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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for ACUGGCC

Z-value: 0.46

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miRNA associated with seed ACUGGCC

NamemiRBASE accession
mmu-miR-193a-3p
MIMAT0000223
mmu-miR-193b-3p
MIMAT0004859

Activity profile of ACUGGCC motif

Sorted Z-values of ACUGGCC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_84479418 1.46 ENSMUST00000091002.1
Fhdc1
FH2 domain containing 1
chr10_-_128401218 1.31 ENSMUST00000042666.5
Slc39a5
solute carrier family 39 (metal ion transporter), member 5
chr18_+_36528145 1.11 ENSMUST00000074298.6
ENSMUST00000115694.2
Slc4a9
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr4_+_13743424 0.73 ENSMUST00000006761.3
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_-_3938354 0.55 ENSMUST00000003369.3
Plag1
pleiomorphic adenoma gene 1
chr11_-_96005872 0.45 ENSMUST00000013559.2
Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
chrX_+_9885622 0.39 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5
synaptotagmin-like 5
chr2_-_153241402 0.39 ENSMUST00000056924.7
Plagl2
pleiomorphic adenoma gene-like 2
chr4_+_17853451 0.38 ENSMUST00000029881.3
Mmp16
matrix metallopeptidase 16
chr10_-_62792243 0.34 ENSMUST00000020268.5
Ccar1
cell division cycle and apoptosis regulator 1
chr2_-_60963192 0.33 ENSMUST00000028347.6
Rbms1
RNA binding motif, single stranded interacting protein 1
chr17_+_8801742 0.33 ENSMUST00000089085.2
Pde10a
phosphodiesterase 10A
chr2_+_24367565 0.32 ENSMUST00000102942.1
Psd4
pleckstrin and Sec7 domain containing 4
chr19_-_41802028 0.32 ENSMUST00000026150.8
ENSMUST00000177495.1
ENSMUST00000163265.1
Arhgap19
Rho GTPase activating protein 19
chr2_+_121955964 0.32 ENSMUST00000036647.6
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr12_-_15816762 0.31 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr5_+_75574916 0.28 ENSMUST00000144270.1
ENSMUST00000005815.6
Kit
kit oncogene
chr12_-_46818749 0.26 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr11_-_49712674 0.25 ENSMUST00000020624.6
ENSMUST00000145353.1
Cnot6
CCR4-NOT transcription complex, subunit 6
chr1_-_186705980 0.24 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr5_-_139325616 0.23 ENSMUST00000110865.1
Adap1
ArfGAP with dual PH domains 1
chr19_+_45363734 0.22 ENSMUST00000065601.5
ENSMUST00000111936.2
Btrc
beta-transducin repeat containing protein
chr11_+_111066154 0.20 ENSMUST00000042970.2
Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr3_-_95228636 0.20 ENSMUST00000065482.5
Mllt11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr11_-_98545800 0.20 ENSMUST00000103141.3
Ikzf3
IKAROS family zinc finger 3
chr16_+_33684460 0.20 ENSMUST00000152782.1
ENSMUST00000179453.1
Heg1
HEG homolog 1 (zebrafish)
chr8_-_86745950 0.19 ENSMUST00000045296.4
Siah1a
seven in absentia 1A
chr2_-_140671462 0.19 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_-_153332724 0.19 ENSMUST00000027752.8
Lamc1
laminin, gamma 1
chr12_-_69681795 0.17 ENSMUST00000183277.1
ENSMUST00000035773.7
Sos2
son of sevenless homolog 2 (Drosophila)
chr9_+_35421541 0.16 ENSMUST00000119129.2
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr5_-_107289561 0.16 ENSMUST00000031224.8
Tgfbr3
transforming growth factor, beta receptor III
chr3_-_153725062 0.16 ENSMUST00000064460.5
St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr6_-_39206782 0.14 ENSMUST00000002305.8
Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr5_-_32854185 0.14 ENSMUST00000130134.2
ENSMUST00000120129.2
Prr14l
proline rich 14-like
chr3_+_38886940 0.14 ENSMUST00000061260.7
Fat4
FAT tumor suppressor homolog 4 (Drosophila)
chr19_+_53600377 0.14 ENSMUST00000025930.9
Smc3
structural maintenance of chromosomes 3
chr16_+_20535475 0.14 ENSMUST00000090023.6
ENSMUST00000007216.8
Ap2m1
adaptor-related protein complex 2, mu 1 subunit
chr9_-_32541589 0.12 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr1_-_152766281 0.12 ENSMUST00000111859.1
ENSMUST00000148865.1
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr11_+_46055973 0.10 ENSMUST00000011400.7
Adam19
a disintegrin and metallopeptidase domain 19 (meltrin beta)
chr10_+_69533761 0.10 ENSMUST00000182884.1
Ank3
ankyrin 3, epithelial
chr9_+_113930934 0.10 ENSMUST00000084885.5
ENSMUST00000009885.7
Ubp1
upstream binding protein 1
chr12_-_90738438 0.10 ENSMUST00000082432.3
Dio2
deiodinase, iodothyronine, type II
chr9_+_32696005 0.09 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1
E26 avian leukemia oncogene 1, 5' domain
chr4_+_15881255 0.09 ENSMUST00000029876.1
Calb1
calbindin 1
chr18_+_69345721 0.08 ENSMUST00000078486.6
ENSMUST00000114982.1
Tcf4
transcription factor 4
chr18_+_78349754 0.08 ENSMUST00000164064.1
Gm6133
predicted gene 6133
chr3_+_152210458 0.08 ENSMUST00000166984.1
ENSMUST00000106121.1
Fubp1
far upstream element (FUSE) binding protein 1
chr7_-_116237767 0.07 ENSMUST00000182834.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr13_+_49341549 0.07 ENSMUST00000110084.2
ENSMUST00000048544.6
ENSMUST00000110085.3
Bicd2
bicaudal D homolog 2 (Drosophila)
chr9_+_106170918 0.07 ENSMUST00000020490.5
Wdr82
WD repeat domain containing 82
chr10_-_128891674 0.07 ENSMUST00000026408.6
Gdf11
growth differentiation factor 11
chr6_+_7844806 0.06 ENSMUST00000040159.4
C1galt1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr6_-_145250177 0.06 ENSMUST00000111710.1
ENSMUST00000155145.1
ENSMUST00000032399.5
Kras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
chr2_+_162931520 0.06 ENSMUST00000130411.1
Srsf6
serine/arginine-rich splicing factor 6
chr11_+_106036867 0.04 ENSMUST00000058438.8
Dcaf7
DDB1 and CUL4 associated factor 7
chr11_-_94321957 0.04 ENSMUST00000166312.1
ENSMUST00000107821.2
ENSMUST00000021226.7
ENSMUST00000107820.1
Luc7l3
LUC7-like 3 (S. cerevisiae)
chr5_+_43868802 0.03 ENSMUST00000030964.4
Cd38
CD38 antigen
chr11_+_107547925 0.03 ENSMUST00000100305.1
ENSMUST00000075012.1
ENSMUST00000106746.1
Helz
helicase with zinc finger domain
chr18_-_46280820 0.03 ENSMUST00000025354.3
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr10_+_128092771 0.02 ENSMUST00000170054.2
ENSMUST00000045621.8
Baz2a
bromodomain adjacent to zinc finger domain, 2A
chr9_+_108795971 0.02 ENSMUST00000085018.4
Ip6k2
inositol hexaphosphate kinase 2
chr1_+_93803945 0.02 ENSMUST00000027505.6
Ing5
inhibitor of growth family, member 5
chr11_+_60537978 0.02 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr4_-_53159885 0.02 ENSMUST00000030010.3
Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr13_-_93499803 0.01 ENSMUST00000065537.7
Jmy
junction-mediating and regulatory protein
chr12_+_16810940 0.01 ENSMUST00000020908.7
E2f6
E2F transcription factor 6
chr12_-_12941827 0.01 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr1_+_43098710 0.01 ENSMUST00000010434.7
AI597479
expressed sequence AI597479
chr12_-_79089623 0.01 ENSMUST00000072154.7
Pigh
phosphatidylinositol glycan anchor biosynthesis, class H
chr4_+_155734800 0.01 ENSMUST00000147721.1
ENSMUST00000127188.2
Tmem240
transmembrane protein 240
chr7_+_97579868 0.01 ENSMUST00000042399.7
ENSMUST00000107153.1
Rsf1
remodeling and spacing factor 1
chr19_+_8819401 0.00 ENSMUST00000096753.3
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr10_-_39133848 0.00 ENSMUST00000134279.1
ENSMUST00000139743.1
ENSMUST00000149949.1
ENSMUST00000124941.1
ENSMUST00000125042.1
ENSMUST00000063204.2
Fam229b
family with sequence similarity 229, member B

Network of associatons between targets according to the STRING database.

First level regulatory network of ACUGGCC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.1 0.3 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.5 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.2 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.3 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.1 0.2 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.1 0.2 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.3 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.2 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.4 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.2 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.0 0.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.2 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 0.5 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.1 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.4 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0030578 PML body organization(GO:0030578) positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0005606 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 0.1 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.1 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0019002 GMP binding(GO:0019002)
0.0 0.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac