Motif ID: Twist1

Z-value: 1.337


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_33957671-0.289.3e-02Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_36942910 16.509 ENSMUST00000040498.5
Rnf39
ring finger protein 39
chr17_+_36943025 11.978 ENSMUST00000173072.1
Rnf39
ring finger protein 39
chr6_-_41035501 10.819 ENSMUST00000031931.5
2210010C04Rik
RIKEN cDNA 2210010C04 gene
chr6_+_30639218 10.068 ENSMUST00000031806.9
Cpa1
carboxypeptidase A1, pancreatic
chr8_-_105933832 9.705 ENSMUST00000034368.6
Ctrl
chymotrypsin-like
chr19_+_39007019 9.676 ENSMUST00000025966.4
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
chr11_-_113710017 7.466 ENSMUST00000018871.1
Cpsf4l
cleavage and polyadenylation specific factor 4-like
chr2_+_31887262 6.830 ENSMUST00000138325.1
ENSMUST00000028187.6
Lamc3

laminin gamma 3

chr7_+_44384803 6.448 ENSMUST00000120262.1
Syt3
synaptotagmin III
chr11_-_113709520 6.285 ENSMUST00000173655.1
ENSMUST00000100248.4
Cpsf4l

cleavage and polyadenylation specific factor 4-like

chr7_-_142679533 5.575 ENSMUST00000162317.1
ENSMUST00000125933.1
ENSMUST00000105931.1
ENSMUST00000105930.1
ENSMUST00000105933.1
ENSMUST00000105932.1
ENSMUST00000000220.2
Ins2






insulin II






chr9_-_45009590 5.242 ENSMUST00000102832.1
Cd3e
CD3 antigen, epsilon polypeptide
chr15_+_100304782 4.873 ENSMUST00000067752.3
Mettl7a1
methyltransferase like 7A1
chr18_-_16809233 4.207 ENSMUST00000025166.7
Cdh2
cadherin 2
chr15_+_100353149 4.070 ENSMUST00000088142.5
ENSMUST00000176287.1
ENSMUST00000075675.5
Mettl7a2

AB099516
methyltransferase like 7A2

cDNA sequence AB099516
chr12_-_4592927 4.014 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr9_+_65265173 3.805 ENSMUST00000048762.1
Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr7_-_31115227 3.768 ENSMUST00000168884.1
ENSMUST00000108102.2
Hpn

hepsin

chr6_-_95718800 3.628 ENSMUST00000079847.5
Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr7_+_127800844 3.488 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr19_+_8664005 3.365 ENSMUST00000035444.3
ENSMUST00000163785.1
Chrm1

cholinergic receptor, muscarinic 1, CNS

chr16_-_18426372 2.947 ENSMUST00000000335.4
Comt
catechol-O-methyltransferase
chr7_-_4789541 2.863 ENSMUST00000168578.1
Tmem238
transmembrane protein 238
chr5_-_34187670 2.832 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr1_-_15892657 2.822 ENSMUST00000040695.4
Sbspon
somatomedin B and thrombospondin, type 1 domain containing
chr4_-_57143437 2.731 ENSMUST00000095076.3
ENSMUST00000030142.3
Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr4_-_130275542 2.728 ENSMUST00000154846.1
ENSMUST00000105996.1
Serinc2

serine incorporator 2

chr4_-_130275523 2.614 ENSMUST00000146478.1
Serinc2
serine incorporator 2
chr2_-_32982007 2.552 ENSMUST00000028129.7
Slc2a8
solute carrier family 2, (facilitated glucose transporter), member 8
chr14_+_53676141 2.531 ENSMUST00000103662.4
Trav9-4
T cell receptor alpha variable 9-4
chr19_-_28963863 2.525 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr8_+_122422020 2.247 ENSMUST00000050963.3
Il17c
interleukin 17C
chr8_+_105305572 2.247 ENSMUST00000109375.2
Elmo3
engulfment and cell motility 3
chr13_+_104109752 2.222 ENSMUST00000160322.1
ENSMUST00000159574.1
Sgtb

small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

chr13_+_73626886 2.210 ENSMUST00000022104.7
Tert
telomerase reverse transcriptase
chr7_-_80401707 2.180 ENSMUST00000120753.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr13_+_104109737 2.180 ENSMUST00000044385.7
Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr17_+_24850484 2.074 ENSMUST00000118788.1
Hagh
hydroxyacyl glutathione hydrolase
chr9_-_63602417 2.071 ENSMUST00000171243.1
ENSMUST00000163982.1
ENSMUST00000163624.1
Iqch


IQ motif containing H


chr17_+_24850654 2.024 ENSMUST00000130989.1
ENSMUST00000024974.9
Hagh

hydroxyacyl glutathione hydrolase

chr8_-_71381907 1.920 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr11_+_97663366 1.912 ENSMUST00000044730.5
Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr7_+_28180272 1.883 ENSMUST00000173223.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_+_28180226 1.861 ENSMUST00000172467.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr2_-_172940299 1.812 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr9_+_60794468 1.771 ENSMUST00000050183.6
Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr6_+_40964760 1.748 ENSMUST00000076638.5
1810009J06Rik
RIKEN cDNA 1810009J06 gene
chr7_+_4119556 1.688 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr3_+_90051630 1.658 ENSMUST00000159064.1
4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr9_-_108567336 1.644 ENSMUST00000074208.4
Ndufaf3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr9_-_114844090 1.601 ENSMUST00000047013.3
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chrX_-_18461371 1.579 ENSMUST00000044188.4
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr15_+_100334929 1.565 ENSMUST00000075420.4
Mettl7a3
methyltransferase like 7A3
chr5_+_31297551 1.547 ENSMUST00000072228.5
Gckr
glucokinase regulatory protein
chr11_+_103103051 1.546 ENSMUST00000152971.1
Acbd4
acyl-Coenzyme A binding domain containing 4
chr2_+_139678178 1.527 ENSMUST00000184404.1
ENSMUST00000099307.3
Ism1

isthmin 1 homolog (zebrafish)

chr6_-_40999479 1.499 ENSMUST00000166306.1
Gm2663
predicted gene 2663
chr16_-_5132458 1.481 ENSMUST00000035672.3
Ppl
periplakin
chr7_+_35119285 1.471 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr17_+_45563928 1.441 ENSMUST00000041353.6
Slc35b2
solute carrier family 35, member B2
chr11_-_119355484 1.403 ENSMUST00000100172.2
ENSMUST00000005173.4
Sgsh

N-sulfoglucosamine sulfohydrolase (sulfamidase)

chr15_-_57892358 1.269 ENSMUST00000022993.5
Derl1
Der1-like domain family, member 1
chr19_-_3686549 1.258 ENSMUST00000025856.10
ENSMUST00000176867.1
Lrp5

low density lipoprotein receptor-related protein 5

chr1_-_172590463 1.247 ENSMUST00000065679.6
Slamf8
SLAM family member 8
chr7_+_4119525 1.221 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1

tweety homolog 1 (Drosophila)

chr1_+_171437535 1.221 ENSMUST00000043839.4
F11r
F11 receptor
chr13_-_58113592 1.195 ENSMUST00000160860.1
Klhl3
kelch-like 3
chr6_+_85187438 1.182 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr14_+_101729907 1.169 ENSMUST00000100337.3
Lmo7
LIM domain only 7
chr13_-_104109576 1.145 ENSMUST00000109315.3
Nln
neurolysin (metallopeptidase M3 family)
chr10_+_89873497 1.117 ENSMUST00000183156.1
ENSMUST00000182936.1
ENSMUST00000099368.4
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr11_+_94741782 1.108 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr5_-_62766153 1.073 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_43309554 0.983 ENSMUST00000031749.9
Nobox
NOBOX oogenesis homeobox
chr6_-_83831736 0.971 ENSMUST00000058383.8
Paip2b
poly(A) binding protein interacting protein 2B
chr11_+_53770458 0.935 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
Irf1



interferon regulatory factor 1



chr9_-_14903932 0.931 ENSMUST00000034409.7
ENSMUST00000117620.1
Folr4

folate receptor 4 (delta)

chr14_+_62760496 0.922 ENSMUST00000181344.1
4931440J10Rik
RIKEN cDNA 4931440J10 gene
chr4_+_149518216 0.911 ENSMUST00000030839.6
Ctnnbip1
catenin beta interacting protein 1
chr2_-_32784424 0.905 ENSMUST00000102813.1
1700019L03Rik
RIKEN cDNA 1700019L03 gene
chr15_-_53902472 0.892 ENSMUST00000078673.6
Samd12
sterile alpha motif domain containing 12
chr6_+_122874526 0.882 ENSMUST00000032477.4
Necap1
NECAP endocytosis associated 1
chr4_-_135494499 0.872 ENSMUST00000105856.2
Nipal3
NIPA-like domain containing 3
chr2_+_74668207 0.835 ENSMUST00000001872.4
Hoxd13
homeobox D13
chr10_+_61175206 0.829 ENSMUST00000079235.5
Tbata
thymus, brain and testes associated
chr5_-_8622855 0.823 ENSMUST00000047485.8
ENSMUST00000115378.1
Rundc3b

RUN domain containing 3B

chr6_-_90716489 0.817 ENSMUST00000101153.3
Iqsec1
IQ motif and Sec7 domain 1
chr2_-_26122769 0.785 ENSMUST00000140993.1
ENSMUST00000028300.5
Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr6_-_134566913 0.760 ENSMUST00000032322.8
Lrp6
low density lipoprotein receptor-related protein 6
chr9_-_14903752 0.757 ENSMUST00000148155.1
ENSMUST00000121116.1
Folr4

folate receptor 4 (delta)

chr17_-_70990751 0.744 ENSMUST00000038446.8
Myl12b
myosin, light chain 12B, regulatory
chr7_-_30861470 0.685 ENSMUST00000052700.3
Ffar1
free fatty acid receptor 1
chr9_+_118478851 0.677 ENSMUST00000150633.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr19_-_11266122 0.673 ENSMUST00000169159.1
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
chr19_+_5740885 0.668 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr11_-_70687917 0.665 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
Camta2




calmodulin binding transcription activator 2




chr4_-_11386757 0.651 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr7_-_70360593 0.642 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr5_-_35729276 0.634 ENSMUST00000070203.7
Sh3tc1
SH3 domain and tetratricopeptide repeats 1
chr15_+_100227819 0.620 ENSMUST00000023769.4
Atf1
activating transcription factor 1
chr17_-_65613521 0.551 ENSMUST00000024897.8
Vapa
vesicle-associated membrane protein, associated protein A
chr4_-_148038769 0.529 ENSMUST00000030879.5
ENSMUST00000137724.1
Clcn6

chloride channel 6

chr9_-_14903866 0.514 ENSMUST00000069408.3
Folr4
folate receptor 4 (delta)
chr9_+_111118070 0.509 ENSMUST00000035078.6
ENSMUST00000098340.2
Lrrfip2

leucine rich repeat (in FLII) interacting protein 2

chr4_+_119539652 0.504 ENSMUST00000044564.8
ENSMUST00000162267.1
ENSMUST00000106310.2
ENSMUST00000138845.2
Foxj3



forkhead box J3



chr9_-_57467985 0.475 ENSMUST00000046587.6
Scamp5
secretory carrier membrane protein 5
chr11_-_76179499 0.475 ENSMUST00000167114.1
ENSMUST00000094015.4
ENSMUST00000108419.2
ENSMUST00000170730.1
ENSMUST00000129256.1
ENSMUST00000056601.4
Vps53





vacuolar protein sorting 53 (yeast)





chr2_+_85991819 0.449 ENSMUST00000050942.2
Olfr1031
olfactory receptor 1031
chrX_+_157818435 0.425 ENSMUST00000087157.4
Klhl34
kelch-like 34
chr18_+_40256960 0.424 ENSMUST00000096572.1
2900055J20Rik
RIKEN cDNA 2900055J20 gene
chr7_-_4844665 0.424 ENSMUST00000066041.5
ENSMUST00000172377.1
Shisa7

shisa homolog 7 (Xenopus laevis)

chr2_-_137116624 0.419 ENSMUST00000028735.7
Jag1
jagged 1
chr11_+_109650574 0.417 ENSMUST00000106676.1
Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
chr11_+_72207537 0.404 ENSMUST00000021158.3
Txndc17
thioredoxin domain containing 17
chr2_-_142901506 0.404 ENSMUST00000043589.7
Kif16b
kinesin family member 16B
chr19_+_25610533 0.397 ENSMUST00000048935.4
Dmrt3
doublesex and mab-3 related transcription factor 3
chr2_-_85519018 0.392 ENSMUST00000099923.1
4833423E24Rik
RIKEN cDNA 4833423E24 gene
chr6_-_29165003 0.357 ENSMUST00000007993.9
Rbm28
RNA binding motif protein 28
chr15_+_100227871 0.345 ENSMUST00000163855.1
Atf1
activating transcription factor 1
chr16_+_62814676 0.339 ENSMUST00000055557.5
Stx19
syntaxin 19
chr18_+_77065195 0.335 ENSMUST00000114777.2
Pias2
protein inhibitor of activated STAT 2
chr11_-_102406783 0.309 ENSMUST00000155104.1
ENSMUST00000130436.1
Slc25a39

solute carrier family 25, member 39

chr8_-_105413473 0.308 ENSMUST00000167294.1
ENSMUST00000063071.6
Kctd19

potassium channel tetramerisation domain containing 19

chr16_+_18811772 0.306 ENSMUST00000168822.1
ENSMUST00000115578.3
Ufd1l

ubiquitin fusion degradation 1 like

chr7_+_82867327 0.289 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr2_-_33942111 0.274 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
Gm13403


predicted gene 13403


chr11_-_99851608 0.272 ENSMUST00000107437.1
Krtap4-16
keratin associated protein 4-16
chr3_-_86002491 0.235 ENSMUST00000061343.3
Prss48
protease, serine, 48
chr14_+_101653967 0.209 ENSMUST00000002289.6
Uchl3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr12_+_4592992 0.209 ENSMUST00000062580.7
Itsn2
intersectin 2
chr8_+_119910792 0.203 ENSMUST00000108988.2
ENSMUST00000108982.4
ENSMUST00000127664.1
Usp10

Gm20388
ubiquitin specific peptidase 10

predicted gene 20388
chr11_+_58009064 0.200 ENSMUST00000071487.6
ENSMUST00000178636.1
Larp1

La ribonucleoprotein domain family, member 1

chr8_-_117082449 0.168 ENSMUST00000098375.4
ENSMUST00000109093.2
Pkd1l2

polycystic kidney disease 1 like 2

chr13_-_98891036 0.132 ENSMUST00000109399.2
Tnpo1
transportin 1
chr4_-_11386679 0.120 ENSMUST00000043781.7
ENSMUST00000108310.1
Esrp1

epithelial splicing regulatory protein 1

chr14_-_50930803 0.100 ENSMUST00000160538.1
ENSMUST00000162957.1
ENSMUST00000161166.1
ENSMUST00000160835.1
ENSMUST00000049312.7
Tmem55b




transmembrane protein 55b




chr8_-_64693027 0.096 ENSMUST00000048967.7
Cpe
carboxypeptidase E

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) neuron projection maintenance(GO:1990535)
1.1 13.8 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
1.0 5.2 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
1.0 2.9 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.9 3.8 GO:0034769 basement membrane disassembly(GO:0034769)
0.9 9.7 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.9 2.6 GO:0015755 fructose transport(GO:0015755)
0.8 5.3 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.8 0.8 GO:0061324 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324)
0.7 2.2 GO:1900369 transcription, RNA-templated(GO:0001172) negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.7 4.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.7 3.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.6 1.9 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.6 1.8 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.5 2.2 GO:0090472 dibasic protein processing(GO:0090472)
0.5 1.5 GO:0009750 response to fructose(GO:0009750)
0.5 1.4 GO:1902559 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.5 1.4 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.4 3.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 4.1 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.4 3.5 GO:0035754 B cell chemotaxis(GO:0035754)
0.4 1.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.4 3.6 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.3 1.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 6.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 0.8 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)
0.2 1.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.2 0.7 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 6.8 GO:0014002 astrocyte development(GO:0014002)
0.2 1.6 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 0.9 GO:0035740 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.2 0.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 0.9 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.1 2.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 1.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.6 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 1.5 GO:0000050 urea cycle(GO:0000050)
0.1 1.2 GO:0070445 radial glial cell differentiation(GO:0060019) oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 1.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.8 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 1.8 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 1.9 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.6 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.1 0.5 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.1 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.1 3.7 GO:0007520 myoblast fusion(GO:0007520)
0.1 1.0 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.5 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.8 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 1.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 2.9 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.7 GO:0042113 B cell activation(GO:0042113)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.3 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629)
0.0 0.5 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.7 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.8 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.0 0.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.3 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.5 GO:0032456 endocytic recycling(GO:0032456)
0.0 1.5 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 1.0 GO:0001541 ovarian follicle development(GO:0001541)
0.0 0.7 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.2 GO:0006909 phagocytosis(GO:0006909)
0.0 0.5 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.7 GO:0070542 positive regulation of calcium ion transport into cytosol(GO:0010524) response to fatty acid(GO:0070542)
0.0 22.5 GO:0006508 proteolysis(GO:0006508)
0.0 2.8 GO:0006898 receptor-mediated endocytosis(GO:0006898)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.6 3.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.6 5.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 2.9 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.5 4.2 GO:0099060 intrinsic component of postsynaptic specialization membrane(GO:0098948) integral component of postsynaptic specialization membrane(GO:0099060)
0.5 1.5 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.4 1.8 GO:0043293 apoptosome(GO:0043293)
0.2 1.0 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.2 5.6 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.2 0.8 GO:1990909 Wnt signalosome(GO:1990909)
0.2 1.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 2.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 2.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.5 GO:1990745 EARP complex(GO:1990745)
0.1 0.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.9 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 4.2 GO:0005604 basement membrane(GO:0005604)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 12.8 GO:0098793 presynapse(GO:0098793)
0.0 2.9 GO:0043197 dendritic spine(GO:0043197)
0.0 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 4.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0031045 dense core granule(GO:0031045)
0.0 1.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.1 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.7 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
1.2 3.6 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.0 2.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206) L-dopa O-methyltransferase activity(GO:0102084)
0.7 2.2 GO:0003968 RNA-directed 5'-3' RNA polymerase activity(GO:0003968)
0.7 2.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.7 2.0 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.7 5.3 GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:0003882)
0.5 1.4 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.5 6.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.4 4.1 GO:0004462 hydroxyacylglutathione hydrolase activity(GO:0004416) lactoylglutathione lyase activity(GO:0004462)
0.3 10.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 3.8 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.3 4.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 3.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 3.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907) G-protein coupled neurotransmitter receptor activity(GO:0099528)
0.2 1.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.2 1.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 13.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.2 1.8 GO:0070700 BMP receptor binding(GO:0070700)
0.1 2.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 2.6 GO:0005536 glucose binding(GO:0005536)
0.1 1.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 6.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.8 GO:0030247 polysaccharide binding(GO:0030247)
0.1 1.5 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 25.3 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 1.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.7 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 1.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.7 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 3.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 2.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 5.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.2 GO:0090079 translation regulator activity, nucleic acid binding(GO:0090079)
0.0 0.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 2.2 GO:0005125 cytokine activity(GO:0005125)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 1.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 5.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 4.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 4.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 4.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 4.1 PID_P73PATHWAY p73 transcription factor network
0.0 7.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 2.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 3.6 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 2.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 4.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.2 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.8 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.2 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 1.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 2.9 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation
0.0 0.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.0 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 0.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.9 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis