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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hmx3

Z-value: 0.34

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Transcription factors associated with Hmx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000040148.5 H6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_131542867-0.202.5e-01Click!

Activity profile of Hmx3 motif

Sorted Z-values of Hmx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_20269162 0.87 ENSMUST00000024155.7
potassium channel, subfamily K, member 16
chr13_+_23746734 0.56 ENSMUST00000099703.2
histone cluster 1, H2bb
chr10_-_80421847 0.50 ENSMUST00000156244.1
transcription factor 3
chr15_+_66670749 0.45 ENSMUST00000065916.7
thyroglobulin
chr9_-_123678873 0.45 ENSMUST00000040960.6
solute carrier family 6 (neurotransmitter transporter), member 20A
chr9_-_123678782 0.44 ENSMUST00000170591.1
ENSMUST00000171647.1
solute carrier family 6 (neurotransmitter transporter), member 20A
chr7_+_24370255 0.39 ENSMUST00000171904.1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr7_-_127208423 0.35 ENSMUST00000120705.1
TBC1 domain family, member 10b
chr4_+_154960915 0.27 ENSMUST00000049621.6
hairy and enhancer of split 5 (Drosophila)
chr1_-_78968079 0.27 ENSMUST00000049117.5
predicted pseudogene 5830
chr7_-_30559828 0.26 ENSMUST00000108164.1
lin-37 homolog (C. elegans)
chr6_+_86371489 0.25 ENSMUST00000089558.5
small nuclear ribonucleoprotein polypeptide G
chr5_-_53707532 0.23 ENSMUST00000031093.3
cholecystokinin A receptor
chr7_-_30559600 0.20 ENSMUST00000043975.4
ENSMUST00000156241.1
lin-37 homolog (C. elegans)
chr8_-_23237623 0.20 ENSMUST00000033950.5
GINS complex subunit 4 (Sld5 homolog)
chr4_-_129261394 0.18 ENSMUST00000145261.1
expressed sequence C77080
chr11_+_69838514 0.16 ENSMUST00000133967.1
ENSMUST00000094065.4
transmembrane protein 256
chr2_+_3114220 0.16 ENSMUST00000072955.5
family with sequence similarity 171, member A1
chr11_+_114668524 0.16 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
ribosomal protein L38
chr2_+_27165233 0.16 ENSMUST00000000910.6
dopamine beta hydroxylase
chrX_+_150594420 0.16 ENSMUST00000112713.2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_+_25681158 0.15 ENSMUST00000108403.3
B9 protein domain 2
chr19_+_41933464 0.15 ENSMUST00000026154.7
zinc finger, DHHC domain containing 16
chr4_+_19818722 0.14 ENSMUST00000035890.7
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr3_-_155055341 0.13 ENSMUST00000064076.3
TNNI3 interacting kinase
chr12_+_52699297 0.13 ENSMUST00000095737.3
A kinase (PRKA) anchor protein 6
chr10_-_92375367 0.13 ENSMUST00000182870.1
predicted gene, 20757
chr7_+_25267669 0.12 ENSMUST00000169266.1
capicua homolog (Drosophila)
chr9_+_19712829 0.12 ENSMUST00000077023.3
olfactory receptor 857
chr2_-_153015331 0.11 ENSMUST00000028972.8
p53 and DNA damage regulated 1
chr4_-_62470868 0.10 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
WD repeat domain 31
chr3_+_60006743 0.10 ENSMUST00000169794.1
arylacetamide deacetylase-like 2
chr3_+_96629919 0.10 ENSMUST00000048915.6
RNA binding motif protein 8a
chr12_+_108179738 0.10 ENSMUST00000101055.4
cyclin K
chr14_-_55560340 0.09 ENSMUST00000066106.3
RIKEN cDNA A730061H03 gene
chr4_+_80834123 0.09 ENSMUST00000133655.1
ENSMUST00000006151.6
tyrosinase-related protein 1
chr18_-_37638719 0.09 ENSMUST00000058635.2
solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2
chr4_+_80834298 0.09 ENSMUST00000102831.1
tyrosinase-related protein 1
chr11_+_103133333 0.08 ENSMUST00000124928.1
ENSMUST00000062530.4
hexamethylene bis-acetamide inducible 2
chr2_+_57997884 0.08 ENSMUST00000112616.1
ENSMUST00000166729.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5
chr4_+_144893127 0.08 ENSMUST00000142808.1
dehydrogenase/reductase (SDR family) member 3
chr1_-_158814469 0.08 ENSMUST00000161589.2
pappalysin 2
chr7_-_45510400 0.08 ENSMUST00000033096.7
nucleobindin 1
chr12_-_104473236 0.07 ENSMUST00000021513.4
goosecoid homeobox
chr11_+_103133303 0.07 ENSMUST00000107037.1
hexamethylene bis-acetamide inducible 2
chrM_+_9452 0.07 ENSMUST00000082411.1
mitochondrially encoded NADH dehydrogenase 3
chr2_+_130424321 0.07 ENSMUST00000128994.1
ENSMUST00000028900.9
vacuolar protein sorting 16 (yeast)
chr5_-_137684665 0.07 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
ArfGAP with FG repeats 2
chr15_+_9436028 0.07 ENSMUST00000042360.3
calcyphosine-like
chrX_+_159708593 0.06 ENSMUST00000080394.6
SH3-domain kinase binding protein 1
chr1_-_175979114 0.06 ENSMUST00000104983.1
RIKEN cDNA B020018G12 gene
chr19_+_8802486 0.06 ENSMUST00000172175.1
zinc finger and BTB domain containing 3
chr1_+_110099295 0.06 ENSMUST00000134301.1
cadherin 7, type 2
chr7_-_126897424 0.06 ENSMUST00000120007.1
transmembrane protein 219
chr11_-_99374895 0.06 ENSMUST00000006963.2
keratin 28
chr17_-_57247632 0.05 ENSMUST00000005975.6
G protein-coupled receptor 108
chr7_+_3645267 0.05 ENSMUST00000038913.9
CCR4-NOT transcription complex, subunit 3
chr14_+_54464141 0.04 ENSMUST00000022782.8
low-density lipoprotein receptor-related protein 10
chr14_+_52769753 0.04 ENSMUST00000178768.2
T cell receptor alpha variable 7D-4
chr4_+_65604984 0.04 ENSMUST00000050850.7
ENSMUST00000107366.1
tripartite motif-containing 32
chr17_-_35697971 0.04 ENSMUST00000146472.1
discoidin domain receptor family, member 1
chr11_-_99337930 0.04 ENSMUST00000100482.2
keratin 26
chr3_-_142169311 0.03 ENSMUST00000106230.1
bone morphogenetic protein receptor, type 1B
chr2_-_84715160 0.03 ENSMUST00000035840.5
zinc finger, DHHC domain containing 5
chr5_+_121777929 0.03 ENSMUST00000160821.1
ataxin 2
chr15_+_101473472 0.03 ENSMUST00000088049.3
keratin 86
chr7_-_121035096 0.03 ENSMUST00000065740.2
predicted gene 9905
chr2_-_72986716 0.03 ENSMUST00000112062.1
predicted gene 11084
chr17_-_35046539 0.03 ENSMUST00000007250.7
mutS homolog 5 (E. coli)
chr12_-_83487708 0.02 ENSMUST00000177959.1
ENSMUST00000178756.1
D4, zinc and double PHD fingers, family 3
chr4_-_45532470 0.02 ENSMUST00000147448.1
src homology 2 domain-containing transforming protein B

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0035524 proline transmembrane transport(GO:0035524)
0.1 0.3 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.2 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 0.5 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.2 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
0.1 0.2 GO:0006589 octopamine biosynthetic process(GO:0006589) octopamine metabolic process(GO:0046333)
0.0 0.5 GO:0015705 iodide transport(GO:0015705)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:1902261 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.2 GO:0048318 axial mesoderm development(GO:0048318)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 0.2 GO:0060205 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.2 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.2 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA