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GSE58827: Dynamics of the Mouse Liver

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Results for Tbp

Z-value: 3.29

Motif logo

Transcription factors associated with Tbp

Gene Symbol Gene ID Gene Info
ENSMUSG00000014767.10 TATA box binding protein

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbpmm10_v2_chr17_+_15499888_154999600.501.8e-03Click!

Activity profile of Tbp motif

Sorted Z-values of Tbp motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_36455378 41.31 ENSMUST00000068182.2
stefin A3
chr16_-_36367623 38.93 ENSMUST00000096089.2
cDNA sequence BC100530
chr16_+_36184082 33.68 ENSMUST00000114858.1
predicted gene 5483
chr16_+_36156801 32.28 ENSMUST00000079184.4
stefin A2 like 1
chr16_+_36277145 30.44 ENSMUST00000042097.9
stefin A1
chr14_+_80000292 28.31 ENSMUST00000088735.3
olfactomedin 4
chr9_+_98490522 26.57 ENSMUST00000035029.2
retinol binding protein 2, cellular
chr11_+_87793470 26.45 ENSMUST00000020779.4
myeloperoxidase
chr6_-_41314700 25.87 ENSMUST00000064324.5
trypsin 5
chr3_-_106167564 25.61 ENSMUST00000063062.8
chitinase 3-like 3
chr3_-_90695706 24.84 ENSMUST00000069960.5
ENSMUST00000117167.1
S100 calcium binding protein A9 (calgranulin B)
chr16_+_36210403 24.43 ENSMUST00000089628.3
predicted gene 5416
chr6_-_41377604 22.86 ENSMUST00000096003.5
protease, serine, 3
chr3_-_106149761 21.62 ENSMUST00000149836.1
chitinase 3-like 3
chr14_-_56102458 20.61 ENSMUST00000015583.1
cathepsin G
chr6_+_142298419 19.94 ENSMUST00000041993.2
islet amyloid polypeptide
chr11_-_55185029 19.92 ENSMUST00000039305.5
solute carrier family 36 (proton/amino acid symporter), member 2
chr11_-_99438143 19.61 ENSMUST00000017743.2
keratin 20
chr9_-_67832325 17.67 ENSMUST00000054500.5
C2 calcium-dependent domain containing 4A
chr7_-_103853199 17.50 ENSMUST00000033229.3
hemoglobin Y, beta-like embryonic chain
chr3_-_20275659 16.48 ENSMUST00000011607.5
carboxypeptidase B1 (tissue)
chr1_+_134182404 15.57 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
chitinase 3-like 1
chr1_+_134182150 15.31 ENSMUST00000156873.1
chitinase 3-like 1
chr6_+_41354105 15.31 ENSMUST00000072103.5
trypsin 10
chr13_+_21717626 15.16 ENSMUST00000091754.2
histone cluster 1, H3h
chr11_-_102107822 14.08 ENSMUST00000177304.1
ENSMUST00000017455.8
peptide YY
chr7_-_103843154 14.02 ENSMUST00000063957.4
hemoglobin Z, beta-like embryonic chain
chr4_+_34893772 13.93 ENSMUST00000029975.3
ENSMUST00000135871.1
ENSMUST00000108130.1
glycoprotein hormones, alpha subunit
chr4_+_120666562 13.91 ENSMUST00000094814.4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr7_-_103813913 13.20 ENSMUST00000098192.3
hemoglobin, beta adult t chain
chr6_-_41035501 13.15 ENSMUST00000031931.5
RIKEN cDNA 2210010C04 gene
chr14_+_56042123 12.91 ENSMUST00000015576.4
mast cell protease 2
chr6_+_41392356 12.76 ENSMUST00000049079.7
predicted gene 5771
chr8_+_94179089 12.74 ENSMUST00000034215.6
metallothionein 1
chr18_-_78123324 12.63 ENSMUST00000160292.1
ENSMUST00000091813.5
solute carrier family 14 (urea transporter), member 1
chr2_-_114052804 12.40 ENSMUST00000090269.6
actin, alpha, cardiac muscle 1
chr6_-_67535783 12.36 ENSMUST00000058178.4
tumor-associated calcium signal transducer 2
chr3_+_103832562 12.18 ENSMUST00000062945.5
BCLl2-like 15
chr11_+_67277124 12.16 ENSMUST00000019625.5
myosin, heavy polypeptide 8, skeletal muscle, perinatal
chr2_-_62483637 12.16 ENSMUST00000136686.1
ENSMUST00000102733.3
glucagon
chr3_-_20242173 12.12 ENSMUST00000001921.1
carboxypeptidase A3, mast cell
chr7_-_45526146 11.83 ENSMUST00000167273.1
ENSMUST00000042105.8
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr7_-_103827922 11.62 ENSMUST00000023934.6
ENSMUST00000153218.1
hemoglobin, beta adult s chain
chr17_-_31129602 11.36 ENSMUST00000024827.4
trefoil factor 3, intestinal
chr10_+_43579161 10.97 ENSMUST00000058714.8
CD24a antigen
chr11_-_69948145 10.94 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
solute carrier family 2 (facilitated glucose transporter), member 4
chr6_+_4747306 10.46 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
paternally expressed 10
chr7_-_143502515 10.34 ENSMUST00000010904.4
pleckstrin homology-like domain, family A, member 2
chr15_-_101491509 10.13 ENSMUST00000023718.7
RIKEN cDNA 5430421N21 gene
chr7_-_44532064 9.94 ENSMUST00000098483.2
ENSMUST00000035323.4
Spi-B transcription factor (Spi-1/PU.1 related)
chr11_-_99024179 9.93 ENSMUST00000068031.7
topoisomerase (DNA) II alpha
chr11_+_76998595 9.84 ENSMUST00000108402.2
ENSMUST00000021195.4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
chr13_-_21780616 9.83 ENSMUST00000080511.2
histone cluster 1, H1b
chr11_-_102897123 9.82 ENSMUST00000067444.3
glial fibrillary acidic protein
chr4_-_41098174 9.77 ENSMUST00000055327.7
aquaporin 3
chr11_-_120551126 9.76 ENSMUST00000026121.2
protein phosphatase 1, regulatory subunit 27
chr11_+_120949053 9.60 ENSMUST00000154187.1
ENSMUST00000100130.3
ENSMUST00000129473.1
ENSMUST00000168579.1
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr13_-_73700721 9.11 ENSMUST00000022048.5
solute carrier family 6 (neurotransmitter transporter), member 19
chr2_-_164356067 9.06 ENSMUST00000165980.1
secretory leukocyte peptidase inhibitor
chr8_-_105933832 9.03 ENSMUST00000034368.6
chymotrypsin-like
chr13_+_23763660 8.88 ENSMUST00000055770.1
histone cluster 1, H1a
chr11_-_100121558 8.77 ENSMUST00000007275.2
keratin 13
chr6_-_87981482 8.75 ENSMUST00000056403.5
H1 histone family, member X
chr2_-_164356507 8.67 ENSMUST00000109367.3
secretory leukocyte peptidase inhibitor
chr11_-_102897146 8.55 ENSMUST00000077902.4
glial fibrillary acidic protein
chr4_-_119658781 8.54 ENSMUST00000106309.2
ENSMUST00000044426.7
guanylate cyclase activator 2b (retina)
chr10_-_88605017 8.52 ENSMUST00000119185.1
ENSMUST00000121629.1
myosin binding protein C, slow-type
chr19_-_3414464 8.49 ENSMUST00000025842.6
galanin
chr7_-_4812351 8.46 ENSMUST00000079496.7
ubiquitin-conjugating enzyme E2S
chr14_-_56062307 8.35 ENSMUST00000043249.8
mast cell protease 4
chr8_+_84969824 8.28 ENSMUST00000125893.1
peroxiredoxin 2
chr2_+_119618717 8.23 ENSMUST00000028771.7
nucleolar and spindle associated protein 1
chr4_+_123282778 8.16 ENSMUST00000106243.1
ENSMUST00000106241.1
ENSMUST00000080178.6
poly(A) binding protein, cytoplasmic 4
chr18_+_34625009 7.96 ENSMUST00000166044.1
kinesin family member 20A
chr8_+_84969767 7.85 ENSMUST00000109733.1
peroxiredoxin 2
chr13_+_23575753 7.80 ENSMUST00000105105.1
histone cluster 1, H3d
chr19_+_60755947 7.74 ENSMUST00000088237.4
nanos homolog 1 (Drosophila)
chr6_+_78425973 7.70 ENSMUST00000079926.5
regenerating islet-derived 1
chr18_+_34624621 7.45 ENSMUST00000167161.1
kinesin family member 20A
chr11_-_100135928 7.33 ENSMUST00000107411.2
keratin 15
chr8_+_84969587 7.24 ENSMUST00000109734.1
ENSMUST00000005292.8
peroxiredoxin 2
chr6_+_78370877 7.19 ENSMUST00000096904.3
regenerating islet-derived 3 beta
chr15_+_79895017 7.10 ENSMUST00000023054.7
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr7_+_131032061 6.90 ENSMUST00000084509.3
deleted in malignant brain tumors 1
chr7_-_16259185 6.84 ENSMUST00000168818.1
complement component 5a receptor 1
chr13_-_23745511 6.69 ENSMUST00000091752.2
histone cluster 1, H3c
chr15_-_101712891 6.65 ENSMUST00000023709.5
keratin 5
chr13_+_23544052 6.61 ENSMUST00000075558.2
histone cluster 1, H3f
chr4_-_140810646 6.61 ENSMUST00000026377.2
peptidyl arginine deiminase, type III
chr10_+_88091070 6.59 ENSMUST00000048621.7
pro-melanin-concentrating hormone
chr18_+_36528145 6.47 ENSMUST00000074298.6
ENSMUST00000115694.2
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr7_-_141655319 6.25 ENSMUST00000062451.7
mucin 6, gastric
chr2_-_119618455 6.23 ENSMUST00000123818.1
Opa interacting protein 5
chr6_-_78378851 6.16 ENSMUST00000089667.1
ENSMUST00000167492.1
regenerating islet-derived 3 delta
chr19_-_34255325 5.91 ENSMUST00000039631.8
actin, alpha 2, smooth muscle, aorta
chr4_-_42853888 5.91 ENSMUST00000107979.1
predicted gene 12429
chr15_-_101694299 5.85 ENSMUST00000023788.6
keratin 6A
chr10_+_79777261 5.84 ENSMUST00000020575.4
follistatin-like 3
chr17_-_24251382 5.78 ENSMUST00000115390.3
cyclin F
chr1_-_134079114 5.73 ENSMUST00000020692.6
B cell translocation gene 2, anti-proliferative
chr13_+_23752267 5.72 ENSMUST00000091703.2
histone cluster 1, H3b
chr7_-_109781538 5.52 ENSMUST00000033331.6
nuclear receptor interacting protein 3
chr3_-_92458715 5.47 ENSMUST00000058142.3
small proline-rich protein 3
chr8_+_15057646 5.43 ENSMUST00000033842.3
myomesin 2
chr3_-_106219477 5.40 ENSMUST00000082219.5
chitinase 3-like 4
chr6_-_72958097 5.38 ENSMUST00000114049.1
thymosin, beta 10
chr11_-_115514374 5.32 ENSMUST00000021083.6
hematological and neurological expressed sequence 1
chr15_-_98482683 5.31 ENSMUST00000023726.3
lactalbumin, alpha
chr13_-_23762378 5.25 ENSMUST00000091701.2
histone cluster 1, H3a
chrX_+_164438039 5.22 ENSMUST00000033755.5
ankyrin repeat and SOCS box-containing 11
chr6_-_125494754 5.20 ENSMUST00000032492.8
CD9 antigen
chr7_-_30612731 5.18 ENSMUST00000006476.4
uroplakin 1A
chr9_+_121777607 5.12 ENSMUST00000098272.2
kelch-like 40
chr5_-_114823460 5.05 ENSMUST00000140374.1
ENSMUST00000100850.4
predicted gene 20499
RIKEN cDNA 2610524H06 gene
chr11_-_100261021 5.04 ENSMUST00000080893.6
keratin 17
chr6_-_113719880 5.03 ENSMUST00000064993.5
ghrelin
chrX_+_164140447 5.02 ENSMUST00000073973.4
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr2_+_13573927 5.00 ENSMUST00000141365.1
ENSMUST00000028062.2
vimentin
chr4_-_132353605 4.96 ENSMUST00000155129.1
regulator of chromosome condensation 1
chrX_+_73774397 4.93 ENSMUST00000002081.5
serine/arginine-rich protein specific kinase 3
chr13_-_21783391 4.90 ENSMUST00000099704.3
histone cluster 1, H3i
chr11_+_82101836 4.77 ENSMUST00000000194.3
chemokine (C-C motif) ligand 12
chr8_-_13254154 4.72 ENSMUST00000033825.4
ADP-ribosylhydrolase like 1
chr17_-_33824346 4.71 ENSMUST00000173879.1
ENSMUST00000166693.2
ENSMUST00000173019.1
ENSMUST00000087342.6
ENSMUST00000173844.1
ribosomal protein S28
chr12_+_81631369 4.61 ENSMUST00000036116.5
tetratricopeptide repeat domain 9
chr13_+_21716385 4.59 ENSMUST00000070124.3
histone cluster 1, H2ai
chr10_-_93589621 4.55 ENSMUST00000020203.6
small nuclear ribonucleoprotein polypeptide F
chr6_-_72958465 4.51 ENSMUST00000114050.1
thymosin, beta 10
chr5_-_99978914 4.38 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
heterogeneous nuclear ribonucleoprotein D
chr17_-_33955658 4.26 ENSMUST00000174609.2
ENSMUST00000008812.7
ribosomal protein S18
chr6_+_48895243 4.24 ENSMUST00000031835.7
amine oxidase, copper-containing 1
chr13_-_23683941 4.23 ENSMUST00000171127.1
histone cluster 1, H2ac
chr17_+_23726336 4.21 ENSMUST00000024701.7
protein kinase, membrane associated tyrosine/threonine 1
chr4_-_133967296 4.20 ENSMUST00000105893.1
high mobility group nucleosomal binding domain 2
chr15_-_80083374 4.17 ENSMUST00000081650.7
ribosomal protein L3
chr5_+_76809964 4.12 ENSMUST00000120818.1
RIKEN cDNA C530008M17 gene
chr11_+_3289880 4.06 ENSMUST00000110043.1
ENSMUST00000094471.3
POZ (BTB) and AT hook containing zinc finger 1
chr11_-_33163072 4.04 ENSMUST00000093201.6
ENSMUST00000101375.4
ENSMUST00000109354.3
ENSMUST00000075641.3
nucleophosmin 1
chr13_-_21787218 3.97 ENSMUST00000091751.2
histone cluster 1, H2an
chr9_-_95815389 3.97 ENSMUST00000119760.1
plastin 1 (I-isoform)
chr15_-_101850778 3.89 ENSMUST00000023790.3
keratin 1
chr19_+_55180799 3.88 ENSMUST00000025936.5
tectorin beta
chr16_-_36131156 3.88 ENSMUST00000161638.1
ENSMUST00000096090.2
cystatin A
chr13_+_23581563 3.87 ENSMUST00000102968.1
histone cluster 1, H4d
chr11_-_57832142 3.77 ENSMUST00000036917.2
heart and neural crest derivatives expressed transcript 1
chr6_-_112696604 3.77 ENSMUST00000113182.1
ENSMUST00000113180.1
ENSMUST00000068487.5
ENSMUST00000077088.4
RAD18 homolog (S. cerevisiae)
chr13_-_23622502 3.65 ENSMUST00000062045.2
histone cluster 1, H1e
chr11_+_94936224 3.61 ENSMUST00000001547.7
collagen, type I, alpha 1
chr15_-_101680281 3.60 ENSMUST00000023786.5
keratin 6B
chr4_+_127021311 3.49 ENSMUST00000030623.7
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr3_-_92485886 3.45 ENSMUST00000054599.7
small proline-rich protein 1A
chr2_+_167062934 3.41 ENSMUST00000125674.1
RIKEN cDNA 1500012F01 gene
chr6_-_87672142 3.19 ENSMUST00000032130.2
ENSMUST00000065997.2
aprataxin and PNKP like factor
chr9_+_95637601 3.17 ENSMUST00000015498.8
procollagen C-endopeptidase enhancer 2
chr19_-_4283033 3.14 ENSMUST00000167215.1
ENSMUST00000056888.6
ankyrin repeat domain 13 family, member D
chr9_+_108508005 3.11 ENSMUST00000006838.8
ENSMUST00000134939.1
glutaminyl-tRNA synthetase
chr14_+_56017964 2.95 ENSMUST00000022836.4
mast cell protease 1
chr1_+_63176818 2.95 ENSMUST00000129339.1
eukaryotic translation elongation factor 1 beta 2
chr4_-_116627478 2.93 ENSMUST00000081182.4
ENSMUST00000030457.5
nuclear autoantigenic sperm protein (histone-binding)
chr9_+_30942541 2.93 ENSMUST00000068135.6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
chr13_-_113663670 2.93 ENSMUST00000054650.4
heat shock protein 3
chr8_+_94137197 2.88 ENSMUST00000034207.6
metallothionein 4
chr19_-_53589067 2.86 ENSMUST00000095978.3
nuclear transport factor 2, pseudogene 1
chr17_+_24720063 2.84 ENSMUST00000170715.1
ENSMUST00000054289.6
ENSMUST00000146867.1
ribosomal protein S2
chr13_-_23571151 2.81 ENSMUST00000102969.3
histone cluster 1, H2ae
chr2_+_153918391 2.81 ENSMUST00000109760.1
BPI fold containing family B, member 3
chr2_+_153938218 2.80 ENSMUST00000109757.1
BPI fold containing family B, member 4
chr7_-_30457515 2.76 ENSMUST00000045817.7
kin of IRRE like 2 (Drosophila)
chr9_+_44334685 2.76 ENSMUST00000052686.2
H2A histone family, member X
chr17_-_80207299 2.76 ENSMUST00000063417.9
serine/arginine-rich splicing factor 7
chr19_+_8723478 2.75 ENSMUST00000180819.1
ENSMUST00000181422.1
small nucleolar RNA host gene (non-protein coding) 1
chr14_-_56778301 2.73 ENSMUST00000022507.5
ENSMUST00000163924.1
paraspeckle protein 1
chr2_+_152736244 2.73 ENSMUST00000038368.8
ENSMUST00000109824.1
inhibitor of DNA binding 1
chr11_-_106301801 2.72 ENSMUST00000103071.3
growth hormone
chr17_-_35074485 2.71 ENSMUST00000007259.3
lymphocyte antigen 6 complex, locus G6D
chr13_+_23574381 2.69 ENSMUST00000090776.4
histone cluster 1, H2ad
chr10_+_79988584 2.69 ENSMUST00000004784.4
ENSMUST00000105374.1
calponin 2
chr10_-_40302186 2.66 ENSMUST00000099945.4
S-adenosylmethionine decarboxylase 1
chr14_+_67745229 2.66 ENSMUST00000111095.2
gonadotropin releasing hormone 1
chr14_+_68083853 2.64 ENSMUST00000022639.7
neurofilament, light polypeptide
chr17_-_6827990 2.59 ENSMUST00000181895.1
predicted gene 2885
chr5_+_115559467 2.58 ENSMUST00000086519.5
ribosomal protein, large, P0
chr17_+_29032664 2.57 ENSMUST00000130216.1
serine/arginine-rich splicing factor 3
chr5_+_115559505 2.57 ENSMUST00000156359.1
ENSMUST00000152976.1
ribosomal protein, large, P0
chr9_+_55541148 2.57 ENSMUST00000034869.4
insulin related protein 2 (islet 2)
chr10_-_128626464 2.56 ENSMUST00000026420.5
ribosomal protein S26
chr9_-_88522876 2.56 ENSMUST00000180563.2
ENSMUST00000183030.1
ENSMUST00000182232.1
small nucleolar RNA host gene 5
chr7_-_142899985 2.56 ENSMUST00000000219.3
tyrosine hydroxylase
chr8_-_13254068 2.56 ENSMUST00000168498.1
ADP-ribosylhydrolase like 1
chr8_-_13254096 2.55 ENSMUST00000171619.1
ADP-ribosylhydrolase like 1
chr18_-_36766198 2.50 ENSMUST00000061522.7
dead end homolog 1 (zebrafish)
chr8_-_70839720 2.46 ENSMUST00000002989.9
arrestin domain containing 2
chr4_+_86930691 2.44 ENSMUST00000164590.1
alkaline ceramidase 2
chr13_-_21750505 2.43 ENSMUST00000102983.1
histone cluster 1, H4k
chr12_+_85473883 2.41 ENSMUST00000021674.6
FBJ osteosarcoma oncogene
chr4_+_41966058 2.40 ENSMUST00000108026.2
predicted gene, 20938
chrX_+_74270812 2.40 ENSMUST00000008826.7
ENSMUST00000151702.1
ENSMUST00000074085.5
ENSMUST00000135690.1
ribosomal protein L10
chr4_-_116627921 2.39 ENSMUST00000030456.7
nuclear autoantigenic sperm protein (histone-binding)
chr19_+_39113898 2.35 ENSMUST00000087234.2
cytochrome P450, family 2, subfamily c, polypeptide 66
chr14_-_79771305 2.35 ENSMUST00000039568.5
protocadherin 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbp

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 26.4 GO:0002148 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
8.3 24.8 GO:0070488 neutrophil aggregation(GO:0070488)
5.0 19.9 GO:0035524 proline transmembrane transport(GO:0035524) glycine import(GO:0036233)
4.5 13.5 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
4.2 12.6 GO:0071918 urea transmembrane transport(GO:0071918)
3.9 11.8 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
3.9 31.5 GO:0015671 oxygen transport(GO:0015671)
3.7 11.0 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
3.4 10.3 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722)
3.3 26.6 GO:0006776 vitamin A metabolic process(GO:0006776)
3.3 9.8 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
2.5 19.9 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
2.5 9.9 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
2.5 12.4 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
2.5 9.8 GO:0021941 negative regulation of cerebellar granule cell precursor proliferation(GO:0021941)
2.3 21.1 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
2.3 18.4 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
2.2 6.6 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
2.1 8.5 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
2.0 4.0 GO:0006407 rRNA export from nucleus(GO:0006407)
2.0 25.5 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
1.9 23.4 GO:0002679 respiratory burst involved in defense response(GO:0002679)
1.9 5.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.8 12.7 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
1.7 12.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
1.6 4.8 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
1.5 40.2 GO:0045109 intermediate filament organization(GO:0045109)
1.5 4.4 GO:1901355 response to rapamycin(GO:1901355)
1.5 46.5 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.4 9.8 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
1.3 5.3 GO:0046351 disaccharide biosynthetic process(GO:0046351)
1.3 6.6 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
1.3 24.6 GO:0033275 actin-myosin filament sliding(GO:0033275)
1.3 3.8 GO:0003218 cardiac left ventricle formation(GO:0003218)
1.2 7.2 GO:0036476 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
1.2 3.5 GO:0007439 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
1.1 6.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
1.0 6.2 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.0 5.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
1.0 4.0 GO:1902896 terminal web assembly(GO:1902896)
1.0 9.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
1.0 13.4 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.9 14.4 GO:0032096 negative regulation of response to food(GO:0032096)
0.9 2.7 GO:0006597 spermine biosynthetic process(GO:0006597)
0.9 14.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.9 5.2 GO:0030913 paranodal junction assembly(GO:0030913)
0.9 2.6 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.9 2.6 GO:0042414 epinephrine metabolic process(GO:0042414)
0.8 5.9 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.8 2.4 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.8 15.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.7 2.2 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.7 14.1 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.7 5.2 GO:0016584 nucleosome positioning(GO:0016584)
0.6 3.2 GO:0090027 negative regulation of monocyte chemotaxis(GO:0090027)
0.6 1.8 GO:0071462 cellular response to mercury ion(GO:0071288) cellular response to water stimulus(GO:0071462)
0.6 8.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.6 2.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.5 3.2 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.5 3.6 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.5 7.1 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.5 3.5 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.5 2.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.5 0.9 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.4 5.8 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.4 2.7 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.4 1.2 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.4 55.6 GO:0007586 digestion(GO:0007586)
0.4 7.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 2.7 GO:1903026 negative regulation of protein homodimerization activity(GO:0090074) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.4 3.9 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 22.0 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 4.2 GO:0071280 cellular response to copper ion(GO:0071280)
0.4 1.1 GO:0009414 hexitol metabolic process(GO:0006059) response to water deprivation(GO:0009414) inner medullary collecting duct development(GO:0072061)
0.4 1.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.4 6.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.4 1.4 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.4 10.9 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.3 10.0 GO:0031424 keratinization(GO:0031424)
0.3 3.6 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.3 2.1 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.3 2.3 GO:0071816 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.3 9.3 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.3 2.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.3 12.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 3.2 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.2 3.9 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.2 0.7 GO:0021590 cerebellum maturation(GO:0021590) cerebellar Purkinje cell layer maturation(GO:0021691) cerebellar cortex maturation(GO:0021699)
0.2 1.7 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.2 7.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.2 1.3 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.2 1.5 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.2 1.5 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.2 6.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 0.5 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.2 8.3 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.2 0.6 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.2 14.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 2.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 11.2 GO:0006334 nucleosome assembly(GO:0006334)
0.2 5.0 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 6.1 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.1 0.6 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 1.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 5.5 GO:0030225 macrophage differentiation(GO:0030225)
0.1 4.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 2.7 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.1 2.5 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.1 2.7 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.1 0.6 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.1 1.8 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 18.4 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 11.9 GO:0043627 response to estrogen(GO:0043627)
0.1 12.6 GO:0006342 chromatin silencing(GO:0006342)
0.1 8.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 2.4 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.1 0.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 0.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 8.2 GO:0061515 myeloid cell development(GO:0061515)
0.1 1.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 2.7 GO:1905144 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 0.6 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 4.9 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.1 1.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.5 GO:0051459 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 0.6 GO:0030823 regulation of cGMP metabolic process(GO:0030823)
0.1 1.3 GO:0031280 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280)
0.1 1.8 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 1.4 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 2.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.4 GO:1901907 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.7 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.1 1.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 0.6 GO:0060689 cell differentiation involved in salivary gland development(GO:0060689)
0.1 0.4 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 1.2 GO:0007625 grooming behavior(GO:0007625)
0.1 5.2 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 1.5 GO:0019236 response to pheromone(GO:0019236)
0.0 2.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 1.8 GO:0006414 translational elongation(GO:0006414)
0.0 0.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.3 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 2.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.2 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 2.6 GO:0051028 mRNA transport(GO:0051028)
0.0 0.9 GO:0021591 ventricular system development(GO:0021591)
0.0 0.7 GO:0009268 response to pH(GO:0009268)
0.0 0.7 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.1 GO:0042255 ribosome assembly(GO:0042255)
0.0 2.1 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 1.4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 2.2 GO:0016331 morphogenesis of embryonic epithelium(GO:0016331)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 56.4 GO:0005833 hemoglobin complex(GO:0005833)
4.6 18.4 GO:0097450 astrocyte end-foot(GO:0097450)
2.6 26.4 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.8 28.3 GO:0042581 specific granule(GO:0042581)
1.2 3.6 GO:0005584 collagen type I trimer(GO:0005584)
1.2 6.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
1.1 2.2 GO:0060205 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
1.1 12.2 GO:0032982 myosin filament(GO:0032982)
1.0 36.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.9 4.5 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.9 2.6 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.8 11.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.8 5.9 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.8 6.2 GO:0042382 paraspeckles(GO:0042382)
0.8 33.1 GO:0000786 nucleosome(GO:0000786)
0.7 3.5 GO:1990745 EARP complex(GO:1990745)
0.6 10.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.6 5.0 GO:0045098 type III intermediate filament(GO:0045098)
0.6 14.9 GO:0042588 zymogen granule(GO:0042588)
0.6 4.0 GO:1990357 terminal web(GO:1990357)
0.6 2.2 GO:0032021 NELF complex(GO:0032021)
0.5 14.0 GO:0005859 muscle myosin complex(GO:0005859)
0.5 54.2 GO:0005882 intermediate filament(GO:0005882)
0.5 1.6 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.5 2.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.5 11.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.5 1.4 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.4 1.8 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.4 2.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.4 2.4 GO:0035976 AP1 complex(GO:0035976)
0.4 2.6 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.4 3.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 8.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 2.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.3 16.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 2.7 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.3 2.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 1.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.3 4.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 3.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.2 6.2 GO:0010369 chromocenter(GO:0010369)
0.2 15.4 GO:0005871 kinesin complex(GO:0005871)
0.2 1.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 2.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.2 6.9 GO:0001533 cornified envelope(GO:0001533)
0.2 0.6 GO:0072534 perineuronal net(GO:0072534)
0.2 3.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 1.9 GO:0045298 tubulin complex(GO:0045298)
0.2 0.6 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.2 2.8 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 11.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 14.0 GO:0005814 centriole(GO:0005814)
0.1 8.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 10.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.2 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.1 34.4 GO:0030141 secretory granule(GO:0030141)
0.1 4.2 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.0 GO:0000812 Swr1 complex(GO:0000812)
0.1 2.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 7.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 3.2 GO:0035861 site of double-strand break(GO:0035861)
0.1 10.2 GO:0042641 actomyosin(GO:0042641)
0.1 0.5 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.4 GO:0005916 fascia adherens(GO:0005916)
0.1 4.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 9.7 GO:0043209 myelin sheath(GO:0043209)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 6.8 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)
0.0 14.9 GO:0005774 vacuolar membrane(GO:0005774)
0.0 15.9 GO:0000790 nuclear chromatin(GO:0000790)
0.0 4.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 8.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 8.8 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 14.2 GO:0030054 cell junction(GO:0030054)
0.0 3.1 GO:0098590 plasma membrane region(GO:0098590)
0.0 9.0 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.1 56.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
9.8 9.8 GO:0015254 glycerol channel activity(GO:0015254)
6.6 19.9 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
3.3 9.8 GO:0005330 dopamine:sodium symporter activity(GO:0005330)
3.1 24.8 GO:0050786 Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786)
2.5 9.8 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
2.2 10.9 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
2.1 10.7 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
2.1 12.6 GO:0015265 urea channel activity(GO:0015265)
2.0 9.9 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
2.0 27.5 GO:0016918 retinal binding(GO:0016918)
1.9 23.4 GO:0008430 selenium binding(GO:0008430)
1.8 7.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
1.8 5.3 GO:0004461 lactose synthase activity(GO:0004461)
1.7 6.8 GO:0001847 opsonin receptor activity(GO:0001847)
1.7 8.5 GO:0004966 galanin receptor activity(GO:0004966)
1.7 5.0 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
1.5 7.3 GO:0030280 structural constituent of epidermis(GO:0030280)
1.4 9.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.3 6.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
1.2 4.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
1.1 53.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.1 33.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.0 5.0 GO:1990254 keratin filament binding(GO:1990254)
0.9 1.8 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.9 2.6 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.8 2.4 GO:0071633 dihydroceramidase activity(GO:0071633)
0.7 2.2 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.7 14.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.7 5.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.6 9.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.6 14.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.6 122.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 3.8 GO:0000403 Y-form DNA binding(GO:0000403)
0.5 4.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.5 1.5 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.5 2.3 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.5 12.2 GO:0000146 microfilament motor activity(GO:0000146)
0.4 4.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.4 23.0 GO:0004601 peroxidase activity(GO:0004601)
0.4 2.2 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.4 1.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 5.8 GO:0048185 activin binding(GO:0048185)
0.4 2.7 GO:0019808 polyamine binding(GO:0019808)
0.4 1.8 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.4 12.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.4 5.0 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.4 2.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 2.7 GO:0005131 growth hormone receptor binding(GO:0005131)
0.3 8.2 GO:0008143 poly(A) binding(GO:0008143)
0.3 2.0 GO:0004111 creatine kinase activity(GO:0004111)
0.3 6.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 4.2 GO:0008097 5S rRNA binding(GO:0008097)
0.3 9.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 2.7 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.3 9.0 GO:0008236 serine-type peptidase activity(GO:0008236)
0.3 1.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.3 3.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 17.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 11.7 GO:0003785 actin monomer binding(GO:0003785)
0.3 15.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 1.7 GO:0048495 Roundabout binding(GO:0048495)
0.2 5.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 5.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.2 1.3 GO:0004969 histamine receptor activity(GO:0004969)
0.2 2.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 1.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 8.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 3.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2 6.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 1.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 3.6 GO:0016208 AMP binding(GO:0016208)
0.2 7.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 12.4 GO:0017022 myosin binding(GO:0017022)
0.1 15.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 13.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 17.7 GO:0005178 integrin binding(GO:0005178)
0.1 22.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.7 GO:0070628 proteasome binding(GO:0070628)
0.1 10.4 GO:0097110 scaffold protein binding(GO:0097110)
0.1 1.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 2.5 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.0 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 5.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.2 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 1.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 3.2 GO:0016504 peptidase activator activity(GO:0016504)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 3.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 2.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.2 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.4 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 0.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 2.0 GO:0043274 phospholipase binding(GO:0043274)
0.1 24.4 GO:0045296 cadherin binding(GO:0045296)
0.1 1.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 7.7 GO:0019903 protein phosphatase binding(GO:0019903)
0.1 7.2 GO:0019838 growth factor binding(GO:0019838)
0.1 1.5 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 3.2 GO:0005507 copper ion binding(GO:0005507)
0.1 2.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 3.2 GO:0019905 syntaxin binding(GO:0019905)
0.1 2.8 GO:0003684 damaged DNA binding(GO:0003684)
0.0 9.5 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.7 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0001962 alpha-1,3-galactosyltransferase activity(GO:0001962)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.8 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 5.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 10.2 GO:0005198 structural molecule activity(GO:0005198)
0.0 2.2 GO:0051087 chaperone binding(GO:0051087)
0.0 5.1 GO:0008017 microtubule binding(GO:0008017)
0.0 3.0 GO:0051015 actin filament binding(GO:0051015)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.4 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 5.4 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 25.7 PID IL23 PATHWAY IL23-mediated signaling events
0.5 24.5 PID AURORA B PATHWAY Aurora B signaling
0.3 10.9 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 12.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 23.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 16.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.2 3.6 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 43.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 11.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 10.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.7 PID IL3 PATHWAY IL3-mediated signaling events
0.1 8.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 12.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 4.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.8 PID ATM PATHWAY ATM pathway
0.1 2.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.7 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 1.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 1.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 2.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 11.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 3.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.2 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 2.6 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 7.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 17.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
1.5 24.0 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.0 51.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
1.0 20.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 9.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.7 10.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.7 11.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6 9.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.6 15.4 REACTOME KINESINS Genes involved in Kinesins
0.5 27.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.5 16.0 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.5 18.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.4 14.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.4 10.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 16.2 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.4 4.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.4 11.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.3 18.6 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 16.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 6.8 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 4.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 4.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 3.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 5.9 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.2 10.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 2.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.1 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 2.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 5.3 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region
0.1 1.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 1.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 5.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 7.0 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 0.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 3.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 14.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 1.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 1.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 2.0 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling