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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zfp128

Z-value: 0.87

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Transcription factors associated with Zfp128

Gene Symbol Gene ID Gene Info
Zfp128
ENSMUSG00000060397.6 zinc finger protein 128

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp128mm10_v2_chr7_+_12881165_128812040.547.0e-04Click!

Activity profile of Zfp128 motif

Sorted Z-values of Zfp128 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_76669811 4.05 ENSMUST00000037824.4
Foxh1
forkhead box H1
chr7_-_45526146 3.71 ENSMUST00000167273.1
ENSMUST00000042105.8
Ppp1r15a
protein phosphatase 1, regulatory (inhibitor) subunit 15A
chr15_-_96642883 3.61 ENSMUST00000088452.4
Slc38a1
solute carrier family 38, member 1
chr11_+_32300069 3.21 ENSMUST00000020535.1
Hbq1a
hemoglobin, theta 1A
chr4_+_126556935 2.50 ENSMUST00000048391.8
Clspn
claspin
chr6_+_128362919 2.43 ENSMUST00000073316.6
Foxm1
forkhead box M1
chr4_+_126556994 2.39 ENSMUST00000147675.1
Clspn
claspin
chr5_-_138170992 2.29 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr5_+_137761680 2.26 ENSMUST00000110983.2
ENSMUST00000031738.4
Tsc22d4
TSC22 domain family, member 4
chrX_-_134583114 2.21 ENSMUST00000113213.1
ENSMUST00000033617.6
Btk
Bruton agammaglobulinemia tyrosine kinase
chr5_-_138171248 2.14 ENSMUST00000153867.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr11_+_9191934 2.08 ENSMUST00000042740.6
Abca13
ATP-binding cassette, sub-family A (ABC1), member 13
chr5_-_138171216 1.96 ENSMUST00000147920.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr6_-_128362812 1.24 ENSMUST00000112152.1
ENSMUST00000057421.8
ENSMUST00000112151.1
Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
chr7_+_45434876 1.22 ENSMUST00000107766.1
Gys1
glycogen synthase 1, muscle
chr6_-_118562226 1.17 ENSMUST00000112830.1
Ankrd26
ankyrin repeat domain 26
chr9_+_3335470 1.10 ENSMUST00000053407.5
Alkbh8
alkB, alkylation repair homolog 8 (E. coli)
chr13_-_59769751 1.06 ENSMUST00000057115.6
Isca1
iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
chr18_-_37644185 0.97 ENSMUST00000066272.4
Taf7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr15_+_76879232 0.88 ENSMUST00000023179.5
Zfp7
zinc finger protein 7
chr3_+_103576081 0.82 ENSMUST00000183637.1
ENSMUST00000117221.2
ENSMUST00000118117.1
ENSMUST00000118563.2
Syt6
synaptotagmin VI
chr8_+_83715177 0.77 ENSMUST00000019576.8
Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr5_-_73632421 0.70 ENSMUST00000087177.2
Lrrc66
leucine rich repeat containing 66
chr5_+_144545883 0.70 ENSMUST00000071782.6
Nptx2
neuronal pentraxin 2
chr2_+_5137756 0.70 ENSMUST00000027988.7
Ccdc3
coiled-coil domain containing 3
chr8_+_83715504 0.68 ENSMUST00000109810.1
Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr7_-_45434590 0.62 ENSMUST00000107771.3
ENSMUST00000141761.1
Ruvbl2
RuvB-like protein 2
chr1_-_195092242 0.58 ENSMUST00000162650.1
ENSMUST00000160817.1
ENSMUST00000162614.1
ENSMUST00000016637.6
Cd46
CD46 antigen, complement regulatory protein
chr8_-_126945841 0.53 ENSMUST00000179857.1
Tomm20
translocase of outer mitochondrial membrane 20 homolog (yeast)
chr14_-_105896819 0.53 ENSMUST00000022709.4
Spry2
sprouty homolog 2 (Drosophila)
chr8_+_83715239 0.51 ENSMUST00000172396.1
Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr19_-_47536997 0.50 ENSMUST00000182808.1
ENSMUST00000049369.9
Obfc1
oligonucleotide/oligosaccharide-binding fold containing 1
chr3_+_79568192 0.46 ENSMUST00000091023.1
4930589L23Rik
RIKEN cDNA 4930589L23 gene
chr3_+_37420273 0.46 ENSMUST00000029277.8
Spata5
spermatogenesis associated 5
chr9_+_21411824 0.46 ENSMUST00000002902.6
Qtrt1
queuine tRNA-ribosyltransferase 1
chr6_-_145210791 0.44 ENSMUST00000111728.1
ENSMUST00000060797.7
Casc1
cancer susceptibility candidate 1
chr7_-_44929410 0.41 ENSMUST00000107857.3
ENSMUST00000085399.6
ENSMUST00000167930.1
ENSMUST00000166972.1
Ap2a1
adaptor-related protein complex 2, alpha 1 subunit
chr14_+_54894133 0.36 ENSMUST00000116476.2
ENSMUST00000022808.7
ENSMUST00000150975.1
Pabpn1
poly(A) binding protein, nuclear 1
chr7_+_45526330 0.36 ENSMUST00000120985.1
ENSMUST00000051810.8
Plekha4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr2_-_127143306 0.35 ENSMUST00000110386.1
Itpripl1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr7_-_79386943 0.34 ENSMUST00000053718.8
ENSMUST00000179243.1
Rlbp1
retinaldehyde binding protein 1
chr9_-_55048544 0.31 ENSMUST00000034854.6
Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chr7_+_24112314 0.30 ENSMUST00000120006.1
ENSMUST00000005413.3
Zfp112
zinc finger protein 112
chr2_+_71055731 0.30 ENSMUST00000154704.1
ENSMUST00000135357.1
ENSMUST00000064141.5
ENSMUST00000112159.2
ENSMUST00000102701.3
Dcaf17
DDB1 and CUL4 associated factor 17
chr2_-_127143410 0.28 ENSMUST00000132773.1
Itpripl1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr4_+_15881255 0.25 ENSMUST00000029876.1
Calb1
calbindin 1
chr15_+_76246747 0.21 ENSMUST00000023225.6
Grina
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr9_-_35176039 0.20 ENSMUST00000119847.1
ENSMUST00000034539.5
Dcps
decapping enzyme, scavenger
chrX_-_53776392 0.17 ENSMUST00000165081.1
ENSMUST00000071711.3
Zfp36l3
zinc finger protein 36, C3H type-like 3
chr17_+_33843085 0.13 ENSMUST00000002379.8
Cd320
CD320 antigen
chr3_-_79567679 0.08 ENSMUST00000076136.4
Fnip2
folliculin interacting protein 2
chr3_-_79567771 0.06 ENSMUST00000133154.1
Fnip2
folliculin interacting protein 2
chr7_-_21427941 0.02 ENSMUST00000177741.1
Gm6882
predicted gene 6882

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp128

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
1.0 4.0 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.7 2.2 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.6 6.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 3.6 GO:0006868 glutamine transport(GO:0006868)
0.4 4.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.3 0.6 GO:0043382 positive regulation of memory T cell differentiation(GO:0043382)
0.2 2.3 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 2.4 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.2 0.6 GO:0071899 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.2 1.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.4 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.8 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.4 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245)
0.1 0.5 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.1 0.3 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 1.1 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.5 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.1 0.2 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 0.7 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 2.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0031296 B cell costimulation(GO:0031296)
0.0 1.0 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.0 0.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 1.2 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 1.1 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.0 0.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.4 6.4 GO:0042555 MCM complex(GO:0042555)
0.3 3.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.6 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 1.0 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.6 GO:0097255 R2TP complex(GO:0097255)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742) ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0032433 filopodium tip(GO:0032433)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.2 GO:0016234 inclusion body(GO:0016234)
0.0 2.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.7 3.6 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.4 1.2 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.2 1.0 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.2 1.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 0.5 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.2 7.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 4.0 GO:0070410 co-SMAD binding(GO:0070410)
0.1 3.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.5 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 2.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 1.1 GO:0008198 ferrous iron binding(GO:0008198)
0.0 2.0 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0 0.3 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.6 GO:0001848 complement binding(GO:0001848)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.3 GO:0042166 acetylcholine binding(GO:0042166)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 2.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.3 PID ATR PATHWAY ATR signaling pathway
0.1 3.7 PID BMP PATHWAY BMP receptor signaling
0.1 2.2 ST GA12 PATHWAY G alpha 12 Pathway
0.1 2.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 4.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID MYC PATHWAY C-MYC pathway
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 4.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 3.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 3.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import