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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Foxd3

Z-value: 0.43

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Transcription factors associated with Foxd3

Gene Symbol Gene ID Gene Info
Foxd3
ENSMUSG00000067261.3 forkhead box D3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxd3mm10_v2_chr4_+_99656299_99656340-0.144.2e-01Click!

Activity profile of Foxd3 motif

Sorted Z-values of Foxd3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_103956891 1.26 ENSMUST00000085054.4
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr1_+_88138364 1.04 ENSMUST00000014263.4
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr12_-_103773592 1.01 ENSMUST00000078869.5
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr10_+_93488766 0.99 ENSMUST00000129421.1
Hal
histidine ammonia lyase
chr12_-_103904887 0.93 ENSMUST00000074051.5
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr12_-_103738158 0.73 ENSMUST00000095450.4
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr5_-_31295862 0.65 ENSMUST00000041266.7
ENSMUST00000172435.1
Fndc4
fibronectin type III domain containing 4
chr3_+_146597077 0.64 ENSMUST00000029837.7
ENSMUST00000121133.1
Uox
urate oxidase
chr15_-_101924725 0.64 ENSMUST00000023797.6
Krt4
keratin 4
chr19_-_38125258 0.57 ENSMUST00000025951.6
Rbp4
retinol binding protein 4, plasma
chr18_+_44334062 0.55 ENSMUST00000025349.5
ENSMUST00000115498.1
Myot
myotilin
chr6_+_72636244 0.54 ENSMUST00000101278.2
Gm15401
predicted gene 15401
chr5_-_34187670 0.49 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4
Max dimerization protein 4
chrX_+_133850980 0.49 ENSMUST00000033602.8
Tnmd
tenomodulin
chr17_+_29090969 0.47 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_+_67655414 0.46 ENSMUST00000107470.1
Ttc23
tetratricopeptide repeat domain 23
chr9_-_50555170 0.43 ENSMUST00000119103.1
Bco2
beta-carotene oxygenase 2
chr2_+_152669461 0.37 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
H13
histocompatibility 13
chr2_+_120977017 0.37 ENSMUST00000067582.7
Tmem62
transmembrane protein 62
chr17_+_28691342 0.35 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14
mitogen-activated protein kinase 14
chr3_-_83049797 0.34 ENSMUST00000048246.3
Fgb
fibrinogen beta chain
chr5_+_148265307 0.32 ENSMUST00000110514.1
Mtus2
microtubule associated tumor suppressor candidate 2
chr12_-_103631404 0.31 ENSMUST00000121625.1
ENSMUST00000044231.5
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_45388772 0.29 ENSMUST00000046191.7
Gnpnat1
glucosamine-phosphate N-acetyltransferase 1
chr3_-_146596588 0.29 ENSMUST00000029836.4
Dnase2b
deoxyribonuclease II beta
chr13_-_56548534 0.29 ENSMUST00000062806.4
Lect2
leukocyte cell-derived chemotaxin 2
chr5_+_148265202 0.29 ENSMUST00000110515.2
Mtus2
microtubule associated tumor suppressor candidate 2
chr15_-_6874969 0.28 ENSMUST00000022746.6
ENSMUST00000176826.1
Osmr
oncostatin M receptor
chr16_+_43235856 0.28 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr10_-_88605017 0.26 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1
myosin binding protein C, slow-type
chr15_+_92597104 0.25 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr11_-_99993992 0.25 ENSMUST00000105049.1
Krtap17-1
keratin associated protein 17-1
chr5_+_148265265 0.24 ENSMUST00000071878.5
Mtus2
microtubule associated tumor suppressor candidate 2
chr4_-_136898803 0.23 ENSMUST00000046285.5
C1qa
complement component 1, q subcomponent, alpha polypeptide
chr3_+_102010138 0.23 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr9_-_20879718 0.22 ENSMUST00000043726.6
Angptl6
angiopoietin-like 6
chr16_-_4880284 0.22 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr13_+_41655697 0.22 ENSMUST00000067176.8
Gm5082
predicted gene 5082
chr13_+_16014457 0.21 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr7_-_99980431 0.21 ENSMUST00000080817.4
Rnf169
ring finger protein 169
chr4_-_82850721 0.20 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr17_+_28691419 0.19 ENSMUST00000124886.1
Mapk14
mitogen-activated protein kinase 14
chr10_-_89621253 0.17 ENSMUST00000020102.7
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr6_+_142298419 0.17 ENSMUST00000041993.2
Iapp
islet amyloid polypeptide
chr13_-_18031616 0.16 ENSMUST00000099736.2
Vdac3-ps1
voltage-dependent anion channel 3, pseudogene 1
chr1_-_173277756 0.16 ENSMUST00000111224.3
Mptx2
mucosal pentraxin 2
chr2_+_9882622 0.16 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr11_+_78920787 0.15 ENSMUST00000018610.6
Nos2
nitric oxide synthase 2, inducible
chr2_-_17460610 0.15 ENSMUST00000145492.1
Nebl
nebulette
chr6_-_142011414 0.14 ENSMUST00000181628.1
ENSMUST00000181791.1
Gm6614
predicted gene 6614
chr12_-_110840905 0.14 ENSMUST00000177224.1
ENSMUST00000084974.4
ENSMUST00000070565.8
Stk30
serine/threonine kinase 30
chr1_+_53061637 0.13 ENSMUST00000027269.5
Mstn
myostatin
chr2_+_131951011 0.13 ENSMUST00000110169.1
Prnd
prion protein dublet
chr10_-_11080956 0.13 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr3_+_70007613 0.12 ENSMUST00000053013.5
Otol1
otolin 1 homolog (zebrafish)
chr12_+_110841021 0.12 ENSMUST00000181348.1
4921507G05Rik
RIKEN cDNA 4921507G05 gene
chr4_+_108847827 0.12 ENSMUST00000102738.2
Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr19_+_8953826 0.12 ENSMUST00000096239.5
Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr1_+_6734827 0.12 ENSMUST00000139838.1
St18
suppression of tumorigenicity 18
chr19_-_7966000 0.11 ENSMUST00000182102.1
ENSMUST00000075619.4
Slc22a27
solute carrier family 22, member 27
chr2_+_131950855 0.10 ENSMUST00000110170.1
ENSMUST00000110172.2
ENSMUST00000110171.2
Prnd
prion protein dublet
chr9_+_36832684 0.10 ENSMUST00000034630.8
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr16_+_13986596 0.10 ENSMUST00000056521.5
ENSMUST00000118412.1
ENSMUST00000131608.1
2900011O08Rik
RIKEN cDNA 2900011O08 gene
chrX_-_101269023 0.10 ENSMUST00000117736.1
Gm20489
predicted gene 20489
chr5_-_97456971 0.09 ENSMUST00000059657.2
Gk2
glycerol kinase 2
chr2_+_181767040 0.09 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr18_+_37725706 0.09 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr10_-_128744014 0.08 ENSMUST00000026414.7
Dgka
diacylglycerol kinase, alpha
chr2_+_52038005 0.08 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr8_+_46739745 0.08 ENSMUST00000034041.7
Irf2
interferon regulatory factor 2
chr9_-_58118807 0.07 ENSMUST00000098681.3
ENSMUST00000098682.3
Ccdc33
coiled-coil domain containing 33
chr5_-_120612558 0.07 ENSMUST00000140554.1
ENSMUST00000031599.2
ENSMUST00000177800.1
1110008J03Rik
RIKEN cDNA 1110008J03 gene
chr8_-_45262012 0.05 ENSMUST00000034064.3
F11
coagulation factor XI
chr14_+_66937365 0.05 ENSMUST00000052898.3
4930578I07Rik
RIKEN cDNA 4930578I07 gene
chr6_+_90122643 0.05 ENSMUST00000174204.1
Vmn1r51
vomeronasal 1 receptor 51
chr9_+_105642957 0.05 ENSMUST00000065778.6
Pik3r4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr5_+_32247351 0.04 ENSMUST00000101376.2
Plb1
phospholipase B1
chr2_+_181767283 0.04 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr2_+_14388434 0.04 ENSMUST00000133258.1
Slc39a12
solute carrier family 39 (zinc transporter), member 12
chrX_+_164373363 0.04 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr17_-_37023199 0.02 ENSMUST00000167275.2
Mog
myelin oligodendrocyte glycoprotein
chr19_-_8713862 0.02 ENSMUST00000010239.4
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_+_88406956 0.01 ENSMUST00000027518.5
Spp2
secreted phosphoprotein 2
chr5_-_88675190 0.01 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1
G-rich RNA sequence binding factor 1
chr6_+_77242644 0.00 ENSMUST00000159616.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr1_-_126830786 0.00 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxd3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0006548 histidine catabolic process(GO:0006548)
0.1 0.6 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.1 0.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.1 1.0 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.3 GO:0006041 glucosamine metabolic process(GO:0006041) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.3 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.4 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.2 GO:0060279 positive regulation of ovulation(GO:0060279)
0.0 0.6 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.1 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.0 0.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.0 0.2 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.2 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.3 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 3.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.3 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 0.2 GO:0043512 inhibin A complex(GO:0043512)
0.1 0.4 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 1.0 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.3 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 0.3 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 0.2 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.6 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.1 GO:0099530 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 4.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol