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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pax8

Z-value: 0.39

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Transcription factors associated with Pax8

Gene Symbol Gene ID Gene Info
Pax8
ENSMUSG00000026976.9 paired box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax8mm10_v2_chr2_-_24475596_24475605-0.372.4e-02Click!

Activity profile of Pax8 motif

Sorted Z-values of Pax8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_52863299 0.58 ENSMUST00000103616.3
Trav15d-1-dv6d-1
T cell receptor alpha variable 15D-1-DV6D-1
chr13_-_62607499 0.56 ENSMUST00000091563.4
6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr5_-_87591582 0.55 ENSMUST00000031201.7
Sult1e1
sulfotransferase family 1E, member 1
chr1_-_139608282 0.53 ENSMUST00000170441.2
Cfhr3
complement factor H-related 3
chr14_+_53676141 0.50 ENSMUST00000103662.4
Trav9-4
T cell receptor alpha variable 9-4
chr7_+_112742025 0.48 ENSMUST00000164363.1
Tead1
TEA domain family member 1
chr16_+_34784917 0.27 ENSMUST00000023538.8
Mylk
myosin, light polypeptide kinase
chr2_+_177508570 0.23 ENSMUST00000108940.2
Gm14403
predicted gene 14403
chr11_-_49114874 0.21 ENSMUST00000109201.1
Olfr1396
olfactory receptor 1396
chr6_+_127072902 0.21 ENSMUST00000000186.6
Fgf23
fibroblast growth factor 23
chr9_+_109052828 0.19 ENSMUST00000124432.1
Shisa5
shisa homolog 5 (Xenopus laevis)
chrX_+_82948861 0.19 ENSMUST00000114000.1
Dmd
dystrophin, muscular dystrophy
chrX_-_7572843 0.19 ENSMUST00000132788.1
Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr2_-_150255591 0.19 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr13_-_62520451 0.18 ENSMUST00000082203.6
ENSMUST00000101547.4
Zfp934
zinc finger protein 934
chr13_-_66852017 0.16 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr7_-_30861470 0.15 ENSMUST00000052700.3
Ffar1
free fatty acid receptor 1
chr9_-_103230262 0.14 ENSMUST00000165296.1
ENSMUST00000112645.1
ENSMUST00000166836.1
Trf
Gm20425
transferrin
predicted gene 20425
chr9_-_103230415 0.14 ENSMUST00000035158.9
Trf
transferrin
chr7_-_29906087 0.14 ENSMUST00000053521.8
Zfp27
zinc finger protein 27
chr12_+_71048338 0.13 ENSMUST00000135709.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr7_+_114768767 0.10 ENSMUST00000151464.1
Insc
inscuteable homolog (Drosophila)
chr10_+_18845071 0.10 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr5_+_91074611 0.10 ENSMUST00000031324.4
Ereg
epiregulin
chr1_+_174050375 0.10 ENSMUST00000062665.3
Olfr432
olfactory receptor 432
chr15_+_54410755 0.09 ENSMUST00000036737.3
Colec10
collectin sub-family member 10
chr11_+_78499087 0.09 ENSMUST00000017488.4
Vtn
vitronectin
chr4_+_103313806 0.09 ENSMUST00000035780.3
Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chrX_-_105391770 0.09 ENSMUST00000136406.1
ENSMUST00000150604.1
5330434G04Rik
RIKEN cDNA 5330434G04 gene
chr7_+_107595051 0.08 ENSMUST00000040056.7
Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_105391726 0.08 ENSMUST00000142109.1
5330434G04Rik
RIKEN cDNA 5330434G04 gene
chr1_+_65186727 0.08 ENSMUST00000097707.4
ENSMUST00000081154.7
Pikfyve
phosphoinositide kinase, FYVE finger containing
chr13_-_62777089 0.07 ENSMUST00000167516.2
Gm5141
predicted gene 5141
chr7_-_42578588 0.07 ENSMUST00000179470.1
Gm21028
predicted gene, 21028
chr12_-_20900867 0.07 ENSMUST00000079237.5
Zfp125
zinc finger protein 125
chr7_+_114768736 0.07 ENSMUST00000117543.1
Insc
inscuteable homolog (Drosophila)
chr1_-_92518515 0.06 ENSMUST00000062353.4
Olfr1414
olfactory receptor 1414
chr6_+_139736895 0.06 ENSMUST00000111868.3
Pik3c2g
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr15_-_101869695 0.05 ENSMUST00000087996.5
Krt77
keratin 77
chr12_+_84996487 0.04 ENSMUST00000101202.3
Ylpm1
YLP motif containing 1
chr8_-_64849818 0.04 ENSMUST00000034017.7
Klhl2
kelch-like 2, Mayven
chr7_-_141100526 0.03 ENSMUST00000097958.2
Sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr16_-_19408078 0.03 ENSMUST00000052516.4
Olfr165
olfactory receptor 165
chr5_+_100196611 0.03 ENSMUST00000066813.1
Gm9932
predicted gene 9932
chr1_+_6487231 0.03 ENSMUST00000140079.1
ENSMUST00000131494.1
St18
suppression of tumorigenicity 18
chr7_+_12897800 0.02 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
Zscan22
zinc finger and SCAN domain containing 22
chr12_-_28582515 0.02 ENSMUST00000110917.1
ENSMUST00000020965.7
Allc
allantoicase
chr19_+_46075842 0.01 ENSMUST00000165017.1
Nolc1
nucleolar and coiled-body phosphoprotein 1
chr9_+_32116040 0.00 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr17_+_21691860 0.00 ENSMUST00000072133.4
Gm10226
predicted gene 10226

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.2 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.3 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.5 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.2 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.0 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.2 GO:2001069 glycogen binding(GO:2001069)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.3 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.2 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression