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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Trp53

Z-value: 1.79

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Transcription factors associated with Trp53

Gene Symbol Gene ID Gene Info
Trp53
ENSMUSG00000059552.7 transformation related protein 53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580359_695803820.829.3e-10Click!

Activity profile of Trp53 motif

Sorted Z-values of Trp53 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_24760311 14.42 ENSMUST00000063956.5
Cd177
CD177 antigen
chr3_+_90669063 11.44 ENSMUST00000069927.8
S100a8
S100 calcium binding protein A8 (calgranulin A)
chr16_+_36253046 9.17 ENSMUST00000063539.6
2010005H15Rik
RIKEN cDNA 2010005H15 gene
chr17_-_33890539 9.02 ENSMUST00000173386.1
Kifc1
kinesin family member C1
chr17_-_33890584 8.88 ENSMUST00000114361.2
ENSMUST00000173492.1
Kifc1
kinesin family member C1
chr17_-_35066170 7.76 ENSMUST00000174190.1
ENSMUST00000097337.1
AU023871
expressed sequence AU023871
chr10_+_75564086 6.65 ENSMUST00000141062.1
ENSMUST00000152657.1
Ggt1
gamma-glutamyltransferase 1
chr4_+_115057683 6.46 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr4_+_115057410 6.23 ENSMUST00000136946.1
Tal1
T cell acute lymphocytic leukemia 1
chr17_+_28207778 6.12 ENSMUST00000002327.5
Def6
differentially expressed in FDCP 6
chr8_+_94977101 6.04 ENSMUST00000179619.1
Gpr56
G protein-coupled receptor 56
chr6_-_116461024 5.70 ENSMUST00000164547.1
ENSMUST00000170186.1
Alox5
arachidonate 5-lipoxygenase
chr14_-_55944536 5.58 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr4_+_155790439 5.36 ENSMUST00000165000.1
Ankrd65
ankyrin repeat domain 65
chr3_-_132950043 5.18 ENSMUST00000117164.1
ENSMUST00000093971.4
ENSMUST00000042729.9
ENSMUST00000042744.9
ENSMUST00000117811.1
Npnt
nephronectin
chr4_-_134254076 5.08 ENSMUST00000060050.5
Grrp1
glycine/arginine rich protein 1
chr8_-_22185758 4.97 ENSMUST00000046916.7
Ckap2
cytoskeleton associated protein 2
chr6_-_116461151 4.85 ENSMUST00000026795.6
Alox5
arachidonate 5-lipoxygenase
chr11_-_102925086 4.78 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr17_+_35821675 4.66 ENSMUST00000003635.6
Ier3
immediate early response 3
chr11_+_58948890 4.61 ENSMUST00000078267.3
Hist3h2ba
histone cluster 3, H2ba
chrX_-_142306170 4.11 ENSMUST00000134825.2
Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr9_+_72438519 4.02 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr15_+_85859689 3.90 ENSMUST00000170629.1
Gtse1
G two S phase expressed protein 1
chr6_-_128891105 3.89 ENSMUST00000178918.1
ENSMUST00000160290.1
BC035044
cDNA sequence BC035044
chr7_+_142498832 3.85 ENSMUST00000078497.8
ENSMUST00000105953.3
ENSMUST00000179658.1
ENSMUST00000105954.3
ENSMUST00000105952.3
ENSMUST00000105955.1
ENSMUST00000074187.6
ENSMUST00000180152.1
ENSMUST00000105950.4
ENSMUST00000105957.3
ENSMUST00000169299.2
ENSMUST00000105958.3
ENSMUST00000105949.1
Tnnt3
troponin T3, skeletal, fast
chr9_+_72438534 3.81 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr4_-_140810646 3.71 ENSMUST00000026377.2
Padi3
peptidyl arginine deiminase, type III
chr11_-_116076986 3.53 ENSMUST00000153408.1
Unc13d
unc-13 homolog D (C. elegans)
chr2_-_69206146 3.45 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_+_155791172 3.32 ENSMUST00000105593.1
Ankrd65
ankyrin repeat domain 65
chr6_-_136941887 3.25 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr16_+_17144600 3.23 ENSMUST00000115702.1
Ydjc
YdjC homolog (bacterial)
chr17_+_26917091 3.20 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chr14_-_37110087 3.16 ENSMUST00000179488.1
2610528A11Rik
RIKEN cDNA 2610528A11 gene
chr4_-_135573623 3.08 ENSMUST00000105855.1
Grhl3
grainyhead-like 3 (Drosophila)
chr9_+_45138437 2.94 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr9_-_21963568 2.92 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr8_-_88636117 2.82 ENSMUST00000034087.7
Snx20
sorting nexin 20
chr12_-_78906929 2.82 ENSMUST00000021544.7
Plek2
pleckstrin 2
chr11_-_102469839 2.79 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr1_-_38664947 2.79 ENSMUST00000039827.7
ENSMUST00000027250.7
Aff3
AF4/FMR2 family, member 3
chr2_-_69206133 2.69 ENSMUST00000112320.1
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr3_-_90389884 2.68 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr6_-_136941494 2.64 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr16_-_17144415 2.57 ENSMUST00000115709.1
Ccdc116
coiled-coil domain containing 116
chr6_-_136941694 2.45 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr13_+_113317084 2.44 ENSMUST00000136755.2
BC067074
cDNA sequence BC067074
chr14_-_54926784 2.38 ENSMUST00000022813.6
Efs
embryonal Fyn-associated substrate
chr5_+_144190284 2.36 ENSMUST00000060747.7
Bhlha15
basic helix-loop-helix family, member a15
chr8_-_105851981 2.36 ENSMUST00000040776.4
Cenpt
centromere protein T
chr11_+_87760533 2.35 ENSMUST00000039627.5
ENSMUST00000100644.3
Bzrap1
benzodiazepine receptor associated protein 1
chr6_+_71707561 2.32 ENSMUST00000121469.1
Reep1
receptor accessory protein 1
chr2_-_163397946 2.23 ENSMUST00000017961.4
ENSMUST00000109425.2
Jph2
junctophilin 2
chr11_-_116077606 2.20 ENSMUST00000106450.1
Unc13d
unc-13 homolog D (C. elegans)
chr1_+_171559186 2.19 ENSMUST00000004829.7
Cd244
CD244 natural killer cell receptor 2B4
chr14_-_78725089 2.19 ENSMUST00000074729.5
Dgkh
diacylglycerol kinase, eta
chr17_+_29090969 2.13 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_+_18718075 2.03 ENSMUST00000108481.1
ENSMUST00000051973.8
Psg22
pregnancy-specific glycoprotein 22
chr7_+_103937382 2.00 ENSMUST00000098189.1
Olfr632
olfactory receptor 632
chr16_+_38458887 1.99 ENSMUST00000099816.2
Cd80
CD80 antigen
chr11_-_106301801 1.97 ENSMUST00000103071.3
Gh
growth hormone
chr7_+_130865835 1.97 ENSMUST00000075181.4
ENSMUST00000048180.5
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_+_47050628 1.94 ENSMUST00000010451.5
Tmem86a
transmembrane protein 86A
chr5_+_34999111 1.94 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr5_-_30073554 1.92 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr5_+_34999046 1.91 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr14_-_70175397 1.87 ENSMUST00000143393.1
Pdlim2
PDZ and LIM domain 2
chr9_-_121792478 1.79 ENSMUST00000035110.4
Hhatl
hedgehog acyltransferase-like
chr4_-_156059414 1.71 ENSMUST00000184348.1
Ttll10
tubulin tyrosine ligase-like family, member 10
chr5_+_34999070 1.70 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr7_+_24884809 1.67 ENSMUST00000156372.1
ENSMUST00000124035.1
Rps19
ribosomal protein S19
chr7_-_24545994 1.66 ENSMUST00000011776.6
Pinlyp
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr7_+_130865756 1.61 ENSMUST00000120441.1
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_+_29889217 1.58 ENSMUST00000123335.1
Odf2
outer dense fiber of sperm tails 2
chr8_+_68880491 1.55 ENSMUST00000015712.8
Lpl
lipoprotein lipase
chr5_+_136057267 1.54 ENSMUST00000006303.4
ENSMUST00000156530.1
Upk3bl
uroplakin 3B-like
chr17_+_78882003 1.51 ENSMUST00000180880.1
Gm26637
predicted gene, 26637
chr10_+_21690845 1.50 ENSMUST00000071008.3
Gm5420
predicted gene 5420
chr5_+_34989473 1.45 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12
regulator of G-protein signaling 12
chr2_+_29890063 1.45 ENSMUST00000028128.6
Odf2
outer dense fiber of sperm tails 2
chr3_+_96172327 1.39 ENSMUST00000076372.4
Sf3b4
splicing factor 3b, subunit 4
chr15_-_102350692 1.36 ENSMUST00000041208.7
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr9_-_120068263 1.35 ENSMUST00000064165.3
ENSMUST00000177637.1
Cx3cr1
chemokine (C-X3-C) receptor 1
chr7_+_19851994 1.34 ENSMUST00000172815.1
Gm19345
predicted gene, 19345
chr5_+_114707760 1.29 ENSMUST00000094441.4
Tchp
trichoplein, keratin filament binding
chr11_-_3527916 1.23 ENSMUST00000020718.4
Smtn
smoothelin
chr13_-_12520377 1.19 ENSMUST00000179308.1
Edaradd
EDAR (ectodysplasin-A receptor)-associated death domain
chr1_-_52232296 1.19 ENSMUST00000114512.1
Gls
glutaminase
chr3_-_92621173 1.19 ENSMUST00000170676.2
Lce6a
late cornified envelope 6A
chr11_-_99322943 1.18 ENSMUST00000038004.2
Krt25
keratin 25
chr2_+_10372426 1.17 ENSMUST00000114864.2
ENSMUST00000116594.2
ENSMUST00000041105.6
Sfmbt2
Scm-like with four mbt domains 2
chr6_+_134981998 1.13 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr10_+_79822617 1.13 ENSMUST00000046833.4
Misp
mitotic spindle positioning
chr4_+_132351768 1.12 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr4_-_42853888 1.11 ENSMUST00000107979.1
Gm12429
predicted gene 12429
chr1_+_133350510 1.11 ENSMUST00000094556.2
Ren1
renin 1 structural
chr13_-_98815408 1.11 ENSMUST00000040340.8
ENSMUST00000099277.4
ENSMUST00000179563.1
ENSMUST00000109403.1
Fcho2
FCH domain only 2
chr14_+_34086008 1.09 ENSMUST00000120077.1
Anxa8
annexin A8
chr5_+_136057138 1.09 ENSMUST00000111137.1
Upk3bl
uroplakin 3B-like
chr11_-_116168138 1.07 ENSMUST00000139020.1
ENSMUST00000103031.1
ENSMUST00000124828.1
Fbf1
Fas (TNFRSF6) binding factor 1
chr14_-_20496780 0.96 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr7_+_24884651 0.95 ENSMUST00000153451.2
ENSMUST00000108429.1
Rps19
ribosomal protein S19
chr13_-_22035589 0.92 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr3_+_59925214 0.86 ENSMUST00000049476.2
C130079G13Rik
RIKEN cDNA C130079G13 gene
chr16_+_57353093 0.85 ENSMUST00000159816.1
Filip1l
filamin A interacting protein 1-like
chr2_+_86007778 0.84 ENSMUST00000062166.1
Olfr1032
olfactory receptor 1032
chr1_+_132880273 0.82 ENSMUST00000027706.3
Lrrn2
leucine rich repeat protein 2, neuronal
chr16_+_92478743 0.81 ENSMUST00000160494.1
2410124H12Rik
RIKEN cDNA 2410124H12 gene
chr10_-_130127055 0.81 ENSMUST00000074161.1
Olfr824
olfactory receptor 824
chr11_+_118476824 0.79 ENSMUST00000135383.2
Engase
endo-beta-N-acetylglucosaminidase
chr4_-_129641060 0.79 ENSMUST00000046425.9
ENSMUST00000133803.1
Txlna
taxilin alpha
chr19_-_10974664 0.77 ENSMUST00000072748.6
Ms4a10
membrane-spanning 4-domains, subfamily A, member 10
chr15_+_100154379 0.74 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr3_-_19265007 0.74 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr9_+_5298517 0.73 ENSMUST00000027015.5
Casp1
caspase 1
chr7_-_114927726 0.73 ENSMUST00000059737.2
Gm6816
predicted gene 6816
chr9_-_100486788 0.73 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr1_+_165485168 0.73 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
Adcy10
adenylate cyclase 10
chr13_+_23574381 0.72 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr1_+_55237177 0.69 ENSMUST00000061334.8
Mars2
methionine-tRNA synthetase 2 (mitochondrial)
chr7_+_24884611 0.68 ENSMUST00000108428.1
Rps19
ribosomal protein S19
chr7_+_75455534 0.68 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13
A kinase (PRKA) anchor protein 13
chr2_+_152962485 0.68 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9
tubulin tyrosine ligase-like family, member 9
chr5_-_115194283 0.66 ENSMUST00000112113.1
Cabp1
calcium binding protein 1
chr10_+_110745433 0.65 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7
E2F transcription factor 7
chr14_-_118925314 0.64 ENSMUST00000004055.8
Dzip1
DAZ interacting protein 1
chr5_-_6876523 0.64 ENSMUST00000164784.1
Zfp804b
zinc finger protein 804B
chr11_-_94782500 0.62 ENSMUST00000162809.2
Tmem92
transmembrane protein 92
chr6_+_127446819 0.62 ENSMUST00000112191.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr15_-_98004634 0.61 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1
collagen, type II, alpha 1
chr3_+_64081642 0.61 ENSMUST00000029406.4
Vmn2r1
vomeronasal 2, receptor 1
chr6_-_38837224 0.59 ENSMUST00000160962.1
Hipk2
homeodomain interacting protein kinase 2
chr12_-_74316394 0.58 ENSMUST00000110441.1
Gm11042
predicted gene 11042
chr14_-_70653081 0.55 ENSMUST00000062629.4
Npm2
nucleophosmin/nucleoplasmin 2
chr8_+_10006656 0.53 ENSMUST00000033892.7
Tnfsf13b
tumor necrosis factor (ligand) superfamily, member 13b
chr10_+_21593151 0.52 ENSMUST00000057341.4
1700020N01Rik
RIKEN cDNA 1700020N01 gene
chr1_-_79858627 0.49 ENSMUST00000027467.4
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr10_+_56377300 0.49 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr1_+_106861144 0.49 ENSMUST00000086701.6
ENSMUST00000112730.1
Serpinb5
serine (or cysteine) peptidase inhibitor, clade B, member 5
chr2_-_127521358 0.49 ENSMUST00000028850.8
ENSMUST00000103215.4
Kcnip3
Kv channel interacting protein 3, calsenilin
chr5_+_24100578 0.46 ENSMUST00000030841.5
ENSMUST00000163409.1
Klhl7
kelch-like 7
chr3_-_92573715 0.45 ENSMUST00000053107.4
Ivl
involucrin
chr6_+_128438757 0.44 ENSMUST00000144745.1
Gm10069
predicted gene 10069
chr11_+_116593687 0.44 ENSMUST00000153476.1
Aanat
arylalkylamine N-acetyltransferase
chr4_-_129640959 0.43 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
Txlna
taxilin alpha
chr5_+_36204016 0.42 ENSMUST00000052224.5
Psapl1
prosaposin-like 1
chr7_+_141079125 0.42 ENSMUST00000159375.1
Pkp3
plakophilin 3
chr1_-_74194631 0.41 ENSMUST00000053389.4
Cxcr1
chemokine (C-X-C motif) receptor 1
chrX_+_74254782 0.41 ENSMUST00000119197.1
ENSMUST00000088313.4
Emd
emerin
chr2_+_136891501 0.39 ENSMUST00000141463.1
Slx4ip
SLX4 interacting protein
chr19_-_47138280 0.39 ENSMUST00000140512.1
ENSMUST00000035822.1
Calhm2
calcium homeostasis modulator 2
chr9_-_76567092 0.37 ENSMUST00000183437.1
Fam83b
family with sequence similarity 83, member B
chr9_-_114982739 0.37 ENSMUST00000053150.5
Gm9846
predicted gene 9846
chr7_+_24399921 0.36 ENSMUST00000108434.1
Smg9
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr15_-_98004695 0.35 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr8_-_111854278 0.34 ENSMUST00000034432.5
Cfdp1
craniofacial development protein 1
chr1_+_51289106 0.33 ENSMUST00000051572.6
Sdpr
serum deprivation response
chr11_-_95699143 0.33 ENSMUST00000062249.2
Gm9796
predicted gene 9796
chr9_+_24097996 0.32 ENSMUST00000133787.1
ENSMUST00000059650.4
Npsr1
neuropeptide S receptor 1
chr14_-_49066368 0.30 ENSMUST00000161504.1
Exoc5
exocyst complex component 5
chr1_-_193130201 0.29 ENSMUST00000085555.1
Diexf
digestive organ expansion factor homolog (zebrafish)
chr16_+_20717665 0.27 ENSMUST00000021405.7
Polr2h
polymerase (RNA) II (DNA directed) polypeptide H
chr10_+_94550852 0.27 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3
transmembrane and coiled coil domains 3
chr11_-_113209633 0.24 ENSMUST00000130373.1
4732490B19Rik
RIKEN cDNA 4732490B19 gene
chr4_+_148558422 0.23 ENSMUST00000017408.7
ENSMUST00000076022.6
Exosc10
exosome component 10
chr9_+_49518336 0.22 ENSMUST00000068730.3
Gm11149
predicted gene 11149
chr10_+_80622677 0.22 ENSMUST00000079773.6
Csnk1g2
casein kinase 1, gamma 2
chr1_+_161969284 0.22 ENSMUST00000160881.1
ENSMUST00000159648.1
Pigc
phosphatidylinositol glycan anchor biosynthesis, class C
chr1_+_161969179 0.21 ENSMUST00000111594.2
ENSMUST00000028021.6
Pigc
phosphatidylinositol glycan anchor biosynthesis, class C
chr12_-_26415256 0.21 ENSMUST00000020971.6
ENSMUST00000062149.4
Rnf144a
ring finger protein 144A
chr4_+_112232245 0.21 ENSMUST00000038455.5
ENSMUST00000170945.1
Skint3
selection and upkeep of intraepithelial T cells 3
chr16_-_20316750 0.20 ENSMUST00000182741.1
Cyp2ab1
cytochrome P450, family 2, subfamily ab, polypeptide 1
chr4_+_42318334 0.19 ENSMUST00000178192.1
Gm21598
predicted gene, 21598
chr18_+_66458587 0.18 ENSMUST00000025399.7
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr19_+_46328179 0.18 ENSMUST00000026256.2
ENSMUST00000177667.1
Fbxl15
F-box and leucine-rich repeat protein 15
chr2_+_129100995 0.15 ENSMUST00000103205.4
ENSMUST00000028874.7
Polr1b
polymerase (RNA) I polypeptide B
chr15_-_98898483 0.15 ENSMUST00000023737.4
Dhh
desert hedgehog
chr6_-_118562226 0.13 ENSMUST00000112830.1
Ankrd26
ankyrin repeat domain 26
chr7_+_24399606 0.12 ENSMUST00000002280.4
Smg9
smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr9_-_106158109 0.10 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk
glycerate kinase
chr12_+_107488632 0.09 ENSMUST00000082269.2
3110018I06Rik
RIKEN cDNA 3110018I06 gene
chr7_-_28962265 0.09 ENSMUST00000068045.7
Actn4
actinin alpha 4
chr3_+_79885930 0.09 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chrX_+_136822781 0.07 ENSMUST00000113085.1
Plp1
proteolipid protein (myelin) 1
chr7_-_28962223 0.07 ENSMUST00000127210.1
Actn4
actinin alpha 4
chr9_-_106656081 0.06 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr5_-_138272786 0.06 ENSMUST00000161279.1
ENSMUST00000161647.1
Gal3st4
galactose-3-O-sulfotransferase 4
chrX_-_56549606 0.03 ENSMUST00000081133.4
Gm648
predicted gene 648
chr2_+_88817173 0.03 ENSMUST00000072057.1
Olfr1202
olfactory receptor 1202
chr16_+_91391721 0.02 ENSMUST00000160764.1
Gm21970
predicted gene 21970
chr15_-_102246439 0.02 ENSMUST00000063339.7
Rarg
retinoic acid receptor, gamma
chr7_+_82851963 0.01 ENSMUST00000179662.1
1700010L04Rik
RIKEN cDNA 1700010L04 gene
chr13_+_41148796 0.00 ENSMUST00000141292.1
Sycp2l
synaptonemal complex protein 2-like
chr7_+_5034118 0.00 ENSMUST00000076791.3
4632433K11Rik
RIKEN cDNA 4632433K11 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 17.9 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
4.2 12.7 GO:0060217 hemangioblast cell differentiation(GO:0060217)
3.8 11.4 GO:0070488 neutrophil aggregation(GO:0070488)
2.6 10.6 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
1.4 7.0 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
1.4 5.6 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
1.3 5.2 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
1.0 8.3 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.8 6.6 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.8 3.3 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.7 3.7 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.7 2.2 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.7 4.7 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.6 5.7 GO:0002432 granuloma formation(GO:0002432)
0.5 1.9 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.5 4.1 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.4 1.7 GO:2001201 regulation of transforming growth factor-beta secretion(GO:2001201)
0.4 7.8 GO:0070986 left/right axis specification(GO:0070986)
0.4 2.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.4 1.8 GO:1903059 regulation of protein lipidation(GO:1903059)
0.3 1.6 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.3 1.2 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.3 1.7 GO:0018094 protein polyglycylation(GO:0018094)
0.3 1.4 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.2 0.7 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.2 0.7 GO:0002884 regulation of type IV hypersensitivity(GO:0001807) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) negative regulation of hypersensitivity(GO:0002884)
0.2 1.1 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.2 0.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 3.7 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 1.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 2.9 GO:0061032 visceral serous pericardium development(GO:0061032)
0.2 3.4 GO:0099623 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623)
0.2 3.1 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.2 2.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 2.1 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 2.3 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 2.2 GO:0046473 phosphatidic acid metabolic process(GO:0046473)
0.1 9.6 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 0.5 GO:0031296 B cell costimulation(GO:0031296)
0.1 2.4 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.1 1.3 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 0.5 GO:0061110 dense core granule biogenesis(GO:0061110)
0.1 0.7 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.4 GO:0002159 desmosome assembly(GO:0002159)
0.1 2.0 GO:0046641 positive regulation of alpha-beta T cell proliferation(GO:0046641)
0.1 0.3 GO:1903999 negative regulation of eating behavior(GO:1903999) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.1 2.0 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.1 1.0 GO:0060174 limb bud formation(GO:0060174)
0.1 3.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.6 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 2.8 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.1 6.1 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 0.8 GO:0006517 protein deglycosylation(GO:0006517)
0.1 0.2 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 0.2 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.0 1.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.2 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.0 0.4 GO:0042435 indole-containing compound biosynthetic process(GO:0042435)
0.0 2.7 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 2.8 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.4 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0 0.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.7 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 1.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.4 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 2.7 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.0 2.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.6 GO:0006342 chromatin silencing(GO:0006342)
0.0 2.0 GO:0051028 mRNA transport(GO:0051028)
0.0 0.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.4 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0033193 Lsd1/2 complex(GO:0033193)
1.0 6.1 GO:0031262 Ndc80 complex(GO:0031262)
1.0 4.8 GO:0000235 astral microtubule(GO:0000235)
0.9 18.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.7 5.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.7 2.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.7 10.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.5 5.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 6.0 GO:0097539 ciliary transition fiber(GO:0097539)
0.4 1.1 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.3 9.6 GO:0001533 cornified envelope(GO:0001533)
0.2 2.2 GO:0030314 junctional membrane complex(GO:0030314)
0.2 3.9 GO:0005861 troponin complex(GO:0005861)
0.2 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 0.7 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 7.0 GO:0097440 apical dendrite(GO:0097440)
0.1 8.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 17.9 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 7.6 GO:0000786 nucleosome(GO:0000786)
0.1 4.4 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.1 1.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 0.4 GO:0005914 spot adherens junction(GO:0005914)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.6 GO:0042627 chylomicron(GO:0042627)
0.1 11.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.2 GO:0005871 kinesin complex(GO:0005871)
0.1 0.5 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 4.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 3.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.2 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 2.0 GO:0005643 nuclear pore(GO:0005643)
0.0 1.1 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 3.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.7 GO:0045178 basal part of cell(GO:0045178)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
1.4 11.4 GO:0050786 Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786)
1.0 8.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7 3.7 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.7 2.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.6 3.9 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.6 17.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.6 2.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.6 1.7 GO:0070737 protein-glycine ligase activity, elongating(GO:0070737)
0.6 2.8 GO:0070051 fibrinogen binding(GO:0070051)
0.6 6.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.4 2.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.4 4.1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.3 1.4 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.3 2.7 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.3 2.0 GO:0045545 syndecan binding(GO:0045545)
0.2 2.0 GO:0005131 growth hormone receptor binding(GO:0005131)
0.2 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 1.7 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.2 12.7 GO:0070888 E-box binding(GO:0070888)
0.2 7.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 1.2 GO:0004359 glutaminase activity(GO:0004359)
0.2 2.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 2.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.4 GO:0019959 interleukin-8 binding(GO:0019959)
0.1 1.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 1.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 6.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.4 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 3.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 8.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.5 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.1 2.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 8.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.6 GO:0046790 virion binding(GO:0046790)
0.1 1.2 GO:0005123 death receptor binding(GO:0005123)
0.1 0.7 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 2.6 GO:0004601 peroxidase activity(GO:0004601)
0.0 1.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 7.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.3 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 2.6 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 3.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 2.3 GO:0005178 integrin binding(GO:0005178)
0.0 3.5 GO:0042393 histone binding(GO:0042393)
0.0 1.2 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.7 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 2.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 10.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 2.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 15.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 4.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 2.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 2.9 PID EPO PATHWAY EPO signaling pathway
0.1 3.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 3.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 2.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 2.6 PID E2F PATHWAY E2F transcription factor network
0.0 1.0 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 17.9 REACTOME KINESINS Genes involved in Kinesins
0.2 5.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.8 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 6.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.9 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 8.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 3.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 0.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 2.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 9.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 6.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)