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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nfat5

Z-value: 0.96

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Transcription factors associated with Nfat5

Gene Symbol Gene ID Gene Info
Nfat5
ENSMUSG00000003847.10 nuclear factor of activated T cells 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293463_107293483-0.067.4e-01Click!

Activity profile of Nfat5 motif

Sorted Z-values of Nfat5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_97417730 5.65 ENSMUST00000043077.7
Thrsp
thyroid hormone responsive
chr2_+_68117713 5.18 ENSMUST00000112346.2
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr1_+_88070765 2.96 ENSMUST00000073772.4
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr10_-_95415484 2.85 ENSMUST00000172070.1
ENSMUST00000150432.1
Socs2
suppressor of cytokine signaling 2
chr4_-_49506538 2.77 ENSMUST00000043056.2
Baat
bile acid-Coenzyme A: amino acid N-acyltransferase
chr10_-_109010955 2.72 ENSMUST00000105276.1
ENSMUST00000064054.7
Syt1
synaptotagmin I
chr3_-_98724543 2.34 ENSMUST00000107022.1
ENSMUST00000107021.1
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_+_88055377 2.20 ENSMUST00000138182.1
ENSMUST00000113142.3
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr1_+_88055467 2.13 ENSMUST00000173325.1
Ugt1a10
UDP glycosyltransferase 1 family, polypeptide A10
chr10_-_95415283 1.87 ENSMUST00000119917.1
Socs2
suppressor of cytokine signaling 2
chr6_+_91684061 1.68 ENSMUST00000032185.7
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr10_-_78351711 1.66 ENSMUST00000105390.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr10_-_78352053 1.65 ENSMUST00000105388.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr4_-_82505707 1.64 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib
nuclear factor I/B
chr1_+_24678536 1.61 ENSMUST00000095062.3
Lmbrd1
LMBR1 domain containing 1
chr10_+_4611971 1.59 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1
estrogen receptor 1 (alpha)
chr5_-_104021919 1.53 ENSMUST00000031251.9
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr5_-_104021799 1.52 ENSMUST00000119025.1
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chrX_+_38772671 1.50 ENSMUST00000050744.5
6030498E09Rik
RIKEN cDNA 6030498E09 gene
chr7_-_30598863 1.49 ENSMUST00000108150.1
Zbtb32
zinc finger and BTB domain containing 32
chr10_-_78352212 1.41 ENSMUST00000146899.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr12_-_83597140 1.39 ENSMUST00000048319.4
Zfyve1
zinc finger, FYVE domain containing 1
chr14_+_17660956 1.39 ENSMUST00000022303.7
ENSMUST00000091471.4
Thrb
thyroid hormone receptor beta
chr5_+_120511168 1.32 ENSMUST00000068326.7
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr15_-_75894474 1.31 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr5_+_120511213 1.30 ENSMUST00000111890.2
ENSMUST00000076051.5
ENSMUST00000147496.1
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr1_+_193301953 1.29 ENSMUST00000016315.9
Lamb3
laminin, beta 3
chr10_-_78351690 1.26 ENSMUST00000166360.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr12_+_36090379 1.26 ENSMUST00000071825.5
Gm5434
predicted gene 5434
chr9_-_71771535 1.24 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
Cgnl1
cingulin-like 1
chr19_+_25236959 1.19 ENSMUST00000049400.8
Kank1
KN motif and ankyrin repeat domains 1
chr11_-_88863717 1.17 ENSMUST00000107904.2
Akap1
A kinase (PRKA) anchor protein 1
chr2_-_177925604 1.16 ENSMUST00000108934.2
ENSMUST00000081529.4
C330013J21Rik
RIKEN cDNA C330013J21 gene
chr11_+_120491840 1.15 ENSMUST00000026899.3
Slc25a10
solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
chr7_-_80402743 1.14 ENSMUST00000122232.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr11_+_119022962 1.06 ENSMUST00000026662.7
Cbx2
chromobox 2
chr9_+_92457369 1.05 ENSMUST00000034941.7
Plscr4
phospholipid scramblase 4
chr4_-_82505749 0.92 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib
nuclear factor I/B
chrX_-_16817339 0.90 ENSMUST00000040820.6
Maob
monoamine oxidase B
chr6_-_144209471 0.86 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr5_-_66451629 0.85 ENSMUST00000160063.1
Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr6_-_144209448 0.80 ENSMUST00000077160.5
Sox5
SRY-box containing gene 5
chr15_+_99579054 0.79 ENSMUST00000023752.4
Aqp2
aquaporin 2
chr9_-_29963112 0.78 ENSMUST00000075069.4
Ntm
neurotrimin
chr14_-_16575456 0.77 ENSMUST00000063750.6
Rarb
retinoic acid receptor, beta
chr12_+_98920567 0.77 ENSMUST00000085109.3
ENSMUST00000079146.6
Ttc8
tetratricopeptide repeat domain 8
chr6_-_144209558 0.77 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5
SRY-box containing gene 5
chrX_+_139684980 0.76 ENSMUST00000096313.3
Tbc1d8b
TBC1 domain family, member 8B
chr16_+_92058270 0.74 ENSMUST00000047429.8
ENSMUST00000113975.2
Mrps6
Slc5a3
mitochondrial ribosomal protein S6
solute carrier family 5 (inositol transporters), member 3
chr16_-_55838827 0.72 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
Nfkbiz
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr11_-_77725281 0.71 ENSMUST00000078623.4
Cryba1
crystallin, beta A1
chr10_+_21993890 0.70 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr13_-_113180897 0.70 ENSMUST00000038212.7
Gzmk
granzyme K
chr18_+_36559972 0.69 ENSMUST00000134146.1
Ankhd1
ankyrin repeat and KH domain containing 1
chr9_-_13446753 0.69 ENSMUST00000167906.2
Gm17571
predicted gene, 17571
chr19_-_5845471 0.66 ENSMUST00000174287.1
ENSMUST00000173672.1
Neat1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr13_+_73626886 0.63 ENSMUST00000022104.7
Tert
telomerase reverse transcriptase
chr4_-_138396438 0.63 ENSMUST00000105032.2
Fam43b
family with sequence similarity 43, member B
chr11_+_102836296 0.63 ENSMUST00000021302.8
ENSMUST00000107072.1
Higd1b
HIG1 domain family, member 1B
chrX_-_155216338 0.59 ENSMUST00000112551.3
Sat1
spermidine/spermine N1-acetyl transferase 1
chr10_+_21994666 0.58 ENSMUST00000020145.5
Sgk1
serum/glucocorticoid regulated kinase 1
chr5_-_66618636 0.57 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr6_-_142964404 0.56 ENSMUST00000032421.3
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr16_+_84774123 0.55 ENSMUST00000114195.1
Jam2
junction adhesion molecule 2
chr6_+_73248382 0.55 ENSMUST00000064740.6
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
chr16_-_16600533 0.55 ENSMUST00000159542.1
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr19_+_20405280 0.54 ENSMUST00000179640.1
1500015L24Rik
RIKEN cDNA 1500015L24 gene
chr7_+_6371364 0.51 ENSMUST00000086323.4
ENSMUST00000108559.2
Zfp78
zinc finger protein 78
chrX_-_155216444 0.50 ENSMUST00000026318.8
Sat1
spermidine/spermine N1-acetyl transferase 1
chr10_-_29535857 0.50 ENSMUST00000092623.3
Rspo3
R-spondin 3 homolog (Xenopus laevis)
chr13_+_73330982 0.48 ENSMUST00000022098.8
Mrpl36
mitochondrial ribosomal protein L36
chr9_+_7764041 0.47 ENSMUST00000052865.9
Tmem123
transmembrane protein 123
chr14_+_63046988 0.47 ENSMUST00000067990.1
ENSMUST00000111203.1
Defb42
defensin beta 42
chr5_-_66618752 0.47 ENSMUST00000162366.1
Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr11_-_111800870 0.46 ENSMUST00000124855.1
Gm11674
predicted gene 11674
chr6_-_101377897 0.45 ENSMUST00000075994.6
Pdzrn3
PDZ domain containing RING finger 3
chr7_+_56239743 0.40 ENSMUST00000032633.5
ENSMUST00000156886.1
Oca2
oculocutaneous albinism II
chr13_+_120154627 0.39 ENSMUST00000179071.1
Gm20767
predicted gene, 20767
chr5_-_66618772 0.39 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr9_-_105521147 0.38 ENSMUST00000176770.1
ENSMUST00000085133.6
Atp2c1
ATPase, Ca++-sequestering
chr17_+_43389436 0.38 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr13_-_119912752 0.37 ENSMUST00000179502.1
Gm21761
predicted gene, 21761
chr2_+_172549581 0.37 ENSMUST00000030391.2
Tfap2c
transcription factor AP-2, gamma
chr3_+_102010138 0.36 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr18_+_61275002 0.36 ENSMUST00000135688.1
Pde6a
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr2_+_158192009 0.35 ENSMUST00000109506.1
1700060C20Rik
RIKEN cDNA 1700060C20 gene
chr3_-_70807284 0.35 ENSMUST00000180497.1
Gm6634
predicted gene 6634
chr6_-_42461017 0.34 ENSMUST00000090156.1
Olfr458
olfactory receptor 458
chr13_+_120317567 0.32 ENSMUST00000178349.1
Tcstv3
2-cell-stage, variable group, member 3
chr14_-_23803304 0.31 ENSMUST00000179836.1
ENSMUST00000172099.2
ENSMUST00000065788.8
ENSMUST00000179097.1
ENSMUST00000177634.1
ENSMUST00000074983.6
ENSMUST00000163322.2
ENSMUST00000100831.4
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr5_-_14978935 0.30 ENSMUST00000096953.4
Gm10354
predicted gene 10354
chr5_-_26022916 0.29 ENSMUST00000072286.6
Gm5862
predicted gene 5862
chr5_+_91027457 0.27 ENSMUST00000041516.8
Epgn
epithelial mitogen
chr17_+_87107621 0.26 ENSMUST00000041369.6
Socs5
suppressor of cytokine signaling 5
chr5_-_26058581 0.25 ENSMUST00000095004.3
Gm7347
predicted gene 7347
chr5_-_26039506 0.24 ENSMUST00000079447.2
Speer4a
spermatogenesis associated glutamate (E)-rich protein 4a
chr5_-_26105362 0.23 ENSMUST00000063524.2
5031410I06Rik
RIKEN cDNA 5031410I06 gene
chr19_-_10525201 0.23 ENSMUST00000025570.6
Sdhaf2
succinate dehydrogenase complex assembly factor 2
chr7_+_6474088 0.23 ENSMUST00000056144.5
Olfr1346
olfactory receptor 1346
chr18_+_36560581 0.22 ENSMUST00000155329.2
Ankhd1
ankyrin repeat and KH domain containing 1
chr16_+_27389911 0.22 ENSMUST00000143823.1
Ccdc50
coiled-coil domain containing 50
chr16_+_84774361 0.22 ENSMUST00000098407.2
Jam2
junction adhesion molecule 2
chr5_-_26121421 0.22 ENSMUST00000088236.3
Gm10220
predicted gene 10220
chr8_+_125730005 0.21 ENSMUST00000143504.1
Ntpcr
nucleoside-triphosphatase, cancer-related
chr11_+_23152135 0.21 ENSMUST00000141678.1
1700061J23Rik
RIKEN cDNA 1700061J23 gene
chr5_-_25954344 0.21 ENSMUST00000162387.4
Gm21671
predicted gene, 21671
chr7_+_141078188 0.21 ENSMUST00000106039.2
Pkp3
plakophilin 3
chr7_-_81493725 0.20 ENSMUST00000119121.1
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr10_+_112165676 0.19 ENSMUST00000170013.1
Caps2
calcyphosphine 2
chr2_+_125136692 0.19 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr5_-_25926215 0.18 ENSMUST00000167847.2
Gm21655
predicted gene, 21655
chr3_-_129755305 0.17 ENSMUST00000029653.2
Egf
epidermal growth factor
chr15_-_38078842 0.17 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr1_+_5588493 0.17 ENSMUST00000160777.1
ENSMUST00000027038.4
Oprk1
opioid receptor, kappa 1
chr3_+_92014583 0.17 ENSMUST00000047660.4
Pglyrp3
peptidoglycan recognition protein 3
chr5_-_26089291 0.15 ENSMUST00000094946.4
Gm10471
predicted gene 10471
chr11_+_54370625 0.14 ENSMUST00000094193.2
4930404A10Rik
RIKEN cDNA 4930404A10 gene
chr3_-_40509737 0.14 ENSMUST00000179966.1
1700017G19Rik
RIKEN cDNA 1700017G19 gene
chr11_-_118401826 0.13 ENSMUST00000106290.3
ENSMUST00000043722.3
Lgals3bp
lectin, galactoside-binding, soluble, 3 binding protein
chr15_+_5185700 0.13 ENSMUST00000081640.5
Ttc33
tetratricopeptide repeat domain 33
chr5_+_17373208 0.11 ENSMUST00000166086.1
Gm3495
predicted gene 3495
chr1_+_83159733 0.11 ENSMUST00000113436.1
ENSMUST00000065436.3
ENSMUST00000065403.6
Daw1
dynein assembly factor with WDR repeat domains 1
chr3_-_145099024 0.08 ENSMUST00000040465.6
Clca5
chloride channel calcium activated 5
chr10_+_86655939 0.08 ENSMUST00000171131.1
Gm5174
predicted gene 5174
chr14_+_8080315 0.06 ENSMUST00000023924.3
Rpp14
ribonuclease P 14 subunit
chr8_-_46124146 0.05 ENSMUST00000170416.1
Snx25
sorting nexin 25
chr7_-_126625676 0.05 ENSMUST00000032961.3
Nupr1
nuclear protein transcription regulator 1
chr15_-_57265126 0.05 ENSMUST00000137764.1
ENSMUST00000022995.6
Slc22a22
solute carrier family 22 (organic cation transporter), member 22
chr19_-_7039987 0.04 ENSMUST00000025918.7
Stip1
stress-induced phosphoprotein 1
chr2_+_176831140 0.02 ENSMUST00000122218.2
ENSMUST00000126726.1
Gm14408
predicted gene 14408
chr7_-_141918481 0.01 ENSMUST00000151890.1
Tollip
toll interacting protein
chr8_-_129131661 0.01 ENSMUST00000108743.1
Gm10999
predicted gene 10999
chr19_-_7711263 0.00 ENSMUST00000025666.7
Slc22a19
solute carrier family 22 (organic anion transporter), member 19
chr9_+_99456243 0.00 ENSMUST00000163199.2
1600029I14Rik
RIKEN cDNA 1600029I14 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfat5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.0 GO:0006710 androgen catabolic process(GO:0006710)
0.6 2.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.6 7.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.6 5.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.4 1.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3 1.4 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.3 4.7 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.3 1.2 GO:0015744 succinate transport(GO:0015744)
0.3 1.1 GO:0090472 dibasic protein processing(GO:0090472)
0.3 2.4 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.3 1.6 GO:0060011 Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523)
0.3 0.8 GO:0071462 cellular response to mercury ion(GO:0071288) cellular response to water stimulus(GO:0071462)
0.2 2.7 GO:0005513 detection of calcium ion(GO:0005513)
0.2 1.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.2 2.8 GO:0019530 taurine metabolic process(GO:0019530)
0.2 0.6 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.2 2.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.9 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.1 1.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 5.6 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.1 0.7 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 0.4 GO:0032468 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.1 0.4 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 1.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.7 GO:0015791 polyol transport(GO:0015791)
0.1 0.6 GO:0006105 succinate metabolic process(GO:0006105)
0.1 0.3 GO:1904305 negative regulation of gastro-intestinal system smooth muscle contraction(GO:1904305) negative regulation of small intestine smooth muscle contraction(GO:1904348)
0.1 0.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.1 0.5 GO:0030035 microspike assembly(GO:0030035)
0.1 0.2 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 0.2 GO:1900045 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 0.2 GO:0051710 regulation of cytolysis in other organism(GO:0051710) positive regulation of cytolysis in other organism(GO:0051714)
0.1 1.6 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.3 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.2 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635)
0.0 1.7 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.2 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.8 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 6.0 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 0.4 GO:0046037 GMP metabolic process(GO:0046037)
0.0 0.5 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.7 GO:0030575 nuclear body organization(GO:0030575)
0.0 1.3 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 1.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 2.3 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.4 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 2.3 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 0.0 GO:0071718 sodium-independent icosanoid transport(GO:0071718)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.3 1.3 GO:0005610 laminin-5 complex(GO:0005610)
0.2 1.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 3.8 GO:0030061 mitochondrial crista(GO:0030061)
0.2 0.8 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1 2.7 GO:0031045 dense core granule(GO:0031045)
0.1 2.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.7 GO:0042382 paraspeckles(GO:0042382)
0.1 0.8 GO:0034464 BBSome(GO:0034464)
0.1 1.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.1 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0005914 spot adherens junction(GO:0005914)
0.0 2.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 3.0 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.6 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)
0.0 3.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.2 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.9 4.7 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.7 2.7 GO:0030348 syntaxin-3 binding(GO:0030348)
0.7 2.6 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.6 1.7 GO:0030977 taurine binding(GO:0030977)
0.5 1.6 GO:0038052 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 1.2 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.3 2.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.3 6.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 1.1 GO:0019809 spermidine binding(GO:0019809)
0.2 3.0 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 7.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 0.6 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.2 1.6 GO:0031419 cobalamin binding(GO:0031419)
0.2 1.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 2.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 1.4 GO:0070324 thyroid hormone receptor activity(GO:0004887) thyroid hormone binding(GO:0070324)
0.1 0.8 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 1.1 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 1.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 0.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 1.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 2.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.6 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 2.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.2 GO:0016019 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.0 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 1.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.5 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 4.7 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 2.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.3 PID FOXO PATHWAY FoxO family signaling
0.0 0.8 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.2 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 3.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 2.7 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 2.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 6.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 1.5 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 4.7 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 2.4 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.8 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.6 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.3 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects