.1
Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr7_+_66839726 0.847 ENSMUST00000098382.3
Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chrX_-_53269786 0.839 ENSMUST00000114841.1
ENSMUST00000071023.5
Fam122b

family with sequence similarity 122, member B

chrX_+_7841800 0.822 ENSMUST00000033494.9
ENSMUST00000115666.1
Otud5

OTU domain containing 5

chr4_+_32983008 0.797 ENSMUST00000098190.3
ENSMUST00000029946.7
Rragd

Ras-related GTP binding D

chr10_-_44458715 0.784 ENSMUST00000039174.4
Prdm1
PR domain containing 1, with ZNF domain
chr15_-_81926148 0.783 ENSMUST00000023113.5
Polr3h
polymerase (RNA) III (DNA directed) polypeptide H
chr5_+_57718021 0.769 ENSMUST00000094783.3
ENSMUST00000068110.7
Pcdh7

protocadherin 7

chr7_-_25412857 0.767 ENSMUST00000074040.3
Cxcl17
chemokine (C-X-C motif) ligand 17
chr4_+_116708467 0.758 ENSMUST00000030452.6
Ccdc163
coiled-coil domain containing 163
chr15_+_98632220 0.740 ENSMUST00000109150.1
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr19_-_5924797 0.734 ENSMUST00000055458.4
Cdc42ep2
CDC42 effector protein (Rho GTPase binding) 2
chr10_-_19015347 0.725 ENSMUST00000019997.4
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr11_+_3650253 0.701 ENSMUST00000096441.3
Morc2a
microrchidia 2A
chr3_-_8923796 0.698 ENSMUST00000042148.5
Mrps28
mitochondrial ribosomal protein S28
chr13_-_41358990 0.654 ENSMUST00000163623.1
Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr19_+_29251748 0.652 ENSMUST00000065796.3
ENSMUST00000025705.6
Jak2

Janus kinase 2

chr16_-_22265950 0.650 ENSMUST00000161286.1
Tra2b
transformer 2 beta homolog (Drosophila)
chr15_+_6422240 0.610 ENSMUST00000163082.1
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr12_-_57197311 0.597 ENSMUST00000044634.5
Slc25a21
solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
chr1_+_171840557 0.585 ENSMUST00000135386.1
Cd84
CD84 antigen
chr19_+_10842531 0.575 ENSMUST00000025646.2
Slc15a3
solute carrier family 15, member 3
chrX_+_134756563 0.563 ENSMUST00000081834.3
ENSMUST00000086880.4
ENSMUST00000086884.4
Armcx3


armadillo repeat containing, X-linked 3


chr2_+_70039114 0.547 ENSMUST00000060208.4
Myo3b
myosin IIIB
chr1_-_44118757 0.538 ENSMUST00000027213.7
ENSMUST00000065767.2
Kdelc1

KDEL (Lys-Asp-Glu-Leu) containing 1

chr8_+_105605220 0.537 ENSMUST00000043531.8
Fam65a
family with sequence similarity 65, member A
chrX_+_7842056 0.478 ENSMUST00000115667.3
ENSMUST00000115668.3
ENSMUST00000115665.1
Otud5


OTU domain containing 5


chr9_-_35176039 0.473 ENSMUST00000119847.1
ENSMUST00000034539.5
Dcps

decapping enzyme, scavenger

chr11_-_3914664 0.465 ENSMUST00000109995.1
ENSMUST00000051207.1
Slc35e4

solute carrier family 35, member E4

chr3_-_81924463 0.458 ENSMUST00000069880.2
Gm9989
predicted gene 9989
chr7_-_109731708 0.449 ENSMUST00000035372.1
Ascl3
achaete-scute complex homolog 3 (Drosophila)
chr2_+_29346803 0.440 ENSMUST00000028139.4
ENSMUST00000113830.4
Med27

mediator complex subunit 27

chr6_-_78468863 0.427 ENSMUST00000032089.2
Reg3g
regenerating islet-derived 3 gamma
chr3_-_145032765 0.413 ENSMUST00000029919.5
Clca3
chloride channel calcium activated 3
chr5_-_6876523 0.408 ENSMUST00000164784.1
Zfp804b
zinc finger protein 804B
chr18_+_66458587 0.405 ENSMUST00000025399.7
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chrX_-_103186618 0.396 ENSMUST00000121720.1
Nap1l2
nucleosome assembly protein 1-like 2
chr7_+_44816088 0.380 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chr3_-_96293953 0.365 ENSMUST00000029748.3
Fcgr1
Fc receptor, IgG, high affinity I
chr15_-_33405976 0.351 ENSMUST00000079057.6
1700084J12Rik
RIKEN cDNA 1700084J12 gene
chr1_+_120121161 0.325 ENSMUST00000027637.6
ENSMUST00000112644.2
ENSMUST00000056038.8
3110009E18Rik


RIKEN cDNA 3110009E18 gene


chr9_+_101074727 0.278 ENSMUST00000085177.3
Msl2
male-specific lethal 2 homolog (Drosophila)
chr5_+_21372642 0.277 ENSMUST00000035799.5
Fgl2
fibrinogen-like protein 2
chr15_+_73834561 0.274 ENSMUST00000154520.1
Gm6569
predicted gene 6569
chr1_-_144177259 0.273 ENSMUST00000111941.1
ENSMUST00000052375.1
Rgs13

regulator of G-protein signaling 13

chr5_-_137149320 0.262 ENSMUST00000041226.8
Muc3
mucin 3, intestinal
chr6_+_34863130 0.253 ENSMUST00000074949.3
Tmem140
transmembrane protein 140
chr10_+_127078886 0.252 ENSMUST00000039259.6
Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr5_-_24445254 0.234 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr2_+_163225363 0.231 ENSMUST00000099110.3
ENSMUST00000165937.1
Tox2

TOX high mobility group box family member 2

chr13_-_115090123 0.224 ENSMUST00000109226.3
Pelo
pelota homolog (Drosophila)
chr7_+_140882430 0.190 ENSMUST00000164681.1
ENSMUST00000163610.1
Psmd13

proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

chr17_+_37529957 0.149 ENSMUST00000097325.3
Olfr111
olfactory receptor 111
chr13_-_14063395 0.147 ENSMUST00000170957.1
Ggps1
geranylgeranyl diphosphate synthase 1
chr16_+_25801907 0.144 ENSMUST00000040231.6
ENSMUST00000115306.1
ENSMUST00000115304.1
ENSMUST00000115305.1
Trp63



transformation related protein 63



chr5_-_24445166 0.122 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr12_-_59219725 0.115 ENSMUST00000043204.7
Fbxo33
F-box protein 33
chr11_-_61930246 0.092 ENSMUST00000102650.3
Akap10
A kinase (PRKA) anchor protein 10
chr14_-_73049107 0.088 ENSMUST00000044664.4
ENSMUST00000169168.1
Cysltr2

cysteinyl leukotriene receptor 2

chr2_+_118900377 0.088 ENSMUST00000151162.1
Bahd1
bromo adjacent homology domain containing 1
chr14_-_56211407 0.084 ENSMUST00000022757.3
Gzmf
granzyme F
chrX_-_61185558 0.053 ENSMUST00000166381.1
Cdr1
cerebellar degeneration related antigen 1
chrX_-_140956675 0.049 ENSMUST00000033805.8
ENSMUST00000112978.1
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr18_+_43764317 0.036 ENSMUST00000043803.6
Scgb3a2
secretoglobin, family 3A, member 2
chr11_-_61930197 0.026 ENSMUST00000108710.1
Akap10
A kinase (PRKA) anchor protein 10
chr10_+_97479470 0.017 ENSMUST00000105287.3
Dcn
decorin
chr15_+_62039216 0.016 ENSMUST00000183297.1
Pvt1
plasmacytoma variant translocation 1
chr8_-_105701077 0.005 ENSMUST00000042608.6
Acd
adrenocortical dysplasia

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 25.9 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
4.9 14.8 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
2.0 6.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
1.8 7.0 GO:0045575 basophil activation(GO:0045575)
1.4 6.9 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
1.4 6.9 GO:0015855 purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
1.2 12.3 GO:0030916 otic vesicle formation(GO:0030916)
0.7 3.7 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.7 2.8 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.6 5.1 GO:1903826 arginine transmembrane transport(GO:1903826)
0.6 1.9 GO:2000349 negative regulation of CD40 signaling pathway(GO:2000349)
0.6 1.7 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.5 3.8 GO:0006561 proline biosynthetic process(GO:0006561)
0.5 1.6 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
0.5 1.4 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.5 1.4 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.4 1.2 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.3 1.0 GO:0021570 rhombomere 4 development(GO:0021570)
0.3 1.3 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.3 1.9 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.3 4.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 1.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.3 1.8 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 0.7 GO:0060399 interleukin-12-mediated signaling pathway(GO:0035722) positive regulation of growth hormone receptor signaling pathway(GO:0060399) cellular response to interleukin-12(GO:0071349)
0.2 1.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.2 1.3 GO:0001757 somite specification(GO:0001757)
0.2 0.9 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.1 0.1 GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.1 0.4 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 1.0 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.1 0.4 GO:0001805 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 8.2 GO:0043627 response to estrogen(GO:0043627)
0.1 0.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 8.1 GO:0048538 thymus development(GO:0048538)
0.1 0.6 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026)
0.1 0.4 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.8 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1 0.4 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.1 0.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 2.4 GO:2000369 regulation of clathrin-dependent endocytosis(GO:2000369)
0.1 2.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.7 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 1.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.7 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.1 1.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 2.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.4 GO:0051715 cytolysis in other organism(GO:0051715)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 4.0 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 0.6 GO:0006857 oligopeptide transport(GO:0006857)
0.0 2.2 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 1.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 1.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.9 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077)
0.0 1.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.8 GO:0010575 positive regulation of vascular endothelial growth factor production(GO:0010575)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.0 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 2.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.0 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.9 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 2.2 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.9 GO:0097306 cellular response to alcohol(GO:0097306)
0.0 1.7 GO:0043200 response to amino acid(GO:0043200)
0.0 1.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 1.2 GO:0006342 chromatin silencing(GO:0006342)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 25.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.9 3.7 GO:0044194 cytolytic granule(GO:0044194)
0.4 1.6 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.3 0.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 4.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 16.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 0.8 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 0.6 GO:0070022 transforming growth factor beta receptor complex(GO:0070022)
0.1 1.8 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.5 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.4 GO:0005922 connexin complex(GO:0005922)
0.1 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 1.0 GO:0032982 myosin filament(GO:0032982)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 7.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0032426 stereocilium tip(GO:0032426)
0.0 1.6 GO:0042629 mast cell granule(GO:0042629)
0.0 2.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.2 GO:0016528 sarcoplasm(GO:0016528)
0.0 7.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.4 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 2.2 GO:0000776 kinetochore(GO:0000776)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.4 GO:0016592 mediator complex(GO:0016592) core mediator complex(GO:0070847)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0045352 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
2.3 6.9 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.6 1.9 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.6 5.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.5 3.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.5 4.2 GO:0070061 fructose binding(GO:0070061)
0.5 3.3 GO:0001515 opioid peptide activity(GO:0001515)
0.4 2.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.4 25.9 GO:0004601 peroxidase activity(GO:0004601)
0.4 2.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 3.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.3 1.4 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.3 0.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 6.1 GO:0030275 LRR domain binding(GO:0030275)
0.2 1.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.5 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 0.7 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 1.0 GO:0019534 toxin transporter activity(GO:0019534)
0.1 9.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.8 GO:0008009 chemokine activity(GO:0008009)
0.1 0.9 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 4.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.6 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.1 14.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0051425 PTB domain binding(GO:0051425)
0.1 1.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 1.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.1 0.3 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 1.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 2.4 GO:0030276 clathrin binding(GO:0030276)
0.0 1.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 1.0 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 1.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.6 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.5 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.6 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 1.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.4 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 25.8 PID_IL23_PATHWAY IL23-mediated signaling events
0.2 8.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 7.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 6.9 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 0.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 1.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 3.7 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 4.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.5 PID_FGF_PATHWAY FGF signaling pathway
0.0 7.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.8 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 2.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 6.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 6.9 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 6.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 4.1 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.9 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 4.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 0.7 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.9 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.9 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.0 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 0.5 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.6 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.8 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.3 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME_GAP_JUNCTION_TRAFFICKING Genes involved in Gap junction trafficking
0.0 5.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 4.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery