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GSE58827: Dynamics of the Mouse Liver

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Results for UAAGACU

Z-value: 0.26

Motif logo

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miRNA associated with seed UAAGACU

NamemiRBASE accession
mmu-miR-499-5p
MIMAT0003482

Activity profile of UAAGACU motif

Sorted Z-values of UAAGACU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_45470201 0.56 ENSMUST00000079390.6
Lin28b
lin-28 homolog B (C. elegans)
chr11_+_44617310 0.48 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1
early B cell factor 1
chr14_-_31577318 0.43 ENSMUST00000112027.2
Colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr12_+_32378692 0.32 ENSMUST00000172332.2
Ccdc71l
coiled-coil domain containing 71 like
chr4_+_17853451 0.30 ENSMUST00000029881.3
Mmp16
matrix metallopeptidase 16
chr5_+_67607873 0.29 ENSMUST00000087241.5
Shisa3
shisa homolog 3 (Xenopus laevis)
chr3_-_116424007 0.28 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr14_+_69029289 0.24 ENSMUST00000014957.8
Stc1
stanniocalcin 1
chr17_-_6655939 0.23 ENSMUST00000179554.1
Dynlt1f
dynein light chain Tctex-type 1F
chr17_-_51832666 0.23 ENSMUST00000144331.1
Satb1
special AT-rich sequence binding protein 1
chr5_+_108065742 0.22 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
Mtf2
metal response element binding transcription factor 2
chr16_-_15594507 0.22 ENSMUST00000115776.1
ENSMUST00000115777.3
Ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr16_-_76373827 0.21 ENSMUST00000121927.1
Nrip1
nuclear receptor interacting protein 1
chr1_-_97661950 0.21 ENSMUST00000053033.7
ENSMUST00000149927.1
D1Ertd622e
DNA segment, Chr 1, ERATO Doi 622, expressed
chr11_+_44518959 0.20 ENSMUST00000019333.3
Rnf145
ring finger protein 145
chr2_+_122028544 0.20 ENSMUST00000028668.7
Eif3j1
eukaryotic translation initiation factor 3, subunit J1
chr5_+_123343834 0.20 ENSMUST00000120593.1
Bcl7a
B cell CLL/lymphoma 7A
chr17_-_6317474 0.20 ENSMUST00000169415.1
Dynlt1a
dynein light chain Tctex-type 1A
chr18_+_53176345 0.19 ENSMUST00000037850.5
Snx2
sorting nexin 2
chr7_-_116038734 0.18 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr12_-_69681795 0.18 ENSMUST00000183277.1
ENSMUST00000035773.7
Sos2
son of sevenless homolog 2 (Drosophila)
chr5_-_5266038 0.18 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
Cdk14
cyclin-dependent kinase 14
chr10_-_23349887 0.17 ENSMUST00000074366.6
ENSMUST00000092665.4
Eya4
eyes absent 4 homolog (Drosophila)
chr2_-_6884975 0.17 ENSMUST00000114924.3
ENSMUST00000170438.1
ENSMUST00000114934.4
Celf2
CUGBP, Elav-like family member 2
chr19_+_21778325 0.16 ENSMUST00000096194.2
ENSMUST00000025663.6
Tmem2
transmembrane protein 2
chr11_+_97415527 0.16 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chr14_-_20546512 0.16 ENSMUST00000022355.4
ENSMUST00000161445.1
ENSMUST00000159027.1
Ppp3cb
protein phosphatase 3, catalytic subunit, beta isoform
chr17_+_6601671 0.15 ENSMUST00000092966.4
Dynlt1c
dynein light chain Tctex-type 1C
chr1_-_21961581 0.15 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
Kcnq5
potassium voltage-gated channel, subfamily Q, member 5
chr13_-_111490111 0.14 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr1_-_119837613 0.14 ENSMUST00000064091.5
Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr11_+_68691906 0.14 ENSMUST00000102611.3
Myh10
myosin, heavy polypeptide 10, non-muscle
chr11_-_6475992 0.14 ENSMUST00000179343.1
Purb
purine rich element binding protein B
chr1_+_74506044 0.13 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr6_-_39206782 0.13 ENSMUST00000002305.8
Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr16_-_63864114 0.12 ENSMUST00000064405.6
Epha3
Eph receptor A3
chr4_-_56865135 0.12 ENSMUST00000107612.2
ENSMUST00000045142.8
Ctnnal1
catenin (cadherin associated protein), alpha-like 1
chr11_-_86357570 0.12 ENSMUST00000043624.8
Med13
mediator complex subunit 13
chr18_+_34220978 0.11 ENSMUST00000079362.5
ENSMUST00000115781.3
Apc
adenomatosis polyposis coli
chr3_-_122984404 0.11 ENSMUST00000090379.2
Usp53
ubiquitin specific peptidase 53
chr14_-_105176860 0.11 ENSMUST00000163545.1
Rbm26
RNA binding motif protein 26
chr6_-_54566484 0.11 ENSMUST00000019268.4
Scrn1
secernin 1
chr12_-_91590009 0.10 ENSMUST00000021345.6
Gtf2a1
general transcription factor II A, 1
chr7_-_66689589 0.10 ENSMUST00000124899.1
Asb7
ankyrin repeat and SOCS box-containing 7
chr4_+_141147911 0.09 ENSMUST00000030757.9
Fbxo42
F-box protein 42
chr4_-_41314877 0.09 ENSMUST00000030145.8
Dcaf12
DDB1 and CUL4 associated factor 12
chr9_+_32696005 0.09 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1
E26 avian leukemia oncogene 1, 5' domain
chr19_-_14597983 0.09 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr6_-_100287441 0.08 ENSMUST00000101118.2
Rybp
RING1 and YY1 binding protein
chr17_+_29549783 0.08 ENSMUST00000048677.7
Tbc1d22b
TBC1 domain family, member 22B
chr2_+_74691090 0.08 ENSMUST00000061745.3
Hoxd10
homeobox D10
chr9_-_72111827 0.08 ENSMUST00000183404.1
ENSMUST00000184783.1
Tcf12
transcription factor 12
chr2_+_74711911 0.08 ENSMUST00000111983.2
Hoxd3
homeobox D3
chr6_-_99666762 0.06 ENSMUST00000032151.2
Eif4e3
eukaryotic translation initiation factor 4E member 3
chr10_-_115315546 0.06 ENSMUST00000020343.7
Rab21
RAB21, member RAS oncogene family
chr4_-_139131058 0.06 ENSMUST00000143971.1
Minos1
mitochondrial inner membrane organizing system 1
chr2_-_125782834 0.06 ENSMUST00000053699.6
Secisbp2l
SECIS binding protein 2-like
chr2_-_37647199 0.06 ENSMUST00000028279.3
Strbp
spermatid perinuclear RNA binding protein
chr1_+_82586942 0.05 ENSMUST00000113457.2
Col4a3
collagen, type IV, alpha 3
chr17_+_29093763 0.05 ENSMUST00000023829.6
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr15_-_93275151 0.05 ENSMUST00000057896.4
ENSMUST00000049484.6
Gxylt1
glucoside xylosyltransferase 1
chr13_-_107890059 0.05 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr3_-_79567679 0.05 ENSMUST00000076136.4
Fnip2
folliculin interacting protein 2
chr11_+_54438188 0.05 ENSMUST00000046835.7
Fnip1
folliculin interacting protein 1
chr10_+_95940663 0.04 ENSMUST00000053484.6
Eea1
early endosome antigen 1
chr11_-_19018956 0.04 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
Meis1
Meis homeobox 1
chr8_+_117257019 0.04 ENSMUST00000166750.1
Cmip
c-Maf inducing protein
chr6_+_38433913 0.03 ENSMUST00000160583.1
Ubn2
ubinuclein 2
chr6_+_77242644 0.02 ENSMUST00000159616.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr3_+_89520152 0.02 ENSMUST00000000811.7
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr7_-_111082997 0.01 ENSMUST00000161051.1
ENSMUST00000160132.1
ENSMUST00000106666.3
ENSMUST00000162415.1
Eif4g2
eukaryotic translation initiation factor 4, gamma 2
chr8_+_90828820 0.01 ENSMUST00000109614.2
ENSMUST00000048665.6
Chd9
chromodomain helicase DNA binding protein 9
chr11_-_82829024 0.01 ENSMUST00000021036.6
ENSMUST00000074515.4
ENSMUST00000103218.2
Rffl
ring finger and FYVE like domain containing protein
chr4_+_123904832 0.00 ENSMUST00000030400.7
Mycbp
c-myc binding protein
chr4_-_126429501 0.00 ENSMUST00000069097.6
Ago3
argonaute RISC catalytic subunit 3
chr9_+_72532214 0.00 ENSMUST00000163401.2
ENSMUST00000093820.3
Rfx7
regulatory factor X, 7
chr9_-_64737623 0.00 ENSMUST00000169058.1
Rab11a
RAB11a, member RAS oncogene family

Network of associatons between targets according to the STRING database.

First level regulatory network of UAAGACU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.1 0.4 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 0.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.2 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.0 0.5 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.2 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.2 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.1 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0030578 PML body organization(GO:0030578)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix