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GSE58827: Dynamics of the Mouse Liver

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Results for Zscan4c

Z-value: 0.59

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Transcription factors associated with Zscan4c

Gene Symbol Gene ID Gene Info
Zscan4c
ENSMUSG00000054272.5 zinc finger and SCAN domain containing 4C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zscan4cmm10_v2_chr7_+_11005722_110057220.401.7e-02Click!

Activity profile of Zscan4c motif

Sorted Z-values of Zscan4c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_28560704 5.13 ENSMUST00000114785.1
ENSMUST00000025062.3
Clps
colipase, pancreatic
chr4_+_49059256 4.87 ENSMUST00000076670.2
E130309F12Rik
RIKEN cDNA E130309F12 gene
chr14_-_60177482 3.80 ENSMUST00000140924.1
Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr10_+_43579161 3.38 ENSMUST00000058714.8
Cd24a
CD24a antigen
chr4_+_115057683 3.13 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr4_+_115057410 3.07 ENSMUST00000136946.1
Tal1
T cell acute lymphocytic leukemia 1
chr14_-_70627008 2.51 ENSMUST00000110984.2
Dmtn
dematin actin binding protein
chr4_-_87806296 2.50 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr13_-_76056996 2.50 ENSMUST00000056130.4
Gpr150
G protein-coupled receptor 150
chr14_+_55765956 2.36 ENSMUST00000057569.3
Ltb4r1
leukotriene B4 receptor 1
chr4_-_87806276 2.34 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr13_+_55369732 1.87 ENSMUST00000063771.7
Rgs14
regulator of G-protein signaling 14
chr9_-_49798905 1.25 ENSMUST00000114476.2
Ncam1
neural cell adhesion molecule 1
chr15_+_80173642 1.04 ENSMUST00000044970.6
Mgat3
mannoside acetylglucosaminyltransferase 3
chr19_+_47228804 1.02 ENSMUST00000111807.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr5_+_86071734 0.93 ENSMUST00000031171.7
Stap1
signal transducing adaptor family member 1
chr15_-_36879816 0.91 ENSMUST00000100713.2
Gm10384
predicted gene 10384
chr15_+_79348061 0.89 ENSMUST00000163691.1
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr10_-_81524225 0.85 ENSMUST00000043709.7
Gna15
guanine nucleotide binding protein, alpha 15
chr9_-_49798729 0.85 ENSMUST00000166811.2
Ncam1
neural cell adhesion molecule 1
chr19_+_16956110 0.74 ENSMUST00000087689.4
Prune2
prune homolog 2 (Drosophila)
chr11_-_101785252 0.72 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4
ets variant gene 4 (E1A enhancer binding protein, E1AF)
chrX_+_48519245 0.72 ENSMUST00000033430.2
Rab33a
RAB33A, member of RAS oncogene family
chr8_-_48555846 0.72 ENSMUST00000110345.1
ENSMUST00000110343.1
Tenm3
teneurin transmembrane protein 3
chr19_-_46044914 0.71 ENSMUST00000026252.7
Ldb1
LIM domain binding 1
chr10_-_42276688 0.68 ENSMUST00000175881.1
ENSMUST00000056974.3
Foxo3
forkhead box O3
chr6_+_28427789 0.67 ENSMUST00000031719.6
Fscn3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)
chr3_+_134236483 0.65 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4
CXXC finger 4
chr6_-_122340499 0.61 ENSMUST00000160843.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr7_-_98178254 0.60 ENSMUST00000040971.7
Capn5
calpain 5
chr19_-_46045194 0.58 ENSMUST00000156585.1
ENSMUST00000152946.1
Ldb1
LIM domain binding 1
chr6_-_145865302 0.54 ENSMUST00000111703.1
Bhlhe41
basic helix-loop-helix family, member e41
chr12_-_112929415 0.53 ENSMUST00000075827.3
Jag2
jagged 2
chr9_+_89909775 0.53 ENSMUST00000034912.4
ENSMUST00000034909.4
Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
chr6_-_145865483 0.48 ENSMUST00000032386.4
Bhlhe41
basic helix-loop-helix family, member e41
chr10_+_74967164 0.45 ENSMUST00000037813.4
Gnaz
guanine nucleotide binding protein, alpha z subunit
chr6_-_122340525 0.45 ENSMUST00000112600.2
Phc1
polyhomeotic-like 1 (Drosophila)
chr2_+_106695594 0.44 ENSMUST00000016530.7
Mpped2
metallophosphoesterase domain containing 2
chr11_-_109473220 0.44 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr13_-_12520377 0.44 ENSMUST00000179308.1
Edaradd
EDAR (ectodysplasin-A receptor)-associated death domain
chr4_-_116464151 0.43 ENSMUST00000106486.1
ENSMUST00000106485.1
Mast2
microtubule associated serine/threonine kinase 2
chr11_-_109473598 0.42 ENSMUST00000070152.5
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr5_+_114896936 0.41 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr15_-_85578070 0.39 ENSMUST00000109424.2
Wnt7b
wingless-related MMTV integration site 7B
chr8_-_116732991 0.38 ENSMUST00000109102.2
Cdyl2
chromodomain protein, Y chromosome-like 2
chr9_+_57940104 0.38 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr3_-_63851251 0.38 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
Plch1
phospholipase C, eta 1
chr10_-_37138863 0.38 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr13_+_15463837 0.36 ENSMUST00000110510.3
Gli3
GLI-Kruppel family member GLI3
chr4_-_129640691 0.36 ENSMUST00000084264.5
Txlna
taxilin alpha
chr7_+_140247316 0.36 ENSMUST00000164583.1
ENSMUST00000093984.2
5830411N06Rik
RIKEN cDNA 5830411N06 gene
chr9_+_36832684 0.35 ENSMUST00000034630.8
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr17_+_78508063 0.34 ENSMUST00000024880.9
Vit
vitrin
chr5_+_27261916 0.31 ENSMUST00000101471.3
Dpp6
dipeptidylpeptidase 6
chr10_-_42276744 0.30 ENSMUST00000105502.1
ENSMUST00000105501.1
Foxo3
forkhead box O3
chr17_+_29090969 0.30 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr16_+_45094036 0.29 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr19_-_28680077 0.28 ENSMUST00000162022.1
ENSMUST00000112612.2
Glis3
GLIS family zinc finger 3
chr2_+_68861564 0.28 ENSMUST00000176018.1
Cers6
ceramide synthase 6
chr8_+_82863351 0.28 ENSMUST00000078525.5
Rnf150
ring finger protein 150
chr2_+_135659625 0.23 ENSMUST00000134310.1
Plcb4
phospholipase C, beta 4
chr7_+_46841475 0.22 ENSMUST00000147535.1
Ldha
lactate dehydrogenase A
chr12_-_69892989 0.20 ENSMUST00000110567.1
ENSMUST00000171211.1
Map4k5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_+_68861433 0.19 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr8_+_117257019 0.18 ENSMUST00000166750.1
Cmip
c-Maf inducing protein
chr5_+_43515513 0.18 ENSMUST00000167522.1
ENSMUST00000144558.1
ENSMUST00000076939.6
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr4_-_117496940 0.16 ENSMUST00000030439.8
Rnf220
ring finger protein 220
chr7_+_144896523 0.16 ENSMUST00000033389.5
Fgf15
fibroblast growth factor 15
chr19_+_53310495 0.16 ENSMUST00000003870.7
Mxi1
Max interacting protein 1
chr11_+_52098681 0.15 ENSMUST00000020608.2
Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
chrX_-_101086020 0.14 ENSMUST00000113710.1
Slc7a3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr4_+_123183722 0.14 ENSMUST00000152194.1
Hpcal4
hippocalcin-like 4
chr1_+_74375203 0.14 ENSMUST00000027368.5
Slc11a1
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
chr6_-_122340200 0.12 ENSMUST00000159384.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr16_-_76403673 0.11 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr2_-_116065047 0.09 ENSMUST00000028639.6
ENSMUST00000102538.4
Meis2
Meis homeobox 2
chr3_+_125404072 0.08 ENSMUST00000173932.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr5_-_44799643 0.08 ENSMUST00000070748.5
Ldb2
LIM domain binding 2
chr10_-_79766872 0.08 ENSMUST00000047203.8
Rnf126
ring finger protein 126
chrX_-_38252398 0.08 ENSMUST00000089056.3
ENSMUST00000089054.4
ENSMUST00000066498.7
Tmem255a
transmembrane protein 255A
chr3_+_10366903 0.06 ENSMUST00000029049.5
Chmp4c
charged multivesicular body protein 4C
chr10_+_81292961 0.06 ENSMUST00000163075.1
ENSMUST00000105327.3
ENSMUST00000045469.8
Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
chr7_+_105425817 0.04 ENSMUST00000181339.1
ENSMUST00000033189.4
Cckbr
cholecystokinin B receptor
chr4_+_118527229 0.04 ENSMUST00000030261.5
2610528J11Rik
RIKEN cDNA 2610528J11 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Zscan4c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0060217 hemangioblast cell differentiation(GO:0060217)
1.1 3.4 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.8 2.5 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.7 2.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.5 3.8 GO:0061091 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.3 1.3 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.3 4.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 0.9 GO:1903972 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.1 1.6 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.9 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 1.0 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.1 0.4 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.1 5.1 GO:0032094 response to food(GO:0032094)
0.1 0.4 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.4 GO:0072054 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) renal outer medulla development(GO:0072054) inner medullary collecting duct development(GO:0072061)
0.1 1.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.7 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 1.0 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1 0.5 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1 0.7 GO:0097264 self proteolysis(GO:0097264)
0.0 1.0 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.1 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
0.0 0.4 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.2 GO:0019661 fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0 2.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.3 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 1.1 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.2 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 0.1 GO:0015822 lysine transport(GO:0015819) ornithine transport(GO:0015822)
0.0 0.3 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.1 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.5 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 1.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.9 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.0 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0033193 Lsd1/2 complex(GO:0033193)
0.6 2.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 3.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 1.2 GO:0001739 sex chromatin(GO:0001739)
0.1 0.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 4.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0030312 external encapsulating structure(GO:0030312)
0.0 1.5 GO:0097440 apical dendrite(GO:0097440)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.9 GO:0000922 spindle pole(GO:0000922)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0004974 leukotriene receptor activity(GO:0004974)
0.3 1.0 GO:0071820 N-box binding(GO:0071820)
0.3 0.9 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.2 3.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.4 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.1 3.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.4 GO:0030274 LIM domain binding(GO:0030274)
0.1 6.2 GO:0070888 E-box binding(GO:0070888)
0.1 0.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.4 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.1 2.1 GO:0030275 LRR domain binding(GO:0030275)
0.1 1.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092) GTPase activating protein binding(GO:0032794)
0.0 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 2.5 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.9 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.0 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.4 GO:0005123 death receptor binding(GO:0005123)
0.0 1.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.1 PID FGF PATHWAY FGF signaling pathway
0.0 0.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 2.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.1 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.7 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis