Motif ID: Tbx2

Z-value: 1.346


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.633.9e-05Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_130826676 18.748 ENSMUST00000027675.7
Pigr
polymeric immunoglobulin receptor
chr1_+_130826762 17.865 ENSMUST00000133792.1
Pigr
polymeric immunoglobulin receptor
chr6_-_141856171 13.528 ENSMUST00000165990.1
ENSMUST00000163678.1
Slco1a4

solute carrier organic anion transporter family, member 1a4

chr6_+_122006798 12.946 ENSMUST00000081777.6
Mug2
murinoglobulin 2
chr19_+_37697792 10.448 ENSMUST00000025946.5
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
chr15_+_6445320 9.318 ENSMUST00000022749.9
C9
complement component 9
chr10_+_79890853 7.884 ENSMUST00000061653.7
Cfd
complement factor D (adipsin)
chr16_+_23107413 5.503 ENSMUST00000023599.6
ENSMUST00000168891.1
Eif4a2

eukaryotic translation initiation factor 4A2

chrX_-_139782353 5.466 ENSMUST00000101217.3
Ripply1
ripply1 homolog (zebrafish)
chr9_-_43239816 5.102 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr5_-_151190154 5.023 ENSMUST00000062015.8
ENSMUST00000110483.2
Stard13

StAR-related lipid transfer (START) domain containing 13

chr1_-_105356658 4.975 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr1_-_51915968 4.852 ENSMUST00000046390.7
Myo1b
myosin IB
chr10_-_24101951 4.627 ENSMUST00000170267.1
Taar8c
trace amine-associated receptor 8C
chr14_-_30943275 4.344 ENSMUST00000006704.8
ENSMUST00000163118.1
Itih1

inter-alpha trypsin inhibitor, heavy chain 1

chr2_-_148045891 4.237 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr19_-_42202150 4.126 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr3_-_107943705 3.977 ENSMUST00000106680.1
ENSMUST00000106684.1
ENSMUST00000106685.2
Gstm6


glutathione S-transferase, mu 6


chr6_+_116264186 3.863 ENSMUST00000036503.7
ENSMUST00000112900.3
Zfand4

zinc finger, AN1-type domain 4

chr2_+_160880642 3.737 ENSMUST00000109456.2
Lpin3
lipin 3
chr1_+_88138364 3.714 ENSMUST00000014263.4
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr4_-_103214791 3.687 ENSMUST00000094947.2
ENSMUST00000036195.6
Slc35d1

solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

chr10_-_120899067 3.582 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_-_175703646 3.394 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr7_+_79810727 3.312 ENSMUST00000107394.1
Mesp2
mesoderm posterior 2
chr2_+_175372436 3.254 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chrX_+_101383726 3.205 ENSMUST00000119190.1
Gjb1
gap junction protein, beta 1
chr1_+_131970589 3.168 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr7_+_45259031 3.147 ENSMUST00000179310.1
Slc6a16
solute carrier family 6, member 16
chr5_-_5514730 3.055 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
Cldn12



claudin 12



chr11_+_103101682 3.045 ENSMUST00000107040.3
ENSMUST00000140372.1
ENSMUST00000024492.8
ENSMUST00000134884.1
Acbd4



acyl-Coenzyme A binding domain containing 4



chr17_+_3397189 3.023 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr9_-_45204083 3.016 ENSMUST00000034599.8
Tmprss4
transmembrane protease, serine 4
chr5_-_108132513 2.958 ENSMUST00000119784.1
ENSMUST00000117759.1
Tmed5

transmembrane emp24 protein transport domain containing 5

chr1_-_52500679 2.921 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr5_-_5514873 2.877 ENSMUST00000060947.7
Cldn12
claudin 12
chr19_-_28963863 2.852 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr3_-_115715031 2.803 ENSMUST00000055676.2
S1pr1
sphingosine-1-phosphate receptor 1
chr15_-_81360739 2.722 ENSMUST00000023040.7
Slc25a17
solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
chr4_-_49549523 2.606 ENSMUST00000029987.9
Aldob
aldolase B, fructose-bisphosphate
chr1_-_138847579 2.602 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chrX_+_42502533 2.378 ENSMUST00000005839.4
Sh2d1a
SH2 domain protein 1A
chr2_+_175469985 2.315 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr4_+_41465134 2.279 ENSMUST00000030154.6
Nudt2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr4_+_53440516 2.164 ENSMUST00000107651.2
ENSMUST00000107647.1
Slc44a1

solute carrier family 44, member 1

chr5_+_120513102 2.138 ENSMUST00000111889.1
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr6_-_94700137 2.126 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr13_-_113180897 2.109 ENSMUST00000038212.7
Gzmk
granzyme K
chr14_+_51893610 2.102 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr1_+_164115264 2.096 ENSMUST00000162746.1
Selp
selectin, platelet
chr14_-_55643251 2.038 ENSMUST00000120041.1
ENSMUST00000121937.1
ENSMUST00000133707.1
ENSMUST00000002391.8
ENSMUST00000121791.1
Tm9sf1




transmembrane 9 superfamily member 1




chr7_+_105404568 2.038 ENSMUST00000033187.4
Cnga4
cyclic nucleotide gated channel alpha 4
chr10_+_106470281 2.036 ENSMUST00000029404.9
ENSMUST00000169303.1
Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr7_+_27607997 2.028 ENSMUST00000142365.1
Akt2
thymoma viral proto-oncogene 2
chr6_+_50110837 2.025 ENSMUST00000167628.1
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr18_+_84088077 2.018 ENSMUST00000060223.2
Zadh2
zinc binding alcohol dehydrogenase, domain containing 2
chr3_+_60031754 2.012 ENSMUST00000029325.3
Aadac
arylacetamide deacetylase (esterase)
chr3_-_84220853 1.971 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
Trim2


tripartite motif-containing 2


chr12_+_84642896 1.949 ENSMUST00000095551.4
Vrtn
vertebrae development associated
chr13_+_112464070 1.912 ENSMUST00000183663.1
ENSMUST00000184311.1
ENSMUST00000183886.1
Il6st


interleukin 6 signal transducer


chr2_-_103797617 1.909 ENSMUST00000028607.6
Caprin1
cell cycle associated protein 1
chr7_-_28302238 1.897 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr1_+_131599239 1.889 ENSMUST00000027690.6
Avpr1b
arginine vasopressin receptor 1B
chr5_-_108132541 1.869 ENSMUST00000119437.1
ENSMUST00000118036.1
Tmed5

transmembrane emp24 protein transport domain containing 5

chr13_+_80886095 1.863 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr1_-_157108632 1.856 ENSMUST00000118207.1
ENSMUST00000027884.6
ENSMUST00000121911.1
Tex35


testis expressed 35


chr10_+_97693053 1.852 ENSMUST00000060703.4
Ccer1
coiled coil glutamate rich protein 1
chr14_-_11162008 1.821 ENSMUST00000162278.1
ENSMUST00000160340.1
ENSMUST00000160956.1
Fhit


fragile histidine triad gene


chr9_-_48495321 1.807 ENSMUST00000170000.2
Rbm7
RNA binding motif protein 7
chr4_+_125490688 1.803 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr11_-_84068766 1.758 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr13_+_54503779 1.734 ENSMUST00000121401.1
ENSMUST00000118072.1
ENSMUST00000159721.1
Simc1


SUMO-interacting motifs containing 1


chr1_-_87089928 1.686 ENSMUST00000027455.6
Alppl2
alkaline phosphatase, placental-like 2
chr5_+_96209463 1.679 ENSMUST00000117766.1
Mrpl1
mitochondrial ribosomal protein L1
chr16_-_38713235 1.659 ENSMUST00000023487.4
Arhgap31
Rho GTPase activating protein 31
chr9_-_22131801 1.656 ENSMUST00000069330.6
Acp5
acid phosphatase 5, tartrate resistant
chr9_+_48495345 1.631 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chr7_+_27607748 1.552 ENSMUST00000136962.1
Akt2
thymoma viral proto-oncogene 2
chr4_+_53440388 1.522 ENSMUST00000102911.3
ENSMUST00000107646.2
Slc44a1

solute carrier family 44, member 1

chr15_-_10470490 1.519 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr1_+_132316112 1.513 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr6_+_83054653 1.462 ENSMUST00000092618.6
Aup1
ancient ubiquitous protein 1
chr3_-_145649970 1.407 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr5_-_108132577 1.372 ENSMUST00000061203.6
ENSMUST00000002837.4
Tmed5

transmembrane emp24 protein transport domain containing 5

chr19_+_8840519 1.364 ENSMUST00000086058.6
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr4_+_94614483 1.351 ENSMUST00000030311.4
ENSMUST00000107104.2
Ift74

intraflagellar transport 74

chr4_+_116221590 1.307 ENSMUST00000147292.1
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr2_-_91182848 1.282 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
Madd


MAP-kinase activating death domain


chr2_+_54436317 1.257 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13


chr9_-_85749308 1.242 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr1_-_172082757 1.229 ENSMUST00000003550.4
Ncstn
nicastrin
chr3_+_32436376 1.195 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr11_+_23306884 1.177 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34
chr2_+_52857844 1.167 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
Fmnl2


formin-like 2


chr1_-_172329261 1.165 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr4_-_58785722 1.163 ENSMUST00000059608.2
Olfr267
olfactory receptor 267
chr2_+_10047838 1.153 ENSMUST00000181588.1
C630004M23Rik
RIKEN cDNA C630004M23 gene
chr7_-_137314394 1.152 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr7_-_108930151 1.122 ENSMUST00000055745.3
Nlrp10
NLR family, pyrin domain containing 10
chr1_+_170214826 1.121 ENSMUST00000159201.1
ENSMUST00000055830.1
4930500M09Rik

RIKEN cDNA 4930500M09 gene

chr4_+_116221633 1.110 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr9_+_54980880 1.095 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr10_+_90576252 1.077 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr2_+_54436432 1.073 ENSMUST00000136642.1
Galnt13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr11_+_58104229 1.053 ENSMUST00000108843.1
ENSMUST00000134896.1
Cnot8

CCR4-NOT transcription complex, subunit 8

chr17_+_36145018 1.050 ENSMUST00000173025.1
ENSMUST00000056774.9
2410017I17Rik

RIKEN cDNA 2410017I17 gene

chr18_-_60591783 1.039 ENSMUST00000056533.7
Myoz3
myozenin 3
chr7_+_133637686 1.012 ENSMUST00000128901.2
2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr19_+_4003334 1.009 ENSMUST00000025806.3
Doc2g
double C2, gamma
chr4_+_84884366 0.993 ENSMUST00000102819.3
Cntln
centlein, centrosomal protein
chr11_-_84068357 0.951 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chrX_+_152001845 0.948 ENSMUST00000026289.3
ENSMUST00000112617.3
Hsd17b10

hydroxysteroid (17-beta) dehydrogenase 10

chr17_+_46681038 0.945 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr11_-_23895208 0.932 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr13_+_40704005 0.919 ENSMUST00000069457.1
Gm9979
predicted gene 9979
chr2_-_164828529 0.878 ENSMUST00000017911.3
Spata25
spermatogenesis associated 25
chrX_+_42502596 0.848 ENSMUST00000115070.1
ENSMUST00000153948.1
Sh2d1a

SH2 domain protein 1A

chr6_-_142008745 0.842 ENSMUST00000111832.1
Gm6614
predicted gene 6614
chr10_+_96136603 0.839 ENSMUST00000074615.6
Gm5426
predicted pseudogene 5426
chr9_+_19641224 0.808 ENSMUST00000079042.6
Zfp317
zinc finger protein 317
chr4_+_42950369 0.803 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr12_-_31634592 0.786 ENSMUST00000020979.7
ENSMUST00000177962.1
Bcap29

B cell receptor associated protein 29

chr1_+_172082509 0.775 ENSMUST00000135192.1
Copa
coatomer protein complex subunit alpha
chr15_-_99967067 0.769 ENSMUST00000100209.4
Fam186a
family with sequence similarity 186, member A
chr7_+_45486360 0.737 ENSMUST00000107758.1
Tulp2
tubby-like protein 2
chr15_+_79229140 0.729 ENSMUST00000163571.1
Pick1
protein interacting with C kinase 1
chr1_+_152954966 0.726 ENSMUST00000043313.8
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr7_-_30563184 0.708 ENSMUST00000043898.6
Psenen
presenilin enhancer 2 homolog (C. elegans)
chr1_+_172082796 0.686 ENSMUST00000027833.5
Copa
coatomer protein complex subunit alpha
chr6_+_15196949 0.668 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chr8_+_107119110 0.644 ENSMUST00000046116.1
C630050I24Rik
RIKEN cDNA C630050I24 gene
chr13_+_13590402 0.590 ENSMUST00000110559.1
Lyst
lysosomal trafficking regulator
chr2_+_164823001 0.565 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr6_+_42286676 0.561 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr4_+_42035113 0.555 ENSMUST00000098127.1
Gm10597
predicted gene 10597
chr11_+_23306910 0.552 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr6_+_42286709 0.542 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr16_+_19028232 0.443 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr4_+_148000722 0.406 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr4_+_116221689 0.366 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr2_+_68861564 0.346 ENSMUST00000176018.1
Cers6
ceramide synthase 6
chr7_-_79793788 0.343 ENSMUST00000032760.5
Mesp1
mesoderm posterior 1
chr1_-_71414881 0.333 ENSMUST00000087268.5
Abca12
ATP-binding cassette, sub-family A (ABC1), member 12
chr3_-_158562199 0.315 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7
chr17_+_71552031 0.297 ENSMUST00000124001.1
ENSMUST00000167641.1
ENSMUST00000064420.5
Spdya


speedy homolog A (Xenopus laevis)


chr5_+_32136458 0.263 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr7_+_3645267 0.242 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr2_+_152081529 0.219 ENSMUST00000064061.3
Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr14_+_53616315 0.200 ENSMUST00000180972.1
ENSMUST00000185023.1
Trav12-2

T cell receptor alpha variable 12-2

chr9_-_54647199 0.175 ENSMUST00000128163.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr4_+_84884276 0.170 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr3_+_96104498 0.160 ENSMUST00000132980.1
ENSMUST00000138206.1
ENSMUST00000090785.2
ENSMUST00000035519.5
Otud7b



OTU domain containing 7B



chr16_-_32868325 0.153 ENSMUST00000089684.3
ENSMUST00000040986.8
ENSMUST00000115105.2
1700021K19Rik


RIKEN cDNA 1700021K19 gene


chr7_+_105425817 0.153 ENSMUST00000181339.1
ENSMUST00000033189.4
Cckbr

cholecystokinin B receptor

chr13_-_103096818 0.136 ENSMUST00000166336.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr7_+_28071230 0.131 ENSMUST00000138392.1
ENSMUST00000076648.7
Fcgbp

Fc fragment of IgG binding protein

chr2_+_68861433 0.116 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr8_-_93535707 0.089 ENSMUST00000077816.6
Ces5a
carboxylesterase 5A
chr4_-_141874879 0.087 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr2_-_60673654 0.083 ENSMUST00000059888.8
ENSMUST00000154764.1
Itgb6

integrin beta 6

chr1_-_173741717 0.071 ENSMUST00000127730.1
AI607873
expressed sequence AI607873
chr10_-_128211788 0.049 ENSMUST00000061995.8
Spryd4
SPRY domain containing 4
chrX_-_134474986 0.032 ENSMUST00000113223.2
Taf7l
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr10_+_101681487 0.031 ENSMUST00000179929.1
ENSMUST00000127504.1
Mgat4c

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)

chr3_-_108154871 0.021 ENSMUST00000062028.1
Gpr61
G protein-coupled receptor 61
chr4_+_114680769 0.021 ENSMUST00000146346.1
Gm12829
predicted gene 12829
chr4_+_84884418 0.018 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chrX_+_169685191 0.009 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 36.6 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
2.6 10.4 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.8 5.5 GO:0001172 transcription, RNA-templated(GO:0001172)
1.4 4.2 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
1.4 4.1 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
1.3 5.0 GO:0097498 endothelial tube lumen extension(GO:0097498)
1.1 17.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.9 2.8 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.9 2.7 GO:0071106 coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.8 3.2 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.7 2.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.7 2.6 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.6 1.9 GO:0070104 negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) interleukin-27-mediated signaling pathway(GO:0070106)
0.6 1.9 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.6 3.6 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.5 2.1 GO:0099093 mitochondrial calcium release(GO:0099093)
0.5 3.7 GO:0008078 mesodermal cell migration(GO:0008078)
0.5 2.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.5 3.6 GO:0030091 protein repair(GO:0030091)
0.5 1.9 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.4 3.7 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.4 1.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.4 13.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.4 1.9 GO:0007386 compartment pattern specification(GO:0007386)
0.3 3.7 GO:0015871 choline transport(GO:0015871)
0.3 6.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.3 3.7 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.3 1.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.3 1.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 0.8 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 1.4 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.2 1.8 GO:0015961 diadenosine polyphosphate catabolic process(GO:0015961)
0.2 2.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.2 3.2 GO:0006968 cellular defense response(GO:0006968)
0.2 3.2 GO:0015865 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.2 2.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.2 0.2 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 0.7 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 1.9 GO:0007220 Notch receptor processing(GO:0007220)
0.1 0.4 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 2.0 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.1 1.8 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.6 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 1.1 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.1 2.8 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.7 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 3.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 1.5 GO:0030157 pancreatic juice secretion(GO:0030157)
0.1 1.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 2.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 2.0 GO:0046710 GDP metabolic process(GO:0046710)
0.1 3.7 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.1 1.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 1.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.7 GO:0097500 receptor localization to non-motile cilium(GO:0097500)
0.1 8.4 GO:0060349 bone morphogenesis(GO:0060349)
0.1 0.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.4 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.1 2.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 0.3 GO:0035627 ceramide transport(GO:0035627)
0.1 2.0 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 1.5 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.0 4.9 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 2.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 1.9 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.2 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 1.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 2.0 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.0 9.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 1.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.9 GO:0051289 protein homotetramerization(GO:0051289)
0.0 1.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.3 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.9 36.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.6 1.9 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.5 2.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.5 2.6 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4 1.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.3 1.5 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.3 2.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 0.7 GO:0098842 postsynaptic early endosome(GO:0098842)
0.2 1.9 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 1.7 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2 3.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 6.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 1.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 4.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 3.2 GO:0005922 connexin complex(GO:0005922)
0.1 2.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 2.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 2.7 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.3 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 5.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 5.0 GO:0005811 lipid droplet(GO:0005811)
0.0 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 5.0 GO:0031301 integral component of organelle membrane(GO:0031301)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 3.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)
0.0 1.7 GO:0030027 lamellipodium(GO:0030027)
0.0 18.7 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 36.6 GO:0019763 immunoglobulin receptor activity(GO:0019763)
3.5 10.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
1.8 5.5 GO:0003968 RNA-directed 5'-3' RNA polymerase activity(GO:0003968)
0.9 2.7 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.8 3.2 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.7 2.0 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.7 2.6 GO:0004454 ketohexokinase activity(GO:0004454) triokinase activity(GO:0050354) fructose-1-phosphate aldolase activity(GO:0061609)
0.6 13.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.6 1.9 GO:0019981 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.6 3.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.6 3.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.5 2.1 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.5 3.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.5 2.1 GO:0042806 fucose binding(GO:0042806)
0.5 1.9 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.5 4.6 GO:0001594 trace-amine receptor activity(GO:0001594)
0.5 1.8 GO:0047710 bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.4 3.7 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.3 2.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 2.0 GO:0005223 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.2 1.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 1.7 GO:0032184 SUMO polymer binding(GO:0032184)
0.2 1.7 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 4.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 2.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 1.9 GO:0005000 vasopressin receptor activity(GO:0005000)
0.2 1.0 GO:0051373 FATZ binding(GO:0051373)
0.2 1.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 3.2 GO:0005243 gap junction channel activity(GO:0005243)
0.2 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 4.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.7 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 2.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.5 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 17.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.2 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.3 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.1 2.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 4.2 GO:0004340 glucokinase activity(GO:0004340)
0.1 3.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 0.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 2.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 4.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 3.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.9 GO:0005112 Notch binding(GO:0005112)
0.1 1.1 GO:0022848 acetylcholine-gated cation-selective channel activity(GO:0022848)
0.1 0.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 2.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.2 GO:0015054 gastrin receptor activity(GO:0015054)
0.0 0.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 6.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.1 GO:0015645 fatty acid ligase activity(GO:0015645)
0.0 1.2 GO:0017048 Rho GTPase binding(GO:0017048)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 39.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.2 3.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 1.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 6.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.8 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 4.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 1.9 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 1.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 3.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 3.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.9 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.5 9.3 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.4 10.4 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.3 3.7 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.2 6.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.2 7.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.2 3.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 4.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 2.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 3.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 1.9 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.9 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 1.5 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.1 4.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.1 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.1 REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1 2.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 1.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 9.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 2.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 3.6 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis