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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sox8

Z-value: 0.41

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Transcription factors associated with Sox8

Gene Symbol Gene ID Gene Info
Sox8
ENSMUSG00000024176.4 SRY (sex determining region Y)-box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox8mm10_v2_chr17_-_25570678_255706940.153.8e-01Click!

Activity profile of Sox8 motif

Sorted Z-values of Sox8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_87793470 1.77 ENSMUST00000020779.4
Mpo
myeloperoxidase
chr11_+_32286946 1.68 ENSMUST00000101387.3
Hbq1b
hemoglobin, theta 1B
chr9_+_65101453 1.49 ENSMUST00000077696.6
ENSMUST00000035499.4
ENSMUST00000166273.1
Igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chr13_+_65512678 1.35 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr9_-_61976563 0.82 ENSMUST00000113990.1
Paqr5
progestin and adipoQ receptor family member V
chr11_-_26591729 0.71 ENSMUST00000109504.1
Vrk2
vaccinia related kinase 2
chr7_-_126800354 0.57 ENSMUST00000106348.1
Aldoa
aldolase A, fructose-bisphosphate
chr11_+_11487671 0.54 ENSMUST00000020410.4
4930415F15Rik
RIKEN cDNA 4930415F15 gene
chr7_-_126800036 0.53 ENSMUST00000133514.1
ENSMUST00000151137.1
Aldoa
aldolase A, fructose-bisphosphate
chr8_-_33747724 0.48 ENSMUST00000179364.1
Smim18
small integral membrane protein 18
chr8_+_94745590 0.46 ENSMUST00000034231.3
Ccl22
chemokine (C-C motif) ligand 22
chr8_+_10006656 0.45 ENSMUST00000033892.7
Tnfsf13b
tumor necrosis factor (ligand) superfamily, member 13b
chr17_-_22007301 0.44 ENSMUST00000075018.3
Gm9772
predicted gene 9772
chr1_+_135783065 0.44 ENSMUST00000132795.1
Tnni1
troponin I, skeletal, slow 1
chr12_-_8539545 0.42 ENSMUST00000095863.3
ENSMUST00000165657.1
Slc7a15
solute carrier family 7 (cationic amino acid transporter, y+ system), member 15
chr2_+_4400958 0.41 ENSMUST00000075767.7
Frmd4a
FERM domain containing 4A
chr11_+_97415527 0.40 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chr4_+_11758147 0.39 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17
cadherin 17
chr2_-_175131864 0.34 ENSMUST00000108929.2
Gm14399
predicted gene 14399
chr7_-_42578588 0.29 ENSMUST00000179470.1
Gm21028
predicted gene, 21028
chr15_-_103215285 0.27 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
Cbx5
chromobox 5
chr9_-_95858320 0.26 ENSMUST00000178038.1
1700065D16Rik
RIKEN cDNA 1700065D16 gene
chr6_-_72380416 0.26 ENSMUST00000101285.3
ENSMUST00000074231.3
Vamp5
vesicle-associated membrane protein 5
chr5_+_17962621 0.24 ENSMUST00000030561.7
Gnat3
guanine nucleotide binding protein, alpha transducing 3
chr11_+_113659283 0.23 ENSMUST00000137878.1
Cog1
component of oligomeric golgi complex 1
chr14_-_49783327 0.22 ENSMUST00000118129.1
ENSMUST00000036972.6
3632451O06Rik
RIKEN cDNA 3632451O06 gene
chr9_-_32541589 0.21 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chrX_+_134404780 0.19 ENSMUST00000113224.2
ENSMUST00000113226.1
Drp2
dystrophin related protein 2
chr11_-_99993992 0.19 ENSMUST00000105049.1
Krtap17-1
keratin associated protein 17-1
chr11_-_118909487 0.18 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
Rbfox3
RNA binding protein, fox-1 homolog (C. elegans) 3
chr13_-_30950298 0.17 ENSMUST00000102946.1
Exoc2
exocyst complex component 2
chr6_+_129397297 0.16 ENSMUST00000032262.7
Clec1b
C-type lectin domain family 1, member b
chr13_+_93304799 0.16 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr15_-_99370427 0.16 ENSMUST00000081224.7
ENSMUST00000120633.1
ENSMUST00000088233.6
Fmnl3
formin-like 3
chr13_-_66851513 0.16 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr3_-_92485886 0.16 ENSMUST00000054599.7
Sprr1a
small proline-rich protein 1A
chr3_-_8667033 0.14 ENSMUST00000042412.3
Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr13_-_66852017 0.14 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr10_-_128180265 0.13 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr11_-_43747963 0.12 ENSMUST00000048578.2
ENSMUST00000109278.1
Ttc1
tetratricopeptide repeat domain 1
chr18_-_62741387 0.12 ENSMUST00000097557.3
Spink13
serine peptidase inhibitor, Kazal type 13
chr10_+_82378593 0.11 ENSMUST00000165906.1
Gm4924
predicted gene 4924
chr4_-_134245579 0.11 ENSMUST00000030644.7
Zfp593
zinc finger protein 593
chr6_+_92869357 0.11 ENSMUST00000113434.1
Gm15737
predicted gene 15737
chr17_+_70561739 0.11 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr11_-_69758630 0.10 ENSMUST00000058470.9
Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
chr3_+_102010138 0.09 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chrX_-_72918284 0.08 ENSMUST00000152200.1
Cetn2
centrin 2
chr18_+_36952621 0.08 ENSMUST00000115661.2
Pcdha2
protocadherin alpha 2
chr4_-_58553553 0.07 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
Lpar1
lysophosphatidic acid receptor 1
chr8_+_34807287 0.07 ENSMUST00000033930.4
Dusp4
dual specificity phosphatase 4
chr7_+_43609907 0.06 ENSMUST00000116324.2
Zfp819
zinc finger protein 819
chr4_-_129578535 0.05 ENSMUST00000052835.8
Fam167b
family with sequence similarity 167, member B
chr11_-_46166397 0.05 ENSMUST00000020679.2
Nipal4
NIPA-like domain containing 4
chr4_-_116405986 0.04 ENSMUST00000123072.1
ENSMUST00000144281.1
Mast2
microtubule associated serine/threonine kinase 2
chr1_+_109993982 0.04 ENSMUST00000027542.6
Cdh7
cadherin 7, type 2
chr3_+_96104498 0.03 ENSMUST00000132980.1
ENSMUST00000138206.1
ENSMUST00000090785.2
ENSMUST00000035519.5
Otud7b
OTU domain containing 7B
chr9_-_95815389 0.02 ENSMUST00000119760.1
Pls1
plastin 1 (I-isoform)
chr1_+_109983737 0.02 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chrX_-_23285532 0.01 ENSMUST00000115319.2
Klhl13
kelch-like 13
chr1_+_172341197 0.01 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr4_+_154142363 0.00 ENSMUST00000030895.5
Wrap73
WD repeat containing, antisense to Trp73

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.5 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.1 0.7 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1 1.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.2 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.2 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.4 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.1 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.1 GO:0060467 negative regulation of fertilization(GO:0060467)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 1.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis