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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Onecut1_Cux2

Z-value: 1.41

Motif logo

Transcription factors associated with Onecut1_Cux2

Gene Symbol Gene ID Gene Info
ENSMUSG00000043013.9 one cut domain, family member 1
ENSMUSG00000042589.12 cut-like homeobox 2
ENSMUSG00000072641.1 cut-like homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.456.4e-03Click!
Cux2mm10_v2_chr5_-_122049822_122049882-0.298.2e-02Click!

Activity profile of Onecut1_Cux2 motif

Sorted Z-values of Onecut1_Cux2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_60921270 10.50 ENSMUST00000096418.3
alpha-1-B glycoprotein
chr16_+_22951072 7.89 ENSMUST00000023590.8
histidine-rich glycoprotein
chr7_+_44207307 5.93 ENSMUST00000077354.4
kallikrein 1-related pepidase b4
chr4_-_104876383 5.77 ENSMUST00000064873.8
ENSMUST00000106808.3
ENSMUST00000048947.8
complement component 8, alpha polypeptide
chr6_+_121346618 5.67 ENSMUST00000032200.9
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr6_-_23132981 4.34 ENSMUST00000031707.7
aminoadipate-semialdehyde synthase
chr4_-_46991842 4.20 ENSMUST00000107749.2
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_-_148040196 3.75 ENSMUST00000136555.1
RIKEN cDNA 9030622O22 gene
chr2_-_84775420 3.38 ENSMUST00000111641.1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775388 3.34 ENSMUST00000023994.3
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_+_101367542 3.25 ENSMUST00000019469.2
glucose-6-phosphatase, catalytic
chr4_-_63154130 3.22 ENSMUST00000030041.4
alpha 1 microglobulin/bikunin
chr3_+_28697901 3.02 ENSMUST00000029240.7
solute carrier family 2 (facilitated glucose transporter), member 2
chr3_+_146597077 2.90 ENSMUST00000029837.7
ENSMUST00000121133.1
urate oxidase
chr2_-_148046896 2.84 ENSMUST00000172928.1
ENSMUST00000047315.3
forkhead box A2
chr1_+_172698046 2.66 ENSMUST00000038495.3
C-reactive protein, pentraxin-related
chr3_+_94372794 2.61 ENSMUST00000029795.3
RAR-related orphan receptor gamma
chr11_+_78499087 2.55 ENSMUST00000017488.4
vitronectin
chr7_+_51880312 2.35 ENSMUST00000145049.1
growth arrest specific 2
chr2_-_32451396 2.30 ENSMUST00000028160.8
ENSMUST00000113310.2
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr14_-_30943275 2.26 ENSMUST00000006704.8
ENSMUST00000163118.1
inter-alpha trypsin inhibitor, heavy chain 1
chr14_+_17981633 2.12 ENSMUST00000022304.8
thyroid hormone receptor beta
chr15_-_78468620 1.83 ENSMUST00000017086.3
transmembrane serine protease 6
chr15_+_55112420 1.77 ENSMUST00000100660.4
DEP domain containing MTOR-interacting protein
chr3_-_146596588 1.69 ENSMUST00000029836.4
deoxyribonuclease II beta
chr11_-_60036917 1.66 ENSMUST00000102692.3
phosphatidylethanolamine N-methyltransferase
chrX_+_101377267 1.54 ENSMUST00000052130.7
gap junction protein, beta 1
chr15_+_55112317 1.42 ENSMUST00000096433.3
DEP domain containing MTOR-interacting protein
chr19_+_26750939 1.42 ENSMUST00000175953.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_+_56294552 1.42 ENSMUST00000034026.8
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr7_+_67647405 1.37 ENSMUST00000032774.8
ENSMUST00000107471.1
tetratricopeptide repeat domain 23
chr7_+_67655414 1.33 ENSMUST00000107470.1
tetratricopeptide repeat domain 23
chr6_-_136922169 1.32 ENSMUST00000032343.6
endoplasmic reticulum protein 27
chr12_+_55598917 1.32 ENSMUST00000051857.3
insulinoma-associated 2
chr19_-_57197377 1.28 ENSMUST00000111546.1
actin-binding LIM protein 1
chr9_-_50739365 1.22 ENSMUST00000117093.1
ENSMUST00000121634.1
DIX domain containing 1
chr2_-_69342600 1.19 ENSMUST00000102709.1
ENSMUST00000102710.3
ENSMUST00000180142.1
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr3_+_5218516 1.15 ENSMUST00000175866.1
zinc finger homeodomain 4
chr1_+_191717834 1.15 ENSMUST00000110855.1
ENSMUST00000133076.1
lysophosphatidylglycerol acyltransferase 1
chr9_-_114844090 1.14 ENSMUST00000047013.3
CKLF-like MARVEL transmembrane domain containing 8
chrM_+_14138 1.13 ENSMUST00000082421.1
mitochondrially encoded cytochrome b
chr19_-_32061438 1.11 ENSMUST00000096119.4
N-acylsphingosine amidohydrolase 2
chr8_+_127064107 1.08 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
par-3 (partitioning defective 3) homolog (C. elegans)
chr15_-_76209056 1.07 ENSMUST00000071869.5
ENSMUST00000170915.1
plectin
chr14_-_55092277 1.07 ENSMUST00000036328.8
zinc finger homeobox 2
chr8_-_13200576 1.03 ENSMUST00000165605.2
GH regulated TBC protein 1
chr19_-_57197435 1.03 ENSMUST00000111550.1
actin-binding LIM protein 1
chr3_+_5218546 1.03 ENSMUST00000026284.6
zinc finger homeodomain 4
chr9_-_29963112 1.00 ENSMUST00000075069.4
neurotrimin
chr3_+_5218589 1.00 ENSMUST00000177488.1
zinc finger homeodomain 4
chr15_+_22549022 0.99 ENSMUST00000163361.1
cadherin 18
chr3_+_102010138 0.97 ENSMUST00000066187.4
nescient helix loop helix 2
chr8_+_127064022 0.96 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
par-3 (partitioning defective 3) homolog (C. elegans)
chr8_-_91801547 0.95 ENSMUST00000093312.4
Iroquois related homeobox 3 (Drosophila)
chrM_-_14060 0.94 ENSMUST00000082419.1
mitochondrially encoded NADH dehydrogenase 6
chr5_+_3596066 0.91 ENSMUST00000006061.6
ENSMUST00000121291.1
ENSMUST00000142516.1
peroxisomal biogenesis factor 1
chr9_+_59589288 0.88 ENSMUST00000121266.1
ENSMUST00000118164.1
CUGBP, Elav-like family member 6
chr2_+_147364989 0.87 ENSMUST00000109968.2
paired box gene 1
chr16_-_37384915 0.84 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
syntaxin binding protein 5-like
chr3_-_79842662 0.83 ENSMUST00000029568.1
transmembrane protein 144
chr19_+_56287911 0.81 ENSMUST00000095948.4
hyaluronic acid binding protein 2
chr5_+_92683625 0.80 ENSMUST00000168878.1
shroom family member 3
chrX_-_142196917 0.76 ENSMUST00000042530.3
guanylate cyclase 2f
chrX_+_41401128 0.75 ENSMUST00000115103.2
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr19_+_31082841 0.69 ENSMUST00000066039.6
cleavage stimulation factor, 3' pre-RNA subunit 2, tau
chr10_-_112928974 0.69 ENSMUST00000099276.2
ataxin 7-like 3B
chrX_+_82948861 0.64 ENSMUST00000114000.1
dystrophin, muscular dystrophy
chr10_-_64090265 0.61 ENSMUST00000105439.1
leucine rich repeat transmembrane neuronal 3
chr7_-_127449109 0.59 ENSMUST00000053392.4
zinc finger protein 689
chr19_-_57197496 0.59 ENSMUST00000111544.1
actin-binding LIM protein 1
chr7_-_127448993 0.57 ENSMUST00000106299.1
zinc finger protein 689
chr16_-_37384940 0.56 ENSMUST00000114781.1
ENSMUST00000114780.1
syntaxin binding protein 5-like
chr6_-_34726905 0.56 ENSMUST00000075773.2
neoplastic progression 2
chr6_+_139843648 0.55 ENSMUST00000087657.6
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr17_+_56990264 0.52 ENSMUST00000002735.7
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit
chr16_-_95459245 0.45 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
avian erythroblastosis virus E-26 (v-ets) oncogene related
chr1_-_173131236 0.44 ENSMUST00000073663.2
olfactory receptor 1408
chr2_-_72986716 0.44 ENSMUST00000112062.1
predicted gene 11084
chr10_-_64090241 0.44 ENSMUST00000133588.1
leucine rich repeat transmembrane neuronal 3
chr8_+_58911755 0.37 ENSMUST00000062978.6
cDNA sequence BC030500
chrX_-_50942710 0.36 ENSMUST00000060650.5
FERM domain containing 7
chrX_+_56609751 0.34 ENSMUST00000144068.1
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr11_+_117484368 0.33 ENSMUST00000092394.3
predicted gene 11733
chr18_-_72351029 0.32 ENSMUST00000114943.3
deleted in colorectal carcinoma
chr19_-_57197556 0.32 ENSMUST00000099294.2
actin-binding LIM protein 1
chr18_-_72351009 0.31 ENSMUST00000073379.5
deleted in colorectal carcinoma
chr8_-_79399513 0.30 ENSMUST00000066091.7
ENSMUST00000109885.1
ENSMUST00000066081.3
SMAD family member 1
chr18_+_35965088 0.30 ENSMUST00000175734.1
pleckstrin and Sec7 domain containing 2
chr3_+_125404292 0.28 ENSMUST00000144344.1
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr18_+_57468478 0.28 ENSMUST00000091892.2
cortexin 3
chr4_-_97584605 0.28 ENSMUST00000107067.1
RIKEN cDNA E130114P18 gene
chr5_+_63649335 0.27 ENSMUST00000159584.1
RIKEN cDNA 3110047P20 gene
chr3_-_33082004 0.25 ENSMUST00000108225.3
peroxisomal biogenesis factor 5-like
chr4_-_97584612 0.23 ENSMUST00000107068.2
RIKEN cDNA E130114P18 gene
chr11_+_97315716 0.23 ENSMUST00000019026.3
ENSMUST00000132168.1
mitochondrial ribosomal protein L45
chr1_-_158958367 0.23 ENSMUST00000159861.2
pappalysin 2
chr1_+_88406956 0.21 ENSMUST00000027518.5
secreted phosphoprotein 2
chr17_-_54299034 0.19 ENSMUST00000095712.3
solute carrier family 5 (choline transporter), member 7
chr8_+_22624019 0.18 ENSMUST00000033936.6
dickkopf homolog 4 (Xenopus laevis)
chr9_+_54980880 0.18 ENSMUST00000093844.3
cholinergic receptor, nicotinic, alpha polypeptide 5
chr8_+_113643206 0.16 ENSMUST00000034219.4
ENSMUST00000095173.1
synaptonemal complex central element protein 1 like
chr11_-_120624973 0.16 ENSMUST00000106183.2
ENSMUST00000080202.5
sirtuin 7
chr1_-_54194048 0.16 ENSMUST00000120904.1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr3_+_70007613 0.16 ENSMUST00000053013.5
otolin 1 homolog (zebrafish)
chr19_-_45235811 0.16 ENSMUST00000099401.4
ladybird homeobox homolog 1 (Drosophila)
chr10_-_117238665 0.16 ENSMUST00000020392.4
RIKEN cDNA 9530003J23 gene
chr5_-_138272786 0.14 ENSMUST00000161279.1
ENSMUST00000161647.1
galactose-3-O-sulfotransferase 4
chr11_+_4902212 0.14 ENSMUST00000142543.1
THO complex 5
chr5_-_138272733 0.13 ENSMUST00000161665.1
ENSMUST00000100530.1
galactose-3-O-sulfotransferase 4
chr13_-_54688246 0.13 ENSMUST00000122935.1
ENSMUST00000128257.1
ring finger protein 44
chr4_-_110292719 0.13 ENSMUST00000106601.1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr19_+_59219648 0.12 ENSMUST00000065204.6
potassium channel, subfamily K, member 18
chrX_-_43274786 0.11 ENSMUST00000016294.7
teneurin transmembrane protein 1
chr10_-_117238647 0.10 ENSMUST00000159193.1
RIKEN cDNA 9530003J23 gene
chr5_-_3596071 0.09 ENSMUST00000121877.1
RNA binding motif protein 48
chr5_-_3596540 0.08 ENSMUST00000042753.7
RNA binding motif protein 48
chr7_-_105810947 0.06 ENSMUST00000176887.1
ENSMUST00000124482.1
mitochondrial ribosomal protein L17
chr16_+_32430895 0.03 ENSMUST00000115137.1
ENSMUST00000079791.4
phosphate cytidylyltransferase 1, choline, alpha isoform
chr15_+_92161343 0.01 ENSMUST00000068378.5
contactin 1
chr16_+_32431225 0.01 ENSMUST00000115140.1
phosphate cytidylyltransferase 1, choline, alpha isoform
chr19_+_55894508 0.01 ENSMUST00000142291.1
transcription factor 7 like 2, T cell specific, HMG box
chrX_-_102505359 0.00 ENSMUST00000087916.4
histone deacetylase 8
chr8_-_58911627 0.00 ENSMUST00000077447.4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut1_Cux2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
2.2 6.7 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.4 4.3 GO:0006553 lysine metabolic process(GO:0006553)
1.4 5.7 GO:0009992 cellular water homeostasis(GO:0009992)
0.9 2.8 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.6 3.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.5 3.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.5 2.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.4 2.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.4 5.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 2.0 GO:0003383 apical constriction(GO:0003383)
0.3 3.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.3 1.7 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.3 2.6 GO:0097421 liver regeneration(GO:0097421)
0.2 2.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 1.1 GO:0033762 response to glucagon(GO:0033762)
0.2 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 2.9 GO:0046415 urate metabolic process(GO:0046415)
0.2 1.2 GO:0046618 drug export(GO:0046618)
0.2 5.9 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.2 1.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 3.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 0.9 GO:0061056 sclerotome development(GO:0061056)
0.1 1.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 1.8 GO:0097264 self proteolysis(GO:0097264)
0.1 1.5 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 0.9 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.1 4.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.6 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 1.4 GO:0007567 parturition(GO:0007567)
0.1 1.2 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 1.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 2.3 GO:0014823 response to activity(GO:0014823)
0.1 1.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.5 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 1.0 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.2 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.1 1.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 0.7 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 1.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.2 GO:0045896 regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0 0.8 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.3 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 2.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.8 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.0 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.9 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.9 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.2 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.6 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 1.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 3.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.0 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0032010 phagolysosome(GO:0032010)
0.8 4.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.5 5.8 GO:0005579 membrane attack complex(GO:0005579)
0.4 2.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 2.0 GO:0033269 internode region of axon(GO:0033269)
0.1 21.7 GO:0072562 blood microparticle(GO:0072562)
0.1 1.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 1.5 GO:0005922 connexon complex(GO:0005922)
0.1 0.6 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.3 GO:0044308 axonal spine(GO:0044308)
0.1 1.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 4.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.7 GO:0030175 filopodium(GO:0030175)
0.0 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 3.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.9 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.9 5.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.7 4.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.6 3.0 GO:0055056 dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056)
0.6 15.1 GO:0001848 complement binding(GO:0001848)
0.5 2.6 GO:0008142 oxysterol binding(GO:0008142)
0.4 1.7 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.4 2.9 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 2.1 GO:0004887 thyroid hormone receptor activity(GO:0004887) thyroid hormone binding(GO:0070324)
0.2 1.4 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.2 3.2 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 4.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.2 2.3 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 1.1 GO:0017040 ceramidase activity(GO:0017040)
0.2 1.7 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 1.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.6 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.5 GO:0005243 gap junction channel activity(GO:0005243)
0.1 7.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 2.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 6.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 2.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 1.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220) choline binding(GO:0033265)
0.0 1.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 1.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.8 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 2.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0042166 acetylcholine binding(GO:0042166)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.5 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 9.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 21.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 2.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.3 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 6.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 5.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 5.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 3.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 4.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 3.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.0 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 7.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 4.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 4.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)