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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Prox1

Z-value: 1.08

Motif logo

Transcription factors associated with Prox1

Gene Symbol Gene ID Gene Info
ENSMUSG00000010175.7 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.115.2e-01Click!

Activity profile of Prox1 motif

Sorted Z-values of Prox1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_51146757 10.17 ENSMUST00000080126.2
ribonuclease, RNase A family, 1 (pancreatic)
chr4_-_137430517 8.88 ENSMUST00000102522.4
chymotrypsin-like elastase family, member 3B
chr3_+_153844209 4.75 ENSMUST00000044089.3
ankyrin repeat and SOCS box-containing 17
chr4_-_137409777 4.69 ENSMUST00000024200.6
predicted gene 13011
chr19_-_15924560 3.87 ENSMUST00000162053.1
phosphoserine aminotransferase 1
chr18_-_68429235 3.62 ENSMUST00000052347.6
melanocortin 2 receptor
chr7_+_142441808 2.72 ENSMUST00000105971.1
ENSMUST00000145287.1
troponin I, skeletal, fast 2
chr17_+_29319183 2.54 ENSMUST00000114699.1
ENSMUST00000155348.1
peptidase inhibitor 16
chr14_-_55944536 2.52 ENSMUST00000022834.6
chymase 1, mast cell
chr4_-_68954351 2.30 ENSMUST00000030036.5
bone morphogenic protein/retinoic acid inducible neural specific 1
chr10_-_80813486 1.96 ENSMUST00000181039.1
ENSMUST00000180438.1
junctional sarcoplasmic reticulum protein 1
chr16_+_23146536 1.46 ENSMUST00000023593.5
ENSMUST00000171309.1
adiponectin, C1Q and collagen domain containing
chr6_+_60944472 1.45 ENSMUST00000129603.1
multimerin 1
chr12_-_36042476 1.44 ENSMUST00000020896.8
tetraspanin 13
chr6_-_131388417 1.32 ENSMUST00000032309.6
ENSMUST00000087865.2
Y box protein 3
chr4_-_133967235 1.27 ENSMUST00000123234.1
high mobility group nucleosomal binding domain 2
chr12_-_83487708 1.25 ENSMUST00000177959.1
ENSMUST00000178756.1
D4, zinc and double PHD fingers, family 3
chr4_+_130913264 1.23 ENSMUST00000156225.1
ENSMUST00000156742.1
lysosomal-associated protein transmembrane 5
chr15_-_80014808 1.19 ENSMUST00000000500.6
platelet derived growth factor, B polypeptide
chr8_+_88289028 1.17 ENSMUST00000171456.1
adenylate cyclase 7
chr12_-_40223149 1.11 ENSMUST00000171553.1
ENSMUST00000001672.5
interferon-related developmental regulator 1
chr17_+_47630690 1.01 ENSMUST00000024779.8
ubiquitin specific peptidase 49
chr19_+_46056539 1.00 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
peroxisome proliferative activated receptor, gamma, coactivator-related 1
chr4_+_140701466 0.98 ENSMUST00000038893.5
ENSMUST00000138808.1
regulator of chromosome condensation 2
chr4_-_131821516 0.97 ENSMUST00000097860.2
protein tyrosine phosphatase, receptor type, U
chr18_-_20682963 0.82 ENSMUST00000165229.2
predicted gene 10269
chr4_+_99829437 0.71 ENSMUST00000124547.1
ENSMUST00000106994.1
EF-hand calcium binding domain 7
chr4_+_130913120 0.71 ENSMUST00000151698.1
lysosomal-associated protein transmembrane 5
chr8_+_60632856 0.69 ENSMUST00000160719.1
microfibrillar-associated protein 3-like
chr8_-_70476911 0.66 ENSMUST00000066597.5
ENSMUST00000166976.1
kelch-like 26
chr17_-_35516780 0.63 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
transcription factor 19
chr8_+_31111816 0.62 ENSMUST00000046941.7
ring finger protein 122
chr18_+_46850034 0.61 ENSMUST00000025358.2
RIKEN cDNA 4833403I15 gene
chr17_-_70924958 0.59 ENSMUST00000180468.1
predicted gene, 26510
chr15_-_86186136 0.57 ENSMUST00000044332.9
ceramide kinase
chr7_+_127777095 0.57 ENSMUST00000144406.1
SET domain containing 1A
chr8_+_60632818 0.57 ENSMUST00000161421.1
microfibrillar-associated protein 3-like
chr2_-_26910569 0.54 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
mediator complex subunit 22
chrX_-_73966329 0.49 ENSMUST00000114372.2
ENSMUST00000033761.6
host cell factor C1
chr5_+_139252314 0.45 ENSMUST00000026976.5
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr12_+_111442653 0.44 ENSMUST00000109792.1
tumor necrosis factor, alpha-induced protein 2
chr5_+_139252343 0.43 ENSMUST00000130326.1
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr4_+_133176336 0.40 ENSMUST00000105912.1
WAS protein family, member 2
chr7_-_126861648 0.39 ENSMUST00000129812.1
ENSMUST00000106342.1
INO80 complex subunit E
chr1_+_78816909 0.38 ENSMUST00000057262.6
potassium voltage-gated channel, Isk-related subfamily, gene 4
chr2_+_36230426 0.38 ENSMUST00000062069.5
prostaglandin-endoperoxide synthase 1
chr17_+_27839974 0.35 ENSMUST00000071006.7
U1 small nuclear ribonucleoprotein C
chr12_+_111442453 0.33 ENSMUST00000102745.3
tumor necrosis factor, alpha-induced protein 2
chr10_-_81496329 0.32 ENSMUST00000020463.7
nicalin homolog (zebrafish)
chr2_+_78051155 0.30 ENSMUST00000145972.1
RIKEN cDNA 4930440I19 gene
chr12_+_40222758 0.30 ENSMUST00000038121.4
predicted gene 7008
chr14_+_24293214 0.29 ENSMUST00000162224.1
ENSMUST00000163055.1
ENSMUST00000161740.1
ENSMUST00000160710.1
ENSMUST00000041413.5
RIKEN cDNA E330034G19 gene
chr5_+_139211934 0.29 ENSMUST00000148772.1
ENSMUST00000110882.1
Sad1 and UNC84 domain containing 1
chr5_+_24100578 0.27 ENSMUST00000030841.5
ENSMUST00000163409.1
kelch-like 7
chr4_+_117835387 0.21 ENSMUST00000169885.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_-_81496313 0.21 ENSMUST00000118498.1
nicalin homolog (zebrafish)
chr1_+_161395409 0.21 ENSMUST00000028024.4
tumor necrosis factor (ligand) superfamily, member 4
chr2_+_128967383 0.20 ENSMUST00000110320.2
ENSMUST00000110319.2
zinc finger CCCH type containing 6
chr11_+_4986824 0.19 ENSMUST00000009234.9
ENSMUST00000109897.1
adaptor protein complex AP-1, beta 1 subunit
chr7_+_28716846 0.19 ENSMUST00000108279.2
F-box protein 17
chr11_-_115933464 0.17 ENSMUST00000021097.3
RecQ protein-like 5
chr2_+_78051220 0.13 ENSMUST00000144728.1
RIKEN cDNA 4930440I19 gene
chr2_-_167062981 0.12 ENSMUST00000048988.7
zinc finger, NFX1-type containing 1
chr6_+_58640536 0.10 ENSMUST00000145161.1
ENSMUST00000114294.1
ATP-binding cassette, sub-family G (WHITE), member 2
chr7_-_127449109 0.10 ENSMUST00000053392.4
zinc finger protein 689
chr17_-_37280418 0.09 ENSMUST00000077585.2
olfactory receptor 99
chr19_+_60144682 0.09 ENSMUST00000065383.4
RIKEN cDNA E330013P04 gene
chr1_-_160792908 0.09 ENSMUST00000028049.7
RAB GTPase activating protein 1-like
chr17_+_86963279 0.05 ENSMUST00000139344.1
ras homolog gene family, member Q
chrX_-_43274786 0.04 ENSMUST00000016294.7
teneurin transmembrane protein 1
chr2_+_136891501 0.03 ENSMUST00000141463.1
SLX4 interacting protein
chr7_-_101868667 0.03 ENSMUST00000150184.1
folate receptor 1 (adult)
chr7_-_127448993 0.01 ENSMUST00000106299.1
zinc finger protein 689
chr2_-_25847248 0.01 ENSMUST00000076989.6
spermatogenesis and oogenesis specific basic helix-loop-helix 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Prox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0072244 metanephric glomerular epithelium development(GO:0072244)
0.8 3.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.6 2.5 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.3 1.3 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2 1.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 1.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.2 0.5 GO:0019046 release from viral latency(GO:0019046)
0.2 2.5 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.1 10.2 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.1 0.9 GO:0071816 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 2.3 GO:0007614 short-term memory(GO:0007614)
0.1 0.4 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 4.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 1.2 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 0.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.2 GO:0002215 defense response to nematode(GO:0002215) memory T cell activation(GO:0035709) positive regulation of memory T cell differentiation(GO:0043382) negative regulation of T-helper 1 cell differentiation(GO:0045626) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 8.9 GO:0008203 cholesterol metabolic process(GO:0008203)
0.1 0.6 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 1.1 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.8 GO:0051601 exocyst localization(GO:0051601)
0.0 0.3 GO:0097240 nuclear matrix organization(GO:0043578) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) nuclear matrix anchoring at nuclear membrane(GO:0090292) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 3.6 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 1.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.1 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.0 0.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.5 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.5 GO:0031648 protein destabilization(GO:0031648)
0.0 1.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0005861 troponin complex(GO:0005861)
0.1 0.9 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.2 GO:0071565 nBAF complex(GO:0071565)
0.0 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.3 GO:0005921 gap junction(GO:0005921)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 10.2 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.6 3.6 GO:0004977 melanocortin receptor activity(GO:0004977)
0.3 2.7 GO:0031014 troponin T binding(GO:0031014)
0.2 0.6 GO:0001729 ceramide kinase activity(GO:0001729)
0.2 1.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.5 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.6 GO:1990188 euchromatin binding(GO:1990188)
0.1 1.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.8 GO:0008483 transaminase activity(GO:0008483)
0.1 11.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.5 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 1.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 2.5 GO:0030414 peptidase inhibitor activity(GO:0030414)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 7.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.6 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 2.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 4.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters