Motif ID: Thrb

Z-value: 1.263


Transcription factors associated with Thrb:

Gene SymbolEntrez IDGene Name
Thrb ENSMUSG00000021779.10 Thrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17981633_179816440.539.7e-04Click!


Activity profile for motif Thrb.

activity profile for motif Thrb


Sorted Z-values histogram for motif Thrb

Sorted Z-values for motif Thrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Thrb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_14863495 17.540 ENSMUST00000029076.4
Car3
carbonic anhydrase 3
chr7_+_25897620 14.878 ENSMUST00000072438.6
ENSMUST00000005477.5
Cyp2b10

cytochrome P450, family 2, subfamily b, polypeptide 10

chr8_+_105048592 14.839 ENSMUST00000093222.5
ENSMUST00000093223.3
Ces3a

carboxylesterase 3A

chr17_+_36942910 13.668 ENSMUST00000040498.5
Rnf39
ring finger protein 39
chr14_-_34355383 12.380 ENSMUST00000052126.5
Fam25c
family with sequence similarity 25, member C
chr17_+_36943025 12.119 ENSMUST00000173072.1
Rnf39
ring finger protein 39
chr2_-_24049389 7.491 ENSMUST00000051416.5
Hnmt
histamine N-methyltransferase
chr9_+_44673227 7.235 ENSMUST00000034609.4
ENSMUST00000071219.5
Treh

trehalase (brush-border membrane glycoprotein)

chr11_-_113709520 6.937 ENSMUST00000173655.1
ENSMUST00000100248.4
Cpsf4l

cleavage and polyadenylation specific factor 4-like

chr10_+_87521920 6.880 ENSMUST00000142088.1
Pah
phenylalanine hydroxylase
chr11_-_113710017 6.517 ENSMUST00000018871.1
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr7_-_105600103 6.454 ENSMUST00000033185.8
Hpx
hemopexin
chr12_+_108334341 6.278 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr2_-_25470031 6.236 ENSMUST00000114251.1
Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25500613 5.586 ENSMUST00000040042.4
C8g
complement component 8, gamma polypeptide
chr14_-_61360395 5.108 ENSMUST00000022494.8
Ebpl
emopamil binding protein-like
chr2_+_119167758 4.937 ENSMUST00000057454.3
Gchfr
GTP cyclohydrolase I feedback regulator
chr10_+_87521795 4.883 ENSMUST00000020241.8
Pah
phenylalanine hydroxylase
chr2_-_25469742 4.705 ENSMUST00000114259.2
ENSMUST00000015234.6
Ptgds

prostaglandin D2 synthase (brain)

chr17_+_56162477 4.457 ENSMUST00000077788.6
Tnfaip8l1
tumor necrosis factor, alpha-induced protein 8-like 1
chr14_-_7994563 4.074 ENSMUST00000026315.7
Dnase1l3
deoxyribonuclease 1-like 3
chr9_-_107668967 3.216 ENSMUST00000177567.1
Slc38a3
solute carrier family 38, member 3
chr4_+_152178126 2.914 ENSMUST00000075363.3
Acot7
acyl-CoA thioesterase 7
chr3_-_79842662 2.617 ENSMUST00000029568.1
Tmem144
transmembrane protein 144
chr11_+_70459611 2.396 ENSMUST00000039093.3
Zmynd15
zinc finger, MYND-type containing 15
chr11_-_115612491 2.131 ENSMUST00000106507.2
Mif4gd
MIF4G domain containing
chr3_-_116712198 1.954 ENSMUST00000120120.1
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr11_-_49114874 1.885 ENSMUST00000109201.1
Olfr1396
olfactory receptor 1396
chr4_+_20042046 1.875 ENSMUST00000098242.3
Ggh
gamma-glutamyl hydrolase
chr12_+_112620030 1.748 ENSMUST00000180015.1
ENSMUST00000021726.6
Adssl1

adenylosuccinate synthetase like 1

chrX_-_71492799 1.745 ENSMUST00000037391.5
ENSMUST00000114586.2
ENSMUST00000114587.2
Cd99l2


CD99 antigen-like 2


chr5_+_35814356 1.463 ENSMUST00000130233.1
Ablim2
actin-binding LIM protein 2
chr5_+_94218025 1.380 ENSMUST00000179743.1
Gm3106
predicted gene 3106
chr11_+_109485606 1.156 ENSMUST00000106697.1
Arsg
arylsulfatase G
chr8_-_121544315 1.128 ENSMUST00000182460.1
1700018B08Rik
RIKEN cDNA 1700018B08 gene
chr5_+_94873797 1.115 ENSMUST00000180076.1
Gm3183
predicted gene 3183
chr9_+_102626278 1.052 ENSMUST00000038673.7
Anapc13
anaphase promoting complex subunit 13
chr3_-_36475688 0.956 ENSMUST00000029266.8
Anxa5
annexin A5
chr11_-_58938851 0.673 ENSMUST00000094151.5
Rnf187
ring finger protein 187
chr2_+_171193222 0.613 ENSMUST00000125631.1
Gm14266
predicted gene 14266
chr11_+_100859351 0.540 ENSMUST00000004145.7
ENSMUST00000133036.1
Stat5a

signal transducer and activator of transcription 5A

chr5_+_130219706 0.535 ENSMUST00000065329.6
Tmem248
transmembrane protein 248
chr10_+_31248140 0.333 ENSMUST00000050717.8
Gm5422
predicted pseudogene 5422
chr11_+_100859492 0.211 ENSMUST00000107356.1
Stat5a
signal transducer and activator of transcription 5A
chr11_-_83522126 0.072 ENSMUST00000019069.3
Gm11435
predicted gene 11435
chrX_+_112311334 0.026 ENSMUST00000026599.3
ENSMUST00000113415.1
Apool

apolipoprotein O-like

chr13_+_37857934 0.013 ENSMUST00000138110.1
Rreb1
ras responsive element binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0006571 tyrosine biosynthetic process(GO:0006571) aromatic amino acid family biosynthetic process(GO:0009073) aromatic amino acid family biosynthetic process, prephenate pathway(GO:0009095)
2.2 10.9 GO:1905937 negative regulation of germ cell proliferation(GO:1905937) negative regulation of male germ cell proliferation(GO:2000255)
2.1 14.9 GO:0042738 exogenous drug catabolic process(GO:0042738)
1.5 7.5 GO:0001692 histamine metabolic process(GO:0001692)
1.1 13.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
1.1 3.2 GO:0006867 asparagine transport(GO:0006867) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) regulation of glutamine transport(GO:2000485)
0.9 6.5 GO:0015886 heme transport(GO:0015886)
0.7 2.9 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) fatty-acyl-CoA catabolic process(GO:0036115) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.7 7.2 GO:0005984 disaccharide metabolic process(GO:0005984)
0.6 1.9 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.6 1.7 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.4 6.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4 17.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.4 2.0 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.3 5.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 4.1 GO:0006309 apoptotic DNA fragmentation(GO:0006309) programmed cell death involved in cell development(GO:0010623)
0.2 0.8 GO:0060376 positive regulation of mast cell differentiation(GO:0060376)
0.2 1.0 GO:0070459 prolactin secretion(GO:0070459)
0.1 4.5 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 2.6 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 5.1 GO:0016125 sterol metabolic process(GO:0016125)
0.0 1.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 4.9 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 2.4 GO:0007286 spermatid development(GO:0007286)
0.0 0.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.5 5.6 GO:0005579 membrane attack complex(GO:0005579)
0.1 4.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 10.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 7.4 GO:0072562 blood microparticle(GO:0072562)
0.0 7.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 33.4 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 3.2 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.9 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
2.4 11.8 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
1.6 6.5 GO:0015232 heme transporter activity(GO:0015232)
1.5 17.5 GO:0016151 nickel cation binding(GO:0016151)
1.1 3.2 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.7 4.9 GO:0019238 cyclohydrolase activity(GO:0019238)
0.5 14.9 GO:0070330 aromatase activity(GO:0070330)
0.4 5.6 GO:0019841 retinol binding(GO:0019841)
0.3 5.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 2.9 GO:0102991 long-chain fatty acyl-CoA binding(GO:0036042) myristoyl-CoA hydrolase activity(GO:0102991)
0.2 13.5 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 1.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 2.0 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 1.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 2.6 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.1 14.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 6.3 GO:0020037 heme binding(GO:0020037)
0.1 7.2 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 4.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.7 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0 1.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 2.4 GO:0042826 histone deacetylase binding(GO:0042826)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 7.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.5 6.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.2 4.9 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 5.6 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.1 1.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 11.8 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules