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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Gata4

Z-value: 3.15

Motif logo

Transcription factors associated with Gata4

Gene Symbol Gene ID Gene Info
ENSMUSG00000021944.9 GATA binding protein 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata4mm10_v2_chr14_-_63271682_632717020.325.9e-02Click!

Activity profile of Gata4 motif

Sorted Z-values of Gata4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_26199008 46.61 ENSMUST00000142410.1
ENSMUST00000120333.1
ENSMUST00000039113.7
protein disulfide isomerase associated 2
chr6_-_41314700 28.39 ENSMUST00000064324.5
trypsin 5
chr6_+_30639218 26.12 ENSMUST00000031806.9
carboxypeptidase A1, pancreatic
chr2_+_84980458 23.24 ENSMUST00000028467.5
proteoglycan 2, bone marrow
chr8_-_85380964 23.11 ENSMUST00000122452.1
myosin light chain kinase 3
chr19_+_58759700 21.97 ENSMUST00000026081.3
pancreatic lipase-related protein 2
chr6_+_41354105 21.40 ENSMUST00000072103.5
trypsin 10
chr4_-_137430517 21.09 ENSMUST00000102522.4
chymotrypsin-like elastase family, member 3B
chr11_+_32276400 20.62 ENSMUST00000020531.2
hemoglobin X, alpha-like embryonic chain in Hba complex
chr4_-_46404224 20.43 ENSMUST00000107764.2
hemogen
chr6_+_41302265 19.39 ENSMUST00000031913.4
trypsin 4
chr5_-_73191848 19.32 ENSMUST00000176910.1
furry homolog-like (Drosophila)
chr4_+_34893772 18.22 ENSMUST00000029975.3
ENSMUST00000135871.1
ENSMUST00000108130.1
glycoprotein hormones, alpha subunit
chr17_-_35085609 18.13 ENSMUST00000038507.6
lymphocyte antigen 6 complex, locus G6F
chr11_+_32276893 17.98 ENSMUST00000145569.1
hemoglobin X, alpha-like embryonic chain in Hba complex
chr2_-_121036750 17.12 ENSMUST00000023987.5
erythrocyte protein band 4.2
chr11_-_83286722 17.09 ENSMUST00000163961.2
schlafen family member 14
chr17_-_35066170 16.83 ENSMUST00000174190.1
ENSMUST00000097337.1
expressed sequence AU023871
chr17_+_36869567 16.65 ENSMUST00000060524.9
tripartite motif-containing 10
chr17_-_28560704 16.63 ENSMUST00000114785.1
ENSMUST00000025062.3
colipase, pancreatic
chr6_+_30541582 16.57 ENSMUST00000096066.4
carboxypeptidase A2, pancreatic
chr7_+_110773658 16.11 ENSMUST00000143786.1
adenosine monophosphate deaminase 3
chr3_-_20242173 15.28 ENSMUST00000001921.1
carboxypeptidase A3, mast cell
chr2_-_121037048 15.03 ENSMUST00000102490.3
erythrocyte protein band 4.2
chr1_-_132367879 15.02 ENSMUST00000142609.1
transmembrane and coiled-coil domains 2
chr5_+_115466234 14.47 ENSMUST00000145785.1
ENSMUST00000031495.4
ENSMUST00000112071.1
ENSMUST00000125568.1
phospholipase A2, group IB, pancreas
chr9_+_7558429 14.39 ENSMUST00000018765.2
matrix metallopeptidase 8
chr4_-_137409777 14.23 ENSMUST00000024200.6
predicted gene 13011
chr7_+_28540863 14.04 ENSMUST00000119180.2
syncollin
chr3_-_84479418 13.09 ENSMUST00000091002.1
FH2 domain containing 1
chr17_+_31208049 12.95 ENSMUST00000173776.1
ubiquitin associated and SH3 domain containing, A
chrX_+_93654863 12.58 ENSMUST00000113933.2
phosphate cytidylyltransferase 1, choline, beta isoform
chr3_+_108364882 12.58 ENSMUST00000090563.5
myosin binding protein H-like
chr11_-_116076986 12.39 ENSMUST00000153408.1
unc-13 homolog D (C. elegans)
chrX_+_93675088 12.37 ENSMUST00000045898.3
phosphate cytidylyltransferase 1, choline, beta isoform
chr1_+_174172738 11.61 ENSMUST00000027817.7
spectrin alpha, erythrocytic 1
chr10_-_62342674 11.48 ENSMUST00000143179.1
ENSMUST00000130422.1
hexokinase 1
chr8_+_84701430 11.19 ENSMUST00000037165.4
lymphoblastomic leukemia 1
chr1_-_171281181 11.05 ENSMUST00000073120.4
protoporphyrinogen oxidase
chr9_+_21029373 10.99 ENSMUST00000001040.5
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr4_-_87806296 10.59 ENSMUST00000126353.1
ENSMUST00000149357.1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr15_-_103251465 10.33 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
nuclear factor, erythroid derived 2
chr6_-_129507107 10.28 ENSMUST00000183258.1
ENSMUST00000182784.1
ENSMUST00000032265.6
ENSMUST00000162815.1
oxidized low density lipoprotein (lectin-like) receptor 1
chr16_+_38362205 10.03 ENSMUST00000023494.6
popeye domain containing 2
chr4_-_87806276 9.68 ENSMUST00000148059.1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_+_119637704 9.44 ENSMUST00000024015.2
guanylate cyclase activator 2a (guanylin)
chr7_-_99238564 8.84 ENSMUST00000064231.7
monoacylglycerol O-acyltransferase 2
chr16_+_38362234 8.72 ENSMUST00000114739.1
popeye domain containing 2
chr6_-_122609964 8.29 ENSMUST00000032211.4
growth differentiation factor 3
chr2_+_103957976 8.22 ENSMUST00000156813.1
ENSMUST00000170926.1
LIM domain only 2
chr9_-_21963568 7.94 ENSMUST00000006397.5
erythropoietin receptor
chr19_-_10678001 7.84 ENSMUST00000025647.5
pepsinogen 5, group I
chrX_-_8145713 7.69 ENSMUST00000115615.2
ENSMUST00000115616.1
ENSMUST00000115621.2
RNA binding motif protein 3
chr10_-_80421847 7.22 ENSMUST00000156244.1
transcription factor 3
chr3_+_103832562 7.05 ENSMUST00000062945.5
BCLl2-like 15
chr11_-_102469839 6.91 ENSMUST00000103086.3
integrin alpha 2b
chr13_-_73700721 6.40 ENSMUST00000022048.5
solute carrier family 6 (neurotransmitter transporter), member 19
chr11_-_116077954 6.39 ENSMUST00000106451.1
ENSMUST00000075036.2
unc-13 homolog D (C. elegans)
chr11_-_116077606 6.35 ENSMUST00000106450.1
unc-13 homolog D (C. elegans)
chr13_-_23465872 6.28 ENSMUST00000041674.7
butyrophilin, subfamily 1, member A1
chr4_+_13751297 6.21 ENSMUST00000105566.2
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_+_40920047 6.21 ENSMUST00000030122.4
serine peptidase inhibitor, Kazal type 4
chr11_-_116077562 6.20 ENSMUST00000174822.1
unc-13 homolog D (C. elegans)
chr11_-_116077927 6.09 ENSMUST00000156545.1
unc-13 homolog D (C. elegans)
chr2_+_14873656 5.93 ENSMUST00000114718.1
ENSMUST00000114719.1
calcium channel, voltage-dependent, beta 2 subunit
chrX_-_107403295 5.84 ENSMUST00000033591.5
integral membrane protein 2A
chr7_+_99535439 5.78 ENSMUST00000098266.2
ENSMUST00000179755.1
arrestin, beta 1
chr8_-_46211284 5.54 ENSMUST00000034049.4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr4_-_43558386 5.48 ENSMUST00000130353.1
talin 1
chr3_-_107221722 5.44 ENSMUST00000029504.8
chymosin
chr16_-_92826004 5.14 ENSMUST00000023673.7
runt related transcription factor 1
chr5_-_24329556 5.12 ENSMUST00000115098.2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr11_-_99322943 5.07 ENSMUST00000038004.2
keratin 25
chr2_+_4559742 5.00 ENSMUST00000176828.1
FERM domain containing 4A
chr11_+_3330781 4.94 ENSMUST00000136536.1
ENSMUST00000093399.4
phosphoinositide-3-kinase interacting protein 1
chr2_-_153241402 4.93 ENSMUST00000056924.7
pleiomorphic adenoma gene-like 2
chr15_+_57985873 4.76 ENSMUST00000050374.2
family with sequence similarity 83, member A
chr2_+_72476225 4.61 ENSMUST00000157019.1
cell division cycle associated 7
chr11_+_101260569 4.53 ENSMUST00000103108.1
WNK lysine deficient protein kinase 4
chr13_-_62858364 4.46 ENSMUST00000021907.7
fructose bisphosphatase 2
chr2_+_72476159 4.39 ENSMUST00000102691.4
cell division cycle associated 7
chr13_-_23465895 4.35 ENSMUST00000110434.1
butyrophilin, subfamily 1, member A1
chr1_+_12718496 4.16 ENSMUST00000088585.3
sulfatase 1
chr11_+_3330401 3.86 ENSMUST00000045153.4
phosphoinositide-3-kinase interacting protein 1
chr1_-_173333503 3.70 ENSMUST00000038227.4
Duffy blood group, chemokine receptor
chr9_-_44342332 3.68 ENSMUST00000097558.3
hydroxymethylbilane synthase
chr10_-_80433615 3.67 ENSMUST00000105346.3
ENSMUST00000020377.6
ENSMUST00000105340.1
ENSMUST00000020379.6
ENSMUST00000105344.1
ENSMUST00000105342.1
ENSMUST00000105345.3
ENSMUST00000105343.1
transcription factor 3
chr14_-_54966570 3.60 ENSMUST00000124930.1
ENSMUST00000134256.1
ENSMUST00000081857.6
ENSMUST00000145322.1
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr6_-_136922169 3.58 ENSMUST00000032343.6
endoplasmic reticulum protein 27
chr7_+_28833975 3.53 ENSMUST00000066723.8
lectin, galactose binding, soluble 4
chr11_+_70505244 3.32 ENSMUST00000019063.2
transmembrane 4 superfamily member 5
chr3_-_102964124 3.29 ENSMUST00000058899.8
nuclear receptor subfamily 1, group H, member 5
chr2_+_74704615 3.26 ENSMUST00000151380.1
homeobox D8
chr11_-_6230127 3.17 ENSMUST00000004505.2
NPC1-like 1
chr6_+_87428986 3.16 ENSMUST00000032125.5
bone morphogenetic protein 10
chrX_+_56779699 3.13 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
four and a half LIM domains 1
chr2_-_59948155 2.94 ENSMUST00000153136.1
bromodomain adjacent to zinc finger domain, 2B
chr17_-_31144271 2.91 ENSMUST00000024826.7
trefoil factor 2 (spasmolytic protein 1)
chr15_-_102231920 2.90 ENSMUST00000001327.3
ENSMUST00000127014.1
integrin beta 7
chrX_+_159840463 2.89 ENSMUST00000112451.1
ENSMUST00000112453.2
SH3-domain kinase binding protein 1
chrX_+_150547375 2.89 ENSMUST00000066337.6
ENSMUST00000112715.1
aminolevulinic acid synthase 2, erythroid
chr2_-_33087169 2.88 ENSMUST00000102810.3
GTPase activating RANGAP domain-like 3
chr3_-_14808358 2.86 ENSMUST00000181860.1
ENSMUST00000144327.2
carbonic anhydrase 1
chr6_+_125552948 2.83 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Von Willebrand factor homolog
chr2_+_164403194 2.81 ENSMUST00000017151.1
recombination signal binding protein for immunoglobulin kappa J region-like
chr17_-_33713372 2.65 ENSMUST00000173392.1
membrane-associated ring finger (C3HC4) 2
chr14_+_75455957 2.64 ENSMUST00000164848.1
seven in absentia homolog 3 (Drosophila)
chr11_+_98386450 2.58 ENSMUST00000041301.7
phenylethanolamine-N-methyltransferase
chr2_+_74704861 2.57 ENSMUST00000019749.3
homeobox D8
chr3_+_98222148 2.51 ENSMUST00000029469.4
regenerating islet-derived family, member 4
chr11_-_57832679 2.48 ENSMUST00000160392.2
ENSMUST00000108845.2
heart and neural crest derivatives expressed transcript 1
chrX_+_56779437 2.43 ENSMUST00000114773.3
four and a half LIM domains 1
chr10_+_80019621 2.36 ENSMUST00000043311.6
histocompatibility (minor) HA-1
chr3_-_144819494 2.28 ENSMUST00000029929.7
chloride channel calcium activated 2
chr3_-_129755305 2.24 ENSMUST00000029653.2
epidermal growth factor
chr18_-_61707583 2.24 ENSMUST00000025472.1
prenylcysteine oxidase 1 like
chr3_-_63851251 2.19 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
phospholipase C, eta 1
chr1_-_160153571 2.16 ENSMUST00000039178.5
tenascin N
chr7_-_98112618 2.15 ENSMUST00000153657.1
myosin VIIA
chr1_+_179803376 2.14 ENSMUST00000097454.2
predicted gene 10518
chr6_+_129397478 2.13 ENSMUST00000112081.2
ENSMUST00000112079.2
C-type lectin domain family 1, member b
chr11_+_4986824 2.09 ENSMUST00000009234.9
ENSMUST00000109897.1
adaptor protein complex AP-1, beta 1 subunit
chr3_+_79884576 1.92 ENSMUST00000145992.1
family with sequence similarity 198, member B
chr4_+_150148905 1.86 ENSMUST00000059893.7
solute carrier family 2 (facilitated glucose transporter), member 7
chr16_+_57353093 1.85 ENSMUST00000159816.1
filamin A interacting protein 1-like
chr16_-_63864114 1.84 ENSMUST00000064405.6
Eph receptor A3
chr12_-_91746020 1.64 ENSMUST00000166967.1
stonin 2
chr4_-_32923455 1.55 ENSMUST00000035719.4
ENSMUST00000084749.1
ankyrin repeat domain 6
chr15_+_76904070 1.45 ENSMUST00000004072.8
ribosomal protein L8
chr7_-_135528645 1.44 ENSMUST00000053716.7
clarin 3
chr3_+_96596628 1.39 ENSMUST00000058943.7
ankyrin repeat domain 34A
chr8_-_122699066 1.36 ENSMUST00000127984.1
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr2_-_33086366 1.33 ENSMUST00000049618.2
GTPase activating RANGAP domain-like 3
chr10_-_19011948 1.32 ENSMUST00000105527.1
tumor necrosis factor, alpha-induced protein 3
chrX_-_7572843 1.28 ENSMUST00000132788.1
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr6_-_124768330 1.23 ENSMUST00000135626.1
enolase 2, gamma neuronal
chr9_+_66350465 1.17 ENSMUST00000042824.6
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr10_+_116177351 1.09 ENSMUST00000155606.1
ENSMUST00000128399.1
protein tyrosine phosphatase, receptor type, R
chr1_-_4496363 1.05 ENSMUST00000116652.2
SRY-box containing gene 17
chrX_+_10485121 1.01 ENSMUST00000076354.6
ENSMUST00000115526.1
tetraspanin 7
chr3_-_59262825 1.00 ENSMUST00000050360.7
purinergic receptor P2Y, G-protein coupled 12
chr9_-_106887000 0.89 ENSMUST00000055843.7
RNA binding motif protein 15B
chr3_-_144849301 0.88 ENSMUST00000159989.1
chloride channel calcium activated 4
chr2_+_71786923 0.87 ENSMUST00000112101.1
ENSMUST00000028522.3
integrin alpha 6
chr18_-_24020307 0.70 ENSMUST00000153337.1
ENSMUST00000148525.1
zinc finger protein 191
chr17_+_57249450 0.67 ENSMUST00000019631.9
thyroid hormone receptor interactor 10
chr12_-_69893162 0.66 ENSMUST00000049239.7
ENSMUST00000110570.1
mitogen-activated protein kinase kinase kinase kinase 5
chr6_+_129397297 0.65 ENSMUST00000032262.7
C-type lectin domain family 1, member b
chr12_+_95692212 0.63 ENSMUST00000057324.3
fibronectin leucine rich transmembrane protein 2
chr10_+_69219357 0.60 ENSMUST00000172261.1
Rho-related BTB domain containing 1
chr2_-_26246707 0.53 ENSMUST00000166349.1
RIKEN cDNA C030048H21 gene
chr3_+_79884496 0.52 ENSMUST00000118853.1
family with sequence similarity 198, member B
chr8_+_74872692 0.51 ENSMUST00000034034.3
intestine specific homeobox
chr13_-_22219820 0.49 ENSMUST00000057516.1
vomeronasal 1 receptor 193
chr10_+_76147451 0.48 ENSMUST00000020450.3
solute carrier family 5, member 4a
chr1_-_4496400 0.45 ENSMUST00000027035.3
SRY-box containing gene 17
chr3_+_59952185 0.43 ENSMUST00000094227.3
predicted gene 9696
chrX_-_95478107 0.42 ENSMUST00000033549.2
ankyrin repeat and SOCS box-containing 12
chr7_-_44892358 0.40 ENSMUST00000003049.6
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr7_+_45413657 0.37 ENSMUST00000058879.6
neurotrophin 5
chr15_-_77153772 0.36 ENSMUST00000166610.1
ENSMUST00000111581.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr11_+_88047693 0.35 ENSMUST00000079866.4
serine/arginine-rich splicing factor 1
chr10_+_39369750 0.34 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
Fyn proto-oncogene
chr6_+_17306415 0.32 ENSMUST00000150901.1
caveolin 1, caveolae protein
chr2_+_131133497 0.31 ENSMUST00000110225.1
predicted gene 11037
chr15_+_60822947 0.31 ENSMUST00000180730.1
RIKEN cDNA 9930014A18 gene
chr10_+_39133981 0.29 ENSMUST00000019991.7
epsilon-tubulin 1
chr18_-_43477764 0.27 ENSMUST00000057110.9
eukaryotic translation initiation factor 3, subunit J2
chrX_+_73757069 0.23 ENSMUST00000002079.6
plexin B3
chrX_+_112311334 0.20 ENSMUST00000026599.3
ENSMUST00000113415.1
apolipoprotein O-like
chr11_-_99351086 0.19 ENSMUST00000017732.2
keratin 27
chr8_-_4325096 0.16 ENSMUST00000098950.4
ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
chr1_-_14310198 0.14 ENSMUST00000168081.2
ENSMUST00000027066.6
eyes absent 1 homolog (Drosophila)
chr2_-_7081207 0.12 ENSMUST00000114923.2
ENSMUST00000182706.1
CUGBP, Elav-like family member 2
chr2_+_65845767 0.11 ENSMUST00000122912.1
cysteine-serine-rich nuclear protein 3
chr10_-_83648631 0.10 ENSMUST00000146876.2
ENSMUST00000176294.1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr1_-_107052331 0.09 ENSMUST00000112717.1
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
chr11_+_88047788 0.09 ENSMUST00000107920.3
serine/arginine-rich splicing factor 1
chrX_+_169685191 0.08 ENSMUST00000112104.1
ENSMUST00000112107.1
midline 1
chr4_-_14621805 0.03 ENSMUST00000042221.7
solute carrier family 26, member 7
chr5_-_123666682 0.02 ENSMUST00000149410.1
CAP-GLY domain containing linker protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 23.2 GO:0002215 defense response to nematode(GO:0002215)
4.8 38.6 GO:0015671 oxygen transport(GO:0015671)
4.8 14.5 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
4.3 38.7 GO:0002432 granuloma formation(GO:0002432)
3.9 23.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
3.1 18.8 GO:0060931 sinoatrial node cell development(GO:0060931)
2.9 8.8 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
2.0 5.9 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
1.9 19.3 GO:0090527 actin filament reorganization(GO:0090527)
1.8 5.5 GO:0015866 ADP transport(GO:0015866)
1.8 16.1 GO:0032264 IMP salvage(GO:0032264)
1.7 5.1 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
1.7 18.2 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
1.6 11.2 GO:0001955 blood vessel maturation(GO:0001955)
1.4 11.5 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
1.4 6.9 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
1.4 21.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.4 10.9 GO:0002326 B cell lineage commitment(GO:0002326)
1.3 22.0 GO:0019374 galactolipid metabolic process(GO:0019374) glycolipid catabolic process(GO:0019377)
1.3 5.1 GO:1902303 negative regulation of potassium ion export(GO:1902303)
1.3 8.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.2 15.3 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
1.1 4.5 GO:0046351 disaccharide biosynthetic process(GO:0046351)
1.1 42.3 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
1.0 4.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
1.0 5.8 GO:0002317 plasma cell differentiation(GO:0002317)
1.0 5.8 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
1.0 8.7 GO:0048859 formation of anatomical boundary(GO:0048859)
0.9 17.1 GO:0016075 rRNA catabolic process(GO:0016075)
0.9 10.3 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.8 2.5 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.8 10.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.7 2.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.7 11.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.7 16.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.7 5.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.7 2.6 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.6 13.0 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.6 1.8 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.6 14.4 GO:0030574 collagen catabolic process(GO:0030574)
0.5 8.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.5 2.2 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.5 7.9 GO:0061032 visceral serous pericardium development(GO:0061032)
0.5 2.6 GO:0042414 epinephrine metabolic process(GO:0042414)
0.5 4.1 GO:0070294 renal sodium ion absorption(GO:0070294)
0.5 1.5 GO:0060796 stem cell fate specification(GO:0048866) regulation of transcription involved in primary germ layer cell fate commitment(GO:0060796) regulation of cardiac cell fate specification(GO:2000043)
0.5 18.2 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.5 2.7 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.4 2.9 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.4 16.6 GO:0032094 response to food(GO:0032094)
0.4 2.2 GO:0007262 STAT protein import into nucleus(GO:0007262) negative regulation of cholesterol efflux(GO:0090370)
0.4 24.9 GO:0001541 ovarian follicle development(GO:0001541)
0.4 4.9 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
0.3 15.0 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.3 1.0 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 2.2 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.2 1.8 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 1.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 5.1 GO:0045109 intermediate filament organization(GO:0045109)
0.2 0.5 GO:1901738 regulation of vitamin A metabolic process(GO:1901738)
0.2 7.7 GO:0009409 response to cold(GO:0009409) production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.2 6.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.2 1.4 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 5.6 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 2.8 GO:0030220 platelet formation(GO:0030220)
0.1 5.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 6.2 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 1.3 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.1 6.9 GO:0070527 platelet aggregation(GO:0070527)
0.1 10.5 GO:0007586 digestion(GO:0007586)
0.1 0.9 GO:0035878 nail development(GO:0035878)
0.1 2.8 GO:0030168 platelet activation(GO:0030168)
0.1 2.9 GO:0072678 T cell migration(GO:0072678)
0.1 0.6 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.3 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.1 0.7 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.1 2.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 8.4 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.1 0.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.1 1.2 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.2 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 6.5 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 4.0 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 1.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 14.0 GO:0006887 exocytosis(GO:0006887)
0.0 61.8 GO:0006508 proteolysis(GO:0006508)
0.0 0.5 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 5.8 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 2.2 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 1.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)
0.0 2.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.2 GO:0031069 hair follicle morphogenesis(GO:0031069)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 38.6 GO:0005833 hemoglobin complex(GO:0005833)
3.6 39.8 GO:0033093 Weibel-Palade body(GO:0033093)
1.9 11.6 GO:0032437 cuticular plate(GO:0032437)
1.5 22.0 GO:0042589 zymogen granule membrane(GO:0042589)
1.3 5.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.7 5.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.5 13.4 GO:0005859 muscle myosin complex(GO:0005859)
0.4 20.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.4 11.5 GO:0097228 sperm principal piece(GO:0097228)
0.3 10.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 2.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.2 10.7 GO:0008305 integrin complex(GO:0008305)
0.2 7.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.2 3.1 GO:0031143 pseudopodium(GO:0031143)
0.2 14.2 GO:0030667 secretory granule membrane(GO:0030667)
0.2 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 2.6 GO:0043196 varicosity(GO:0043196)
0.1 16.1 GO:0072562 blood microparticle(GO:0072562)
0.1 18.8 GO:0042383 sarcolemma(GO:0042383)
0.1 156.8 GO:0005615 extracellular space(GO:0005615)
0.1 9.1 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 9.5 GO:0005923 bicellular tight junction(GO:0005923)
0.1 9.6 GO:0032993 protein-DNA complex(GO:0032993)
0.1 12.6 GO:0030427 site of polarized growth(GO:0030427)
0.1 5.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.6 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 3.8 GO:0005882 intermediate filament(GO:0005882)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 5.5 GO:0001726 ruffle(GO:0001726)
0.0 5.5 GO:0043209 myelin sheath(GO:0043209)
0.0 3.7 GO:0005925 focal adhesion(GO:0005925)
0.0 6.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.3 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.0 3.7 GO:0000793 condensed chromosome(GO:0000793)
0.0 6.3 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 2.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 24.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 45.3 GO:0005576 extracellular region(GO:0005576)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 24.9 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
4.8 38.6 GO:0005344 oxygen transporter activity(GO:0005344)
4.2 46.6 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
3.3 23.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.2 8.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.9 5.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
1.9 9.4 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
1.8 58.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.8 16.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
1.8 8.8 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
1.6 14.5 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
1.5 22.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.4 6.9 GO:0070051 fibrinogen binding(GO:0070051)
1.4 10.9 GO:0070644 vitamin D response element binding(GO:0070644)
1.3 11.5 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
1.2 5.9 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
1.0 2.9 GO:0016748 succinyltransferase activity(GO:0016748)
0.9 7.7 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.9 5.1 GO:1902282 phosphorelay sensor kinase activity(GO:0000155) voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.8 4.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.7 2.2 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.7 10.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.6 3.7 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.6 11.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.5 3.2 GO:0031433 telethonin binding(GO:0031433)
0.5 3.5 GO:0016936 galactoside binding(GO:0016936)
0.5 6.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.5 13.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.5 5.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.5 94.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 5.5 GO:0030274 LIM domain binding(GO:0030274)
0.4 4.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.4 2.9 GO:0004064 arylesterase activity(GO:0004064)
0.3 1.3 GO:2001069 glycogen binding(GO:2001069)
0.3 4.5 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.3 1.8 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.3 17.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.3 2.2 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.3 11.6 GO:0030552 cAMP binding(GO:0030552)
0.3 4.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2 10.3 GO:0050699 WW domain binding(GO:0050699)
0.2 2.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 1.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 40.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 10.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 2.8 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 1.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.9 GO:0038132 neuregulin binding(GO:0038132)
0.1 17.1 GO:0005179 hormone activity(GO:0005179)
0.1 1.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 6.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 2.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 2.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 5.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 11.6 GO:0005178 integrin binding(GO:0005178)
0.1 1.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 3.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 17.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.4 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 0.2 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 6.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 1.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 5.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 5.6 GO:0044325 ion channel binding(GO:0044325)
0.0 2.6 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 1.5 GO:0019843 rRNA binding(GO:0019843)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 11.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 9.2 GO:0008047 enzyme activator activity(GO:0008047)
0.0 0.5 GO:0005550 pheromone binding(GO:0005550)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0046965 retinoid X receptor binding(GO:0046965)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 22.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.5 47.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.4 10.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 11.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 8.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 8.0 PID ARF6 PATHWAY Arf6 signaling events
0.2 5.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 16.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 33.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 9.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.7 PID EPO PATHWAY EPO signaling pathway
0.1 2.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.3 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 2.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.8 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 18.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.8 16.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.8 15.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.8 23.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.7 14.5 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.6 13.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.5 5.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.3 1.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.3 11.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 10.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 7.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 9.8 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 1.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 6.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 8.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 5.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 2.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 5.9 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 4.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 6.7 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 1.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 2.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.7 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 1.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation