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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for ACCCUGU

Z-value: 0.41

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miRNA associated with seed ACCCUGU

NamemiRBASE accession
mmu-miR-10a-5p
MIMAT0000648
mmu-miR-10b-5p
MIMAT0000208

Activity profile of ACCCUGU motif

Sorted Z-values of ACCCUGU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_77565050 0.56 ENSMUST00000182153.1
ENSMUST00000182146.1
ENSMUST00000026494.7
ENSMUST00000182024.1
Rnf165
ring finger protein 165
chr10_-_83337845 0.53 ENSMUST00000039956.5
Slc41a2
solute carrier family 41, member 2
chr16_-_23988852 0.48 ENSMUST00000023151.5
Bcl6
B cell leukemia/lymphoma 6
chr16_-_17928136 0.43 ENSMUST00000003622.8
Slc25a1
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
chr7_+_49910112 0.36 ENSMUST00000056442.5
Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr6_-_113195380 0.35 ENSMUST00000162280.1
Lhfpl4
lipoma HMGIC fusion partner-like protein 4
chr12_+_8771317 0.34 ENSMUST00000020911.7
Sdc1
syndecan 1
chr19_+_32757497 0.33 ENSMUST00000013807.7
Pten
phosphatase and tensin homolog
chr13_+_117602439 0.29 ENSMUST00000006991.7
Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
chr9_-_48835932 0.28 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr13_-_40733768 0.28 ENSMUST00000110193.2
Tfap2a
transcription factor AP-2, alpha
chr19_-_19001099 0.26 ENSMUST00000040153.8
ENSMUST00000112828.1
Rorb
RAR-related orphan receptor beta
chr12_-_75177325 0.25 ENSMUST00000042299.2
Kcnh5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr7_-_4844665 0.24 ENSMUST00000066041.5
ENSMUST00000172377.1
Shisa7
shisa homolog 7 (Xenopus laevis)
chr9_+_68653761 0.24 ENSMUST00000034766.7
Rora
RAR-related orphan receptor alpha
chr18_+_40258361 0.22 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr9_+_74861888 0.21 ENSMUST00000056006.9
Onecut1
one cut domain, family member 1
chr1_-_13589717 0.21 ENSMUST00000027068.4
Tram1
translocating chain-associating membrane protein 1
chr13_+_41606216 0.20 ENSMUST00000129449.1
Tmem170b
transmembrane protein 170B
chr7_-_134938264 0.20 ENSMUST00000171394.1
Fam196a
family with sequence similarity 196, member A
chr5_-_92505518 0.20 ENSMUST00000031377.7
Scarb2
scavenger receptor class B, member 2
chr2_+_172549581 0.19 ENSMUST00000030391.2
Tfap2c
transcription factor AP-2, gamma
chr11_-_103749815 0.19 ENSMUST00000018630.2
Wnt9b
wingless-type MMTV integration site 9B
chr18_-_61400363 0.18 ENSMUST00000063307.5
ENSMUST00000075299.6
Ppargc1b
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
chr3_-_84304762 0.17 ENSMUST00000107692.1
Trim2
tripartite motif-containing 2
chr6_-_136171722 0.17 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_+_119325784 0.17 ENSMUST00000102517.3
Dll4
delta-like 4 (Drosophila)
chr12_+_64917901 0.17 ENSMUST00000058135.4
Gm527
predicted gene 527
chr11_-_6065737 0.16 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
Camk2b
calcium/calmodulin-dependent protein kinase II, beta
chr4_-_91372028 0.16 ENSMUST00000107110.1
ENSMUST00000008633.8
ENSMUST00000107118.1
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_-_120493807 0.16 ENSMUST00000178687.1
Cecr6
cat eye syndrome chromosome region, candidate 6
chr12_-_119238794 0.15 ENSMUST00000026360.8
Itgb8
integrin beta 8
chr3_-_152982240 0.15 ENSMUST00000044278.5
St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr11_+_4186789 0.15 ENSMUST00000041042.6
ENSMUST00000180088.1
Tbc1d10a
TBC1 domain family, member 10a
chr8_-_17535251 0.14 ENSMUST00000082104.6
Csmd1
CUB and Sushi multiple domains 1
chr4_+_123904832 0.14 ENSMUST00000030400.7
Mycbp
c-myc binding protein
chr2_+_32606979 0.14 ENSMUST00000113289.1
ENSMUST00000095044.3
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr5_+_125532377 0.14 ENSMUST00000031446.6
Tmem132b
transmembrane protein 132B
chr4_+_57434247 0.12 ENSMUST00000102905.1
Palm2
paralemmin 2
chr4_+_149518216 0.12 ENSMUST00000030839.6
Ctnnbip1
catenin beta interacting protein 1
chr1_-_67038824 0.12 ENSMUST00000119559.1
ENSMUST00000149996.1
ENSMUST00000027149.5
ENSMUST00000113979.3
Lancl1
LanC (bacterial lantibiotic synthetase component C)-like 1
chr7_+_5350542 0.12 ENSMUST00000056639.6
Gm5065
predicted gene 5065
chr14_+_120478443 0.11 ENSMUST00000062117.6
Rap2a
RAS related protein 2a
chr18_-_24530203 0.11 ENSMUST00000046206.3
Rprd1a
regulation of nuclear pre-mRNA domain containing 1A
chr2_-_64097994 0.11 ENSMUST00000131615.2
Fign
fidgetin
chr2_+_65845767 0.11 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr18_+_11052487 0.11 ENSMUST00000047762.7
Gata6
GATA binding protein 6
chr2_+_74691090 0.10 ENSMUST00000061745.3
Hoxd10
homeobox D10
chr7_+_46796088 0.10 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1
general transcription factor II H, polypeptide 1
chr4_+_124802543 0.10 ENSMUST00000138807.1
ENSMUST00000030723.2
ENSMUST00000175875.1
Mtf1
metal response element binding transcription factor 1
chrX_-_13846508 0.10 ENSMUST00000115436.2
ENSMUST00000033321.4
ENSMUST00000115438.3
Cask
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chr1_-_134361933 0.10 ENSMUST00000049470.4
Tmem183a
transmembrane protein 183A
chr13_+_80883403 0.09 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr14_+_34673888 0.09 ENSMUST00000048263.7
Wapal
wings apart-like homolog (Drosophila)
chr11_+_42419729 0.09 ENSMUST00000007797.4
Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr4_+_129820702 0.08 ENSMUST00000165853.1
Ptp4a2
protein tyrosine phosphatase 4a2
chr11_-_37235882 0.08 ENSMUST00000102801.1
Tenm2
teneurin transmembrane protein 2
chr11_-_118212715 0.08 ENSMUST00000106302.2
ENSMUST00000151165.1
Cyth1
cytohesin 1
chr6_+_103510874 0.08 ENSMUST00000066905.6
Chl1
cell adhesion molecule with homology to L1CAM
chr11_-_20831009 0.07 ENSMUST00000047028.8
Lgalsl
lectin, galactoside binding-like
chr12_+_24651346 0.07 ENSMUST00000020982.5
Klf11
Kruppel-like factor 11
chr5_+_65537209 0.07 ENSMUST00000142407.1
Ube2k
ubiquitin-conjugating enzyme E2K
chr5_+_119834663 0.07 ENSMUST00000018407.6
Tbx5
T-box 5
chr8_-_27128615 0.07 ENSMUST00000033877.4
Brf2
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
chrX_-_88115632 0.07 ENSMUST00000113966.1
ENSMUST00000113964.1
Il1rapl1
interleukin 1 receptor accessory protein-like 1
chr7_-_128740471 0.07 ENSMUST00000119081.1
ENSMUST00000057557.7
Mcmbp
MCM (minichromosome maintenance deficient) binding protein
chr18_+_32163073 0.06 ENSMUST00000096575.3
Map3k2
mitogen-activated protein kinase kinase kinase 2
chr16_+_32332238 0.05 ENSMUST00000115151.3
Ubxn7
UBX domain protein 7
chr5_+_150952607 0.05 ENSMUST00000078856.6
Kl
klotho
chr16_-_67620880 0.05 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2
cell adhesion molecule 2
chr2_-_73892530 0.05 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2
activating transcription factor 2
chr1_-_136960427 0.05 ENSMUST00000027649.7
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr2_+_122028544 0.05 ENSMUST00000028668.7
Eif3j1
eukaryotic translation initiation factor 3, subunit J1
chr8_+_88199194 0.05 ENSMUST00000119033.1
ENSMUST00000066748.3
ENSMUST00000118952.1
Papd5
PAP associated domain containing 5
chr19_-_5118224 0.05 ENSMUST00000113728.1
ENSMUST00000113727.1
ENSMUST00000025798.6
Klc2
kinesin light chain 2
chr1_-_63114516 0.05 ENSMUST00000097718.2
Ino80d
INO80 complex subunit D
chr18_+_24205303 0.04 ENSMUST00000000430.7
Galnt1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
chr4_-_136956784 0.04 ENSMUST00000030420.8
Epha8
Eph receptor A8
chr11_+_93996082 0.04 ENSMUST00000041956.7
Spag9
sperm associated antigen 9
chr13_-_9764371 0.04 ENSMUST00000146059.1
ENSMUST00000110637.1
Zmynd11
zinc finger, MYND domain containing 11
chr4_-_49845549 0.04 ENSMUST00000093859.4
ENSMUST00000076674.3
Grin3a
glutamate receptor ionotropic, NMDA3A
chr3_-_122619663 0.04 ENSMUST00000162409.1
Fnbp1l
formin binding protein 1-like
chr1_+_153652943 0.03 ENSMUST00000041776.5
Rgs8
regulator of G-protein signaling 8
chrX_+_151198078 0.03 ENSMUST00000184730.1
ENSMUST00000184392.1
ENSMUST00000096285.4
Wnk3
WNK lysine deficient protein kinase 3
chr1_+_70725715 0.03 ENSMUST00000053922.5
Vwc2l
von Willebrand factor C domain-containing protein 2-like
chr8_-_84800024 0.03 ENSMUST00000126806.1
ENSMUST00000076715.6
Nfix
nuclear factor I/X
chr16_-_50432340 0.03 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
Bbx
bobby sox homolog (Drosophila)
chr11_-_97187872 0.03 ENSMUST00000001479.4
Kpnb1
karyopherin (importin) beta 1
chr18_+_76241580 0.03 ENSMUST00000168423.1
ENSMUST00000091831.6
Smad2
SMAD family member 2
chr2_-_50296680 0.03 ENSMUST00000144143.1
ENSMUST00000102769.4
ENSMUST00000133768.1
Mmadhc
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr15_+_80234071 0.03 ENSMUST00000023048.4
ENSMUST00000166030.1
Mief1
mitochondrial elongation factor 1
chr9_+_59578192 0.02 ENSMUST00000118549.1
ENSMUST00000034840.3
Celf6
CUGBP, Elav-like family member 6
chr4_+_31964081 0.02 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
Map3k7
mitogen-activated protein kinase kinase kinase 7
chr4_+_132274369 0.02 ENSMUST00000030731.4
Taf12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_-_65567465 0.02 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr9_+_21165714 0.02 ENSMUST00000039413.8
Pde4a
phosphodiesterase 4A, cAMP specific
chr8_+_14095849 0.02 ENSMUST00000152652.1
ENSMUST00000133298.1
Dlgap2
discs, large (Drosophila) homolog-associated protein 2
chr10_+_75060885 0.02 ENSMUST00000164107.1
Bcr
breakpoint cluster region
chr5_-_144965793 0.02 ENSMUST00000110677.1
ENSMUST00000085684.4
ENSMUST00000100461.2
Smurf1
SMAD specific E3 ubiquitin protein ligase 1
chr13_+_44731265 0.02 ENSMUST00000173246.1
Jarid2
jumonji, AT rich interactive domain 2
chr12_+_29528382 0.01 ENSMUST00000049784.9
Myt1l
myelin transcription factor 1-like
chr7_-_80115294 0.01 ENSMUST00000107384.3
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr15_-_96699698 0.01 ENSMUST00000023099.6
Slc38a2
solute carrier family 38, member 2
chr6_+_92091378 0.01 ENSMUST00000113460.1
Nr2c2
nuclear receptor subfamily 2, group C, member 2
chr1_+_187997821 0.01 ENSMUST00000027906.6
Esrrg
estrogen-related receptor gamma
chr1_+_6214627 0.00 ENSMUST00000027040.6
Rb1cc1
RB1-inducible coiled-coil 1
chr15_+_80711292 0.00 ENSMUST00000067689.7
Tnrc6b
trinucleotide repeat containing 6b
chr6_+_90369486 0.00 ENSMUST00000113539.1
ENSMUST00000075117.3
ENSMUST00000045740.6
Zxdc
ZXD family zinc finger C
chr4_-_126429501 0.00 ENSMUST00000069097.6
Ago3
argonaute RISC catalytic subunit 3
chr4_-_82859571 0.00 ENSMUST00000156055.1
ENSMUST00000030110.8
Zdhhc21
zinc finger, DHHC domain containing 21

Network of associatons between targets according to the STRING database.

First level regulatory network of ACCCUGU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0048294 regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 0.3 GO:0048627 myoblast development(GO:0048627)
0.1 0.3 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 0.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.3 GO:0021622 oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.1 0.4 GO:0036233 glycine import(GO:0036233)
0.1 0.4 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.1 0.2 GO:1903588 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.2 GO:0060466 activation of meiosis involved in egg activation(GO:0060466)
0.0 0.2 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.0 0.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.2 GO:0072181 mesonephric duct formation(GO:0072181)
0.0 0.1 GO:0007493 endodermal cell fate determination(GO:0007493)
0.0 0.3 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.0 0.2 GO:0010694 positive regulation of alkaline phosphatase activity(GO:0010694)
0.0 0.3 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.1 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.6 GO:0060384 innervation(GO:0060384)
0.0 0.0 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.0 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098855 HCN channel complex(GO:0098855)
0.0 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0000439 core TFIIH complex(GO:0000439)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.4 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1 0.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.1 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis