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GSE58827: Dynamics of the Mouse Liver

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Results for Tfap2e

Z-value: 0.39

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Transcription factors associated with Tfap2e

Gene Symbol Gene ID Gene Info
Tfap2e
ENSMUSG00000042477.7 transcription factor AP-2, epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_1267362450.067.4e-01Click!

Activity profile of Tfap2e motif

Sorted Z-values of Tfap2e motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_91945703 2.09 ENSMUST00000178895.1
Gm9821
predicted gene 9821
chr7_+_30787897 2.03 ENSMUST00000098559.1
Krtdap
keratinocyte differentiation associated protein
chr4_-_140774196 1.99 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr11_-_102897146 1.90 ENSMUST00000077902.4
Gfap
glial fibrillary acidic protein
chr12_+_109544498 1.89 ENSMUST00000126289.1
Meg3
maternally expressed 3
chr11_-_102897123 1.89 ENSMUST00000067444.3
Gfap
glial fibrillary acidic protein
chr2_+_129228022 1.79 ENSMUST00000148548.1
A730036I17Rik
RIKEN cDNA A730036I17 gene
chr9_+_110857958 1.36 ENSMUST00000051097.1
Prss50
protease, serine, 50
chr8_+_94152607 1.17 ENSMUST00000034211.8
Mt3
metallothionein 3
chrX_+_93675088 1.00 ENSMUST00000045898.3
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr3_+_152165374 0.87 ENSMUST00000181854.1
D630002J18Rik
RIKEN cDNA D630002J18 gene
chr1_+_136131382 0.87 ENSMUST00000075164.4
Kif21b
kinesin family member 21B
chr2_-_34754364 0.86 ENSMUST00000142436.1
ENSMUST00000113099.3
ENSMUST00000028224.8
Gapvd1
GTPase activating protein and VPS9 domains 1
chr15_-_97831460 0.76 ENSMUST00000079838.7
ENSMUST00000118294.1
Hdac7
histone deacetylase 7
chr7_-_44524642 0.73 ENSMUST00000165208.2
Mybpc2
myosin binding protein C, fast-type
chr2_-_38287174 0.69 ENSMUST00000130472.1
Dennd1a
DENN/MADD domain containing 1A
chr6_-_82774448 0.68 ENSMUST00000000642.4
Hk2
hexokinase 2
chr3_-_153725062 0.65 ENSMUST00000064460.5
St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr8_+_41239718 0.59 ENSMUST00000045218.7
Pcm1
pericentriolar material 1
chr7_+_24636566 0.58 ENSMUST00000080718.4
Lypd3
Ly6/Plaur domain containing 3
chr11_+_98386450 0.56 ENSMUST00000041301.7
Pnmt
phenylethanolamine-N-methyltransferase
chr1_-_125913101 0.55 ENSMUST00000161361.1
Lypd1
Ly6/Plaur domain containing 1
chr11_+_101260569 0.55 ENSMUST00000103108.1
Wnk4
WNK lysine deficient protein kinase 4
chr9_-_44454757 0.54 ENSMUST00000047740.2
Upk2
uroplakin 2
chr9_-_97111117 0.54 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr13_+_37825975 0.51 ENSMUST00000138043.1
Rreb1
ras responsive element binding protein 1
chr2_-_129297205 0.45 ENSMUST00000052708.6
Ckap2l
cytoskeleton associated protein 2-like
chr10_-_127211528 0.40 ENSMUST00000013970.7
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr8_+_109705549 0.39 ENSMUST00000034163.8
Zfp821
zinc finger protein 821
chr2_+_149830788 0.38 ENSMUST00000109935.1
Syndig1
synapse differentiation inducing 1
chr2_+_149830840 0.31 ENSMUST00000109934.1
ENSMUST00000140870.1
Syndig1
synapse differentiation inducing 1
chr17_-_35697971 0.29 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr4_+_148039097 0.29 ENSMUST00000141283.1
Mthfr
5,10-methylenetetrahydrofolate reductase
chr1_+_135836380 0.28 ENSMUST00000178204.1
Tnnt2
troponin T2, cardiac
chr15_-_102524615 0.27 ENSMUST00000023814.7
Npff
neuropeptide FF-amide peptide precursor
chr8_-_84687839 0.25 ENSMUST00000001975.4
Nacc1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr3_-_84040151 0.24 ENSMUST00000052342.7
D930015E06Rik
RIKEN cDNA D930015E06 gene
chr15_+_99591028 0.24 ENSMUST00000169082.1
Aqp5
aquaporin 5
chr16_+_93832121 0.24 ENSMUST00000044068.6
Morc3
microrchidia 3
chr6_-_39725448 0.24 ENSMUST00000002487.8
Braf
Braf transforming gene
chr7_+_141447645 0.21 ENSMUST00000106004.1
ENSMUST00000106003.1
Rplp2
ribosomal protein, large P2
chr2_+_22895583 0.20 ENSMUST00000152170.1
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr3_+_103914560 0.19 ENSMUST00000106806.1
Rsbn1
rosbin, round spermatid basic protein 1
chr11_-_102218923 0.19 ENSMUST00000131254.1
Hdac5
histone deacetylase 5
chr5_-_113908685 0.19 ENSMUST00000004646.6
Coro1c
coronin, actin binding protein 1C
chr9_+_109931774 0.18 ENSMUST00000169851.2
Map4
microtubule-associated protein 4
chr17_-_63863791 0.17 ENSMUST00000050753.3
A930002H24Rik
RIKEN cDNA A930002H24 gene
chr13_+_37826018 0.16 ENSMUST00000110238.2
Rreb1
ras responsive element binding protein 1
chr2_+_27165233 0.16 ENSMUST00000000910.6
Dbh
dopamine beta hydroxylase
chr11_-_3371307 0.14 ENSMUST00000101642.3
ENSMUST00000101640.3
Limk2
LIM motif-containing protein kinase 2
chr7_-_45333754 0.14 ENSMUST00000042194.8
Trpm4
transient receptor potential cation channel, subfamily M, member 4
chr10_+_112083345 0.14 ENSMUST00000148897.1
ENSMUST00000020434.3
Glipr1l2
GLI pathogenesis-related 1 like 2
chr7_+_81057589 0.14 ENSMUST00000107348.1
Alpk3
alpha-kinase 3
chr8_+_33386325 0.12 ENSMUST00000078058.3
ENSMUST00000070340.4
Purg
purine-rich element binding protein G
chr1_+_159737510 0.11 ENSMUST00000111669.3
Tnr
tenascin R
chr5_-_117389029 0.11 ENSMUST00000111953.1
ENSMUST00000086461.6
Rfc5
replication factor C (activator 1) 5
chr2_+_9882622 0.11 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr6_-_39725193 0.11 ENSMUST00000101497.3
Braf
Braf transforming gene
chr1_+_74771886 0.10 ENSMUST00000006716.6
Wnt6
wingless-related MMTV integration site 6
chrX_+_73716712 0.09 ENSMUST00000114461.2
Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr1_+_86154752 0.08 ENSMUST00000113309.2
ENSMUST00000027434.8
ENSMUST00000131412.1
Armc9
armadillo repeat containing 9
chr9_+_108953578 0.07 ENSMUST00000112070.1
Col7a1
collagen, type VII, alpha 1
chr19_+_42518795 0.07 ENSMUST00000160107.1
ENSMUST00000160893.1
R3hcc1l
R3H domain and coiled-coil containing 1 like
chr15_+_58872646 0.05 ENSMUST00000036937.7
Trmt12
tRNA methyltranferase 12
chr14_+_51451962 0.05 ENSMUST00000159611.1
ENSMUST00000159734.1
Vmn2r89
vomeronasal 2, receptor 89
chr8_+_107293500 0.04 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
Nfat5
nuclear factor of activated T cells 5
chr11_-_100248902 0.04 ENSMUST00000007280.8
Krt16
keratin 16
chr9_-_121759788 0.04 ENSMUST00000181325.1
E530011L22Rik
RIKEN cDNA E530011L22 gene
chr8_-_111854278 0.03 ENSMUST00000034432.5
Cfdp1
craniofacial development protein 1
chr9_+_108953597 0.03 ENSMUST00000026740.5
Col7a1
collagen, type VII, alpha 1
chr4_+_156331103 0.02 ENSMUST00000074107.6
ENSMUST00000096792.5
Vmn2r-ps159
vomeronasal 2, receptor, pseudogene 159
chr7_-_116443439 0.02 ENSMUST00000170430.1
Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
chr9_-_44735189 0.02 ENSMUST00000034611.8
Phldb1
pleckstrin homology-like domain, family B, member 1
chr9_-_110117379 0.01 ENSMUST00000111991.2
ENSMUST00000149199.1
ENSMUST00000035056.7
ENSMUST00000148287.1
ENSMUST00000127744.1
Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr8_+_107293463 0.00 ENSMUST00000169453.1
Nfat5
nuclear factor of activated T cells 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2e

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.4 2.0 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.4 1.2 GO:0097212 lysosomal membrane organization(GO:0097212)
0.1 0.7 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.1 0.7 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.6 GO:0042414 epinephrine metabolic process(GO:0042414)
0.1 0.3 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.1 0.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.4 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 0.5 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.6 GO:0070294 renal sodium ion absorption(GO:0070294) negative regulation of pancreatic juice secretion(GO:0090188)
0.1 1.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.2 GO:0046333 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.1 0.8 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 0.1 GO:1903116 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047) positive regulation of actin filament-based movement(GO:1903116)
0.0 0.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.4 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.3 GO:0070253 somatostatin secretion(GO:0070253)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.7 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0048690 neuron cell-cell adhesion(GO:0007158) regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.6 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.0 0.2 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.6 GO:1905145 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 1.0 GO:0001541 ovarian follicle development(GO:0001541)
0.0 0.1 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.2 GO:0006744 ubiquinone biosynthetic process(GO:0006744)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 2.0 GO:0042599 lamellar body(GO:0042599)
0.1 0.2 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.0 0.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.7 GO:0005859 muscle myosin complex(GO:0005859) myosin filament(GO:0032982)
0.0 0.6 GO:0043196 varicosity(GO:0043196)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.7 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.2 GO:0016600 flotillin complex(GO:0016600)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.2 1.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.7 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.6 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 0.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 1.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.1 0.2 GO:0000010 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.0 0.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.0 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 0.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport