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GSE58827: Dynamics of the Mouse Liver

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Results for Zkscan3

Z-value: 0.77

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Transcription factors associated with Zkscan3

Gene Symbol Gene ID Gene Info
Zkscan3
ENSMUSG00000021327.12 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_214027550.154.0e-01Click!

Activity profile of Zkscan3 motif

Sorted Z-values of Zkscan3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_111691002 7.73 ENSMUST00000034435.5
Ctrb1
chymotrypsinogen B1
chr10_+_75568648 5.91 ENSMUST00000134503.1
ENSMUST00000125770.1
ENSMUST00000128886.1
ENSMUST00000151212.1
Ggt1
gamma-glutamyltransferase 1
chr11_-_102365111 5.81 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr1_+_131638485 5.36 ENSMUST00000112411.1
Ctse
cathepsin E
chr10_+_75568630 5.10 ENSMUST00000145928.1
Ggt1
gamma-glutamyltransferase 1
chr1_+_131638306 5.02 ENSMUST00000073350.6
Ctse
cathepsin E
chr10_+_75568641 4.85 ENSMUST00000131565.1
Ggt1
gamma-glutamyltransferase 1
chr13_-_100786402 4.60 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
Ccnb1
cyclin B1
chr18_+_82554463 3.40 ENSMUST00000062446.7
ENSMUST00000102812.4
ENSMUST00000075372.5
ENSMUST00000080658.4
ENSMUST00000152071.1
ENSMUST00000114674.3
ENSMUST00000142850.1
ENSMUST00000133193.1
ENSMUST00000123251.1
ENSMUST00000153478.1
ENSMUST00000132369.1
Mbp
myelin basic protein
chr13_+_73467197 3.16 ENSMUST00000022099.8
Lpcat1
lysophosphatidylcholine acyltransferase 1
chr2_+_154200371 2.75 ENSMUST00000028987.6
Bpifb1
BPI fold containing family B, member 1
chr16_+_32735886 2.61 ENSMUST00000132475.1
ENSMUST00000096106.3
Muc4
mucin 4
chr3_+_79629074 2.49 ENSMUST00000029388.8
4930579G24Rik
RIKEN cDNA 4930579G24 gene
chr2_+_118772766 2.49 ENSMUST00000130293.1
ENSMUST00000061360.3
Phgr1
proline/histidine/glycine-rich 1
chr13_-_32851176 2.44 ENSMUST00000091668.5
ENSMUST00000076352.6
Serpinb1a
serine (or cysteine) peptidase inhibitor, clade B, member 1a
chr7_+_19411086 2.34 ENSMUST00000003643.1
Ckm
creatine kinase, muscle
chr5_-_100572192 2.31 ENSMUST00000031264.5
Plac8
placenta-specific 8
chr16_-_57071346 2.13 ENSMUST00000067173.6
2310005G13Rik
RIKEN cDNA 2310005G13 gene
chr8_-_72009619 2.10 ENSMUST00000003574.4
Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
chrX_+_164140447 1.95 ENSMUST00000073973.4
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr6_+_125071277 1.80 ENSMUST00000140346.2
ENSMUST00000171989.1
Lpar5
lysophosphatidic acid receptor 5
chr7_-_98178254 1.78 ENSMUST00000040971.7
Capn5
calpain 5
chr1_-_65123108 1.70 ENSMUST00000050047.3
ENSMUST00000148020.1
D630023F18Rik
RIKEN cDNA D630023F18 gene
chr6_-_113719880 1.50 ENSMUST00000064993.5
Ghrl
ghrelin
chr18_+_67800101 1.45 ENSMUST00000025425.5
Cep192
centrosomal protein 192
chr8_+_124897877 1.39 ENSMUST00000034467.5
Sprtn
SprT-like N-terminal domain
chr8_+_106893616 1.26 ENSMUST00000047629.5
Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr6_+_125552948 1.20 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf
Von Willebrand factor homolog
chr18_-_34651703 1.08 ENSMUST00000025228.5
ENSMUST00000133181.1
Cdc23
CDC23 cell division cycle 23
chr1_-_173333503 1.02 ENSMUST00000038227.4
Darc
Duffy blood group, chemokine receptor
chr19_+_45998131 1.00 ENSMUST00000181820.1
4930505N22Rik
RIKEN cDNA 4930505N22 gene
chr8_+_70616816 0.98 ENSMUST00000052437.3
Lrrc25
leucine rich repeat containing 25
chr10_+_81328719 0.97 ENSMUST00000105325.2
Tbxa2r
thromboxane A2 receptor
chr7_-_81345189 0.96 ENSMUST00000080813.4
Rps17
ribosomal protein S17
chr1_+_180935022 0.90 ENSMUST00000037361.8
Lefty1
left right determination factor 1
chr6_-_142473075 0.86 ENSMUST00000032371.7
Gys2
glycogen synthase 2
chr8_+_33732237 0.84 ENSMUST00000171010.1
Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr5_+_114003833 0.83 ENSMUST00000086599.4
Dao
D-amino acid oxidase
chr1_+_135232045 0.82 ENSMUST00000110798.3
Gm4204
predicted gene 4204
chr8_-_106893581 0.74 ENSMUST00000176437.1
ENSMUST00000177068.1
ENSMUST00000169312.1
ENSMUST00000176515.1
Chtf8
CTF8, chromosome transmission fidelity factor 8
chr13_-_38658991 0.69 ENSMUST00000001757.7
Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr7_+_101896340 0.64 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15
anaphase prompoting complex C subunit 15
chr18_+_61105844 0.56 ENSMUST00000115268.3
Csf1r
colony stimulating factor 1 receptor
chr2_+_121295437 0.52 ENSMUST00000110639.1
Map1a
microtubule-associated protein 1 A
chr8_-_106893515 0.51 ENSMUST00000176090.1
Chtf8
CTF8, chromosome transmission fidelity factor 8
chr8_+_31091593 0.46 ENSMUST00000161713.1
Dusp26
dual specificity phosphatase 26 (putative)
chr19_+_6276725 0.44 ENSMUST00000025684.3
Ehd1
EH-domain containing 1
chr2_+_31670714 0.41 ENSMUST00000038474.7
ENSMUST00000137156.1
Exosc2
exosome component 2
chr13_+_44730726 0.38 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
Jarid2
jumonji, AT rich interactive domain 2
chr5_+_122643878 0.37 ENSMUST00000100737.3
ENSMUST00000121489.1
ENSMUST00000031425.8
ENSMUST00000086247.5
P2rx7
purinergic receptor P2X, ligand-gated ion channel, 7
chr14_-_32685246 0.37 ENSMUST00000096038.3
3425401B19Rik
RIKEN cDNA 3425401B19 gene
chr17_-_24150910 0.35 ENSMUST00000052462.6
Pdpk1
3-phosphoinositide dependent protein kinase 1
chr8_-_124897685 0.29 ENSMUST00000098312.2
Exoc8
exocyst complex component 8
chr11_-_33578933 0.29 ENSMUST00000020366.1
ENSMUST00000135350.1
Gabrp
gamma-aminobutyric acid (GABA) A receptor, pi
chr6_+_127453667 0.26 ENSMUST00000112193.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr7_+_19518731 0.25 ENSMUST00000078908.4
Nkpd1
NTPase, KAP family P-loop domain containing 1
chr19_-_10869757 0.24 ENSMUST00000120524.1
ENSMUST00000025645.7
Tmem132a
transmembrane protein 132A
chr2_+_104069819 0.23 ENSMUST00000111131.2
ENSMUST00000111132.1
ENSMUST00000129749.1
Cd59b
CD59b antigen
chr8_+_94810446 0.22 ENSMUST00000034232.1
Ccl17
chemokine (C-C motif) ligand 17
chr5_+_24586721 0.17 ENSMUST00000121863.1
ENSMUST00000088295.4
Chpf2
chondroitin polymerizing factor 2
chr4_+_156026120 0.17 ENSMUST00000103173.3
Tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr18_-_77713978 0.17 ENSMUST00000074653.4
8030462N17Rik
RIKEN cDNA 8030462N17 gene
chr6_+_127453705 0.15 ENSMUST00000039680.5
Parp11
poly (ADP-ribose) polymerase family, member 11
chr9_+_114688782 0.14 ENSMUST00000047404.6
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr8_-_116978908 0.11 ENSMUST00000070577.5
1700030J22Rik
RIKEN cDNA 1700030J22 gene
chr12_+_69724939 0.09 ENSMUST00000021372.5
Atp5s
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s
chr4_+_139192899 0.07 ENSMUST00000102508.3
ENSMUST00000131912.1
ENSMUST00000102507.3
Capzb
capping protein (actin filament) muscle Z-line, beta
chr17_-_34475937 0.05 ENSMUST00000065841.4
Btnl4
butyrophilin-like 4
chr16_-_38433145 0.04 ENSMUST00000002926.6
Pla1a
phospholipase A1 member A
chr10_-_33951190 0.01 ENSMUST00000048222.4
Zufsp
zinc finger with UFM1-specific peptidase domain
chr4_+_156026304 0.01 ENSMUST00000040274.7
ENSMUST00000122001.1
Tnfrsf18
tumor necrosis factor receptor superfamily, member 18

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 15.9 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
1.5 4.6 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.1 3.4 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.8 3.2 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.7 2.1 GO:0009233 menaquinone metabolic process(GO:0009233) phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.6 10.4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.5 1.5 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.5 1.9 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.4 2.6 GO:0002835 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.3 2.8 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.3 0.8 GO:0055130 D-serine catabolic process(GO:0036088) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.2 0.9 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.2 5.8 GO:0015701 bicarbonate transport(GO:0015701)
0.2 0.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 1.3 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.4 GO:1904170 positive regulation of interleukin-1 alpha secretion(GO:0050717) regulation of bleb assembly(GO:1904170)
0.1 0.6 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.4 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 1.4 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.4 GO:0071051 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 1.8 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 1.4 GO:0046599 regulation of centriole replication(GO:0046599)
0.1 2.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.8 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.3 GO:0001927 exocyst assembly(GO:0001927)
0.0 6.2 GO:0007586 digestion(GO:0007586)
0.0 1.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 2.3 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.0 1.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 1.0 GO:1900048 positive regulation of blood coagulation(GO:0030194) positive regulation of hemostasis(GO:1900048)
0.0 0.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.2 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.0 0.3 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.2 GO:0006968 cellular defense response(GO:0006968)
0.0 0.9 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 1.2 GO:0030168 platelet activation(GO:0030168)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.4 3.4 GO:0033269 internode region of axon(GO:0033269)
0.3 0.8 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.2 0.6 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.4 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 1.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.6 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.4 GO:0000242 pericentriolar material(GO:0000242)
0.1 5.9 GO:0014704 intercalated disc(GO:0014704)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0043218 compact myelin(GO:0043218)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 15.9 GO:0036374 glutathione hydrolase activity(GO:0036374)
1.2 4.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.1 3.2 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.7 2.1 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871)
0.7 2.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.5 1.5 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.4 2.3 GO:0004111 creatine kinase activity(GO:0004111)
0.4 10.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.3 5.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 0.9 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.3 1.9 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.3 3.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 0.9 GO:0038100 nodal binding(GO:0038100)
0.2 0.8 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.2 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 1.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.0 GO:0004954 prostanoid receptor activity(GO:0004954)
0.1 1.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 7.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.3 GO:0004890 GABA-A receptor activity(GO:0004890)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.3 ST GA13 PATHWAY G alpha 13 Pathway
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.4 15.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 7.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 3.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 2.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.0 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.1 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 5.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.4 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 1.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.9 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism