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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Irx5

Z-value: 1.01

Motif logo

Transcription factors associated with Irx5

Gene Symbol Gene ID Gene Info
ENSMUSG00000031737.10 Iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_92357801-0.447.2e-03Click!

Activity profile of Irx5 motif

Sorted Z-values of Irx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_87254804 5.53 ENSMUST00000075858.3
UDP glucuronosyltransferase 2 family, polypeptide B37
chr5_-_86926521 5.33 ENSMUST00000031183.2
UDP glucuronosyltransferase 2 family, polypeptide B1
chr5_-_87337165 5.12 ENSMUST00000031195.2
UDP glucuronosyltransferase 2 family, polypeptide A3
chr7_-_14438538 3.97 ENSMUST00000168252.2
RIKEN cDNA 2810007J24 gene
chr19_-_7802578 3.83 ENSMUST00000120522.1
ENSMUST00000065634.7
solute carrier family 22 (organic cation transporter), member 26
chr4_+_43632185 3.46 ENSMUST00000107874.2
natriuretic peptide receptor 2
chr4_+_43631935 3.00 ENSMUST00000030191.8
natriuretic peptide receptor 2
chr15_-_82394022 2.13 ENSMUST00000170255.1
cytochrome P450, family 2, subfamily d, polypeptide 11
chr3_+_19957037 1.92 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
ceruloplasmin
chr2_+_173153048 1.90 ENSMUST00000029017.5
phosphoenolpyruvate carboxykinase 1, cytosolic
chr19_+_26623419 1.88 ENSMUST00000176584.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chrX_+_20549780 1.83 ENSMUST00000023832.6
regucalcin
chr4_+_104766334 1.61 ENSMUST00000065072.6
complement component 8, beta polypeptide
chr4_+_104766308 1.60 ENSMUST00000031663.3
complement component 8, beta polypeptide
chr14_+_48120841 1.55 ENSMUST00000073150.4
pellino 2
chrX_+_38772671 1.53 ENSMUST00000050744.5
RIKEN cDNA 6030498E09 gene
chr12_-_99393010 1.51 ENSMUST00000177451.1
forkhead box N3
chr1_+_13668739 1.45 ENSMUST00000088542.3
X Kell blood group precursor related family member 9 homolog
chr2_-_160872552 1.41 ENSMUST00000103111.2
zinc fingers and homeoboxes 3
chr3_+_19957088 1.40 ENSMUST00000108328.1
ceruloplasmin
chr12_+_85288591 1.34 ENSMUST00000059341.4
zinc finger, C2HC-type containing 1C
chr3_+_63963631 1.19 ENSMUST00000181653.1
predicted gene, 26850
chr3_+_19957240 1.18 ENSMUST00000108325.2
ceruloplasmin
chr5_+_23787691 1.05 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
RAD50 interactor 1
chr2_+_104027721 1.02 ENSMUST00000028603.3
F-box protein 3
chr13_+_24943144 0.98 ENSMUST00000021773.5
glycosylphosphatidylinositol specific phospholipase D1
chr3_-_88762244 0.97 ENSMUST00000183267.1
synaptotagmin XI
chr2_-_101621033 0.93 ENSMUST00000090513.4
RIKEN cDNA B230118H07 gene
chr12_-_85288419 0.91 ENSMUST00000121930.1
acylphosphatase 1, erythrocyte (common) type
chr5_+_138255608 0.88 ENSMUST00000062067.6
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr6_+_50110837 0.85 ENSMUST00000167628.1
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr12_+_55598917 0.80 ENSMUST00000051857.3
insulinoma-associated 2
chr5_-_88675190 0.78 ENSMUST00000133532.1
ENSMUST00000150438.1
G-rich RNA sequence binding factor 1
chr1_-_169969143 0.77 ENSMUST00000027989.6
ENSMUST00000111353.3
hydroxysteroid (17-beta) dehydrogenase 7
chr16_-_22811399 0.75 ENSMUST00000040592.4
crystallin, gamma S
chr14_+_48446340 0.74 ENSMUST00000111735.2
transmembrane protein 260
chr11_-_46389454 0.72 ENSMUST00000101306.3
IL2 inducible T cell kinase
chr1_-_132707304 0.72 ENSMUST00000043189.7
neurofascin
chr4_-_43653542 0.66 ENSMUST00000084646.4
sperm associated antigen 8
chr11_-_69395333 0.65 ENSMUST00000108660.1
ENSMUST00000051620.4
cytochrome b5 domain containing 1
chr18_+_76944384 0.62 ENSMUST00000156454.1
ENSMUST00000150990.1
ENSMUST00000026485.7
ENSMUST00000148955.1
haloacid dehalogenase-like hydrolase domain containing 2
chr14_+_14820765 0.62 ENSMUST00000112631.2
ENSMUST00000178538.1
ENSMUST00000112630.2
NIMA (never in mitosis gene a)- related kinase 10
chr4_-_89311021 0.61 ENSMUST00000097981.4
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr7_-_103840427 0.60 ENSMUST00000106866.1
hemoglobin beta, bh2
chr4_-_43653560 0.59 ENSMUST00000107870.2
sperm associated antigen 8
chr11_-_28339867 0.58 ENSMUST00000042595.6
predicted pseudogene 6685
chr11_-_121519326 0.58 ENSMUST00000092298.5
zinc finger protein 750
chr5_-_100429503 0.56 ENSMUST00000181873.1
ENSMUST00000180779.1
RIKEN cDNA 5430416N02 gene
chr16_-_55838827 0.56 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr3_-_79737794 0.55 ENSMUST00000078527.6
relaxin/insulin-like family peptide receptor 1
chr2_+_104027823 0.53 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
F-box protein 3
chr12_-_108893197 0.49 ENSMUST00000161154.1
ENSMUST00000161410.1
tryptophanyl-tRNA synthetase
chr16_-_19408078 0.48 ENSMUST00000052516.4
olfactory receptor 165
chr1_+_58278309 0.48 ENSMUST00000114366.1
aldehyde oxidase 2
chr12_-_67222549 0.47 ENSMUST00000037181.8
MAM domain containing glycosylphosphatidylinositol anchor 2
chr5_+_87666200 0.44 ENSMUST00000094641.4
casein alpha s1
chrX_+_134187492 0.44 ENSMUST00000064476.4
ADP-ribosylation factor-like 13A
chr11_+_78176711 0.41 ENSMUST00000098545.5
TLC domain containing 1
chr16_+_30065333 0.39 ENSMUST00000023171.7
hairy and enhancer of split 1 (Drosophila)
chr18_-_35215008 0.39 ENSMUST00000091636.3
leucine rich repeat transmembrane neuronal 2
chr11_+_69395647 0.38 ENSMUST00000144531.1
LSM domain containing 1
chr4_-_43700807 0.38 ENSMUST00000055545.3
olfactory receptor 70
chr5_+_139543889 0.36 ENSMUST00000174792.1
ENSMUST00000031523.8
UNC homeobox
chr6_+_121183667 0.36 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
peroxisomal biogenesis factor 26
chr13_-_106547060 0.36 ENSMUST00000076359.2
DPH3B, KTI11 homolog B (S. cerevisiae), pseudogene
chr17_-_35643684 0.36 ENSMUST00000095467.3
diffuse panbronchiolitis critical region 1 (human)
chr3_+_87357874 0.33 ENSMUST00000015998.6
CD5 antigen-like
chr12_+_69893105 0.32 ENSMUST00000021466.8
atlastin GTPase 1
chr12_+_71048338 0.31 ENSMUST00000135709.1
AT rich interactive domain 4A (RBP1-like)
chr17_+_87025550 0.31 ENSMUST00000024959.3
ENSMUST00000160269.1
cysteine-rich PDZ-binding protein
chr17_+_21657582 0.26 ENSMUST00000039726.7
RIKEN cDNA 3110052M02 gene
chr4_-_132144486 0.26 ENSMUST00000056336.1
opioid receptor, delta 1
chr7_+_56239743 0.25 ENSMUST00000032633.5
ENSMUST00000156886.1
oculocutaneous albinism II
chr11_-_99285260 0.25 ENSMUST00000017255.3
keratin 24
chr14_-_14120904 0.23 ENSMUST00000022256.3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr7_+_102803480 0.23 ENSMUST00000061096.6
olfactory receptor 564
chr14_-_59142886 0.21 ENSMUST00000022548.3
ENSMUST00000162674.1
ENSMUST00000159858.1
ENSMUST00000162271.1
RIKEN cDNA 1700129C05 gene
chr3_+_139205887 0.19 ENSMUST00000062306.6
sperm tail PG rich repeat containing 2
chr9_+_78051938 0.18 ENSMUST00000024104.7
glial cells missing homolog 1 (Drosophila)
chr9_+_32393963 0.17 ENSMUST00000172015.1
potassium inwardly-rectifying channel, subfamily J, member 1
chr8_+_4240105 0.16 ENSMUST00000110994.1
ENSMUST00000110995.1
mitogen-activated protein kinase kinase 7
chr15_+_102990576 0.13 ENSMUST00000001703.6
homeobox C8
chr17_-_22007301 0.13 ENSMUST00000075018.3
predicted gene 9772
chr9_-_7835255 0.12 ENSMUST00000074246.6
baculoviral IAP repeat-containing 2
chr10_-_130112788 0.11 ENSMUST00000081469.1
olfactory receptor 823
chr16_-_56024628 0.10 ENSMUST00000119981.1
ENSMUST00000096021.3
PEST proteolytic signal containing nuclear protein
chr6_+_40442863 0.10 ENSMUST00000038907.8
ENSMUST00000141490.1
WEE1 homolog 2 (S. pombe)
chr8_+_85171322 0.09 ENSMUST00000076896.5
predicted gene 6531
chr5_-_144026596 0.08 ENSMUST00000031622.6
ENSMUST00000110702.1
oncomodulin
chr9_-_110624361 0.08 ENSMUST00000035069.9
neurotrophin receptor associated death domain
chr7_+_34095431 0.05 ENSMUST00000108083.1
ENSMUST00000174820.1
secretoglobin, family 1B, member 30
chr2_-_79908428 0.05 ENSMUST00000102652.3
ENSMUST00000102651.3
phosphodiesterase 1A, calmodulin-dependent
chr1_-_173982842 0.04 ENSMUST00000000266.7
interferon activated gene 202B
chr3_+_92352141 0.04 ENSMUST00000068399.1
small proline-rich protein 2E
chr13_+_94173992 0.03 ENSMUST00000121618.1
lipoma HMGIC fusion partner-like 2
chr7_+_45785331 0.02 ENSMUST00000120005.1
ENSMUST00000123585.1
lemur tyrosine kinase 3
chr13_-_64497792 0.02 ENSMUST00000180282.1
RIKEN cDNA 1190003K10 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0018879 biphenyl metabolic process(GO:0018879)
0.7 6.6 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.6 1.9 GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.5 1.8 GO:0051344 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) positive regulation of calcium-transporting ATPase activity(GO:1901896) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.3 1.0 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.3 5.1 GO:0006063 uronic acid metabolic process(GO:0006063) glucuronate metabolic process(GO:0019585) cellular glucuronidation(GO:0052695)
0.3 1.0 GO:0006507 GPI anchor release(GO:0006507)
0.3 1.0 GO:1990927 calcium ion regulated lysosome exocytosis(GO:1990927)
0.3 3.8 GO:0015747 urate transport(GO:0015747)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 3.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.6 GO:0060618 nipple development(GO:0060618)
0.2 0.5 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.6 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 4.5 GO:0046688 response to copper ion(GO:0046688)
0.1 0.4 GO:0042668 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of forebrain neuron differentiation(GO:2000978)
0.1 0.5 GO:0009115 xanthine catabolic process(GO:0009115)
0.1 1.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 0.3 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.1 0.3 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.4 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.6 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.0 0.1 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.9 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 1.9 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.2 GO:1901979 renal sodium ion absorption(GO:0070294) regulation of inward rectifier potassium channel activity(GO:1901979)
0.0 0.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.0 1.4 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.2 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.8 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.3 GO:0032092 positive regulation of protein binding(GO:0032092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0070939 Dsl1p complex(GO:0070939)
0.3 3.2 GO:0005579 membrane attack complex(GO:0005579)
0.2 5.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 0.7 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.9 GO:0071986 Ragulator complex(GO:0071986)
0.1 1.9 GO:0071564 npBAF complex(GO:0071564)
0.1 1.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 4.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 5.5 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.4 4.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 16.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.3 0.8 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.3 3.8 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2 0.9 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 0.5 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.4 GO:0071820 N-box binding(GO:0071820)
0.1 1.0 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.5 GO:0016623 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1 0.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 1.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 2.1 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 1.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 4.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription