Project

avrg: GSE58827: Dynamics of the Mouse Liver

Navigation
Downloads

Results for Nkx2-1

Z-value: 1.15

Motif logo

logo of

Transcription factors associated with Nkx2-1

Gene Symbol Gene ID Gene Info
Nkx2-1
ENSMUSG00000001496.9 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.241.6e-01Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_68429235 7.45 ENSMUST00000052347.6
Mc2r
melanocortin 2 receptor
chr9_+_98490522 6.91 ENSMUST00000035029.2
Rbp2
retinol binding protein 2, cellular
chr10_+_75568648 4.78 ENSMUST00000134503.1
ENSMUST00000125770.1
ENSMUST00000128886.1
ENSMUST00000151212.1
Ggt1
gamma-glutamyltransferase 1
chr10_+_75568630 4.34 ENSMUST00000145928.1
Ggt1
gamma-glutamyltransferase 1
chr10_+_75568641 4.20 ENSMUST00000131565.1
Ggt1
gamma-glutamyltransferase 1
chr15_+_66670749 3.48 ENSMUST00000065916.7
Tg
thyroglobulin
chr14_-_47411666 3.47 ENSMUST00000111778.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr2_-_170406501 2.87 ENSMUST00000154650.1
Bcas1
breast carcinoma amplified sequence 1
chr11_+_117849223 2.67 ENSMUST00000081387.4
Birc5
baculoviral IAP repeat-containing 5
chr8_-_111691002 2.64 ENSMUST00000034435.5
Ctrb1
chymotrypsinogen B1
chr6_-_41636389 2.36 ENSMUST00000031902.5
Trpv6
transient receptor potential cation channel, subfamily V, member 6
chr6_+_72304625 2.33 ENSMUST00000070437.8
Sftpb
surfactant associated protein B
chr16_+_48994185 2.31 ENSMUST00000117994.1
ENSMUST00000048374.5
C330027C09Rik
RIKEN cDNA C330027C09 gene
chr6_+_127577963 2.29 ENSMUST00000071563.4
Efcab4b
EF-hand calcium binding domain 4B
chrX_+_49463926 2.14 ENSMUST00000130558.1
Arhgap36
Rho GTPase activating protein 36
chr9_+_56089962 2.12 ENSMUST00000059206.7
Pstpip1
proline-serine-threonine phosphatase-interacting protein 1
chr11_+_117849286 1.98 ENSMUST00000093906.4
Birc5
baculoviral IAP repeat-containing 5
chr19_-_11266122 1.96 ENSMUST00000169159.1
Ms4a1
membrane-spanning 4-domains, subfamily A, member 1
chrX_-_111463103 1.90 ENSMUST00000137712.2
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr10_+_14523062 1.86 ENSMUST00000096020.5
Gm10335
predicted gene 10335
chr2_-_121235689 1.76 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr11_+_69098937 1.75 ENSMUST00000021271.7
Per1
period circadian clock 1
chr10_+_88091070 1.74 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr1_+_63176818 1.72 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr9_-_121792478 1.67 ENSMUST00000035110.4
Hhatl
hedgehog acyltransferase-like
chr7_-_29125142 1.58 ENSMUST00000179893.1
ENSMUST00000032813.9
Ryr1
ryanodine receptor 1, skeletal muscle
chrX_-_111463043 1.52 ENSMUST00000065976.5
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr1_+_74153981 1.49 ENSMUST00000027372.7
ENSMUST00000106899.2
Cxcr2
chemokine (C-X-C motif) receptor 2
chr9_+_119937606 1.49 ENSMUST00000035100.5
Ttc21a
tetratricopeptide repeat domain 21A
chr4_-_44704006 1.43 ENSMUST00000146335.1
Pax5
paired box gene 5
chr12_-_84698769 1.41 ENSMUST00000095550.2
Syndig1l
synapse differentiation inducing 1 like
chr8_+_23411490 1.41 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chr6_+_72304592 1.40 ENSMUST00000183018.1
Sftpb
surfactant associated protein B
chr8_+_95703037 1.39 ENSMUST00000073139.7
ENSMUST00000080666.7
Ndrg4
N-myc downstream regulated gene 4
chr1_-_120505084 1.39 ENSMUST00000027639.1
Marco
macrophage receptor with collagenous structure
chr2_+_121506715 1.36 ENSMUST00000028676.5
Wdr76
WD repeat domain 76
chr1_-_181842334 1.34 ENSMUST00000005003.6
Lbr
lamin B receptor
chr4_+_98923845 1.33 ENSMUST00000091358.4
Usp1
ubiquitin specific peptidase 1
chr14_-_70524068 1.30 ENSMUST00000022692.3
Sftpc
surfactant associated protein C
chr3_+_88532314 1.25 ENSMUST00000172699.1
Mex3a
mex3 homolog A (C. elegans)
chr2_-_73775341 1.22 ENSMUST00000112024.3
ENSMUST00000166199.1
ENSMUST00000180045.1
Chn1
chimerin (chimaerin) 1
chr2_+_121506748 1.16 ENSMUST00000099473.3
ENSMUST00000110602.2
Wdr76
WD repeat domain 76
chrX_+_73892102 1.13 ENSMUST00000033765.7
ENSMUST00000101470.2
ENSMUST00000114395.1
Avpr2
arginine vasopressin receptor 2
chr10_+_81176631 1.12 ENSMUST00000047864.9
Eef2
eukaryotic translation elongation factor 2
chrX_+_159697308 1.10 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chrX_+_144688907 1.09 ENSMUST00000112843.1
Zcchc16
zinc finger, CCHC domain containing 16
chr10_+_21690845 1.06 ENSMUST00000071008.3
Gm5420
predicted gene 5420
chr3_-_95142346 1.01 ENSMUST00000013851.3
Tnfaip8l2
tumor necrosis factor, alpha-induced protein 8-like 2
chr1_+_12718496 1.00 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr6_-_52246214 1.00 ENSMUST00000048026.8
Hoxa11
homeobox A11
chr2_-_120731503 0.99 ENSMUST00000110701.1
ENSMUST00000110700.1
Cdan1
congenital dyserythropoietic anemia, type I (human)
chr11_+_63133068 0.98 ENSMUST00000108700.1
Pmp22
peripheral myelin protein 22
chr1_+_135232045 0.96 ENSMUST00000110798.3
Gm4204
predicted gene 4204
chr14_+_75455957 0.96 ENSMUST00000164848.1
Siah3
seven in absentia homolog 3 (Drosophila)
chr3_-_150073620 0.95 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr10_-_123196916 0.94 ENSMUST00000020334.7
Usp15
ubiquitin specific peptidase 15
chr1_+_75375271 0.92 ENSMUST00000087122.5
Speg
SPEG complex locus
chr18_+_49832622 0.91 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr14_+_51114455 0.90 ENSMUST00000100645.3
Eddm3b
epididymal protein 3B
chr9_-_71896047 0.90 ENSMUST00000184448.1
Tcf12
transcription factor 12
chr5_+_128601106 0.89 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr4_+_45203921 0.87 ENSMUST00000107804.1
Frmpd1
FERM and PDZ domain containing 1
chr10_+_22645011 0.85 ENSMUST00000042261.4
Slc2a12
solute carrier family 2 (facilitated glucose transporter), member 12
chr11_-_83462961 0.85 ENSMUST00000021020.6
ENSMUST00000119346.1
ENSMUST00000103209.3
ENSMUST00000108137.2
Mmp28
matrix metallopeptidase 28 (epilysin)
chr6_-_113434529 0.77 ENSMUST00000133348.1
Cidec
cell death-inducing DFFA-like effector c
chr1_-_173535957 0.74 ENSMUST00000139092.1
BC094916
cDNA sequence BC094916
chr2_+_80638798 0.73 ENSMUST00000028382.6
ENSMUST00000124377.1
Nup35
nucleoporin 35
chr15_-_89410230 0.71 ENSMUST00000109314.2
Syce3
synaptonemal complex central element protein 3
chr11_-_86257518 0.67 ENSMUST00000136469.1
ENSMUST00000018212.6
Ints2
integrator complex subunit 2
chr5_+_75574916 0.67 ENSMUST00000144270.1
ENSMUST00000005815.6
Kit
kit oncogene
chr16_-_4523056 0.66 ENSMUST00000090500.3
ENSMUST00000023161.7
Srl
sarcalumenin
chrX_+_56346390 0.66 ENSMUST00000101560.3
Zfp449
zinc finger protein 449
chr17_-_45733843 0.66 ENSMUST00000178179.1
1600014C23Rik
RIKEN cDNA 1600014C23 gene
chr1_+_128103297 0.65 ENSMUST00000036288.4
R3hdm1
R3H domain containing 1
chr12_-_30911593 0.65 ENSMUST00000062740.7
ENSMUST00000074038.5
Acp1
acid phosphatase 1, soluble
chr7_+_128246953 0.64 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chrX_+_100730178 0.63 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr3_+_68584154 0.63 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr7_+_35397046 0.59 ENSMUST00000079414.5
Cep89
centrosomal protein 89
chr17_+_32621319 0.58 ENSMUST00000077639.5
Gm9705
predicted gene 9705
chr1_+_97024681 0.56 ENSMUST00000054664.7
Gm6430
predicted gene 6430
chr11_-_86257553 0.56 ENSMUST00000132024.1
ENSMUST00000139285.1
Ints2
integrator complex subunit 2
chrX_+_114474312 0.56 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4
kelch-like 4
chr7_+_128246812 0.55 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr13_+_93304940 0.53 ENSMUST00000109497.1
ENSMUST00000109498.1
ENSMUST00000060490.4
ENSMUST00000109492.1
ENSMUST00000109496.1
ENSMUST00000109495.1
Homer1
homer homolog 1 (Drosophila)
chr3_+_37420273 0.52 ENSMUST00000029277.8
Spata5
spermatogenesis associated 5
chr7_-_28372233 0.52 ENSMUST00000094644.4
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr10_+_85102627 0.51 ENSMUST00000095383.4
AI597468
expressed sequence AI597468
chr17_-_25861456 0.50 ENSMUST00000079461.8
ENSMUST00000176923.1
Wdr90
WD repeat domain 90
chr2_-_57114970 0.50 ENSMUST00000028166.2
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr11_+_70029742 0.49 ENSMUST00000132597.2
Dlg4
discs, large homolog 4 (Drosophila)
chr7_-_126200413 0.48 ENSMUST00000163959.1
Xpo6
exportin 6
chr2_-_121473993 0.47 ENSMUST00000056732.3
Mfap1b
microfibrillar-associated protein 1B
chr2_-_121085835 0.47 ENSMUST00000028721.7
Tgm5
transglutaminase 5
chrX_+_114474509 0.47 ENSMUST00000113370.2
Klhl4
kelch-like 4
chr8_-_83442648 0.47 ENSMUST00000167525.1
Scoc
short coiled-coil protein
chr2_+_71786923 0.44 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6
integrin alpha 6
chr13_+_55635002 0.43 ENSMUST00000172272.1
ENSMUST00000099479.3
Ddx46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr12_+_91400990 0.40 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr
thyroid stimulating hormone receptor
chr2_-_121506639 0.40 ENSMUST00000089926.5
Mfap1a
microfibrillar-associated protein 1A
chr7_-_28372597 0.39 ENSMUST00000144700.1
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr6_-_82939676 0.35 ENSMUST00000000641.9
ENSMUST00000113982.1
Sema4f
sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
chrX_-_73966329 0.34 ENSMUST00000114372.2
ENSMUST00000033761.6
Hcfc1
host cell factor C1
chr1_-_133131782 0.33 ENSMUST00000180528.1
Gm26616
predicted gene, 26616
chr15_-_88978958 0.32 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
chr18_-_63386457 0.31 ENSMUST00000183217.1
Piezo2
piezo-type mechanosensitive ion channel component 2
chr5_-_110779937 0.29 ENSMUST00000112426.1
Pus1
pseudouridine synthase 1
chr11_+_70432627 0.29 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
Arrb2
arrestin, beta 2
chr1_-_54194048 0.28 ENSMUST00000120904.1
Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chrX_+_114474569 0.28 ENSMUST00000133447.1
Klhl4
kelch-like 4
chr4_+_43727181 0.26 ENSMUST00000095109.3
Hrct1
histidine rich carboxyl terminus 1
chr17_-_25570678 0.24 ENSMUST00000025003.3
ENSMUST00000173447.1
Sox8
SRY-box containing gene 8
chr11_+_115974930 0.24 ENSMUST00000106460.2
Itgb4
integrin beta 4
chr2_+_164698501 0.23 ENSMUST00000017454.7
Spint4
serine protease inhibitor, Kunitz type 4
chr2_+_19344820 0.22 ENSMUST00000150514.1
ENSMUST00000136456.1
4930447M23Rik
RIKEN cDNA 4930447M23 gene
chr3_-_95411176 0.22 ENSMUST00000177599.1
Gm5070
predicted gene 5070
chrY_+_2904133 0.22 ENSMUST00000166474.2
Gm10352
predicted gene 10352
chr13_+_111867931 0.21 ENSMUST00000128198.1
Gm15326
predicted gene 15326
chr13_+_109903089 0.21 ENSMUST00000120664.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr16_-_76403673 0.21 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr16_+_44139821 0.20 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr11_+_96292453 0.19 ENSMUST00000173432.1
Hoxb6
homeobox B6
chr17_+_47737030 0.18 ENSMUST00000086932.3
Tfeb
transcription factor EB
chr11_-_120086790 0.18 ENSMUST00000106227.1
ENSMUST00000106229.1
ENSMUST00000180242.1
Azi1
5-azacytidine induced gene 1
chr16_+_92612755 0.15 ENSMUST00000180989.1
Gm26626
predicted gene, 26626
chr3_+_138352378 0.15 ENSMUST00000090166.4
Adh6b
alcohol dehydrogenase 6B (class V)
chr3_-_108200807 0.13 ENSMUST00000106655.1
ENSMUST00000065664.6
Cyb561d1
cytochrome b-561 domain containing 1
chr17_-_32388885 0.12 ENSMUST00000087703.5
ENSMUST00000170603.1
Wiz
widely-interspaced zinc finger motifs
chr7_-_30743681 0.10 ENSMUST00000182634.1
Gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr2_-_122118364 0.10 ENSMUST00000036450.7
Spg11
spastic paraplegia 11
chr5_+_30105161 0.09 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like
chr4_-_41517326 0.08 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik
RIKEN cDNA 1110017D15 gene
chr1_-_14755966 0.08 ENSMUST00000027062.5
Msc
musculin
chr13_+_23738804 0.08 ENSMUST00000040914.1
Hist1h1c
histone cluster 1, H1c
chr19_+_8819401 0.07 ENSMUST00000096753.3
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr5_-_43235352 0.07 ENSMUST00000140650.2
Gm7854
predicted gene 7854
chr15_+_99702278 0.06 ENSMUST00000023759.4
Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr15_+_98634743 0.06 ENSMUST00000003442.7
Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr11_+_100622971 0.03 ENSMUST00000142993.1
Nkiras2
NFKB inhibitor interacting Ras-like protein 2
chr15_-_10470490 0.02 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr11_-_116238077 0.01 ENSMUST00000037007.3
Evpl
envoplakin

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 13.3 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.9 6.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.8 4.7 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.6 1.7 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.5 1.4 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.4 1.5 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.4 1.8 GO:0097167 circadian regulation of translation(GO:0097167)
0.3 3.5 GO:0015705 iodide transport(GO:0015705)
0.3 1.7 GO:1903059 regulation of protein lipidation(GO:1903059)
0.3 1.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.3 3.4 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.3 1.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 1.6 GO:0071313 cellular response to caffeine(GO:0071313)
0.2 0.7 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.2 2.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.2 2.4 GO:0035898 parathyroid hormone secretion(GO:0035898) calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 1.0 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.2 0.8 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.2 0.5 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 0.7 GO:1904306 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.2 1.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 1.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 2.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.3 GO:0019046 release from viral latency(GO:0019046)
0.1 1.4 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.1 7.8 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.1 0.9 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.2 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 1.5 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 0.9 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 1.0 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.1 0.2 GO:0072034 renal vesicle induction(GO:0072034)
0.1 1.4 GO:0031280 negative regulation of adenylate cyclase activity(GO:0007194) negative regulation of cyclase activity(GO:0031280)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.7 GO:0035878 nail development(GO:0035878)
0.1 1.4 GO:0051573 lateral ventricle development(GO:0021670) negative regulation of histone H3-K9 methylation(GO:0051573)
0.1 0.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 3.7 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 1.0 GO:0032060 bleb assembly(GO:0032060)
0.0 0.3 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.9 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.7 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.8 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.3 GO:0071397 cellular response to cholesterol(GO:0071397)
0.0 2.3 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 1.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.7 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.6 GO:0001553 luteinization(GO:0001553)
0.0 1.5 GO:0045471 response to ethanol(GO:0045471)
0.0 2.6 GO:0007586 digestion(GO:0007586)
0.0 0.1 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 1.3 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.3 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.0 0.2 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.0 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 2.1 GO:0000910 cytokinesis(GO:0000910)
0.0 0.3 GO:0071260 cellular response to mechanical stimulus(GO:0071260)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.7 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.4 5.0 GO:0097208 alveolar lamellar body(GO:0097208)
0.4 1.6 GO:0014802 terminal cisterna(GO:0014802)
0.3 1.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 2.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 3.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 1.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 2.1 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.5 GO:0042629 mast cell granule(GO:0042629)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.2 GO:0032039 integrator complex(GO:0032039)
0.1 0.7 GO:0000801 central element(GO:0000801)
0.1 0.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.6 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 1.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 5.3 GO:0001650 fibrillar center(GO:0001650)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.4 GO:0005581 collagen trimer(GO:0005581)
0.0 22.1 GO:0005615 extracellular space(GO:0005615)
0.0 0.5 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.4 GO:0004977 melanocortin receptor activity(GO:0004977)
1.1 13.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.5 1.6 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.5 1.5 GO:0019959 interleukin-8 binding(GO:0019959)
0.5 6.9 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.4 2.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.2 1.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 1.2 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 2.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 5.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.7 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 0.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 2.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 0.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 1.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.6 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 3.5 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.2 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 2.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 4.6 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 3.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.1 PID AURORA A PATHWAY Aurora A signaling
0.1 1.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 6.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 0.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.5 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.4 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 4.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 1.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 2.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.1 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 13.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 2.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 6.9 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 2.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.4 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 11.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 0.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 4.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.8 REACTOME TRANSLATION Genes involved in Translation